scholarly journals Advanced Stage at Diagnosis and Worse Clinicopathologic Features in Young Women with Breast Cancer in Brazil: A Subanalysis of the AMAZONA III Study (GBECAM 0115)

2019 ◽  
pp. 1-10 ◽  
Author(s):  
Maria Alice Franzoi ◽  
Daniela D. Rosa ◽  
Facundo Zaffaroni ◽  
Gustavo Werutsky ◽  
Sérgio Simon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Clinicopathological Features ◽  
Categorical Variables ◽  
Advanced Stage ◽  
Real World Data ◽  
Luminal B ◽  
Baseline Information ◽  
Her 2 ◽  
Grade 3

PURPOSE Breast cancer (BC) in young women is uncommon and tends to present with more aggressive characteristics. To better understand and characterize this scenario in Brazil through real-world data, we performed a subanalysis of AMAZONA III study (ClinicalTrials.gov identifier: NCT02663973 ). METHODS The AMAZONA III study (GBECAM 0115) is a prospective registry that included 2,950 women newly diagnosed with invasive BC in Brazil from January 2016 until March 2018 at 22 sites. Valid data were obtained from 2,888 patients regarding age at diagnosis and complete baseline information. To compare epidemiologic and clinicopathological features at the time of diagnosis, patients with BC were divided into two groups according to age: ≤ 40 years and > 40 years. Quantitative variables were described as means, and categorical variables were described as frequencies and percentages and compared using the Pearson’s χ2 test. RESULTS Of 2,888 women diagnosed with BC, 486 (17%) were ≤ 40 years old. Young women had higher educational level, most were employed and a significant number were married ( P < .001 for all associations). Younger patients were more symptomatic at BC diagnosis ( P < .001), and they also presented more frequently with stage III, T3/T4, grade 3 tumors, HER-2–positive, luminal B, and triple-negative subtypes. CONCLUSION Brazilian women younger than age 40 years have unfavorable clinicopathological features of BC at diagnosis, with more aggressive subtypes and advanced stage when compared with older women. These differences are not explained by socioeconomic or ethnic imbalances. The causes of a higher prevalence of BC among young women in Brazil deserve additional investigation.

Breast cancer in young women: Indian scenario.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 52-52
Author(s):  
Veda Padma Priya Selvakumar ◽  
Shubha Garg ◽  
Rajeev Kumar
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Histopathological Examination ◽  
Breast Conservation ◽  
Adjuvant Radiation ◽  
Kaplan Meier ◽  
Stage 4 ◽  
Clinicopathological Profile ◽  
Her 2 ◽  
Grade 3

52 Background: Breast cancer in young women tends to be more advanced at presentation, more aggressive in nature with poorer survival. In this background we sought to study the clinicopathological profile of patients less than 40 years diagnosed with breast cancer at our institute. Methods: Out of the 1,330 patients who underwent surgery from December 2010 to December 2014 in the breast unit at our institute, 211 women were younger than 40. We retrospectively reviewed the clinic-pathological profile of these patients. SPSS 22 was used for statistical analysis and Kaplan Meier graphs plotted. Results: Mean age of patients was 35 years. The stage distribution was Stage 0: 2, Stage I: 9, Stage II: 81, Stage III: 95 and Stage 4: 2. 123 women underwent MRM and 85 breast conservation. On histopathological examination 202 were IDC, 1 ILC, 3 Mucinous Ca and 5 DCIS. 95(45 %) were Grade 3, 54 Grade 2 and 9 Grade 1. 55 patients were TNBC and 57 Her-2-neu positive. 57 underwent NACT while the rest underwent adjuvant chemotherapy, 170 received adjuvant radiation therapy and 122 adjuvant hormonal therapy. Overall survival is 98.9 % and DFS is 91.5 % at mean follow up of 17 months. Conclusions: In contrast to worldwide literature, around 15 % of women with breast cancer presenting to our institute were less than 40 years of age. They presented late with a higher stage, higher grade, and aggressive biology.

Understanding international genomic diversity for breast cancer: Comparison of molecular subtypes of breast cancer in very young women (age ≤ 35) between Izmir (Western Turkey) and Boston (Massachusetts, USA).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12509-e12509
Author(s):  
Burcak Karaca ◽  
Tracy Ann Battaglia ◽  
Naomi Ko ◽  
Moly McCoy ◽  
Hatice Yasdik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Diversity ◽  
Young Women ◽  
Triple Negative ◽  
Molecular Subtypes ◽  
The United States ◽  
Genomic Diversity ◽  
Molecular Subtyping ◽  
Luminal B ◽  
Her 2

e12509 Background: One in forty women is diagnosed with breast cancer at a very young age (≤35 years). Studies suggest breast cancer molecular subtypes are different in young women, with a higher prevalence of triple negative and HER-2+ disease. Objective: Explore the impact of genetic diversity on molecular subtyping of very young breast cancer patients in geographically and ethnically diverse populations: Turkey and the United States. Methods: A retrospective analysis of women ≤35 years of age diagnosed with breast cancer from 1999-2011 at Ege University Faculty of Medicine (EUFM) and Boston Medical Center (BMC). Data were collected and abstracted from hospital cancer registries and electronic medical records. Molecular subtyping was based on immunohistochemical evaluation of estrogen, progesterone receptors, Ki-67, and HER2/neu. Bivariate analysis was conducted using Chi-Square and Fisher’s Exact tests. Results: There were 206 and 45 patients from EUFM and BMC, respectively. Mean age at diagnosis was 31.4±3; most were white (87%), parous (70%), had breast fed (74%), and no1st degree relatives with breast cancer (92%). BMC patients were younger (31.7±3 v. 29.9±3 p=.0006) and more racially diverse (0% v. 60% black/hispanic p <.0001). There were clinicopathological differences between EUFM and BMC, including: histological subtype (IDC 68% v. 93% p=.02), HER-2/neu positivity (60% v. 16% p <.0001), and Ki67 ≥15% (54% v. 83% p=.008). Missing data precluded subtyping in 25% and 22% of women at EUFM and BMC. Of subtypes determined, prevalence was the same; however, EUFM had more Luminal B and less Triple negative patients then BMC. Conclusions: Population-level similarities and proportional distinctions exist in molecular subtypes of breast cancer for women ≤35 years. In both countries, Luminal B and triple negative sybtypes were most common suggesting younger age rather than genetic diversity is an important determinant of molecular subtyping. [Table: see text]

New Developments in Breast Cancer Prognosis: Molecular Predictors of Treatment Response and Survival

2013 ◽  
Vol 28 (2) ◽  
pp. 131-140 ◽  
Author(s):  
Eleanor MN Foo ◽  
Maureen V Boost ◽  
Anthony SW Wong ◽  
Wings TY Loo ◽  
Louis WC Chow ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Disease Free Survival ◽  
Clinicopathological Features ◽  
Cancer Prognosis ◽  
Rank Test ◽  
Survival Outcomes ◽  
Luminal A ◽  
Luminal B ◽  
Her 2

Aim This study aimed to assess the molecular subtypes of breast cancer for patients attending a dedicated breast care center and examine the association with clinicopathological features, treatment and survival outcomes. Methods Demographic, clinicopathological and treatment details were collected from women with primary breast cancer. Immunohistochemical subtypes were also collected. The association between breast cancer subtypes and clinicopathological features was assessed using the chi-square or Fisher's exact test. Survival outcomes were compared among subtypes with the log-rank test. Results Immunohistochemical subtypes were not associated with tumor size, lymphovascular invasion or lymph node involvement but differed by histological grade (p=0.014) and nuclear grade of tumors (p=0.001). The 5-year overall survival estimates for luminal A, luminal B, HER-2-positive and triple-negative tumors were 100%, 96.2%, 71.4% and 92.3% respectively. Compared to luminal A tumors (93.4%), luminal B (80.8%), HER-2-positive (71.4%) and triple-negative (76.9%) tumors exhibited a reduced disease-free survival (DFS). Patients with ER-positive tumors had a higher DFS than their ER-negative counterparts (p=0.036). Patients with tumors expressing a low Ki-67 level had a more favorable prognosis (p=0.02). Conclusions The most prevalent luminal A subtype is associated with relatively better prognosis, whereas HER-2-positive and triple-negative tumors are prone to early relapse with diminished survival.

Molecular classification of breast cancer. Treatment and prognosis implications.

2021 ◽  
Vol 32 (2) ◽  
pp. 155-159
Author(s):  
M Alcaide Lucena ◽  
CJ Rodríguez González ◽  
S de Reyes Lartategui ◽  
R Gallart Aragón ◽  
MT Sánchez Barrón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Molecular Classification ◽  
Breast Cancer Treatment ◽  
Cáncer De Mama ◽  
Luminal A ◽  
Luminal B ◽  
Her 2

Resumen Los avances recientes en el campo de la biología molecular y la secuenciación del genoma se han traducido en una nueva clasificación del cáncer de mama, que busca mayor precisión y se correlaciona mejor con el riesgo de recaída de la enfermedad y la respuesta al tratamiento. Establece cuatro subtipos de cáncer de mama: luminal A, luminal B, HER 2 positivo y triple negativo, siendo el subtipo luminal A el de mejor pronóstico, y el triple negativo, el de peor pronóstico. Si combinamos la clasificación clásica histológica con la nueva molecular, nos permite encuadrar a estas pacientes de una forma más precisa en función del riesgo, definiendo así un manejo terapéutico adaptado.

scholarly journals Breast Cancer Subtypes Based on ER, PR and HER2/neu Expression and Its Clinico-pathological Correlation

2020 ◽  
Vol 7 (1) ◽  
pp. 30-35
Author(s):  
Nur E Jannatul Ferdous ◽  
Dabashish Patowary ◽  
Yeasmin Nahar ◽  
Mohammad Shafiul Islam ◽  
Suporna Saleh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Tumor Size ◽  
Reactivity Pattern ◽  
Cancer Subtypes ◽  
Luminal B ◽  
Therapeutic Implications ◽  
North East ◽  
The North ◽  
Her 2

Background: Carcinoma of the breast is one of the most common cancer in women and it is the second cause of cancer deaths only to lung cancer. Recent attention has been directed singularly at molecular classifications of breast cancer. Molecular subtypes have different prognostic and therapeutic implications. Objective: The aim of this study was to assess the ER, PR, and HER-2/neu reactivity pattern in breast carcinomas and to correlate this reactivity pattern with stage tumor size and lymph node metastasis. Methodology: This is a prospective analytical observational study was conducted in the North East Cancer Hospital and Department of Pathology of North East Medical College, Sylhet, Bangladesh during a 42 months period from July 2015 to December 2018. Result: Among 67 Cases of primary invasive breast carcinoma only one case was male and 66 were female. In aspect of tumor size most of the patient presented with 2 to 5cm tumor, 47(70.2%) cases and (80.6%) presented with more than 2cm tumor size. In our study 38(56.7%) cases of breast cancer found ER positive, 38.8%(26 cases) PR positive and 22.4% (15 cases) HER2/neu positive, most common presentation of the disease was at stage llB(29 cases,45%), lymph node positivity 46(68.7%) cases and lymph node negative 21(31.3%) cases, 5(7.5%)cases. In aspect of molecular subtyping we found luminl A 29 (43.3%) cases Luminal B 11.9% (8 cases) basal like 22(32.8%) cases and HER-2/neu over expressed 8(11.9%) cases. Conclusion: Cancer screening and early detection program can improve our scenario. Journal of Current and Advance Medical Research 2020;7(1): 30-35

scholarly journals Survival of Spinal Metastasis Disease based on Immunohistochemistry Subtype of Breast Cancer: A Systematic Review and Meta-analysis

2021 ◽  
Vol 9 (F) ◽  
pp. 101-105
Author(s):  
Ivan Hugo Hadisaputra ◽  
Tjokorda Gde Bagus Mahadewa ◽  
Putu Eka Mardhika
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Survival Time ◽  
Spinal Metastasis ◽  
Meta Analysis ◽  
Spinal Metastases ◽  
Luminal A ◽  
Luminal B ◽  
Moderate Growth ◽  
Her 2

BACKGROUND: Breast cancer is categorized as a slow-growth tumor in the spinal metastases disease (SMD) scoring system. Based on immunohistochemistry, breast cancer has four subtypes: Luminal A (LumA), luminal B (LumB), human epidermal growth factor 2 (Her-2) type, and triple-negative breast cancer (TNBC). TNBC has the poorest prognosis. AIM: This study aimed to describe the survival time of breast cancer with SMD based on immunohistochemistry subtypes through systematic review and meta-analysis. METHODS: This is a systematic review and meta-analysis study. This study used electronic articles published in PubMed and CENTRAL online database. We used keywords ([breast] AND [cancer] AND [spine] AND [metastasis]) to find eligible studies. Articles included were full-text studies in English. Survival time as the outcome was pooled according to the immunohistochemistry subtype of breast cancer. Statistical analysis was performed using software Stata. RESULTS: Five articles met our inclusion and exclusion criteria. LumA, LumB, Her-2 type, and TNBC have a survival time of 32.84 months, 35.20 months, 60.8 months, and 14.27 months, respectively. CONCLUSION: TNBC has the lowest survival time in the pooled analysis. We proposed TNBC be categorized as a moderate growth primary tumor.

Immunohistochemical Profiles of Breast Cancer Patients at MRCCC Siloam Semanggi Hospital in 2018

2021 ◽  
Vol 11 (5) ◽  
pp. 392-400
Author(s):  
Fajar Lamhot Gultom ◽  
Marliana Nurprilinda ◽  
Ryani Nur Cahyaning Hutami
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Subtype ◽  
Breast Cancer Patients ◽  
Ki 67 ◽  
Proliferation Markers ◽  
Luminal B ◽  
Cancer Subtype ◽  
Anatomy Laboratory ◽  
Grade Ii ◽  
Her 2

Immunohistochemistry examination (IHC) is one of the additional tests to diagnose and determine breast cancer subtype. IHC examination is a method to check intracellular protein using a monoclonal and polyclonal antibody to detect the antigen in tissue. IHC examination determined by hormone receptor markers (ER and PR), HER-2/Neu expression, and apoptotic and proliferation markers (Ki-67 and p53) can be used to determine therapy and prognosis. This study aims to determine the hormonal status of breast cancer patient at Siloam Semanggi Hospital in 2018, in the form of age, gender, pathology diagnose, and the result of IHC (ER, PR, HER2, and Ki-67). This study is a retrospective descriptive study using pathological anatomy laboratory results of breast cancer in MRCCC Siloam Semanggi Hospital and 208 patients following inclusion and exclusion criteria. The result obtained is that the age group with the highest frequency is 50-59 years, with 34.1%. The highest frequency by gender is a woman with 99.5%. Carcinoma mammae NST with grade II and III was found in 38.0% of patients. The hormonal receptor with ER and PR positive was found in 51.0% of patients. HER2 expression negative was found in 56.7% of patients. High proliferation Ki-67 was found in 82.7% of patients. Luminal B with HER2 negative subtype was found in 32.2% of patients. Patients in 50-59 years with Luminal B with HER2 negative subtype was found in 26 patients. Patients in carcinoma mammae NST with grade II with Luminal B with HER2 negative subtype was found in 27 patients. Keywords: Breast cancer, pathologic anatomy, immunohistochemistry, breast cancer subtype

Real world data of trastuzumab in the treatment of early stage HER- 2 positive breast cancer in southern of Brazil

The Breast ◽  
2019 ◽  
Vol 44 ◽  
pp. S56
Author(s):  
T. Belladona Cardoso ◽  
J.D. Lyra Batista ◽  
R.J. Vargas Alves ◽  
K. Arima Tiscoski ◽  
F. Pontes Grando
Keyword(s):  
Breast Cancer ◽  
Real World ◽  
Early Stage ◽  
Real World Data ◽  
World Data ◽  
Her 2 ◽  
Positive Breast Cancer

scholarly journals Clinical Significance of ARID1A and ANXA1 in HER-2 Positive Breast Cancer

2020 ◽  
Vol 9 (12) ◽  
pp. 3911
Author(s):  
Rita Silva-Oliveira ◽  
Filipa Ferreira Pereira ◽  
Sara Petronilho ◽  
Ana Teresa Martins ◽  
Ana Lameirinhas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Early Stage ◽  
Breast Cancer Mortality ◽  
Inverse Association ◽  
Patient Stratification ◽  
Breast Cancer Patients ◽  
Trastuzumab Resistance ◽  
Luminal B ◽  
Her 2

Background: trastuzumab is considered the standard of care for human epidermal growth factor receptor-2 (HER-2+) breast cancer patients. Regardless of the benefits of its use, many early-stage patients eventually recur, and usually, the disease progresses within a year. Since about half of the HER-2+ patients do not respond to trastuzumab, new biomarkers of prognosis and prediction are warranted to allow a better patient stratification. Annexin A1 (ANXA1) was previously reported to contribute to trastuzumab resistance through AKT activation. An association between adenine thymine-rich interactive domain 1A (ARID1A) loss and ANXA1 upregulation was also previously suggested by others. Methods: in this study, we examined tissue samples from 215 HER-2+ breast cancer patients to investigate the value of ARID1A and ANXA1 protein levels in trastuzumab response prediction and patient outcome. Expression of ARID1A and ANXA1 were assessed by immunohistochemistry. Results: contrary to what was expected, no inverse association was found between ARID1A and ANXA1 expression. HER-2+ (non-luminal) tumours displayed higher ANXA1 expression than luminal B-like (HER-2+) tumours. Concerning trastuzumab resistance, ARID1A and ANXA1 proteins did not demonstrate predictive value as biomarkers. Nevertheless, an association was depicted between ANXA1 expression and breast cancer mortality and relapse. Conclusions: overall, our results suggest that ANXA1 may be a useful prognostic marker in HER-2+ patients. Additionally, its ability to discriminate between HER-2+ (non-luminal) and luminal B-like (HER-2+) patients might assist in patient stratification regarding treatment strategy.

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