231 Background: Cancer is a complex disease that manifests differently. Quality care relies on the coordinated integration of many providers with varied background, experience, and expertise. Because care coordination spans across multiple processes (e.g., detection, diagnosis, and treatment), levels (e.g., individuals and teams), provider types (e.g., nurse and physician), specialties (e.g., surgery, radiology, and oncology), we argue that a team-based approach is necessary but solely insufficient. The current system provides care that is fragmented and evidence suggests such fragmentation is associated with missed opportunities, repetitive testing and increased costs. To mitigate fragmentation, effective cancer care requires the synthesis of multiple teams. A single team is characterized by two or more individuals working interdependently towards a shared goal. However, due to the complexity of cancer care, effective care coordination warrants multiple teams with collective, shared goals as well as potentially different, proximal goals. Effective multiteam systems (MTSs) need guidance, particularly for cancer care where this thinking is still relatively novel. With this in mind, the purpose of this paper is to contribute a theoretically grounded foundation and initial guiding principles that can inform efforts to mitigate the fragmentation in cancer care by providing insights on how to facilitate optimal MTSs. Methods: We culled the MTS literature to distill principles that are applicable for cancer care. Results: We offer seven recommendations that practitioners and healthcare delivery researchers can use to strengthen the integrated, coordinative efforts of cancer care: (1) Define the specific cancer care MTS & potential future component teams; (2) Determine critical interdependencies among the component teams; (3) Identify optimal boundary spanner(s); (4) Educate the boundary spanner on the role and responsibilities; (5) Explicate the shared and competing goals; (6) Establish a salient social identity; and (7) Incorporate pre-briefs and debriefs with ‘unlikely’ team members. Conclusions: We posit that a MTS approach is more accurate and more fruitful for examining and improving the delivery of cancer care across the cancer continuum.