Nutraceuticals Impacting Uterine Growth, Gestational Age and Mortality Rate

2019 ◽  
pp. 197-209
Author(s):  
Shrushti Patil ◽  
Natalia Mercado ◽  
Yashwant Pathak ◽  
Priyanka Bhatt
Keyword(s):  
Mortality Rate ◽  
Gestational Age ◽  
Uterine Growth

scholarly journals 39 Early Higher Parenteral Lipid Intake Decreases Extra-Uterine Growth Restriction in Very Low Birth weight Infants: A Randomized Controlled Trial

2020 ◽  
Vol 25 (Supplement_2) ◽  
pp. e15-e16
Author(s):  
Wissam Alburaki ◽  
Belal Alshaikh ◽  
Kamran Yusuf
Keyword(s):  
Weight Loss ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Very Low Birth Weight ◽  
Intervention Group ◽  
Excessive Weight Loss ◽  
Vlbw Infants ◽  
Excessive Weight ◽  
Uterine Growth

Abstract Background Approximately 43-65% of very low birth weight (VLBW) infants develop extra-uterine growth restriction (EUGR). EUGR is associated with a significant increase in the risk of neurodevelopmental impairment. Inadequate early postnatal nutrition results in excessive weight loss that cannot be explained by the physiologic contraction of body water alone. EUGR and postnatal growth failure are usually associated with negative early energy and nitrogen balance in the first week of life. Growth trajectories after initial weight loss have similar slopes regardless of gestational age, which indicates that the early excessive weight loss is a lead cause for EUGR. Objectives To study whether an early and higher parenteral lipid intake in the first week after birth would decrease the percentage of weight loss and subsequently the incidence of EUGR. Design/Methods This was a randomized, open-label, control trial of appropriate-for-gestational age VLBW infants admitted to our level III NICU. Lipid intake in the control group started at 0.5-1 g/kg/day and was increased daily by 0.5-1 g/kg/day until 3 g/kg/day was reached. The intervention group was started on 2 g/kg/day then increased to 3 g/kg/day the following day. Triglyceride levels were measured the day after the start and after each increase in lipid intake. Results Among the 176 infants assessed for eligibility, eighty-three were included in the trial. There were no significant differences between the control and the intervention group in mean gestational age (27.3 ± 2.4 vs. 27.1 ± 2.3 weeks respectively) or birth weight (1011 ± 250 vs. 1019 ± 271 g respectively). Infants in the intervention group were started on lipid earlier (13.8±7.8 vs. 17.5±7.8 h; p=0.03) and had higher cumulative lipid intake in the first 7 days of age (13.5±4.2 vs. 10.9±3.5 g/kg; p=0.004) that led to a protein to energy ratio; closer to the recommended values. Total fluid intake was similar between the two groups. Infants in the intervention group had a lower percentage of weight loss (10.4±3.6 vs. 12.7±4.6; p=0.02). The mean triglyceride level was higher in the intervention group (1.91± 0.79 vs. 1.49±0.54 mmol/L; p= 0.01), however, hypertriglyceridemia was similar between the two groups at 2 and 3 g/kg/day of lipid intake. Enteral energy and protein intake calculated weekly between the time of parenteral nutrition discontinuation and 36 weeks corrected gestational age (CGA) were similar between the 2 groups. EUGR at 36 weeks CGA was significantly lower in the intervention group (38.6% vs. 67.6%; p=0.01). Conclusion In VLBW infants, the provision of an early and higher dose of parenteral lipid in the first week of life results in less weight loss and lower incidence of EUGR.

Analysis of Infant Mortality Rate in Korea Concerning According to Birth Weight and Gestational Age from 2005 to 2009

2011 ◽  
Vol 18 (2) ◽  
pp. 182 ◽  
Author(s):  
Mi Jin Cho ◽  
Jin Hee Ko ◽  
Sung Hoon Chung ◽  
Yong Sung Choi ◽  
Won Ho Hahn ◽  
...  
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Infant Mortality ◽  
Gestational Age ◽  
Infant Mortality Rate

THE RELATIONSHIPS BETWEEN MOTHER AGES, AGE OF PREGNANCY AND GRAVIDA THROUGH THE INCIDENT OF PREEKLAMPSIA IN RSUD HOSPITAL

2018 ◽  
Vol 10 (2) ◽  
pp. 32-43
Author(s):  
Desi Desi Nurseha Meirita
Keyword(s):  
Multivariate Analysis ◽  
Mortality Rate ◽  
Maternal Mortality ◽  
Gestational Age ◽  
Medical Records ◽  
Maternal Age ◽  
P Value ◽  
Third Trimester ◽  
Maternal Mortality Rate ◽  
Secondary Methods

Based on the 2016 National Health Indicator Survey the maternal mortality rate in Indonesia is still high at 305 dead mothers per 100,000 people. The high maternal mortality rate was influenced by 28.8% due to preeclampsia. With the SDGs planned, 13 targets in point number three, one of which mentions by 2030, reduce maternal mortality to below 70 per 100,000 live births. Find out the correlation of maternal age, gestational age and gravides with the incidence of preeclampsia in RSUD Hospital Bogor in 2018. This type of research is analytical with retrospective research design. The researcher use 89 respondents to conudct this research. The Date collection is obtained by secondary methods, namely data taken from medical records. The analysis used is univariate, bivariate and multivariate analysis. Based on the results of the study found maternal age as many as 56 (62.9%) respondents, gestational age in the third trimester 70 (78.7%) respondents, multigravida as many as 59 (66.3%). Bivariate variables were found to correlate maternal age with the incidence of preeclampsia with p value of 0,004, The correlation of gestational age and the incidence of preeclampsia with p value of 0,069, The correlation of gravida with the incidence of preeclampsia with p value of 0,013. The results of multivariate analysis showed that the maternal age gravida variable had an opportunity of 0,013times greater than the gravida who experienced the incidence of preeclampsia. Maternal age variables have a greater chance of 3,006 times compared to the gravidaand gestational age that experienced the incidence of preeclampsia.

SOMATOMEDIN-LIKE ACTIVITY IN PLASMA AFTER FOETAL HYPOPHYSECTOMY OR NEPHRECTOMY AND IN EXPERIMENTAL INTRA-UTERINE GROWTH RETARDATION IN SHEEP

1979 ◽  
Vol 83 (1) ◽  
pp. 119-127 ◽  
Author(s):  
J. FALCONER ◽  
J. M. FORBES ◽  
I. C. HART ◽  
J. S. ROBINSON ◽  
G. D. THORBURN
Keyword(s):  
Growth Hormone ◽  
Gestational Age ◽  
Growth Retardation ◽  
Costal Cartilage ◽  
Maternal Plasma ◽  
Plasma Samples ◽  
Foetal Growth ◽  
Uterine Growth ◽  
The Mean ◽  
Intra Uterine Growth Retardation

SUMMARY Plasma samples from pregnant ewes and their foetuses during the last quarter of gestation were assayed for somatomedin-like activity (SLA) using the porcine costal cartilage assay. In maternal plasma, the mean potency (compared with pooled serum from six sheep) was 0·84 ± 0·05 (s.e.m.) units/ml (n = 15). Somatomedin-like activity in the plasma of five control foetuses (0·91 ± 0·1 units/ml) was similar to the maternal levels and did not change with gestational age. After foetal hypophysectomy the SLA in foetal plasma (0·37 ± 0·05 units/ ml, n = 4) was significantly less than in control animals. In two nephrectomized foetuses, the mean SLA in plasma (0·08 and 0·51 units/ml respectively) was less than in control animals. Retardation of intra-uterine foetal growth was induced by removal of endometrial caruncles before pregnancy in four sheep. The SLA in plasma from these foetuses was 0·38 ± 0·05 units/ml (P< 0·01 v. control animals). The results suggest that SLA in the foetus may be important in the regulation of foetal growth, but they also indicate that factors other than growth hormone may be important in the control of SLA in foetal plasma.

scholarly journals Nationwide Birth Weight and Gestational Age-specific Neonatal Mortality Rate in Taiwan

2015 ◽  
Vol 56 (3) ◽  
pp. 149-158 ◽  
Author(s):  
Shuo-Tse Hsu ◽  
Chia-Jung Hsieh ◽  
Hung-Wen Chen ◽  
Suh-Fang Jeng ◽  
Hui-Chen Wu ◽  
...  
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Neonatal Mortality ◽  
Gestational Age ◽  
Neonatal Mortality Rate

scholarly journals Early neonatal mortality rate and the risk factors in Wangaya hospital

2016 ◽  
Vol 48 (5) ◽  
pp. 306
Author(s):  
Made Lndah Nastiti Utami Budha ◽  
Wayan Retayasa ◽  
Made Kardana
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Mortality Rate ◽  
Neonatal Mortality ◽  
Gestational Age ◽  
Neonatal Death ◽  
Early Neonatal Death ◽  
Neonatal Mortality Rate ◽  
Early Neonatal Mortality ◽  
Early Neonatal Mortality Rate

Background The first week of life of a neonate is a critical period.In Asia, early neonatal mortality rate remains high.Objective To investigate early neonatal mortality rate and the riskfactors in Wangaya Hospital.Methods A cross sectional study was carried out retrospectivelyon neonates registered at Perinatology Unit, Wangaya HospitalDenpasar, Bali since January 2006. The study was done fromOctober to November 2007. Data was obtained from medicalrecord, analyzed as univariate using chi-square test or Fisher'sexact test and multivariate logistic regression analysis model.Results Early neonatal mortality rate in Wangaya Hospital was 38.7per 1000 livebirths. Univariate analyses showed that there werefive significant risk factors of early neonatal death, i.e., respiratorydistress, asphyxia, birth weight less than 2500 grams, sepsis, andgestational age less than 3 7 weeks. Multivariate analysis showedthat those five variables were significant as risk factors of earlyneonatal death i.e., OR (95% confidence interval) for respiratorydistress: 16.8 (3.7 to 76.6)], asphyxia: 13.5 (6.1 to 29.9)], birthweight <2500 grams: 8.1 (3.3 to 19.9)], sepsis: 7.3 (3.1 to 17.1),and gestational age <37 weeks: 3.5 (1.6 to 7.8)].Conclusions Early neonatal mortality rate in Wangaya Hospitalremains high. Respiratory distress, asphyxia, birth weight <2500gram, sepsis, and gestational age <37 weeks were independent riskfactors of early neonatal death.

scholarly journals OUTCOME OF PRETERM BABIES WITH RESPIRATORY DISTRESS SYNDROME

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Shaitan Singh Balai ◽  
Vivek Arora
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prospective Study ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Preterm Neonates ◽  
Medical College ◽  
Preterm Babies

Background: To study outcome of preterm babies with RDS in babies admitted in NICU. Methods: This study was hospital based prospective study of preterm neonates with respiratory distress syndrome admitted in NICU of MBGH RNT medical college Udaipur, from February 2017 to January 2018. Results: Among 200 preterm neonates included in the study 31 neonates expired. Mortality was 15.5%. The mortality was 10.17% among the preterm neonates with RDS and hospitalized within 6 hrs. It was 31.81% among neonates hospitalized between 6-12 hrs and 62.5% and 66.66% among neonates hospitalized between 12-24 hrs and after 24 hrs of birth respectively. Conclusion: Mortality rate is inversely related to birth weight and gestational age and directly related to age at admission and severity of respiratory distress (Silverman-Anderson score). Keywords: Preterm, Neonates, Birth weight.

scholarly journals Difference in The Incidence Severe Preeclampsia and Eclampsia between Maternal Age 20-34 Years and >34 Years in dr. Soebandi Hospital Jember

2017 ◽  
Vol 3 (2) ◽  
pp. 18
Author(s):  
Muhammad Fakhri Ali ◽  
Yonas Hadisubroto ◽  
Jauhar Firdaus
Keyword(s):  
Data Analysis ◽  
Mortality Rate ◽  
Maternal Mortality ◽  
Gestational Age ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Severe Preeclampsia ◽  
Cross Sectional ◽  
Maternal Mortality Rate ◽  
Significant Difference

Maternal Mortality Rate (MMR) in Indonesia is still high. The maternal mortality rate continues to rise due to hypertension, one of which is caused by pre-eclampsia and eclampsia. Many factors cause preeclampsia, including advanced maternal age. The purpose of this study was to determine the effect of advanced maternal age during pregnancy with severe preeclampsia and eclampsia in RSD dr. Soebandi Jember. This study used cross sectional approach using 264 samples were divided into two groups, there are pregnant women aged 20-34 years and >34 years. The results of data analysis using Chi Square for severe preeclampsia and obtained p = 0.015 and OR = 2.494, which means there is a significant difference in comparison severe preeclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 28 people suffering from severe preeclampsia (12.9%). Whereas at the age of mother> 34 years of 48 people found 13 people (27.1%) suffered severe preeclampsia Results of data analysis obtained eclampsia using Fisher and p = 0.554, which means there are no significant differences in comparison eclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 3 people suffering from eclampsia (1.38%). While at mother age> 34 years from 48 people found 1 person (2.08%) suffered eclampsia.

scholarly journals Survival and associated factors of mortality of preterm neonates admitted to Felege Hiwot specialized hospital, Bahir Dar, Ethiopia

2020 ◽  
Vol 8 ◽  
pp. 205031212095364
Author(s):  
Ayanaw Tamene ◽  
Gedefaw Abeje ◽  
Zelalem Addis
Keyword(s):  
Survival Rate ◽  
Mortality Rate ◽  
Neonatal Mortality ◽  
Gestational Age ◽  
Associated Factors ◽  
Cox Regression ◽  
Preterm Neonates ◽  
Bahir Dar ◽  
Specialized Hospital ◽  
Management Of Complications

Background: The complication of prematurity is the second commonest cause of under-five mortality in Ethiopia. Amhara region has the highest neonatal mortality rate in the country. There was no previous study and this study aimed to assess the survival of preterm neonates and its associated factors of preterm neonatal mortality admitted to Felege Hiwot Specialized Hospital, Bahir Dar, Ethiopia, to take necessary action to maximize survival of preterm babies in developing countries. Methods: A retrospective cross-sectional study was conducted among 686 preterm neonates admitted in Felege Hiwot Specialized Hospital from 1 August 2017 to 30 July 2018. Kaplan–Meier survival curve was used to show the survival rate of preterm neonates and the multivariate Cox proportional hazards model was used to identify covariates of survival of preterm neonates. Those variables having a p-value less than 0.05 were statistically significant for the survival of preterm neonates. Result: Out of 686 preterm neonates admitted from 1 August 2017 to 30 July 2018, 49.1% neonates were improved and discharged and 36.1% died. The survival rate was 0%, 19.4%, 46.7% and 75% for gestational age <28 weeks, 28–31 + 6 weeks, 32–33 + 6 weeks and 34–36 + 6 weeks, respectively. In the multivariate Cox regression model, respiratory distress syndrome, necrotizing enterocolitis, asphyxia, hospital-acquired infection, birth weight, gestational age and place of delivery were significantly associated with time to death of preterm neonates at 95% confidence level (p < 0.05). Conclusion: The mortality rate (36.1%) of preterm neonates is unacceptably high in Felege Hiwot hospital compared to other similar hospitals in Ethiopia. More than 50% of preterm neonatal deaths can be prevented with available resources. Neonatal units with adequate and committed manpower, using a strict aseptic technique, proper follow-up, early detection and timely management of complications, are recommended to improve the survival of preterm neonates.

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