Survival and associated factors of mortality of preterm neonates admitted to Felege Hiwot specialized hospital, Bahir Dar, Ethiopia

Background: The complication of prematurity is the second commonest cause of under-five mortality in Ethiopia. Amhara region has the highest neonatal mortality rate in the country. There was no previous study and this study aimed to assess the survival of preterm neonates and its associated factors of preterm neonatal mortality admitted to Felege Hiwot Specialized Hospital, Bahir Dar, Ethiopia, to take necessary action to maximize survival of preterm babies in developing countries. Methods: A retrospective cross-sectional study was conducted among 686 preterm neonates admitted in Felege Hiwot Specialized Hospital from 1 August 2017 to 30 July 2018. Kaplan–Meier survival curve was used to show the survival rate of preterm neonates and the multivariate Cox proportional hazards model was used to identify covariates of survival of preterm neonates. Those variables having a p-value less than 0.05 were statistically significant for the survival of preterm neonates. Result: Out of 686 preterm neonates admitted from 1 August 2017 to 30 July 2018, 49.1% neonates were improved and discharged and 36.1% died. The survival rate was 0%, 19.4%, 46.7% and 75% for gestational age <28 weeks, 28–31 + 6 weeks, 32–33 + 6 weeks and 34–36 + 6 weeks, respectively. In the multivariate Cox regression model, respiratory distress syndrome, necrotizing enterocolitis, asphyxia, hospital-acquired infection, birth weight, gestational age and place of delivery were significantly associated with time to death of preterm neonates at 95% confidence level (p < 0.05). Conclusion: The mortality rate (36.1%) of preterm neonates is unacceptably high in Felege Hiwot hospital compared to other similar hospitals in Ethiopia. More than 50% of preterm neonatal deaths can be prevented with available resources. Neonatal units with adequate and committed manpower, using a strict aseptic technique, proper follow-up, early detection and timely management of complications, are recommended to improve the survival of preterm neonates.

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Fetal, neonatal, and post-neonatal mortality in the 2015 Pelotas (Brazil) birth cohort and associated factors

Cadernos de Saúde Pública ◽

10.1590/0102-311x00072918 ◽

2019 ◽

Vol 35 (7) ◽

Author(s):

Andrea Ramirez Varela ◽

Bruna Celestino Schneider ◽

Susana Bubach ◽

Mariangela Freitas Silveira ◽

Andréa Dâmaso Bertoldi ◽

...

Keyword(s):

Neonatal Mortality ◽

Birth Cohort ◽

Gestational Age ◽

Associated Factors ◽

Reference Group ◽

Multinomial Logistic Regression ◽

First Year ◽

Chi Square ◽

Neonatal Deaths ◽

First Year Of Life

This study aimed to describe fetal, neonatal, and post-neonatal mortality and associated factors in participants of the 2015 Pelotas (Brazil) birth cohort. The child mortality sub-study followed up all deaths in the first year of life. Data were collected on intrauterine fetal deaths (weight ≥ 500g and/or gestational age ≥ 20 weeks), neonatal deaths (< 28 days of life), and post-neonatal deaths (from 28 days to the end of the first year of life). Descriptive analyses using the Pearson chi-square test and a multinomial logistic regression to estimate the risk of fetal, neonatal, and post-neonatal deaths compared to live infants in the cohort (reference group) were performed. Data from 4,329 eligible births were collected, of which 54 died during the fetal period. Of the 4,275 eligible live births, 59 died in the first year of life. An association between fetal, neonatal, and post-neonatal deaths (OR = 15.60, 7.63, and 5.51 respectively) was found, as well as less than six prenatal consultations. Compared to live infants, fetal deaths were more likely to occur in non-white mothers, and neonatal deaths were 14.09 times more likely to occur in a preterm gestational age (< 37 weeks). Compared to live infants, infants that were born in a C-section delivery had 3.71 increased odds of post-neonatal death. Additionally, neonatal deaths were 102.37 times more likely to have a low Apgar score on the fifth minute after birth. These findings show the need for early interventions during pregnancy, ensuring access to adequate prenatal care.

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Nationwide Birth Weight and Gestational Age-specific Neonatal Mortality Rate in Taiwan

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2014.07.006 ◽

2015 ◽

Vol 56 (3) ◽

pp. 149-158 ◽

Cited By ~ 4

Author(s):

Shuo-Tse Hsu ◽

Chia-Jung Hsieh ◽

Hung-Wen Chen ◽

Suh-Fang Jeng ◽

Hui-Chen Wu ◽

...

Keyword(s):

Birth Weight ◽

Mortality Rate ◽

Neonatal Mortality ◽

Gestational Age ◽

Neonatal Mortality Rate

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Early neonatal mortality rate and the risk factors in Wangaya hospital

Paediatrica Indonesiana ◽

10.14238/pi48.5.2008.306-11 ◽

2016 ◽

Vol 48 (5) ◽

pp. 306

Author(s):

Made Lndah Nastiti Utami Budha ◽

Wayan Retayasa ◽

Made Kardana

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Mortality Rate ◽

Neonatal Mortality ◽

Gestational Age ◽

Neonatal Death ◽

Early Neonatal Death ◽

Neonatal Mortality Rate ◽

Early Neonatal Mortality ◽

Early Neonatal Mortality Rate

Background The first week of life of a neonate is a critical period.In Asia, early neonatal mortality rate remains high.Objective To investigate early neonatal mortality rate and the riskfactors in Wangaya Hospital.Methods A cross sectional study was carried out retrospectivelyon neonates registered at Perinatology Unit, Wangaya HospitalDenpasar, Bali since January 2006. The study was done fromOctober to November 2007. Data was obtained from medicalrecord, analyzed as univariate using chi-square test or Fisher'sexact test and multivariate logistic regression analysis model.Results Early neonatal mortality rate in Wangaya Hospital was 38.7per 1000 livebirths. Univariate analyses showed that there werefive significant risk factors of early neonatal death, i.e., respiratorydistress, asphyxia, birth weight less than 2500 grams, sepsis, andgestational age less than 3 7 weeks. Multivariate analysis showedthat those five variables were significant as risk factors of earlyneonatal death i.e., OR (95% confidence interval) for respiratorydistress: 16.8 (3.7 to 76.6)], asphyxia: 13.5 (6.1 to 29.9)], birthweight <2500 grams: 8.1 (3.3 to 19.9)], sepsis: 7.3 (3.1 to 17.1),and gestational age <37 weeks: 3.5 (1.6 to 7.8)].Conclusions Early neonatal mortality rate in Wangaya Hospitalremains high. Respiratory distress, asphyxia, birth weight <2500gram, sepsis, and gestational age <37 weeks were independent riskfactors of early neonatal death.

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OUTCOME OF PRETERM BABIES WITH RESPIRATORY DISTRESS SYNDROME

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i8.2118 ◽

2021 ◽

Vol 5 (8) ◽

Author(s):

Shaitan Singh Balai ◽

Vivek Arora

Keyword(s):

Birth Weight ◽

Mortality Rate ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Prospective Study ◽

Gestational Age ◽

Distress Syndrome ◽

Preterm Neonates ◽

Medical College ◽

Preterm Babies

Background: To study outcome of preterm babies with RDS in babies admitted in NICU. Methods: This study was hospital based prospective study of preterm neonates with respiratory distress syndrome admitted in NICU of MBGH RNT medical college Udaipur, from February 2017 to January 2018. Results: Among 200 preterm neonates included in the study 31 neonates expired. Mortality was 15.5%. The mortality was 10.17% among the preterm neonates with RDS and hospitalized within 6 hrs. It was 31.81% among neonates hospitalized between 6-12 hrs and 62.5% and 66.66% among neonates hospitalized between 12-24 hrs and after 24 hrs of birth respectively. Conclusion: Mortality rate is inversely related to birth weight and gestational age and directly related to age at admission and severity of respiratory distress (Silverman-Anderson score). Keywords: Preterm, Neonates, Birth weight.

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Prevalence of Neonatal Mortality and Its Associated Factor among Neonates Who Admitted In Neonatal Intensive Care Unit At Debre Tabor General Hospital, South Gondar, Amhara, Ethiopia

10.21203/rs.3.rs-147885/v1 ◽

2021 ◽

Author(s):

Solomon kebede Demis ◽

Tigabu Munye ◽

Biniam Munye

Keyword(s):

General Hospital ◽

Neonatal Mortality ◽

Gestational Age ◽

Associated Factors ◽

Neonatal Intensive Care ◽

Sub Saharan Africa ◽

Forceps Delivery ◽

Cross Sectional ◽

Debre Tabor ◽

South Gondar

Abstract BackgroundNeonatal mortality is the death of newborn babies from the time of birth to 28 completed days of life which are the most vulnerable time for a child's survival. About one million of them passed away on their first day of life, and more than two thirds (38%) of the deaths were in sub-Saharan Africa where Ethiopia is one of the countries with the highest neonatal mortality in the world which accounts for 29 deaths per 1,000 live births.ObjectiveTo assess the prevalence and associated factors of neonatal mortality among neonates admitted in Debre Tabor General Hospital in South Gondar, Ethiopia.MethodsInstitutional based retrospective cross-sectional study design was conducted from November 1, 2018, up to January 30, 2019, in Debre Tabor General Hospital. A Structured interviewer-administered pre-tested questionnaire was used to collect data. The collected data were entered into Epi data version 4.2 and then exported into SPSS window version 24. Bivariate and multivariate analysis was undertaken and information was presented by using simple frequency tables, graphs, and pie charts.Resultthe prevalence of neonatal mortality was found to be 12.3%. Gestational age group 28–32 weeks (AOR = 9.5, 95% CI: 2.39–37.97), Gestational Age beyond 42 weeks (AOR = 4.6, 95% CI: 6.3–33.8), and forceps delivery (AOR = 0.18, 95% CI: 0.05–0.68) were found to be statistically significant.Conclusion and recommendationNeonatal mortality was higher than the national with independently associated factors of prematurity and post maturity while forceps delivery as a preventive factor. Therefore, this might be essential to the hospital NICU to plan for managing prematurity and post maturity in better quality as well as providing quality ANC and identifying most predisposing factors for prematurity.

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Short Term Outcomes of Gastric Cancer at University Teaching Hospital of Kigali (CHUK), Rwanda.

10.21203/rs.3.rs-50726/v1 ◽

2020 ◽

Author(s):

Irénée Niyongombwa ◽

Irénée David Karenzi ◽

Isaie Sibomana ◽

Vital Muvunyi ◽

Jean Marie Vianney Kagimbangabo ◽

...

Keyword(s):

Gastric Cancer ◽

Survival Rate ◽

Mortality Rate ◽

Hospital Mortality ◽

Cox Regression ◽

Advanced Disease ◽

Survival Rates ◽

University Teaching ◽

Short Term ◽

The Mean

Abstract Background: Gastric cancer is the 4th most common cause of cancer death worldwide with an annual global incidence of 985,600; two thirds of them being in the developing countries. Gastric cancer is endemic in the so called stomach cancer region comprising Rwanda, Burundi, South Western Uganda and eastern Kivu province of Democratic Republic of Congo and its incidence in Rwanda is estimated around 13 to 15 per 100,000 population. To date, the outcomes of gastric cancer in the East African region are under investigated, and the survival rate in Rwanda is not known. The aim of this study was to describe the short term outcomes (in-hospital mortality rate, length of hospital stay, 3, 6, 12 and 24 months survival rates) in patients treated for gastric cancer at CHUK.Methods: We retrospectively reviewed the data collected from records of patients who consulted CHUK over a period of 10 years from September 2007 to August 2016. Patients were followed in hospital and after discharge for survival length. Descriptive statistics were used for baseline demographic data, Kaplan-Meier model and univariate cox regression were used for survival analysis.Results: Of the 199 patients enrolled in the study, 92 (46%) were males and 107 (54%) females. The mean age was 55.4 ranging between 24 and 93. The mean symptoms duration was 15 months. Most patients consulted with advanced disease, 62.3% with distant metastases. Treatment with curative intent was offered for only 19.9% of patients. The in-hospital mortality rate was 13.3%. The 3, 6, 12 and 24 months survival rate was 52%, 40.5%, 28% and 23.4% respectively. The Overall survival rate was 7 months.Conclusion: Patients with gastric cancer have delayed consultations and advanced disease at the time of presentation. This cancer is associated with poor outcomes in terms of hospital mortality and post discharge survival rates.

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CLINICAL RISK INDEX FOR BABIES (CRIB SCORE) AS A PREDICTOR OF NEONATAL MORTALITY

Journal of University Medical & Dental College ◽

10.37723/jumdc.v10i4.70 ◽

2019 ◽

Vol 10 (4) ◽

pp. 5-10

Author(s):

Zarmast Khan ◽

Nasir Zulﬁqar ◽

Hamid Mahmood et al.

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Neonatal Mortality ◽

Gestational Age ◽

Very Low Birth Weight ◽

Risk Index ◽

Preterm Neonates ◽

Cross Sectional ◽

Study Population ◽

Crib Score

ABSTRACT:OBJECTIVE: It is very important to predict the outcome among preterm and very low birth weight babies as mortality rates are quite high. CRIB score is used to predict the outcomes in preterm neonates. The objective of this study was to determine the strength of CRIB score in detecting neonatal mortality in babies presenting with very low birth weight. STUDY DESIGN: Cross-sectional study. SUBJECTS: A total of 254 newborns with birth weight of between 500 to 1500 grams and gestational age of ≤35 weeks were included. The study was conducted over a period of 6 months in neonatology department of Shifa International Hospital, Islamabad. METHODS: CRIB score was obtained through a prospective way in all neonates and its association was assessed with mortality during neonatal intensive care unit (NICU) stay. RESULTS: The percentage of male and female newborn subjects was 54.3% (n=138) and 45.7% (n=116) respectively. Mean gestational age was 33.3 weeks ± 1.04 and mean birth weight of study population was 1129.9 grams ± 210.6. Mean CRIB score among the study population was 6.3 ± 3.1 and overall mortality was found to be 54.7% (n=139). Mean CRIB score was found to be 8.27 ± 2.1 among mortality group and it was 3.87 ± 3.4 among newborns who were discharged (P<0.05). Mortality was present in 4.3% (n=4) of neonates with CRIB score between 1-5, 87.1% (n=121) who had CRIB score between 6-10 and 100% (n=14) of neonates who had CRIB score between 1115 (P<0.05). CONCLUSION: Signiﬁcantly higher mortality was noted among neonates with higher CRIB scores.

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Comparison of Efficacy of Oral Ibuprofen versus Paracetamol for PDA Closure in Preterm Neonates

10.53350/pjmhs211582529 ◽

2021 ◽

Vol 15 (8) ◽

pp. 2529-2532

Author(s):

Muhammad Arif ◽

Asif Saleem Afridi ◽

Farman Ali ◽

Syed Ul Abrar Buneri ◽

Muhammad Salman

Keyword(s):

Mortality Rate ◽

Gestational Age ◽

Ductus Arteriosus ◽

Adverse Outcomes ◽

Preterm Neonates ◽

Closure Rate ◽

Cesarean Birth ◽

Group I ◽

Oral Ibuprofen ◽

Group Ii

Objective: The aim of this study is to compare the efficacy of oral ibuprofen versus paracetamol for PDA closure in preterm neonates. Study Design: Randomized Control trial Place and Duration: The study was conducted at Neonatology department North West General Hospital, Peshawar for duration of three years from April 2018 to March 2021. Methods: Total one hundred and fifty preterm neonates were included in this study. Patients’ detailed demographics including gestational age, gender; birth and diameter were recorded after taking informed written consent from the parents. Patients were equally divided into two groups, I and II. Group I had 75 patients and received paracetamol for closure for patent ductus arteriosus and group II received oral ibuprofen for closure of PDA. Outcomes among both groups were calculated in terms of effectiveness, mortality and post-operative complications. Data was analyzed by SPSS 22.0 version. Results: Mean gestational age of the patients in group I was 29.12±7.44 weeks and in group II mean gestational age was 30.09±4.66 weeks. 45 (65%) male in group I and in group II 40 (53.3%) were male babies. Mean ductal diameter in group I was 3.02±1.13 and in group II mean diameter was 2.98±0.16 mm. In group I cesarean birth was found in 50 (66.7%) and in group II 48 (64%) cesarean birth was found. Mean duration of closure was lower in group I 4.24±1.03 days as compared to group II 5.01±0.03 days. PDA closure rate was higher in group I 62 (82.7%) and in group II its frequency was 58 (77.3%). Re-opening of ductus was found in 6 (8%) in group I and 8 (10.7%) in group II. Adverse outcomes were renal failure, hyperbilirubinemia and gastrointestinal bleeding among both groups. Mortality rate in ibuprofen group was higher 7 (9.3%) as compared to group I 4 (5.3%). Conclusion: We concluded in this study that the use of drug paracetamol is effective for the closure of PDA in preterm neonates as compared to oral ibuprofen with less adverse outcomes and mortality rate. Keywords: PDA, Neonates, Paracetamol, Ibuprofen, Complications, Mortality

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Birthweight and gestational age‐specific neonatal mortality rate in tertiary care facilities in Eastern Central Uganda

Health Science Reports ◽

10.1002/hsr2.196 ◽

2020 ◽

Vol 3 (4) ◽

Author(s):

Paul Mubiri ◽

Harriet Nambuya ◽

Darious Kajjo ◽

Elizabeth Butrick ◽

Gertrude Namazzi ◽

...

Keyword(s):

Mortality Rate ◽

Neonatal Mortality ◽

Gestational Age ◽

Tertiary Care ◽

Neonatal Mortality Rate ◽

Care Facilities

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Prevalence of Neonatal Mortality and Its Associated Factors among Neonates Admitted In Neonatal Intensive Care Unit in Debre Tabor General Hospital, South Gondar, Ethiopia

10.21203/rs.3.rs-117809/v1 ◽

2020 ◽

Author(s):

Solomon Kebede Demis ◽

Tigabu Munye ◽

Biniam Munye

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

General Hospital ◽

Neonatal Mortality ◽

Gestational Age ◽

Associated Factors ◽

Neonatal Intensive Care ◽

Forceps Delivery ◽

Debre Tabor ◽

South Gondar

Abstract Neonatal mortality is the death of newborn babies from the time of birth to 28 completed days of life which is the most vulnerable time for a child's survival. About one million of them passed away on their first day of life, and more than two thirds (38%) of the deaths were in sub-Saharan Africa where Ethiopia is one of the countries with the highest neonatal mortality in the world which accounts for 29 deaths per 1,000 live births. Objective: To assess the prevalence and associated factors of neonatal mortality among neonates admitted in Debre Tabor General Hospital in South Gondar, Ethiopia. Methods: Institutional based retrospective cross-sectional study design was conducted from November 1, 2018, up to January 30, 2019, in Debre Tabor General Hospital. A Structured interviewer-administered pre-tested questionnaire was used to collect data. The collected data were entered into Epi data version 4.2 and then exported into SPSS window version 24. Bivariate and multivariate analysis was undertaken and information was presented by using simple frequency tables, graphs, and pie charts. Result: the prevalence of neonatal mortality was found to be 12.3%. Gestational age group 28-32 weeks (AOR=9.5, 95% CI: 2.39-37.97), Gestational Age beyond 42 weeks (AOR=4.6, 95% CI: 6.3-33.8), and forceps delivery (AOR=0.18, 95% CI: 0.05-0.68) were found to be statistically significant. Conclusion and recommendation: Neonatal mortality was higher than the national with independently associated factors of prematurity and post maturity while forceps delivery as a preventive factor. Therefore, this might be essential to the hospital neonatal intensive care unit nurse to plan for managing prematurity and post maturity in better nursing care as well as providing quality ANC and identifying most predisposing factors for prematurity.

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