Microarray Analysis of Lipid Metabolism in Drug Abuse, Neurological and Psychiatric Disorders

Author(s):  
David J. Nutt ◽  
Fergus D. Law

Drug abuse, misuse, and addiction are major issues in society because of their enormous personal, social, and economic costs and their important psychiatric components. Many drug treatment programmes are run by psychiatrists, and the evidence strongly supports the notion that a significant proportion of severe drug abusers are psychiatrically ill. Moreover, drug misuse appears to be becoming more frequent in patients with other psychiatric disorders, where it can lead to problems in treatment and poorer outcomes. It is therefore essential for all psychiatrists and related health professionals to have a good understanding of the basis of drug misuse.


1997 ◽  
Vol 42 (7) ◽  
pp. 722-729 ◽  
Author(s):  
Roger C Bland ◽  
Stephen C Newman ◽  
Helene Orn

Objective: To examine the relationship between remission of psychiatric disorders and age. Methods: We interviewed 3258 randomly selected adult residents of Edmonton using the Diagnostic Interview Schedule (DIS), which yielded DIS/DSM-III diagnoses. Remission was defined as being free of symptoms of the index lifetime disorder in the year preceding the interview, this being the difference between the lifetime and one-year prevalence. For each age group, the proportion of cases with and without symptoms in the preceding year was calculated. Numbers and proportions of cases were estimated after adjusting to the census population and weighting for household size. Only the more common disorders were examined; any comorbidities were ignored. Results: Drug abuse or dependence, antisocial personality disorder (in both sexes), and alcohol abuse or dependence (in men) all showed remission rates that increased with age. Panic disorder and obsessive–compulsive disorder (OCD) showed a decreased likelihood of remission with increasing age. Major depression and phobias showed little tendency to remission with age. Considering all disorders together, the one-year remission rate for all ages combined was only 33.2%, with a tendency for lower remission rates to be found in those aged 55 to 64. Conclusions: As may be expected, antisocial personality, drug abuse or dependence, and alcohol abuse or dependence tend to show increased remission rates with increasing age. In OCD and panic disorder, the low rates of remission found in all age groups indicate that these disorders produce significant long-term morbidity. For depression, which had an overall remission rate of less than 50%, the stable low rate of remission probably indicates not only the difficulties of treatment but also the low rates at which cases get treated.


2015 ◽  
Vol 4 (1) ◽  
pp. 58-77
Author(s):  
Nurbani Ulfah

The main problem drug users with psychiatric disorders is the difficulty of communicating the reason they use drugs and express their feelings on the condition of the Counselor or Social Worker (Therapist). The existence of the program of art therapy for patients with drug with psychiatric disorders (dual diagnosis) is part of psychotherapy as an adjunct therapy in the form of art to channel emotions, express their feelings when communicate verbally is difficult, and to express themselves freely in order to improve their condition in the direction better in recovering. In an effort to redress for victims of drug abuse, especially for people with dual diagnosis due to drug addiction, the Drug Dependency Hospital (RSKO) is a reference center for rehabilitation using the Therapeutic Community (TC) based hospitals that have programs therapies to restore health and capabilities in the field of art, one through the art therapy program.Keywords: Evaluasi Program, Art Therapy, Dual Diagnosis (NAPZA-Skizofrenia), dan Pekerja Sosial Medis/Klinis.


2002 ◽  
Vol 18 (6) ◽  
pp. 1571-1575 ◽  
Author(s):  
Claudia S. Lopes ◽  
Rosely Sichieri

We evaluated alcohol and psychiatric disorders as risk factors for the pattern of drug abuse/dependence in a matched case-control study (370 adults). Cases (drug abusers) and controls were selected in the community using the snowball technique and matched by sex, age, and friendship. Information was gathered using the "Composite International Diagnostic Interview" (CIDI). Three patterns of drug abuse/dependence were evaluated: any drug abuse/dependence, only cannabis, and cocaine and other drugs. Logistic conditional regression showed that alcohol dependence was strongly associated with pattern of drug abuse/dependence. Thus, compared to the "no drug abuse group", the odds ratio for association with diagnosis of abuse/dependence on cocaine and other drugs was 10.2 (95% CI: 4.9-21.2), whereas for abuse/dependence on cannabis only, the odds ratio was 1.0. For affective disorders, the odds ratio was 2.0 (95% CI: 1.10-3.64) for the group that received a diagnosis of abuse/dependence on cocaine and other drugs, whereas no association was found for those with abuse/dependence on cannabis only. In conclusion, there is not a homogeneous group of "drug users", and the role of risk factors depends on the drug use pattern.


PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0138874 ◽  
Author(s):  
Xinfeng Liu ◽  
Chunling Bai ◽  
Xiangbin Ding ◽  
Zhuying Wei ◽  
Hong Guo ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3406
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Kento Mio

We previously showed that supplementation of a high fat diet with paramylon (PM) reduces the postprandial glucose rise, serum total and LDL cholesterol levels, and abdominal fat accumulation in mice. The purpose of this study was to explore the underlying mechanism of PM using microarray analysis. Male mice (C57BL/BL strain) were fed an experimental diet (50% fat energy) containing 5% PM isolated from Euglena gracilis EOD-1 for 12 weeks. After confirming that PM had an improving effect on lipid metabolism, we assessed ileal and hepatic mRNA expression using DNA microarray and subsequent analysis by gene ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The results suggested that dietary supplementation with PM resulted in decreased abdominal fat accumulation and serum LDL cholesterol concentrations via suppression of the digestion and absorption pathway in the ileum and activation of the hepatic PPAR signaling pathway. Postprandial glucose rise was reduced in mice fed PM, whereas changes in the glucose metabolism pathway were not detected in GO classification and KEGG pathway analysis. PM intake might enhance serum secretory immunoglobulin A concentrations via promotion of the immunoglobulin production pathway in the ileum.


Author(s):  
A. Thomas McLellan ◽  
George E. Woody ◽  
Charles P. O'Brien

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