Vitamin E and Gene Expression

2001 ◽  
pp. 393-424
Author(s):  
Simin Nikbin Meydani ◽  
Kate J. Claycombe ◽  
Catarina Sacristán
Keyword(s):  
Gene Expression ◽  
Vitamin E

Vitamin E Mediates Cell Signaling and Regulation of Gene Expression

2004 ◽  
Vol 1031 (1) ◽  
pp. 86-95 ◽  
Author(s):  
ANGELO AZZI ◽  
RENÉ GYSIN ◽  
PETRA KEMPNÁ ◽  
ADELINA MUNTEANU ◽  
YESIM NEGIS ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin E ◽  
Cell Signaling ◽  
Regulation Of Gene Expression

scholarly journals Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 533 ◽  
Author(s):  
Shuichi Shibuya ◽  
Toshihiko Toda ◽  
Yusuke Ozawa ◽  
Mario Jose Villegas Yata ◽  
Takahiko Shimizu
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Vitamin E ◽  
Unsaturated Fatty Acids ◽  
Single Injection ◽  
Hypoxic Condition ◽  
Brazilian Amazon ◽  
Euterpe Oleracea ◽  
Anti Inflammatory ◽  
Euterpe Oleracea Mart

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

scholarly journals Age and Vitamin E-Induced Changes in Gene Expression Profiles of T Cells

2006 ◽  
Vol 177 (9) ◽  
pp. 6052-6061 ◽  
Author(s):  
Sung Nim Han ◽  
Oskar Adolfsson ◽  
Cheol-Koo Lee ◽  
Tomas A. Prolla ◽  
Jose Ordovas ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Vitamin E ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Induced Changes

scholarly journals Effects of Palm Vitamin E on Bone-Formation-Related Gene Expression in Nicotine-Treated Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Seham Salem Ahmed Abukhadir ◽  
Norazlina Mohamed ◽  
Suzana Makpol ◽  
Norliza Muhammad
Keyword(s):  
Gene Expression ◽  
Vitamin E ◽  
Bone Formation ◽  
Olive Oil ◽  
Normal Saline ◽  
Bone Morphogenetic Protein 2 ◽  
Male Rats ◽  
Oral Supplementation ◽  
Nicotine Administration ◽  
Related Transcription Factor

The study determines the effects of palm vitamin E on the gene expression of bone-formation-related genes in nicotine-treated rats. Male rats were divided into three groups: normal saline olive oil (NSO), nicotine olive oil (NO), and nicotine palm vitamin E (NE). The treatment was carried out in 2 phases. During the first 2 months, the NSO group received normal saline while the NO and NE groups received nicotine 7 mg/kg, 6 days a week, intraperitoneally. The following 2 months, normal saline and nicotine administration was stopped and was replaced with oral supplementation of olive oil for the NSO and NO groups and oral supplementation of palm vitamin E (60 mg/kg) for the NE group. Both femurs were harvested to determine the gene expression of bone morphogenetic protein-2 (BMP-2), Osterix (OSX), and Runt-related transcription factor 2 (RUNX2). Nicotine significantly downregulated the gene expression. This effect was reversed by palm vitamin E treatment. In conclusion, palm vitamin E may play a role in osteoblast differentiation and can be considered as an anabolic agent to treat nicotine-induced osteoporosis.

scholarly journals Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults

Clinics ◽  
2019 ◽  
Vol 74 ◽  
Author(s):  
Siti Madiani Abdul Ghani ◽  
Jo Aan Goon ◽  
Nor Helwa Ezzah Nor Azman ◽  
Siti Nor Asyikin Zakaria ◽  
Zalina Hamid ◽  
...  
Keyword(s):  
Gene Expression ◽  
Older Adults ◽  
Vitamin E ◽  
Healthy Older Adults ◽  
Tocotrienol Rich Fraction

Changes in hepatic gene expression and serum metabolites after oral administration of overdosed vitamin-E-loaded nanoemulsion in rats

2017 ◽  
Vol 109 ◽  
pp. 421-427 ◽  
Author(s):  
Chae Young Park ◽  
Chul Ho Jang ◽  
Do Yup Lee ◽  
Hyung Taek Cho ◽  
Young Jun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin E ◽  
Oral Administration ◽  
Hepatic Gene Expression ◽  
Serum Metabolites

Acai Extract Increases the Red Blood Cell Population via Erythropoietin Upregulation in Mice

2020 ◽  
Author(s):  
Shuichi Shibuya ◽  
Toshihiko Toda ◽  
Yusuke Ozawa ◽  
Takahiko Shimizu
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Vitamin E ◽  
Blood Cell ◽  
Blood Cells ◽  
Unsaturated Fatty Acids ◽  
Single Injection ◽  
Brazilian Amazon ◽  
Euterpe Oleracea ◽  
Euterpe Oleracea Mart

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. We then examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also significantly upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the number of blood cells through an increased erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

Effects of nicotine in the presence and absence of vitamin E on morphology, viability and osteogenic gene expression in MG-63 osteoblast-like cells

2016 ◽  
Vol 27 (6) ◽  
Author(s):  
Maryam Torshabi ◽  
Zeinab Rezaei Esfahrood ◽  
Parisan Gholamin ◽  
Elahe Karami
Keyword(s):  
Gene Expression ◽  
Vitamin E ◽  
Bone Loss ◽  
Marker Genes ◽  
Proliferation And Differentiation ◽  
Osteogenic Gene Expression ◽  
Polymerase Chain ◽  
Presence And Absence ◽  
Osteoblast Markers ◽  
Osteogenic Gene

AbstractBackground:Evidence shows that oxidative stress induced by nicotine plays an important role in bone loss. Vitamin E with its antioxidative properties may be able to reverse the effects of nicotine on bone. This study aimed to assess the effects of nicotine in the presence and absence of vitamin E on morphology, viability and osteogenic gene expression in MG-63 (osteosarcoma) human osteoblast-like cells.Methods:We treated the cells with 5 mM nicotine. The viability and morphology of cells were evaluated respectively using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) and crystal violet assays. The effect of nicotine on osteogenic gene expression in MG-63 cells was assessed by real-time reverse-transcription polymerase chain reaction of osteoblast markers, namely, alkaline phosphatase, osteocalcin and bone sialoprotein.Results:The results revealed that survival and proliferation of MG-63 cells were suppressed following exposure to nicotine, and cytoplasm vacuolization occurred in the cells. Nicotine significantly down-regulated the expression of osteogenic marker genes. Such adverse effects on morphology, viability and osteogenic gene expression of MG-63 cells were reversed by vitamin E therapy.Conclusions:In conclusion, vitamin E supplementation may play a role in proliferation and differentiation of osteoblasts, and vitamin E can be considered as an anabolic agent to treat nicotine-induced bone loss.

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