Artemisia annua  and Its Bioactive Compounds as Anti-Inflammatory Agents

2017 ◽  
pp. 83-113
Keyword(s):  
Bioactive Compounds ◽  
Artemisia Annua ◽  
Anti Inflammatory

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

scholarly journals Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)

Plants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Hosakatte Niranjana Murthy ◽  
Guggalada Govardhana Yadav ◽  
Yaser Hassan Dewir ◽  
Abdullah Ibrahim
Keyword(s):  
Biological Activity ◽  
Middle East ◽  
Bioactive Compounds ◽  
Phenolic Acids ◽  
Tree Species ◽  
Indian Subcontinent ◽  
Therapeutic Agents ◽  
Root Bark ◽  
Balanites Aegyptiaca ◽  
Anti Inflammatory

Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. Balanites aegyptiaca (L.) Delile belongs to the Zygophyllaceae family and is popularly known as “desert date”, reflecting its edible fruits. This tree grows naturally in Africa, the Middle East and the Indian subcontinent. Local inhabitants use fruits, leaves, roots, stem and root bark of the species for the treatment of various ailments. Several research studies demonstrate that extracts and phytochemicals isolated from desert date display antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, hepatoprotective and molluscicidal activities. Mesocarp of fruits, seeds, leaves, stem and root bark are rich sources of saponins. These tissues are also rich in phenolic acids, flavonoids, coumarins, alkaloids and polysterols. Some constituents show antioxidant, anticancer and antidiabetic properties. The objective of this review is to summarize studies on diverse bioactive compounds and the beneficial properties of B. aegyptiaca.

scholarly journals Pharmacological Insights into Halophyte Bioactive Extract Action on Anti-Inflammatory, Pain Relief and Antibiotics-Type Mechanisms

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3140
Author(s):  
Rocco Giordano ◽  
Zeinab Saii ◽  
Malthe Fredsgaard ◽  
Laura Sini Sofia Hulkko ◽  
Thomas Bouet Guldbæk Poulsen ◽  
...  
Keyword(s):  
Pain Relief ◽  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Medicinal Products ◽  
Salt Tolerant ◽  
Salicornia Europaea ◽  
Pharmacological Activities ◽  
Sustainable Resources ◽  
Anti Inflammatory ◽  
Significant Attention

The pharmacological activities in bioactive plant extracts play an increasing role in sustainable resources for valorization and biomedical applications. Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies. In this systematic review, the availability of bioactive compounds from several salt-tolerant plant species, mainly focusing on the three promising species Aster tripolium, Crithmum maritimum and Salicornia europaea, are summarized and discussed. All three of them have been widely used in natural folk medicines and are now in the focus for future nutraceutical and pharmacological applications.

Anti-inflammatory Effects of Plant-based Foods and of their Constituents

2008 ◽  
Vol 78 (6) ◽  
pp. 293-298 ◽  
Author(s):  
Bernhard Watzl
Keyword(s):  
Cardiovascular Diseases ◽  
Bioactive Compounds ◽  
Pathological Condition ◽  
Wide Spectrum ◽  
Bioactive Constituents ◽  
Plant Foods ◽  
Whole Wheat ◽  
Markers Of Inflammation ◽  
Inflammatory Processes ◽  
Anti Inflammatory

Inflammation is a pathological condition underlying a number of diseases including cardiovascular diseases, cancer, and chronic inflammatory diseases. In addition, healthy, obese subjects also express markers of inflammation in their blood. Diet provides a variety of nutrients as well as non-nutritive bioactive constituents which modulate immunomodulatory and inflammatory processes. Epidemiological data suggest that dietary patterns strongly affect inflammatory processes. Primarily the intake of fruit and vegetables as well as of whole wheat is inversely associated with the risk of inflammation. In addition to observational studies there are also data from human intervention studies suggesting an anti-inflammatory potential of these plant foods. At the level of bioactive compounds occurring in plant foods, primarily carotenoids and flavonoids seem to modulate inflammatory as well as immunological processes. In conclusion, there is convincing evidence that plant foods and non-nutritive constituents associated with these foods modulate immunological and inflammatory processes. By means of anti-inflammatory activities a plant-based diet may contribute to the lower risk of cardiovascular diseases and cancer. A high intake of vegetables, fruit, and whole wheat as recommended by all international nutrition authorities provides a wide spectrum of bioactive compounds at health-promoting concentrations.

An Overview of Novel Bioactive Compounds with Potent Anti-Inflammatory Activity via Dual COX-2 and 5-LOX Enzyme Inhibition

2021 ◽  
Vol 18 ◽  
Author(s):  
Roopal Mittal ◽  
Shailesh Sharma ◽  
Ajay Singh Kushwah
Keyword(s):  
Bioactive Compounds ◽  
Enzyme Inhibitors ◽  
World Health Organisation ◽  
The Body ◽  
Inflammatory Activity ◽  
World Health ◽  
Quality Data ◽  
The World ◽  
Cox 2 ◽  
Anti Inflammatory

Background: Inflammation is the earliest body defence mechanism in which the immune system recognises and counters the antigens and aids in healing the disease. The World Health Organisation suggests that inflammation is one of the greatest causes of death in the world. Inflammation could be acute or chronic due to the release of inflammatory mediators i.e. prostaglandins, leukotrienes due to mitogens, antigens or cytokines found in the body. Methods: Bibliographic database using pub med cites for peer-reviewed research articles with titles containing dual COX-2 and 5-LOX enzyme inhibitors, heterocyclic moieties, with AND Boolean operator's terms since last ten years of literature work. The quality papers containing the natural or synthetic lead compounds were extracted; the detailed study and conceptual framework attracted its attention. Results: Out of 127 research and review articles evaluated, 54 articles were cited to provide high quality data regarding pharmacoactive molecules having anti-inflammatory activity via dual COX-2/5-LOX inhibition. In addition, highlighting their in silico and experimental wet laboratory studies in increasing order over the past decade with the best illustration of dual enzyme inhibitory activity. Conclusion: This review gathered details of isolated bioactive compounds such as pyrazole, coumaperine, indoles, phenanthrene derivatives that have been significantly reported for anti-inflammatory activities.

scholarly journals Identifying bioactive phytochemicals in spent coffee grounds for cosmetic application through global metabolite analysis

2017 ◽  
Author(s):  
◽  
Jihyun Park
Keyword(s):  
Bioactive Compounds ◽  
Raw Materials ◽  
Costa Rican ◽  
Raw Material ◽  
Spent Coffee Grounds ◽  
Metabolite Analysis ◽  
Coffee Grounds ◽  
Chemical Profiles ◽  
Anti Oxidant ◽  
Anti Inflammatory

Annually, more than 6 million tons of spent coffee grounds (SCG) are generated worldwide. The present study explores the possible use of spent coffee grounds as the raw materials for cosmetics industry. The main objective of this project are to investigate the chemical profiles and identify the bioactive compounds for cosmetics application through global metabolite analysis. The compounds extracted from SCG of Ethiopia coffee (Yirgacheffe), Costa Rican coffee (Tarrazu) and Hawaiian coffee (Kona) were analyzed by ultra-high pressure liquid chromatography coupled with mass spectrometry (UPLC-MS). The ion chromatograms were submitted to XCMS platform operated by Center for Metabolomics at the Scripps Research Institute. The peak detection, peak grouping, spectra extraction, and retention alignment were processed by XCMS. The spectra were annotated and the compounds were identified and categorized by integration with METLIN, the world's largest metabolite database. Multivariate and univariate statistical analysis including PCA and cloud-plot were performed by XCMS to compare the chemical profiles between the three coffee cultivars. These analyses indicated that each cultivar showed a specific cluster. Over 200 compounds related to anti-oxidant, anti-inflammatory, anti-tyrosinase and anti-tumor for skin care application were identified by XCMS. Therefore, the presence of bioactive compounds in SCG makes it a potential source of raw material for cosmetic application (e.g., anti-oxidant, anti-inflammatory, skin-whiting, and anti-aging).

Marine Bioactive Compounds: Stereospecific Anti-Inflammatory Activity of Natural and Synthetic Cordiachromene A

1992 ◽  
Vol 32 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Abdel Fattah Benslimane ◽  
Yves François Pouchus ◽  
Jean-François Verbist ◽  
Jean-Yves Petit ◽  
En Nassiri Khettab ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Natural And Synthetic
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