Short-Term Measurement of Linear Growth in Preterm Infants: Validation of a Hand-Held Knemometer

AbstractAdiponectin and leptin are involved in appetite control and body weight regulation. We aimed to evaluate the relationship between breast milk adipokine levels and short-term growth of preterm and term infants. Thirty-one preterm (median=35.3 weeks) and 34 term (median=38.7 weeks) infants were enrolled. Enzyme-linked immunosorbent assay was used to detect adipokines in mature milk. Infant growth was followed during the first 3 months. Although weight gain in the first month was insufficient, positive linear growth was observed in the following months for preterm infants, while term infants had positive steady linear growth. The median level of adipokines was found to be higher in preterm infants (P>0.05). Adiponectin showed significant negative correlations with some anthropometric measurements of term infants. However, in preterm infants, adiponectin was negatively correlated with length increment and positively correlated with body mass index (BMI) increment in the second–third month. In addition, leptin was negatively associated with the head circumference at birth in preterm infants and the triceps skinfold thickness increment in the first–second month term infants (P<0.05). In linear regression models, while gestational age, adiponectin and leptin were not related, maternal age and pre-pregnancy BMI had effects on body weight increment in 0–1 months (P<0.05). In conclusion, adiponectin may affect short-term growth, while leptin has no important effect. It would be beneficial to carry out longitudinal studies to evaluate the effects of these adipokines on the growth of infants.

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Effect of short-term antenatal dexamethasone administration on type I collagen synthesis and degradation in preterm infants at birth

Acta Paediatrica ◽

10.1080/08035250118565 ◽

2001 ◽

Vol 90 (8) ◽

pp. 921-925

Author(s):

T Saarela, J Risteli, A Kauppila, Mai

Keyword(s):

Preterm Infants ◽

Collagen Synthesis ◽

Type I Collagen ◽

Type I ◽

Short Term ◽

Synthesis And Degradation

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The Effect of Histological Chorioamnionitis on the Short-Term Outcome of Preterm Infants Weighing ≤1,500 Grams: A Single-Center Study

American Journal of Perinatology ◽

10.1055/s-0036-1592396 ◽

2016 ◽

Vol 33 (S 01) ◽

Author(s):

M. Rinaldi ◽

C. Melillo ◽

G. Maffei ◽

A. Savastio ◽

M. Matteo ◽

...

Keyword(s):

Preterm Infants ◽

Single Center ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Single Center Study ◽

Center Study

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ASSOCIATION OF PATENT DUCTUS ARTERIOSUS SIZE WITH CLINICAL FEATURES AND SHORT-TERM OUTCOMES IN PRETERM INFANTS LESS THAN 34 WEEKS

Indian Journal of Child Health ◽

10.32677/ijch.2020.v07.i03.003 ◽

2020 ◽

Vol 07 (03) ◽

pp. 105-108

Author(s):

Chandrakala Bada Shekharappa ◽

Edison Albert Balakrishnan Elizabeth ◽

Bharathi Balachander

Keyword(s):

Patent Ductus Arteriosus ◽

Preterm Infants ◽

Clinical Features ◽

Ductus Arteriosus ◽

Short Term ◽

Patent Ductus

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A New Liquid Human Milk Fortifier and Linear Growth in Preterm Infants

PEDIATRICS ◽

10.1542/peds.2011-3120d ◽

2012 ◽

Vol 130 (4) ◽

pp. X34-X34

Keyword(s):

Human Milk ◽

Preterm Infants ◽

Linear Growth ◽

Human Milk Fortifier

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Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial

Trials ◽

10.1186/s13063-021-05351-0 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Francesco Cresi ◽

Federica Chiale ◽

Elena Maggiora ◽

Silvia Maria Borgione ◽

Mattia Ferroglio ◽

...

Keyword(s):

Preterm Infants ◽

Work Of Breathing ◽

Respiratory Rhythm ◽

Assisted Ventilation ◽

Positive Pressure ◽

Invasive Ventilation ◽

Short Term ◽

Non Invasive ◽

Non Invasive Ventilation ◽

Short Term Effects

Abstract Background Non-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infant’s breathing efforts. The aim of the study is to evaluate the short-term effects of SNIPPV vs. NIPPV on the cardiorespiratory events, trying to identify the best ventilation modality for preterm infants at their first approach to NIV ventilation support. Methods An unmasked randomized crossover study with three treatment phases was designed. All newborn infants < 32 weeks of gestational age with RDS needing NIV ventilation as first intention or after extubation will be consecutively enrolled in the study and randomized to the NIPPV or SNIPPV arm. After stabilization, enrolled patients will be alternatively ventilated with two different techniques for two time frames of 4 h each. NIPPV and SNIPPV will be administered with the same ventilator and the same interface, maintaining continuous assisted ventilation without patient discomfort. During the whole duration of the study, the patient’s cardiorespiratory data and data from the ventilator will be simultaneously recorded using a polygraph connected to a computer. The primary outcome is the frequency of episodes of oxygen desaturation. Secondary outcomes are the number of the cardiorespiratory events, FiO2 necessity, newborn pain score evaluation, synchronization index, and thoracoabdominal asynchrony. The calculated sample size was of 30 patients. Discussion It is known that NIPPV produces a percentage of ineffective acts due to asynchronies between the ventilator and the infant’s breaths. On the other hand, an ineffective synchronization could increase work of breathing. Our hypothesis is that an efficient synchronization could reduce the respiratory work and increase the volume per minute exchanged without interfering with the natural respiratory rhythm of the patient with RDS. The results of this study will allow us to evaluate the effectiveness of the synchronization, demonstrating whether SNIPPV is the most effective non-invasive ventilation mode in preterm infants with RDS at their first approach to NIV ventilation. Trial registration ClinicalTrials.gov NCT03289936. Registered on September 21, 2017.

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Maternal Vaginal Ureaplasma spp. Colonization in Early Pregnancy Is Associated with Adverse Short- and Long-Term Outcome of Very Preterm Infants

Children ◽

10.3390/children8040276 ◽

2021 ◽

Vol 8 (4) ◽

pp. 276

Author(s):

Judith Rittenschober-Böhm ◽

Tanja Habermüller ◽

Thomas Waldhoer ◽

Renate Fuiko ◽

Stefan M. Schulz ◽

...

Keyword(s):

Preterm Infants ◽

Early Pregnancy ◽

Short Term ◽

Term Outcome ◽

Long Term Outcome ◽

Very Preterm Infants ◽

Very Preterm ◽

Vaginal Colonization ◽

Short And Long Term

Vaginal colonization with Ureaplasma (U.) spp. has been shown to be associated with adverse pregnancy outcome; however, data on neonatal outcome are scarce. The aim of the study was to investigate whether maternal vaginal colonization with U. spp. in early pregnancy represents a risk factor for adverse short- or long-term outcome of preterm infants. Previously, 4330 pregnant women were enrolled in an observational multicenter study, analyzing the association between vaginal U. spp. colonization and spontaneous preterm birth. U. spp. colonization was diagnosed via PCR analysis from vaginal swabs. For this study, data on short-term outcome were collected from medical records and long-term outcome was examined via Bayley Scales of Infant Development at 24 months adjusted age. Two-hundred-and-thirty-eight children were born <33 weeks gestational age. After exclusion due to asphyxia, malformations, and lost-to-follow-up, data on short-term and long-term outcome were available from 222 and 92 infants, respectively. Results show a significant association between vaginal U. spp. colonization and severe intraventricular hemorrhage (10.4% vs. 2.6%, p = 0.03), retinopathy of prematurity (21.7% vs. 10.3%, p = 0.03), and adverse psychomotor outcome (24.3% vs. 1.8%, OR 13.154, 95%CI 1.6,110.2, p = 0.005). The data suggest an association between vaginal U. spp. colonization in early pregnancy and adverse short- and long-term outcome of very preterm infants.

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