The Relationship of Gastrinoma in MEN 1 to Helicobacter pylori infection

2020 ◽  
Vol 105 (3) ◽  
pp. e676-e682
Author(s):  
Ryan Endall ◽  
Michael Thompson ◽  
Venkat Parameswaran ◽  
John Burgess
Keyword(s):  
Helicobacter Pylori ◽  
Serum Gastrin ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Men 1 ◽  
Serum Gastrin Concentration ◽  
H Pylori ◽  
Sectional Analysis ◽  
Relationship Of ◽  
The Relationship

Abstract Context Helicobacter pylori and Multiple Endocrine Neoplasia Type 1 (MEN 1) are risk factors for hypergastrinemia. Gastrin-secreting neoplasms of the foregut mucosa are both a source of, and potentially stimulated by, hypergastrinemia. Objective To determine the relationship between H pylori exposure and the prevalence and severity of hypergastrinemia in patients with MEN 1. Design, setting & patients Cross-sectional analysis of patients with a common MEN1 gene mutation managed at a tertiary referral hospital that underwent fasting serum gastrin and H pylori serum IgG measurement. Intervention H pylori IgG and serum gastrin concentration, determined via immunoassay. Main outcome measures The prevalence and severity of hypergastrinemia and its relationship to past H pylori exposure. Results Thirty-four of 95 (36%) patients were H pylori IgG seropositive. H pylori seropositive patients were significantly more likely to exhibit hypergastrinemia compared with seronegative patients (relative risk [RR] 1.72, P = .023). H pylori exposure also predicted severe hypergastrinemia (RR 3.52, P = .026 and RR 9.37, P = .031 for patients with gastrin ≥ ×4 and ≥ ×8 the upper limit of normal [ULN], respectively). Gastrin concentrations ≥ ×10 ULN occurred exclusively in H pylori seropositive patients (0/61 vs 6/34, P = .001). Serum gastrin and alpha subunit were positively associated in H pylori-exposed (β = 0.69, P = .001), but not in H pylori-unexposed patients. Conclusion Past H pylori exposure was associated with increased prevalence and severity of hypergastrinemia in MEN 1 patients. Past H pylori-related hypergastrinemia may contribute to the pathogenesis of ongoing gastrin hypersecretion by susceptible foregut neuroendocrine tissues.

scholarly journals Presence of Helicobacter pylori infection in gastroduodenal perforations

2020 ◽  
Vol 7 (6) ◽  
pp. 1908
Author(s):  
Kemparaj T. ◽  
Ashika Bagur
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Ulcer Disease ◽  
Surgical Emergencies ◽  
Gastroduodenal Perforation ◽  
H Pylori ◽  
A Prospective Study ◽  
Duodenal Perforations ◽  
Relationship Of ◽  
The Relationship

Background: Gastroduodenal perforations constitute one of the commonest surgical emergencies encountered. Helicobacter pylori is a gram negative bacterium that has infected more than half the world’s population. The most commonly recognized manifestation of H. pylori infection in India is peptic ulcer disease. Although the relationship between H. pylori infection and peptic ulcer has been well defined, the relationship of H. pylori infection with gastroduodenal perforation is still controversial. The objective of the study was to determine the presence of H. pylori in gastroduodenal perforations.Methods: We conducted a prospective study, noting the number of cases which turned out to be positive for H. pylori in cases of gastroduodenal perforations intraoperatively, using rapid urease test.Results: Out of 100 cases of gastroduodenal perforations operated, 74% were positive for the test. Gastric perforations positive for the test were 81.4% and duodenal perforations positive for the test were 68.42%.Conclusions: There is a positive attribution between H. pylori infection and gastroduodenal perforations.

The Relationship of Venous Diameter to Reflux, Cephalad Thrombus and Cephalad Reflux Following Deep Venous Thrombosis

1997 ◽  
Vol 77 (03) ◽  
pp. 462-465 ◽  
Author(s):  
M J Tullis ◽  
M H Meissner ◽  
R O Bergelin ◽  
M T Caps ◽  
R A Manzo ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Previous History ◽  
Cross Sectional ◽  
History Of ◽  
Venous Diameter ◽  
The Common ◽  
Sectional Analysis ◽  
Relationship Of ◽  
The Relationship

SummaryDuplex ultrasonography was used to measure the diameters of the common femoral, superficial femoral and popliteal vein segments in 123 patients following DVT. A cross sectional analysis was done based on the most recent visit to determine chronic venous diameter changes following DVT.Venous diameters in recanalized segments were smaller at all levels compared to those never occluded (p = 0.06 for CFV and p <0.05 for SFV and PV). After accounting for a previous history of occlusion, the diameters of the segments with and without reflux were not significantly different. There was also no evidence of venodilation in segments caudal to cephalad reflux or thrombus.Recanalized veins are smaller in diameter than those which were never thrombosed. Cephalad thrombus or reflux is not associated with venodilatation of caudal segments. Reflux following DVT is probably secondary to valvular damage rather than hypertension, since there was no diameter difference between refluxing and non-refluxing segments.

scholarly journals The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

2020 ◽  
Vol 17 (7) ◽  
pp. 2524
Author(s):  
Yun-A Kim ◽  
Yoon Jeong Cho ◽  
Sang Gyu Kwak
Keyword(s):  
Helicobacter Pylori ◽  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
H Pylori ◽  
Irritable Bowel ◽  
The Relationship

The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case–control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93–1.29, I2: 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93–1.30, I2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.

scholarly journals Correlation between the Intensity of Helicobacter pylori Colonization and Severity of Gastritis

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Hamid Reza Ghasemi Basir ◽  
Mehdi Ghobakhlou ◽  
Parvin Akbari ◽  
Arash Dehghan ◽  
Mohamad Ali Seif Rabiei
Keyword(s):  
Helicobacter Pylori ◽  
Chronic Gastritis ◽  
Cross Sectional Study ◽  
Lymphoid Follicle ◽  
Pathological Findings ◽  
Sectional Study ◽  
Cross Sectional ◽  
H Pylori ◽  
The Relationship ◽  
Colonization Rates

Background. The most common cause of chronic gastritis is infection with Helicobacter pylori. Identifying the relationship between intensities of colonization and activity of gastritis helps the clinician in more effective treatment and posttreatment follow-ups. Methods. In this cross-sectional study, endoscopic gastric biopsy samples of 544 patients who complained symptoms of dyspepsia for more than three months referring to the laboratory were studied. To determine the colonization rate of H. pylori and other pathological findings, Giemsa and H&E stains were, respectively, used. Results. Among 544 subjects, 47 (8.64%) patients had no gastritis, 203 (37.32%) had mild gastritis, 278 (10.51%) suffered moderate gastritis, and 16 (2.94%) had severe gastritis. In this study, patients with mild H. pylori colonization rates had the highest level of mild activity (33.52%); in contrast, those with severe H. pylori colonization had the highest level of severe activity (43.75%). 93.96% of people with severe H. pylori colonization suffered from moderate and severe chronic gastritis. There is a significant statistical relationship between the intensity of H. pylori colonization and histopathological findings including intestinal metaplasia, atrophy, and lymphoid follicle formation. Conclusions. According to the present study, with increasing intensity of H. pylori colonization, chronicity and activity of gastritis and its complications increase.

scholarly journals Sex differences in the relationship among alcohol, smoking, and Helicobacter pylori infection in asymptomatic individuals

2020 ◽  
Vol 48 (5) ◽  
pp. 030006052092603
Author(s):  
Wenzhi Wu ◽  
Marcis Leja ◽  
Vladislav Tsukanov ◽  
Zarrin Basharat ◽  
Dong Hua ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Alcohol Consumption ◽  
Logistic Regression Analysis ◽  
Helicobacter Pylori Infection ◽  
Multivariable Logistic Regression Analysis ◽  
H Pylori ◽  
Relationship Of ◽  
The Relationship

Objective We aimed to investigate the relationship of Helicobacter pylori infection with alcohol and smoking. Methods We conducted a cross-sectional study among participants who underwent health check-ups for H. pylori infection between January 2013 and March 2017. We subsequently investigated the relationship of H. pylori infection with alcohol and smoking. Results A total of 7169 participants were enrolled in this study. The overall prevalence of H. pylori infection was 55.2%. Participants with H. pylori infection were more likely to be older than those without H. pylori infection. For male participants with H. pylori infection, multivariable logistic regression analysis indicated that both smoking (odds ratio (OR): 1.61; 95% confidence interval (CI): 1.41–1.83) and alcohol consumption (OR: 1.30; 95% CI: 1.10–1.52) were independently positively associated with H. pylori infection. For female participants, multivariable logistic regression analysis indicated that both smoking (OR: 0.03; 95% CI: 0.02–0.07) and alcohol consumption (OR: 0.20; 95% CI: 0.12–0.33) were inversely significantly associated with H. pylori infection after adjustment for age. Conclusions Smoking and alcohol consumption were risk factors for male participants but these were protective factors for female individuals with H. pylori infection.

Intertemporal changes in the antecedents of migration in 1990-2000 period

2014 ◽  
Vol 41 (4) ◽  
pp. 266-277
Author(s):  
Chee Seong Ow ◽  
Abdul Hamid Baharom ◽  
Muzafar Shah Habibullah
Keyword(s):  
Consumer Price Index ◽  
Real Income ◽  
Cross Sectional ◽  
Content Type ◽  
Income Differential ◽  
Econometric Approach ◽  
Macro Variables ◽  
Sectional Analysis ◽  
Relationship Of ◽  
The Relationship

Purpose – The purpose of paper is to investigate and determine the intertemporal changes in linkages between migration (both emigration and immigration) and economic conditions in during 1990-2000 period. Design/methodology/approach – The paper employed cross-sectional analysis to investigate the relationship by employing data on immigration and emigration and as for economic condition the paper employed macro-variables such as real income differential (real gross domestic per capita), price level differential (consumer price index) and distance among the countries. Two different points of time were regressed cross-sectionally, with White standard being employed to remove traces of heterogeneity, albeit, 1990 and 2000. Findings – Results clearly indicate that there are significant changes in terms of the relationship of chosen variables with migration over time. The results provide some evidence on the important role played by these variables in influencing migration throughout the period in question. Research limitations/implications – Data covered is limited to 24 countries. The results from these countries alone are not sufficient to address the full impact of migration. Originality/value – The study covers the traditional topic of migration with an econometric approach, with some empirical regression and findings.

scholarly journals Association of self-reported sleep duration and quality with BaPWV levels in hypertensive patients

2020 ◽  
Vol 43 (12) ◽  
pp. 1392-1402
Author(s):  
Huan Hu ◽  
Huan Li ◽  
Xiao Huang ◽  
Huihui Bao ◽  
Yun Song ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Sectional Analysis ◽  
Relationship Of ◽  
The Relationship

AbstractThe association between sleep conditions and arterial stiffness remains inconclusive. We aimed to investigate the relationship of sleep duration and quality with brachial-ankle pulse-wave velocity (baPWV) in hypertensive patients. A total of 14,485 hypertensive adults were included in this cross-sectional analysis. Information about sleep duration and quality was obtained via questionnaire. A baPWV level ≥1800 cm/s was defined as indicative of arterial stiffness. Compared with participants with a sleep duration <8 h per day, participants with a sleep duration ≥8 h per day had a significantly higher baPWV level (β = 13.7 cm/s; 95% CI: 3.9, 23.5) and a nonsignificantly higher prevalence of arterial stiffness (39.7% vs. 33.0%; OR, 1.08; 95% CI: 0.99–1.19). Similarly, compared with participants with good or medium sleep quality, participants with poor sleep quality had a significantly higher baPWV level (β = 16.3 cm/s; 95% CI: 0.1, 32.6) and a nonsignificantly greater prevalence of arterial stiffness (36.6% vs. 35.3%; OR, 1.13; 95% CI: 0.97–1.32). When sleep duration and quality were examined jointly, participants with a sleep duration ≥8 h and/or poor sleep quality had a significantly higher baPWV level (β = 14.4 cm/s; 95% CI: 5.3, 23.4) and a greater prevalence of arterial stiffness (38.8% vs. 32.7%; OR, 1.10; 95% CI: 1.01–1.20) than those with a sleep duration <8 h and good/medium sleep quality. In summary, among hypertensive patients, a longer sleep duration (≥8 h per day) and poor sleep quality were associated with higher baPWV levels and a higher prevalence of arterial stiffness.

Sign in / Sign up

Export Citation Format

Share Document