Follicle-stimulating hormone level and changes in bone mass and body composition in older women and men

2021 ◽  
Author(s):  
Karin C Wu ◽  
Susan K Ewing ◽  
Xiaojuan Li ◽  
Sigurður Sigurðsson ◽  
Vilmundur Guðnason ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Composition ◽  
Bone Mass ◽  
Body Fat ◽  
Follicle Stimulating Hormone ◽  
Community Dwelling ◽  
Mean Difference ◽  
Mineral Density ◽  
Composition Changes ◽  
Stimulating Hormone

Abstract Context Follicle-stimulating hormone (FSH) may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. Objective We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. Setting, Design, Participants We studied 162 women and 158 men (mean age 82 ±4 years) from the AGES-BMA cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. Main Outcomes Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. Results There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7, 3.3) mg/cm 2/year in women, and -0.2 (-2.6, 2.2) mg/cm 2/year in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03, 3.62) cm 2/year in women, and -0.33 (-3.73, 3.06) cm 2/year in men. Conclusions Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes.

scholarly journals Serum FSH Is Associated with BMD, Bone Marrow Adiposity and Body Composition in the AGES-Reykjavik Study of Older Adults

2020 ◽  
Author(s):  
Annegreet G Veldhuis-Vlug ◽  
Gina N Woods ◽  
Sigurdur Sigurdsson ◽  
Susan K Ewing ◽  
Phuong T Le ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Marrow ◽  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Mineral Density ◽  
1H Mrs ◽  
Testosterone Levels ◽  
Marrow Adiposity

Abstract Context Follicle stimulating hormone (FSH) concentrations increase during the perimenopausal transition and remain high post menopause. Loss of bone mineral density (BMD) and gain of bone marrow adiposity (BMA) and body fat mass also occur during this time. In mice, blocking the action of FSH increases bone mass and decreases fat mass. Objective To investigate the associations between endogenous FSH levels and BMD, BMA and body composition in older adults, independent of estradiol and testosterone levels. Design, setting and participants Older adults from the AGES-Reykjavik Study, an observational cohort study. Main outcome measures Areal BMD, total body fat, and lean mass were measured with DXA. Lumbar vertebral BMA was measured by 1H-MRS. Volumetric BMD and visceral and subcutaneous adipose tissue (VAT, SAT) areas were measured with QCT. The least squares means procedure was used to determine sex-hormone adjusted associations between quartiles of serum FSH and BMD, BMA, and body composition. Results In women (N=238, mean age 81y), those in the highest FSH quartile, compared with the lowest quartile, had lower adjusted mean spine integral BMD (-8.6%), lower spine compressive strength index (-34.8%), higher BMA (+8.4%), lower weight (-8.4%), lower VAT (-17.6%), lower lean mass (-6.1%), and lower fat mass (-11.9%) (all P < 0.05). In men, FSH level was not associated with any outcome. Conclusions Older postmenopausal women with higher FSH levels have higher BMA, but lower BMD and lower fat and lean mass, independent of estradiol and testosterone levels. Longitudinal studies are needed to better understand the underlying mechanisms.

scholarly journals Follicle-stimulating hormone, interleukin-1, and bone density in adult women

2010 ◽  
Vol 298 (3) ◽  
pp. R790-R798 ◽  
Author(s):  
Joseph G. Cannon ◽  
Miriam Cortez-Cooper ◽  
Eric Meaders ◽  
Judith Stallings ◽  
Sara Haddow ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Follicle Stimulating Hormone ◽  
Surface Expression ◽  
Receptor Expression ◽  
Type I ◽  
Mineral Density ◽  
Tnf Α ◽  
Skeletal Site ◽  
Stimulating Hormone

Recent studies have indicated that follicle-stimulating hormone (FSH) promotes bone loss. The present study tested the hypothesis that FSH enhances the activity of bone-resorbing cytokines [interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6], either by inducing their secretion or by altering their receptor expression. Thirty-six women between the ages of 20 and 50 were assessed for bone mineral density (BMD), reproductive hormone, cytokine ligand and soluble receptor concentrations, and surface expression of cytokine receptors on monocytes. In addition, isolated mononuclear cells were incubated in vitro with exogenous FSH. Univariate regression analyses indicated that BMD was inversely related to serum FSH ( r = −0.29 to −0.51, P = 0.03–0.001, depending upon the skeletal site). Physical activity and body composition were also identified as significant factors by multiple regressions. Exogenous FSH induced isolated cells to secrete IL-1β, TNF-α, and IL-6 in proportion to the surface expression of FSH receptors on the monocytes. Endogenous (serum) FSH concentrations correlated with the circulating concentrations of these cytokines. None of these individual cytokines was related to BMD, but the IL-1β to IL-1 receptor antagonist (IL-1Ra) ratio was inversely related to BMD ( r = −0.53, P = 0.002) in all but the most physically active women, who had significantly lower expression of IL-1 type I receptors relative to type II (decoy receptors, P = 0.01). Physical activity also correlated positively with secretion of inhibitory soluble IL-1 receptors ( r = 0.53, P = 0.003). Moreover, IL-1Ra correlated strongly with percent body fat ( r = 0.66, P < 0.0001). These results indicate that BMD is related to FSH concentration, physical activity, and body composition. Although each of these factors likely has direct effects on bone, the present study suggests that each may also influence BMD by modulating the activity of the osteoresorptive cytokine IL-1β.

scholarly journals Vitamin D and Physical Activity Status: Associations With Five-Year Changes in Body Composition and Muscle Function in Community-Dwelling Older Adults

2015 ◽  
Vol 100 (2) ◽  
pp. 670-678 ◽  
Author(s):  
David Scott ◽  
Peter R. Ebeling ◽  
Kerrie M. Sanders ◽  
Dawn Aitken ◽  
Tania Winzenberg ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Vitamin D ◽  
Body Composition ◽  
Body Fat ◽  
Muscle Function ◽  
Community Dwelling ◽  
Accelerometer Data ◽  
High Vitamin ◽  
Community Dwelling Older Adults

Abstract Context: High vitamin D and physical activity (PA) levels are independently associated with improved body composition and muscle function in older adults. Objective: The objective of this study was to investigate the interaction of 25-hydroxyvitamin D (25OHD) and PA status in maintenance of body composition and muscle function in older adults. Design and Setting: This was a 5-year prospective population-based study of Australian community-dwelling older adults. Participants: Participants in the study included 615 community-dwelling volunteers aged 50 years old or older [61.4 ± 6.9 (mean ± SD) y; 48% female] randomly selected from electoral rolls and categorized according to baseline serum 25OHD (≥ or &lt;50 nmol/L) and PA (≥ or &lt;10 000 pedometer determined steps/d) levels as follows: high 25OHD and high PA (VitD+PA+); high 25OHD and low PA (VitD+PA−); low 25OHD and high PA (VitD-PA+); and low 25OHD and low PA (VitD-PA−). A subset of 518 participants completed accelerometer assessments during follow-up. Main Outcome Measures: Changes in dual-energy X-ray absorptiometry-assessed body composition and lower-limb muscle function were measured. Results: VitD+PA+ had significantly smaller increases in body fat over 5 years compared with other groups (all P &lt; .05). Higher baseline pedometer-determined PA resulted in declines in total body fat (β = −.23 kg per 100 steps/d, P = .001) over 5 years for participants with high 25OHD but not those with low 25OHD (P &gt; .05). Among participants with accelerometer data, these associations were generally mediated by higher levels of moderate/vigorous PA. Conclusions: High vitamin D status appears to enhance PA-related declines in body fat during aging, but the mechanism may be greater amounts of outdoor moderate/vigorous PA rather than a direct effect of 25OHD.

scholarly journals Withdrawal of Long-Term Physiological Growth Hormone (GH) Administration: Differential Effects on Bone Density and Body Composition in Men with Adult-Onset GH Deficiency*

2000 ◽  
Vol 85 (3) ◽  
pp. 970-976 ◽  
Author(s):  
Beverly M. K. Biller ◽  
Gemma Sesmilo ◽  
Howard B. A. Baum ◽  
Douglas Hayden ◽  
David Schoenfeld ◽  
...  
Keyword(s):  
Body Composition ◽  
Bone Density ◽  
Bone Mass ◽  
Body Fat ◽  
Bone Mineral ◽  
Lean Mass ◽  
Gh Deficiency ◽  
Serum Insulin ◽  
Fold Increase ◽  
Mineral Density

Abstract Adults with acquired GH deficiency (GHD) have been shown to have osteopenia associated with a 3-fold increase in fracture risk and exhibit increased body fat and decreased lean mass. Replacement of GH results in decreased fat mass, increased lean mass, and increased bone mineral density (BMD). The possible differential effect of withdrawal of GH replacement on body composition compartments and regional bone mass is not known. We performed a randomized, single blind, placebo-controlled 36-month cross-over study of GH vs. placebo (PL) in adults with GHD and now report the effect of withdrawal of GH on percent body fat, lean mass, and bone density, as measured by dual energy x-ray absorptiometry. Forty men (median age, 51 yr; range, 24–64 yr) with pituitary disease and peak serum GH levels under 5μ g/L in response to two pharmacological stimuli were randomized to GH therapy (starting dose, 10 μg/kg·day, final dose 4 μg/kg·day) vs. PL for 18 months. Replacement was provided in a physiological range by adjusting GH doses according to serum insulin-like growth factor I levels. After discontinuation of GH, body fat increased significantly (mean ± sem, 3.18 ± 0.44%; P = 0.0001) and returned to baseline. Lean mass decreased significantly (mean loss, 2133 ± 539 g; P = 0.0016), but remained slightly higher (1276 ± 502 g above baseline;P = 0.0258) than at study initiation. In contrast to the effect on body composition, BMD did not reverse toward pretreatment baseline after discontinuation of GH. Bone density at the hip continued to rise during PL administration, showing a significant increase (0.0014 ± 0.00042, g/cm2·month; P = 0.005) between months 18–36. Every bone site except two (radial BMD and total bone mineral content), including those without a significant increase in BMD during the 18 months of GH administration, showed a net increase over the entire 36 months. Therefore, there is a critical differential response of the duration of GH action on different body composition compartments. Physiological GH administration has a persistent effect on bone mass 18 months after discontinuation of GH.

Body Mass and Body Composition Changes over 7 Years in a Male Professional Rugby Union Team

2021 ◽  
Author(s):  
Clíodhna McHugh ◽  
Karen Hind ◽  
Aoife O'Halloran ◽  
Daniel Davey ◽  
Gareth Farrell ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Mass ◽  
Body Fat ◽  
Lean Mass ◽  
Total Mass ◽  
Rugby Union ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Dxa Scans ◽  
Composition Changes

AbstractThe purpose of this study was to investigate longitudinal body mass and body composition changes in one professional rugby union team (n=123), (i) according to position [forwards (n=58) versus backs (n=65)], analysis of players with 6 consecutive seasons of DXA scans (n=21) and, (iii) to examine differences by playing status [academy and international], over 7 years. Players [mean age: 26.8 y, body mass index: 28.9+kg.m2] received DXA scans at fourtime points within each year. A modest (but non-significant) increase in mean total mass (0.8 kg) for professional players was reflected by increased lean mass and reduced body fat mass. At all-time points, forwards had a significantly greater total mass, lean mass and body fat percentage compared to backs (p<0.05). Academy players demonstrated increased total and lean mass and decreased body fat percentage over the first 3 years of senior rugby, although this was not significant. Senior and academy international players had greater lean mass and lower body fat percentage (p<0.05) than non-international counterparts. Despite modest increases in total mass; reflected by increased lean mass and reduced fat mass, no significant changes in body mass or body composition, irrespective of playing position were apparent over 7 years.

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