scholarly journals Follicle-stimulating hormone, interleukin-1, and bone density in adult women

2010 ◽  
Vol 298 (3) ◽  
pp. R790-R798 ◽  
Author(s):  
Joseph G. Cannon ◽  
Miriam Cortez-Cooper ◽  
Eric Meaders ◽  
Judith Stallings ◽  
Sara Haddow ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Follicle Stimulating Hormone ◽  
Surface Expression ◽  
Receptor Expression ◽  
Type I ◽  
Mineral Density ◽  
Tnf Α ◽  
Skeletal Site ◽  
Stimulating Hormone

Recent studies have indicated that follicle-stimulating hormone (FSH) promotes bone loss. The present study tested the hypothesis that FSH enhances the activity of bone-resorbing cytokines [interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6], either by inducing their secretion or by altering their receptor expression. Thirty-six women between the ages of 20 and 50 were assessed for bone mineral density (BMD), reproductive hormone, cytokine ligand and soluble receptor concentrations, and surface expression of cytokine receptors on monocytes. In addition, isolated mononuclear cells were incubated in vitro with exogenous FSH. Univariate regression analyses indicated that BMD was inversely related to serum FSH ( r = −0.29 to −0.51, P = 0.03–0.001, depending upon the skeletal site). Physical activity and body composition were also identified as significant factors by multiple regressions. Exogenous FSH induced isolated cells to secrete IL-1β, TNF-α, and IL-6 in proportion to the surface expression of FSH receptors on the monocytes. Endogenous (serum) FSH concentrations correlated with the circulating concentrations of these cytokines. None of these individual cytokines was related to BMD, but the IL-1β to IL-1 receptor antagonist (IL-1Ra) ratio was inversely related to BMD ( r = −0.53, P = 0.002) in all but the most physically active women, who had significantly lower expression of IL-1 type I receptors relative to type II (decoy receptors, P = 0.01). Physical activity also correlated positively with secretion of inhibitory soluble IL-1 receptors ( r = 0.53, P = 0.003). Moreover, IL-1Ra correlated strongly with percent body fat ( r = 0.66, P < 0.0001). These results indicate that BMD is related to FSH concentration, physical activity, and body composition. Although each of these factors likely has direct effects on bone, the present study suggests that each may also influence BMD by modulating the activity of the osteoresorptive cytokine IL-1β.

Follicle-stimulating hormone level and changes in bone mass and body composition in older women and men

2021 ◽  
Author(s):  
Karin C Wu ◽  
Susan K Ewing ◽  
Xiaojuan Li ◽  
Sigurður Sigurðsson ◽  
Vilmundur Guðnason ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Composition ◽  
Bone Mass ◽  
Body Fat ◽  
Follicle Stimulating Hormone ◽  
Community Dwelling ◽  
Mean Difference ◽  
Mineral Density ◽  
Composition Changes ◽  
Stimulating Hormone

Abstract Context Follicle-stimulating hormone (FSH) may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. Objective We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. Setting, Design, Participants We studied 162 women and 158 men (mean age 82 ±4 years) from the AGES-BMA cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. Main Outcomes Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. Results There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7, 3.3) mg/cm 2/year in women, and -0.2 (-2.6, 2.2) mg/cm 2/year in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03, 3.62) cm 2/year in women, and -0.33 (-3.73, 3.06) cm 2/year in men. Conclusions Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes.

Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jaak Jürimäe ◽  
Vita Karvelyte ◽  
Liina Remmel ◽  
Anna-Liisa Tamm ◽  
Priit Purge ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Muscle Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Adolescent Females ◽  
Age At Menarche ◽  
Type I ◽  
Multivariate Linear Regression Analysis ◽  
Tnf Α

Abstract Objectives Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Methods A total of 73 adolescent females who were physically active and aged 14–18 years old participated in the study. Sclerostin, leptin, resistin, tumour necrosis factor (TNF)-α, interleukin (IL)-6, irisin, osteocalcin, C-terminal telopeptide of type I collagen (CTx), insulin-like growth factor (IGF)-1 and insulin were obtained from fasting blood samples. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and analyzed for body fat mass, lean body mass, bone mineral content and muscle mass. Results Serum sclerostin (117.9 ± 60.3 pg/mL) was correlated with age, age at menarche, body fat, muscle mass, training activity, leptin, TNF-α, irisin, osteocalcin, CTx and IGF-1. Multivariate linear regression analysis demonstrated that fat mass (β = 0.434; p = 0.001), leptin (β = −0.308; p = 0.015), irisin (β = 0.227; p = 0.024) and CTx (β = 0.290; p = 0.031) were the most important predictors of serum sclerostin concentration. Conclusions Bone-derived sclerostin is associated with specific adipokine, myokine and osteokine values in lean adolescent females with increased physical activity. These results suggest that the interactions between bone, adipose and muscle tissues could also be associated with circulating sclerostin concentrations.

scholarly journals Follicle stimulating hormone and estradiol alter immune response in osteoarthritic mice in an opposite manner

2021 ◽  
Vol 35 ◽  
pp. 205873842110161
Author(s):  
Lyudmila Belenska-Todorova ◽  
Ralitsa Zhivkova ◽  
Maya Markova ◽  
Nina Ivanovska
Keyword(s):  
Follicle Stimulating Hormone ◽  
Endocrine System ◽  
Synovial Cell ◽  
Nuclear Factor Κb ◽  
Cartilage Degradation ◽  
Osteoclast Formation ◽  
Blue Staining ◽  
Serum Osteocalcin ◽  
Tnf Α ◽  
Stimulating Hormone

Although a number of studies have shown that the occurrence and progression of osteoarthritis (OA) is related to endocrine system dysfunction, there is limited evidence about what roles sex hormones play. The aim of the present study was to examine the capacity of 17β-estradiol (ED) and follicle stimulating hormone (FSH) to alter the differentiation of bone marrow (BM) cells in arthritic mice. The experiments were conducted in collagenase-induced osteoarthritis in mice. Cartilage degradation was observed by safranin and toluidine blue staining. Flow cytometry was used to define different BM and synovial cell populations. The influence of FSH and ED on osteoclastogenesis was studied in BM cultures and on the osteoblastogenesis in primary calvarial cultures. The levels of IL-8, TNF-α, FSH, and osteocalcin were estimated by ELISA. FSH increased cartilage degradation and serum osteocalcin levels, while ED abolished it and lowered serum osteocalcin. FSH elevated the percentage of monocytoid CD14+/RANK+ and B cell CD19+/RANK+ cells in contrast to ED which inhibited the accumulation of these osteogenic populations. Also, ED changed the percentage of CD105+/F4/80+ and CD11c+ cells in the synovium. FSH augmented and ED suppressed macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast (OC) formation, and this correlated with a respective increase and decrease of IL-8 secretion. FSH did not influence osteoblast (OB) formation while ED enhanced this process in association with changes of TNF-α, IL-8, and osteocalcin production. ED reduced osteoclast generation in bone. The key outcome of the current study is that both hormones influenced BM cell differentiation, with FSH favoring osteoclast formation and ED favoring osteoblast accumulation.

scholarly journals Bone mineral density in young adults: the influence of vitamin D status, biochemical indicators, physical activity and body composition

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Anna Kopiczko ◽  
Monika Łopuszańska-Dawid ◽  
Karol Gryko
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Vitamin D ◽  
Body Composition ◽  
Total Cholesterol ◽  
Bone Mineral ◽  
Activity Levels ◽  
Fat Percentage ◽  
Mineral Density ◽  
Physical Activity Levels

Abstract Summary The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Physical activity has the most significant effect on bone status especially in men. Purpose The aim of the study was to assess the associations of bone mineral density and bone mass with physical activity levels, vitamin D, phosphorus, magnesium, total cholesterol and triglyceride concentration and body composition in young women and men. Methods One hundred subjects aged 19–24 years were included. Bone mineral density (BMD) in distal and proximal parts was evaluated by forearm densitometry. Body composition was analysed with the use of JAWON-Medical-x-scan. The following biochemical indicators were analysed: 25(OH) D and 1,25(OH)2D, magnesium, phosphorus, total cholesterol and triglycerides. Physical activity levels were assessed by interview. Results Significant correlations between BMD and physical activity, skeletal muscle mass and body fat percentage were revealed in men. Among women, considerably weaker correlations of BMD with body composition and physical activity were noted than in men. BMD in the distal part correlated only with lean body mass, soft lean mass and body fat percentage. The strongest relationship between physical activity and bone mineral status parameters was noted for BMD in men. In women, physical activity did not affect BMD. Conclusions Physical activity has the most significant effect on bone status especially in men.

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