scholarly journals Association of maternal total cholesterol with SGA or LGA birth at term: The Japan Environment and Children's Study

2021 ◽  
Author(s):  
Kayo Kaneko ◽  
Yuki Ito ◽  
Takeshi Ebara ◽  
Sayaka Kato ◽  
Taro Matsuki ◽  
...  
Keyword(s):  
Weight Gain ◽  
Standard Deviation ◽  
Total Cholesterol ◽  
Gestational Age ◽  
Fetal Development ◽  
Maternal Serum ◽  
Birth Cohort Study ◽  
Glucose Levels ◽  
Singleton Birth ◽  
Weight Gain During Pregnancy

Abstract Context Maternal cholesterol is important for fetal development. Whether maternal serum total cholesterol (maternal TC) levels in mid-pregnancy are associated with small- (SGA) or large- (LGA) for-gestational-age independent of pre-pregnancy body mass index (BMI) and weight gain during pregnancy is inconclusive. Objective To prospectively investigate the association between maternal TC in mid-pregnancy and SGA or LGA. Design and Setting The Japan Environment and Children’s Study is a nationwide prospective birth cohort study in Japan. Participants A total of 37,449 non-diabetic, non-hypertensive mothers with singleton birth at term without congenital abnormalities. Outcome Measures Birth weight for the gestational age <10 percentile and ≥90 percentile were respectively defined as SGA and LGA by the Japanese neonatal anthropometric charts. Results The mean gestational age at blood sampling was 22.7±4.0 weeks. After adjustment for maternal age, sex of child, parity, weight gain during pregnancy, pre-pregnancy BMI, smoking, alcohol drinking, blood glucose levels, household income, and Study Areas, one standard deviation decrement of maternal TC was linearly associated with SGA [odds ratio (OR): 95% confidence intervals (CI) = 1.20: 1.15-1.25]. In contrast, one standard deviation increment of maternal TC was linearly associated with LGA [OR: 95% CI = 1.13: 1.09-1.16]. Associations did not differ according to pre-pregnancy BMI and gestational weight gain (p for interaction>0.20). Conclusion Maternal TC levels in mid-pregnancy were associated with SGA or LGA in Japanese. Maternal TC in mid-pregnancy may help to predict SGA and LGA. Favorable maternal lipid profiles for fetal development must be explored.

Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

2020 ◽  
Author(s):  
Tamer A. Abdel-Hamid ◽  
Dalia AbdelLatif ◽  
Eman Ahmed ◽  
Mazen Abdel-Rasheed ◽  
Ahmed A-Mageed
Keyword(s):  
Birth Weight ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Gestational Age ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Maternal Serum ◽  
Serum Lipid Profile ◽  
Maternal Malnutrition

Objective Maternal malnutrition with disturbed lipid metabolism during pregnancy may affect the fetal lipid profile. We aimed to detect the relation between maternal and neonatal serum lipid profile, as well as to detect the serum lipid profile difference between small for gestational age (SGA) infants and appropriate for gestational age (AGA) infants to disclose the impact of maternal malnutrition on birth weight. Study Design A cross-sectional study was conducted on 150 pregnant women coming to the labor room. Before delivery, maternal serum levels of high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TGs), and total cholesterol were assessed, then after delivery, cord blood samples were taken for assessment of the neonatal lipid profile. Birth weights were measured, then the neonates were divided into SGA and AGA groups. Results Serum levels of LDL, TGs, and total cholesterol in the SGA infants were lower than that in the AGA infants. A positive correlation between maternal and neonatal serum TGs levels was found. Besides, there was a positive correlation between birth weight and maternal serum levels of LDL, TGs, and total cholesterol. Conclusion Maternal serum lipid profile could be an indicator of the neonatal serum lipid profile and birth weight. Key Points

scholarly journals Circulating Spexin levels in pregnant women with and without gestational diabetes

2019 ◽  
Vol 8 (10) ◽  
pp. 4056
Author(s):  
Coskun Simsir ◽  
Muberra Namli Kalem ◽  
Ziya Kalem ◽  
Turgut Var ◽  
Batuhan Bakirarar ◽  
...  
Keyword(s):  
Weight Gain ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Fasting Blood Glucose ◽  
Appetite Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lipid Parameters ◽  
Weight Gain During Pregnancy ◽  
Hba1c Levels

Background: Several previous studies suggest that SPX plays a role in appetite control and body weight and blood glucose regulation. The aim of this study to determine SPX levels in healthy pregnancies and in gestational diabetes (GDM) and to investigate the association of SPX levels with weight gain and lipid and glucose metabolism in subjects with and without GDM.Methods: A total of 44 women with GDM and 44 women without GDM were randomly enrolled who applied for GDM screening during the 24-28th week of pregnancy. Demographics, blood glucose and lipid profiles and Spexin levels were compared between groups.Results: The mean age, BMI, and weight gain during pregnancy were higher in the GDM group. The LDL cholesterol, Hba1c, SPX and glucose levels in response to OGTT were higher in the GDM group. The SPX levels were correlated with Hba1c and blood glucose levels after OGTT, and were not correlated with the age, BMI, weight gain during pregnancy, lipid parameters, and fasting blood glucose levels in the whole study population.Conclusions: SPX levels were higher in the GDM group compared with non-GDM group and SPX levels were correlated with HbA1c levels and post-OGTT glucose levels but not with fasting glucose levels.

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan

2016 ◽  
Vol 92 ◽  
pp. 33-36 ◽  
Author(s):  
Emi Akahoshi ◽  
Kazuhiko Arima ◽  
Kiyonori Miura ◽  
Takayuki Nishimura ◽  
Yasuyo Abe ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Pregnancy Weight ◽  
Weight Gain During Pregnancy

Interaction of Maternal and Neonatal Obesity

PEDIATRICS ◽  
1978 ◽  
Vol 62 (1) ◽  
pp. 17-21
Author(s):  
John N. Udall ◽  
Gail G. Harrison ◽  
Yvonne Vaucher ◽  
Philip D. Walson ◽  
Grant Morrow
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Gestational Age ◽  
Subcutaneous Fat ◽  
Large For Gestational Age ◽  
Maternal Weight ◽  
Muscle Area ◽  
Cross Sectional ◽  
Skin Fold ◽  
Weight Gain During Pregnancy

Maternal weight and height before pregnancy and weight gain during pregnancy were recorded for each of 109 mothers who were delivered of normal infants after gestations of 37 to 43 weeks. Infant parameters obtained included gestational age, birth weight, bilateral mid-arm circumference, and eight skin fold thickness measurements. The eight skin fold thicknesses were summed (SSFT) for each infant. Infants with SSFTs greater than 40 mm (N = 8) for the group were classified as "fatter" infants. All of the fatter infants were large for gestational age (LGA), but accounted for only one third of the LGA infants in the study. Birth weight, length, and cross-sectional mid-arm fat area were significantly increased in the fatter LGA group when compared to other LGA infants. Cross-sectional mid-arm muscle area was not significantly different for the fatter LGA infants compared to the other LGA group. Mothers were defined as obese or nonobese according to pregnant weight for height. Obese mothers had infants with significantly increased SSFTs when compared with infants of nonobese mothers. Multiple regression analysis showed that both prepregnant weight for height and weight gain during pregnancy were associated with increased subcutaneous fat in the neonate. Weight gain during pregnancy was associated with increased neonatal fatness and length, while prepregnant weight for height was associated with neonatal fatness independent of neonatal length.

scholarly journals Relatively Low Maternal Aflatoxin Exposure Is Associated with Small-for-Gestational-Age but Not with Other Birth Outcomes in a Prospective Birth Cohort Study of Nepalese Infants

2019 ◽  
Vol 149 (10) ◽  
pp. 1818-1825 ◽  
Author(s):  
Johanna Y Andrews-Trevino ◽  
Patrick Webb ◽  
Gerald Shively ◽  
Beatrice L Rogers ◽  
Kedar Baral ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Weight ◽  
Birth Cohort ◽  
Birth Outcomes ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Maternal Serum ◽  
Birth Cohort Study ◽  
Adverse Birth Outcomes ◽  
Z Scores

ABSTRACT Background Exposure to aflatoxin has garnered increased attention as a possible contributor to adverse birth outcomes. Objective The objective of this study was to investigate the relation of maternal aflatoxin exposure with adverse birth outcomes such as birth weight, birth length, anthropometric z scores, low birth weight (LBW), small-for-gestational-age (SGA), stunting, and preterm birth (PTB). Methods This study used maternal and newborn data from the AflaCohort Study, an ongoing birth cohort study in Banke, Nepal (n = 1621). Data on aflatoxin B1 (AFB1)-lysine adducts in maternal serum were collected once during pregnancy (at mean ± SD: 136 ± 43 d of gestation). Maternal serum AFB1-lysine adduct concentration was measured via HPLC. Linear and logistic regression analyses were used to determine if maternal aflatoxin exposure was associated with 1) birth weight and length (primary outcomes) and 2) anthropometric z scores, LBW (weight <2.5 kg), SGA (weight <10th percentile for gestational age and sex), stunting at birth (length-for-age z score less than −2), or PTB (born <37 weeks of gestation) (secondary outcomes). Results The geometric mean of maternal serum AFB1-lysine adduct concentration was 1.37 pg/mg albumin (95% CI: 1.30, 1.44 pg/mg albumin). Twenty percent of infants were of LBW and 32% were SGA. Sixteen percent of infants were stunted at birth. In addition, 13% of infants were born preterm. In logistic multivariate regression models, mean maternal serum AFB1-lysine adduct concentrations were significantly associated with SGA (OR: 1.13; 95% CI: 1.00, 1.27; P < 0.05). Conclusions Findings from this study suggest a small but significant association between serum AFB1-lysine adduct concentrations in pregnant women and SGA. Maternal aflatoxin exposure was not associated with other birth outcomes. These results highlight the need for future research on a threshold level of aflatoxin exposure needed to produce detectable adverse birth outcomes. This trial was registered at clinicaltrials.gov as NCT03312049.

scholarly journals Prevalence and correlates of low birth weight babies born in a tertiary care teaching hospital in Eastern India

2020 ◽  
Vol 7 (8) ◽  
pp. 3052
Author(s):  
Tanaya Paul ◽  
Kaustav Chakraborty ◽  
Nayan Sarkar ◽  
Moumita Chatterjee ◽  
Suman Kumar Roy
Keyword(s):  
Blood Pressure ◽  
Weight Gain ◽  
Birth Weight ◽  
Gestational Age ◽  
Normal Birth Weight ◽  
Clinical Factors ◽  
Normal Birth ◽  
Total Weight Gain ◽  
History Of ◽  
Weight Gain During Pregnancy

Background: Low birth weight (LBW) is one of the long-standing birth outcomes amongst all adverse pregnancy outcomes, which have lasting influences in the later life span. The objective of the study was to determine the prevalence of LBW babies; to examine the correlation between maternal socio-demographic, lifestyle, obstetrics, and clinical factors with LBW; and to compare the above factors between mothers with low and normal birth weight babies.Methods: All the pregnant women admitted for delivery in the inpatient Department of Gynaecology and Obstetrics and providing informed consent were interviewed with the help of the semi-structured questionnaire. The antenatal card and labour room log book were also scrutinized for relevant data.Results: The prevalence of LBW and VLBW were 33.8% and 2.8% respectively. A significant positive correlation was found between strenuous working environment, duration of standing, consumption of alcohol and smoking in pregnancy, previous history of premature birth and LBW babies, high blood pressure and pre-eclampsia during pregnancy, total weight gain during pregnancy and gestational age at birth and LBW. Mothers of LBW and normal birth weight babies significantly differed in their age, total weight gain during pregnancy, religion, level of education, history of premature baby and LBW baby, high blood pressure and preeclampsia during pregnancy. In the regression model, there was also a significant positive linear relationship between LBW and strenuous work environment & gestational age at birth.Conclusions: One third of the pregnant mothers delivered LBW child and various socio-demographic and clinical factors had significant correlation with LBW.

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