scholarly journals Impact of Month of Birth on the Risk of Development of Autoimmune Addison’s Disease

2016 ◽  
Vol 101 (11) ◽  
pp. 4214-4218 ◽  
Author(s):  
Agnieszka Pazderska ◽  
Marta Fichna ◽  
Anna L. Mitchell ◽  
Catherine M. Napier ◽  
Earn Gan ◽  
...  
Keyword(s):  
United Kingdom ◽  
General Population ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Distribution Analysis ◽  
Month Of Birth ◽  
Ratio Distribution ◽  
Autoimmune Thyroid ◽  
The United Kingdom ◽  
Increased Risk

Context: The pathogenesis of autoimmune Addison’s disease (AAD) is thought to be due to interplay of genetic, immune, and environmental factors. A month-of-birth effect, with increased risk for those born in autumn/winter months, has been described in autoimmune conditions such as type 1 diabetes and autoimmune thyroid disease. Objective: Month-of-birth effect was investigated in 2 independent cohorts of AAD subjects. Design, Setting, and Patients: The monthly distribution of birth in AAD patients was compared with that of the general population using the cosinor test. A total of 415 AAD subjects from the United Kingdom cohort were compared with 8 180 180 United Kingdom births, and 231 AAD subjects from the Polish cohort were compared with 2 421 384 Polish births. Main Outcome Measures: Association between month of birth and the susceptibility to AAD. Results: In the entire cohort of AAD subjects, month-of-birth distribution analysis showed significant periodicity with peak of births in December and trough in May (P = .028). Analysis of the odds ratio distribution based on month of birth in 2 cohorts of patients with AAD versus the general population revealed a December peak and May trough, and January peak and July trough, in the United Kingdom and Polish cohorts, respectively. Conclusion: For the first time, we demonstrate that month of birth exerts an effect on the risk of developing AAD, with excess risk in individuals born in winter months and a protective effect when born in the summer. Exposure to seasonal viral infections in the perinatal period, coupled with vitamin D deficiency, could lead to dysregulation of innate immunity affecting the risk of developing AAD.

scholarly journals Impact of Month of Birth on the Development of Autoimmune Thyroid Disease in the United Kingdom and Europe

2014 ◽  
Vol 99 (8) ◽  
pp. E1459-E1465 ◽  
Author(s):  
Alexander Hamilton ◽  
Paul R. Newby ◽  
Jacqueline D. Carr-Smith ◽  
Giulio Disanto ◽  
Amit Allahabadia ◽  
...  
Keyword(s):  
United Kingdom ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Month Of Birth ◽  
Autoimmune Thyroid ◽  
The United Kingdom

A new ELISA for autoantibodies to steroid 21-hydroxylase

2018 ◽  
Vol 56 (6) ◽  
pp. 933-938 ◽  
Author(s):  
Maria del Pilar Larosa ◽  
Shu Chen ◽  
Nora Steinmaus ◽  
Hannah Macrae ◽  
Liang Guo ◽  
...  
Keyword(s):  
Blood Donors ◽  
Addison’S Disease ◽  
Test Sample ◽  
Adult Patients ◽  
Addison's Disease ◽  
Systemic Lupus Erythematosis ◽  
Autoimmune Thyroid ◽  
Increased Risk ◽  
Streptavidin Peroxidase

Abstract Background: A new ELISA for autoantibodies to steroid 21-hydroxylase (21-OH Ab) is described. Methods: In the assay test sample autoantibodies form a bridge between 21-OH coated onto the plate well and liquid phase 21-OH-biotin. Bound 21-OH-biotin is detected by the addition of streptavidin peroxidase and colorogenic peroxidase substrate. Results: Of 100 samples from patients with autoimmune Addison’s disease, 86 (86%) were positive for 21-OH Ab ELISA whereas 84 (84%) were positive in an immunoprecipitation assay based on 125I-labeled 21-OH. Six (0.6%) of 928 healthy adult blood donors and 1 (2.0%) of 49 adult patients with type 1 diabetes mellitus (T1DM) were positive by ELISA. No samples from adult patients with Graves’ disease (GD; n=50), celiac disease (n=29), systemic lupus erythematosis (n=9) or rheumatoid arthritis (n=20) were positive by ELISA. However, 2/51 (3.9%) children with GD, 3/69 (4.3%) children with Hashimoto’s thyroiditis (HT) and 3/119 (2.5%) children with T1DM alone or associated with autoimmune thyroid disorders were ELISA positive. Conclusions: The new assay should be useful for screening patients known to be at increased risk of developing clinical autoimmune Addison’s disease, in particular children with HT, GD and/or T1DM.

scholarly journals MANAGEMENT OF ENDOCRINE DISEASE Disease burden and treatment challenges in patients with both Addison’s disease and type 1 diabetes mellitus

2020 ◽  
Vol 183 (1) ◽  
pp. R1-R11
Author(s):  
Dimitrios Chantzichristos ◽  
Björn Eliasson ◽  
Gudmundur Johannsson
Keyword(s):  
Type 1 Diabetes ◽  
Management Strategies ◽  
Treatment Strategies ◽  
Specific Treatment ◽  
Addison’S Disease ◽  
Adrenal Crisis ◽  
Addison's Disease ◽  
Autoimmune Thyroid ◽  
Increased Risk

Concurrent type 1 diabetes (T1D) and Addison’s disease (AD) is a rare combination of diseases and, in approximately one third of these patients, it is also combined with an autoimmune thyroid disease. Recently, it was shown that patients with both T1D and AD have a higher risk of premature death compared to patients with T1D alone, the most common causes of death being due to diabetic complications and cardiovascular disease. These patients receiving replacement therapies with both insulin and glucocorticoids face an increased risk of hypo- and hyperglycemia and diabetic ketoacidosis and have a higher risk of adrenal crisis than patients with AD alone. Treatment challenges include the opposing effects of insulin and glucocorticoids on glucose homeostasis and the need to balance and synchronize these two treatments. The rarity of this disease combination may explain the paucity of data on outcome and specific treatment strategies in this patient group. Based on this review, we suggest management strategies for their insulin and glucocorticoid replacement therapies and indicate future areas of research.

scholarly journals Test–retest reliability of the EQ-5D-5L and the reworded QOLIBRI-OS in the general population of Italy, the Netherlands, and the United Kingdom

2021 ◽  
Author(s):  
Di Long ◽  
Suzanne Polinder ◽  
Gouke J. Bonsel ◽  
Juanita A. Haagsma
Keyword(s):  
United Kingdom ◽  
General Population ◽  
The Netherlands ◽  
Web Based ◽  
Retest Reliability ◽  
The United Kingdom ◽  
Sum Score ◽  
Summary Index ◽  
Test Retest Reliability ◽  
Eq Vas

Abstract Purpose To assess the test–retest reliability of the EQ-5D-5L and the reworded Quality of Life After Traumatic Brain Injury Overall Scale (QOLIBRI-OS) for the general population of Italy, the Netherlands, and the United Kingdom (UK). Methods The sample contains 1864 members of the general population (aged 18–75 years) of Italy, the Netherlands, and the UK who completed a web-based questionnaire at two consecutive time points. The survey included items on gender, age, level of education, occupational status, household annual income, chronic health status, and the EQ-5D-5L and reworded QOLIBRI-OS instrument. Test–retest reliability of the EQ-5D-5L dimensions, EQ-5D-5L summary index, EQ VAS, reworded QOLIBRI-OS dimensions and reworded QOLIBRI-OS level sum score was examined by Gwet’s Agreement Coefficient (Gwet’s AC) and Intraclass Correlation Coefficient (ICC). Results Gwet’s AC ranged from 0.64 to 0.97 for EQ-5D-5L dimensions. The ICC ranged from 0.73 to 0.84 for the EQ-5D-5L summary index and 0.61 to 0.68 for EQ VAS in the three countries. Gwet’s AC ranged from 0.35 to 0.55 for reworded QOLIBRI-OS dimensions in the three countries. The ICC ranged from 0.69 to 0.77 for reworded QOLIBRI-OS level sum score. Conclusion Test–retest reliability of the EQ-5D-5L administered via a web-based questionnaire was substantial to almost perfect for the EQ-5D-5L dimensions, good for EQ-5D-5L summary index, and moderate for the EQ VAS. However, test–retest reliability was less satisfactory for the reworded QOLIBRI-OS. This indicates that the web-based EQ-5D-5L is a reliable instrument for the general population, but further research of the reworded QOLIBRI-OS is required.

scholarly journals Seasonality of month of birth of patients with Graves’ and Hashimoto’s diseases differ from that in the general population

2007 ◽  
Vol 156 (6) ◽  
pp. 631-636 ◽  
Author(s):  
Gerasimos E Krassas ◽  
Konstantinos Tziomalos ◽  
Nikolaos Pontikides ◽  
Hadas Lewy ◽  
Zvi Laron
Keyword(s):  
General Population ◽  
Perinatal Period ◽  
Thyroid Peroxidase ◽  
Month Of Birth ◽  
Autoimmune Thyroid ◽  
Common Etiology ◽  
Antibody Titers ◽  
Low Levels ◽  
Antibody Levels

Objective: We aimed to test the viral hypothesis in the pathogenesis of autoimmune thyroid disease (AITD). Design: We determined the pattern of month of birth (MOB) distribution in patients with AITD and in the general population and searched for differences between them. Methods: A total of 1023 patients were included in this study; 359 patients had Graves’ hyperthyroidism (GrH) and 664 had Hashimoto’s hypothyroidism (HH). We divided the patients with HH into three subgroups according to their thyroid peroxidase (TPO) antibody titers at diagnosis: low levels (<500 IU/ml), high levels (500–1000 IU/ml), and extremely high levels (>1000 IU/ml). We used cosinor analysis to analyze the data. Results: Overall, patients with GrH and HH had a different pattern of MOB distribution when compared with the general population and between groups. Furthermore, among both patients with GrH and HH, both genders had a different pattern of MOB distribution when compared with the general population and this pattern was also different between genders. Finally, only women with extremely high titers of TPO antibodies at diagnosis and men with low or extremely high TPO antibody levels showed rhythmicity in MOB, with a pattern of MOB distribution different from that in controls. Conclusions: The different MOB seasonality in both GrH and HH points towards a similar maybe even common etiology with type 1 diabetes mellitus and multiple sclerosis, namely a seasonal viral infection as the initial trigger in the perinatal period, the clinical disease resulting from further specific damage over time.

Is there a link between low parental income and childhood obesity?

2015 ◽  
Vol 15 (3) ◽  
pp. 238-255 ◽  
Author(s):  
Nichola Shackleton
Keyword(s):  
United Kingdom ◽  
Weight Status ◽  
Social Inequalities ◽  
Child Obesity ◽  
Income Poverty ◽  
Regression Analyses ◽  
Child Weight ◽  
The United Kingdom ◽  
Childhood Weight ◽  
Increased Risk

The association between familial socioeconomic status and child obesity has created the expectation that low familial income increases the risk of child obesity. Yet, there is very little evidence in the United Kingdom to suggest that this is the case. This article focuses on whether low familial income and family poverty are associated with an increased risk of child obesity. Data from the Millennium Cohort Study (age 7) are analysed. Sequential logistic regression analyses are used to determine whether income has a direct link to childhood weight. The results show no direct relationship between familial income/poverty and weight in childhood. Numerous robustness checks provide considerable evidence that low familial income has no association with children’s weight status in the United Kingdom. The results demonstrate that social inequalities in child weight are not driven by differences in income.

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