SUN-575 Levels of Nesfatin-1 in Adolescents, and Its Association with Body Mass Index and Risk of Cardiovascular Disease

Abstract Nesfastin-1 is a recently discovered anorexigenic neuropeptide, which seems to follow the signaling pathway of melanocortin, and is involved in cardiovascular regulation (1). It is expressed in several tissues, including pancreatic islet cells, the central nervous system, In subcutaneous and visceral fat tissue, among others (2). There are few and controversial data that assess the levels of nesfatin-1 and its relationship with the cardiovascular disease. The aim of this study was to evaluate the serum levels of nesfatin-1 in adolescents with different metabolic status and BMI and its association with cardiovascular risk factors (glucose, lipid profile). Material and methods: This cross-sectional study included adolescents between 15 and 19 years old, classified in 3 groups according to BMI and HOMA-IR: adolescents with normal weight without metabolic alterations (n = 30), metabolically healthy obese (MHO) n = 30 and metabolically unhealthy obese adolescents (MUO) n = 42. Anthropometric measurements were performed, a fasting blood sample was taken to quantify glucose, lipid profile and creatinine. Insulin and nesfatin-1 concentrations were measured by ELISA. Statistical tests employed were Kruskal Wallis, Spearman correlation. Results: the group of adolescents MUO had higher levels of total-C (p<0.0002); triglycerides (p<0.00001) compared to the control and MHO; higher levels of nesfatin-1 (p=0.0002) and lower levels of HDL-C (p<0.002) compared to the control group. A positive correlation was between nesfatin-1 and BMI (p<0.001), triglycerides (p<0.027), and HOMA-IR (p<0.025) and negative correlation with HDL-C (p<0.026) Conclusion: Our results show that metabolically unhealthy obese adolescents have higher concentrations of nesfatin-1, showing an association with traditional cardiovascular risk factors, which could lead to the development of cardiovascular disease. Nothing to disclose GK, KC, GOA, LCC, FMM, GA, GSME Sources of research support: Grant University of Guanajuato (DAIP 302/2018) References: (1) Oh-I et al., Nature. 2006; 443:709–712. (2) Stengel A et al., Regulatory Peptides. 2010; 163:18–23

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Effect of Dietary Education on Cardiovascular risk Factors in Rheumatoid Arthritis Patients

Current Rheumatology Reviews ◽

10.2174/1573397116666200907112338 ◽

2020 ◽

Vol 16 ◽

Author(s):

Rahil Taheri ◽

Shahram Molavynejad ◽

Parvin Abedi ◽

Elham Rajaei ◽

Mohammad Hosein Haghighizadeh

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Statistical Tests ◽

Intervention Group ◽

Serum Levels ◽

Control Group ◽

Dietary Education

Aim: The aim of this study was to investigate the effect of dietary education on cardiovascular risk factors in patients with rheumatoid arthritis. Method: In this randomized clinical trial, 112 patients with rheumatoid arthritis were randomly assigned into two groups, intervention and control. Dietary education was provided for the intervention group in 4 sessions; anthropometric measurements, serum levels of RF, triglycerides, cholesterol, HDL, LDL, and fasting blood sugar were measured before and three months after intervention. Data was analyzed using SPSS software and appropriate statistical tests. Results: The mean of total cholesterol (p <0.001), triglycerides (p = 0.004), LDL (p <0.001), systolic blood pressure (p = 0.001), diastolic blood pressure (p = 0.003), FBS and BMI (p <0.001) were decreased significantly in the intervention group after education compared the control group. Conclusion: Traditional care for rheumatoid arthritis patients is not enough. Patients need more education in order to improve their situation.

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Serum Vitamin D Binding Protein Level Associated with Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome

Hormone and Metabolic Research ◽

10.1055/a-0759-7533 ◽

2018 ◽

Vol 51 (01) ◽

pp. 54-61 ◽

Cited By ~ 4

Author(s):

Justyna Kuliczkowska-Plaksej ◽

Renato Pasquali ◽

Andrzej Milewicz ◽

Felicja Lwow ◽

Diana Jedrzejuk ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Polycystic Ovary ◽

Serum Insulin ◽

Normal Weight ◽

Control Group ◽

Vitamin D Binding Protein ◽

Ovary Syndrome

AbstractThe objective of the study was to measure the levels of 25-hydroxyvitamin D [25(OH)D] and vitamin D binding protein (VDBP) and assess their relationships with cardiovascular risk factors in women with the polycystic ovary syndrome (PCOS). A group of 267 women, aged 20–35 years (24.7 ± 4.9): 167 with PCOS and 100 healthy women were divided according to body mass index. Biochemical and hormonal parameters were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA. In the normal weight control group total, free, bioavailable 25(OH)D (p<0.001 for all) were significantly higher than in its overweight/obese counterpart, while VDBP levels were comparable. In PCOS women total 25(OH)D (p<0.001), and VDBP (p –0.006) were lower in the overweight/obese subgroups than in the normal weight ones. In both groups serum VDBP levels correlated negatively with serum insulin and positively with sex hormone binding globulin. In PCOS group, in contrast to control group, VDPB was negatively correlated with abdominal fat deposit, BMI, fasting glucose and positively with HDL. Despite lower total 25(OH)D in obese PCOS women, all women with PCOS (lean and obese) had comparable free and bioavailable 25(OH)D, which might be a result of concomitantly lowered serum VDBP levels in obese PCOS women. VDBP might play important role in the regulation of availability of active fractions of 25(OH)D in PCOS women. VDBP seems to be associated with cardiovascular risk factors such as BMI, waist circumference, visceral fat, and fasting serum insulin in women with PCOS.

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Risk of Cardiovascular Disease among Diabetic Patients in Manipur, Northeast India

Journal of Anthropology ◽

10.1155/2014/421439 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Mary Grace Tungdim ◽

T. Ginzaniang ◽

G. Poufullung Kabui ◽

Deepali Verma ◽

Satwanti Kapoor

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Premature Mortality ◽

Northeast India ◽

Risk Level ◽

Diabetic Patients ◽

Atherosclerotic Cardiovascular Disease ◽

Cross Sectional

Atherosclerotic cardiovascular disease is the major cause of premature mortality in patients with type 2 diabetes. The present study was conducted to assess cardiovascular risk among diabetic patients of Northeast India. The present cross-sectional study included 81 diabetic patients (39 males and 42 females) aged 36–74 years from the district Imphal of Manipur, Northeast India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10-year risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level. Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.3% patients were at high risk, 37.0% at moderate risk and 24.7% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride, and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications, taking into consideration the traditional dietary pattern of the population.

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Relationship between Physical Activity and Cardiovascular Risk Factors: A Cross-Sectional Study among Low-Income Housewives in Kuala Lumpur

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18116090 ◽

2021 ◽

Vol 18 (11) ◽

pp. 6090

Author(s):

Nur Zakiah Mohd Saat ◽

Siti Aishah Hanawi ◽

Nor M. F. Farah ◽

Hazilah Mohd Amin ◽

Hazlenah Hanafiah ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Low Income ◽

Cross Sectional Study ◽

Kuala Lumpur ◽

Sectional Study ◽

Cross Sectional

Cardiovascular disease is a significant public health concern worldwide, including in Malaysia. Various attempts have been made to resolve this issue. One of the most important methods of controlling cardiovascular risk factors is physical exercise. However, today’s women, especially housewives, are often identified by a lack of physical activity. This is alarming to society, as cardiovascular disease can affect the quality of their life. The aim of this study is to determine the relationship between physical activity and cardiovascular risk factors among low-income housewives in Kuala Lumpur. A total of 63 housewives participated in this cross-sectional study. All participating housewives were asked to fill out a sociodemographic questionnaire and the short version of the International Physical Activity Questionnaire (IPAQ). To evaluate cardiovascular risk factors, anthropometric measurements and blood samples were taken. Findings showed that an average of 70.5 ± 232.4 min/week was spent on moderate-to-vigorous physical activity (MVPA), which indicated a low level of physical activity. Data showed that 90.5% of the subjects had low physical activity, 6.3% were moderate, and 3.2% were considered as having a high level of physical activity. For body mass index (BMI), 58.7% of the respondents were obese, 28.6% were overweight (29.10 ± 5.67 kg m–2), and 81.0% of subjects had a waist circumference (WC) value above the normal range (92.74 ± 16.40 cm). A two-way ANOVA test revealed significant mean differences between systolic blood pressure (mm/Hg) and age groups (p > 0.05). Nevertheless, there was a significant association between MVPA and cardiovascular risk factors using negative binomial regression (p < 0.01). The findings of this study highlight the need for health promotional programs to raise awareness, educate, and engage low-income housewives in lifestyle-enhancing behaviors.

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Frequency of subclinical thyroid dysfunction and risk factors for cardiovascular disease among women at a workplace

Sao Paulo Medical Journal ◽

10.1590/s1516-31802010000100005 ◽

2010 ◽

Vol 128 (1) ◽

pp. 18-23 ◽

Cited By ~ 11

Author(s):

Rodrigo Diaz-Olmos ◽

Antônio-Carlos Nogueira ◽

Daniele Queirós Fucciolo Penalva ◽

Paulo Andrade Lotufo ◽

Isabela Martins Benseñor

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Thyroid Function ◽

Subclinical Hypothyroidism ◽

Thyroid Disease ◽

Thyroid Dysfunction ◽

Free T4 ◽

Cross Sectional

CONTEXT AND OBJECTIVE: Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them. DESIGN AND SETTING: Cross-sectional study on 314 women aged 40 years or over who were working at Universidade de São Paulo (USP). METHODS: All the women answered a questionnaire on sociodemographic characteristics and risk factors for cardiovascular disease and the Rose angina questionnaire. Anthropometric variables were measured and blood samples were analyzed for blood glucose, total cholesterol and fractions, high-sensitivity C-reactive protein, thyroid-stimulating hormone (TSH), free thyroxine (free-T4) and anti-thyroperoxidase antibodies (anti-TPO). RESULTS: The frequencies of subclinical hypothyroidism and hyperthyroidism were, respectively, 7.3% and 5.1%. Women with subclinical thyroid disease presented higher levels of anti-TPO than did women with normal thyroid function (P = 0.01). There were no differences in sociodemographic factors and cardiovascular risk factors according to thyroid function status, except for greater sedentarism among the women with subclinical hypothyroidism. Restricting the comparison to women with subclinical hypothyroidism (TSH > 10 mIU/l) did not change the results. CONCLUSION: In this sample of women, there was no association between poor profile of cardiovascular risk factors and presence of subclinical thyroid disease that would justify screening at the workplace.

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Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers

Texas Heart Institute Journal ◽

10.14503/thij-16-6052 ◽

2018 ◽

Vol 45 (3) ◽

pp. 144-150 ◽

Cited By ~ 16

Author(s):

John E. Thomas ◽

Seungho Kang ◽

Charles J. Wyatt ◽

Forest S. Kim ◽

A. David Mangelsdorff ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Medical Records ◽

Vascular Function ◽

Oxidant Stress ◽

The United States ◽

Cross Sectional ◽

Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044–1.867; P <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels. Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.

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Knowledge regarding lifestyle and cardiovascular risk factors in rural community

International Journal of Biological and Pharmaceutical Sciences Archive ◽

10.53771/ijbpsa.2021.2.1.0064 ◽

2021 ◽

Vol 2 (1) ◽

pp. 062-071

Author(s):

Priti Lata Mondal ◽

Jayanta Sadhu ◽

Abdul Karim ◽

Beauty Begum

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Rural Community ◽

Public Health Problem ◽

Cross Sectional Study ◽

Good Knowledge ◽

Major Public Health Problem ◽

Cross Sectional

Cardiovascular Disease (CVD) is one of the leading causes of death worldwide, making it a major public health problem in Bangladesh also. A descriptive cross-sectional study was carried out in Joykhali village, Batiaghata upazilla in Khulna district from January to December 2019 to assess the level of knowledge regarding lifestyle and cardiovascular risk factors in rural community. A total of 288 people were selected from each house by conveniently. Data were collected by using pre tested semi-structured questionnaire with face-to-face interview. Out of the 288 respondents, 43 (14.9%) had good knowledge while others had average (n=211, 73.3%) and poor (n=34, 11.8%) knowledge regarding risk factors of cardiovascular disease. Only 25 (8.7%) respondents had good knowledge while others had average (n=190, 66.0%) and poor (n=73, 25.3%) knowledge regarding sign and symptoms of cardiovascular disease. Majority of the respondents (61.1%) had good knowledge while others had average (n=105, 36.5%) and poor (n=7, 2.4%) knowledge regarding prevention of cardiovascular disease. There is an apparent need to establish more wide-spread and effective educational intervention, which should be sensitive to the abilities of targeted individuals.

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Aortic distensibility and dilation in Turner’s syndrome

Cardiology in the Young ◽

10.1017/s1047951109990874 ◽

2009 ◽

Vol 19 (6) ◽

pp. 568-572 ◽

Cited By ~ 21

Author(s):

Jayendra Sharma ◽

Deborah Friedman ◽

Swati Dave-Sharma ◽

Madeleine Harbison

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Hormonal Therapy ◽

Aortic Distensibility ◽

Control Group ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Aortic Dilation ◽

Cross Sectional

AbstractBackgroundAortic dilation and dissection is reported in patients with Turner’s syndrome, both with and without cardiovascular risk factors. The bicuspid aortic valve is closely associated with dilated aortic root, although expression of aortic dilation is variable. The determinants for variable expression of aortic dilation in individuals with Turner’s syndrome, however, are unknown.HypothesisA primary mesenchymal defect is prevalent in individuals with Turner’s syndrome, suggested by having abnormalities in bone matrix, and lymphatic and peripheral blood vessels. We hypothesize that an abnormal intrinsic elastic property of aorta is a forerunner of aortic dilation in Turner’s syndrome.ObjectiveAssess utility of aortic distensibility as a measure of aortic elasticity for the stratification of the risk for aortic dilation, and its relationship with age, karyotype, and hormonal therapy.DesignProspective cross-sectional study.Patients and methodWe performed cross-sectional M-mode and Doppler echocardiography in 24 individuals with Turner’s syndrome. Dimensions of the aortic root, and its distensibility, were calculated using standard techniques. We also examined a control group of 24 age matched normotensive patients with structurally normal hearts, who had been referred for evaluation of cardiac murmurs or chest pain.ResultsAortic dilation was the most common cardiac anomaly, seen in 11 of 24 (46%) individuals with Turner’s syndrome, and none in control group. Of these individuals, 5 without cardiovascular risk factors had aortic dilation. In 2 young girls, aortic dimensions were normal, albeit with reduced distensibility. Aortic dilation correlated inversely with aortic distensibility, but not with age, karyotype or hormonal therapy.ConclusionIndividuals with Turner’s syndrome, even without cardiovascular risk factors, do develop aortic dilation accompanied by decreased aortic distensibility, suggestive of an intrinsic abnormality in elastic property of the ascending aorta.

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Food habits and risk of cardiovascular disease in schoolchildren from Ouro Preto, Minas Gerais

Revista de Nutrição ◽

10.1590/1415-52732015000200002 ◽

2015 ◽

Vol 28 (2) ◽

pp. 133-142 ◽

Cited By ~ 1

Author(s):

Lorene Gonçalves Coelho ◽

Ana Paula Carlos Cândido ◽

George Luiz Lins Machado-Coelho ◽

Silvia Nascimento de Freitas

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cardiovascular Risk ◽

Food Intake ◽

Cardiovascular Risk Factors ◽

Food Habits ◽

Population Based ◽

Minas Gerais ◽

Linear Regression Models ◽

Cross Sectional

OBJECTIVE: To investigate the relationship between food habits and risk factors for cardiovascular disease in schoolchildren of the city Ouro Preto, Minas Gerais. METHODS: A cross-sectional study was conducted in a population-based sample of 738 schoolchildren aged 6-14 years. A semi-structured questionnaire was used for collecting demographic, socioeconomic, biochemical, clinical, and anthropometric data. Food intake was determined by a food-frequency questionnaire. Food habits were evaluated according to the adapted Recommended Food Score. Multiple linear regression models were constructed to assess how food consumption was associated with cardiovascular risk factors. RESULTS: The schoolchildren presented a dietary pattern characterized by low consumption of healthy foods. Association of cardiovascular risk factors showed that the consumption of foods according to the adapted Recommended Food Score was negatively and significantly associated with tetrapolar percentage of body fat (p=0.030) and systolic blood pressure (p=0.049) in children aged 6-9 years. CONCLUSION: Children's dietary patterns proved to be an important determinant of some of the cardiovascular risk factors studied. Thus, food intake assessment is a primary tool for the prevention and early intervention on cardiovascular risk factors during childhood.

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Effects of Rehabilitation Exercise on Cardiovascular Risk Factors and Muscle Cross-Sectional Area in Overweight Patients with Low Back Pain

Healthcare ◽

10.3390/healthcare9070809 ◽

2021 ◽

Vol 9 (7) ◽

pp. 809

Author(s):

Won-Moon Kim ◽

Su-Ah Lee ◽

Yun-Jin Park ◽

Yong-Gon Seo

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Exercise Intervention ◽

Exercise Program ◽

Normal Weight ◽

Post Intervention ◽

Cross Sectional ◽

Lumbar Muscle ◽

Rehabilitation Exercise

Limited studies exist on the effects of exercise therapy on obese and normal-weight patients. Herein, we investigated the effect of a 12-week rehabilitation exercise program on cardiovascular risk factors, Oswestry Disability Index (ODI), and change in the cross-sectional area (CSA) of lumbar muscles in patients with obesity and normal-weight low back pain (LBP). LBP patients were allocated to the overweight LBP group (OLG; n = 15) and normal-weight LBP group (NLG; n = 15). They performed a rehabilitation exercise program three times per week for 12 weeks. Cardiovascular risk factors, ODI score, and lumbar muscle CSA were assessed pre- and post-intervention. Body composition, body weight (p < 0.001), and body mass index (p < 0.001) significantly improved after the exercise intervention in OLG. Body fat percentage significantly decreased in both groups, but OLG (p < 0.001) showed slightly greater improvement than NLG (p = 0.034). Total cholesterol (p = 0.013) and low-density lipoprotein (p = 0.002) significantly improved in OLG. ODI score improved significantly in both groups (p = 0.000). Lumbar muscle CSA showed a significant difference in the context of the time result (p = 0.008). OLG showed a significant improvement post-intervention (p = 0.003). The rehabilitation exercise program was more beneficial on cardiovascular risk factors and change in lumbar muscle CSA in OLG, suggesting an intensive exercise intervention needed for overweight patients with LBP.

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