scholarly journals Weighting and standardization of frequencies to determine prevalence of AD imaging biomarkers

Neurology ◽  
2017 ◽  
Vol 89 (20) ◽  
pp. 2039-2048 ◽  
Author(s):  
Rosebud O. Roberts ◽  
David S. Knopman ◽  
Jeremy A. Syrjanen ◽  
Jeremiah A. Aakre ◽  
Maria Vassilaki ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Imaging Biomarkers ◽  
Carrier Status ◽  
Elderly Persons ◽  
Amyloid A ◽  
Age Related ◽  
Amyloid Accumulation ◽  
Thickness Measure ◽  
Prevalence Estimates ◽  
Future Burden

Objective:To estimate the prevalence of elevated brain amyloid and reduced cortical thickness (as a marker for neurodegeneration) in a defined population.Methods:Mayo Clinic Study of Aging participants underwent MRI to assess a composite Alzheimer disease (AD) signature cortical thickness measure and PET to assess brain amyloid accumulation. Participants were characterized as having elevated amyloid (A+/A−), reduced cortical thickness (N+/N−), and A+N+, A+N−, A−N+, or A−N−. The prevalence of AD biomarkers was derived by adjusting for nonparticipation and standardizing to the Olmsted County, Minnesota, population.Results:Among 1,646 participants without dementia (mean age 70.8 years; 53.2% men), the prevalence (95% confidence interval) of amyloidosis was 21.1% (19.1%–23.2%): women, 24.3%; men, 17.5%. The prevalence of reduced cortical thickness was 28.9% (26.4%–31.5%): women, 27.9%; men, 30.2%. The prevalence estimates of biomarker categories were as follows: A−N−: 61.4%; A+N−: 9.7%; A−N+: 17.4%; and A+N+: 11.5%, and varied by sex and byAPOEε4 carrier status. In men, prevalence estimates were as follows: A−N−: 62.6%; A+N−: 7.3%; A−N+: 19.9%; and A+N+: 10.2%. In women, prevalence estimates were as follows: A−N−: 60.4%; A+N−: 11.7%; A−N+: 15.3%; and A+N+: 12.6%. In ε4 carriers, prevalence estimates were as follows: A−N−: 54.6%; A+N−: 16.6%; A−N+: 12.4%; and A+N+: 16.4%. In non-ε4 carriers, prevalence estimates were as follows: A−N−: 63.3%; A+N−: 6.9%; A−N+: 19.9%; and A+N+: 10.0%.Conclusions:These prevalence estimates are important for understanding age-related trends in amyloid positivity and AD signature cortical thickness in the population, and for potentially projecting the future burden of biomarkers in elderly persons.

Cortical Thickness in Cocaine Use Disorder and its Relation to Age-Related Brain Atrophy

2021 ◽  
Vol 89 (9) ◽  
pp. S368-S369
Author(s):  
Lucca Pizzato Tondo ◽  
Wyllians Vendramini Borelli ◽  
Leonardo Melo Rothmann ◽  
Eduardo Leal-Conceição ◽  
Alexandre Rosa Franco ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Brain Atrophy ◽  
Cocaine Use ◽  
Age Related

scholarly journals Long-term cyclic aerobic training preserves the brain's health in elderly persons (brief review)

2016 ◽  
Vol 24 (4) ◽  
pp. 152-163
Author(s):  
A S Radchenko ◽  
B B Davydov ◽  
A N Kalinichenko
Keyword(s):  
Aerobic Training ◽  
Brain Perfusion ◽  
Favorable Effect ◽  
Elderly Persons ◽  
Periodical Literature ◽  
Brain Health ◽  
Memory State ◽  
Age Related ◽  
The Brain

It was identified on the base of special periodical literature analyze that cyclic muscular work systematically performed during large part of the person's life (former athlete) provides mainly the favorable effect on the brain. Ventricular-arterial coupling improvement ameliorates brain perfusion, and creates function advantages to brain health in old age. At that, the gray and white matter fading hampered, especially in structures that associated with visual control and human body spatial orientation, motor control and memory state, and age-related attenuation of cognitive functions in comparison with sedentary persons of the same age.

scholarly journals Septoplasty in elderly patients

2020 ◽  
Vol 4 (4) ◽  
pp. 243-246
Author(s):  
S.A. Karpishchenko ◽  
◽  
G.V. Lavrenova ◽  
O.E. Vereshchagina ◽  
P.I. Gas’kova ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Donor Site ◽  
Management Strategies ◽  
Scoring Systems ◽  
Postoperative Management ◽  
Septal Cartilage ◽  
Elderly Persons ◽  
Nasal Breathing ◽  
Deviated Septum ◽  
Age Related

This review article attempts to systematize and summarize the data on the major age-related pathophysiological, biomechanical, and histological processes that contribute to the progression of nasal breathing impairment or the appearance of these symptoms in elderly patients. The specifics of risk assessment of deviated septum surgery using various questionnaires and scoring systems is discussed. The article demonstrates that deviated septum surgery can be performed in these patients and addresses the specificity of donor site selection for a septal graft in elderly patients considering the histological features of various septal cartilage regions. Prior assessment of individual risks is of particular importance since it determines surgical success and favorable postoperative course in these patients. Studies addressing the perspective use of tissue-engineering transplants are unraveled. Management strategies that consider aging biomechanisms potentially affecting treatment efficacy are described. Finally, the article highlights preoperative management, treatment choice, drug dosage regimens, and postoperative management after septoplasty. KEYWORDS: deviated septum, septoplasty, elderly persons, age-related disorders, neuromuscular tone, nasal breathing impairment. FOR CITATION: Karpishchenko S.A., Lavrenova G.V., Vereshchagina O.E., Gas’kova P.I. Septoplasty in elderly patients. Russian Medical Inquiry. 2020;4(4):243–246. DOI: 10.32364/2587-6821-2020-4-4-243-246.

scholarly journals Repetitive mTBI is associated with age-related reductions in cerebral blood flow but not cortical thickness

2020 ◽  
pp. 0271678X1989744 ◽  
Author(s):  
Alexandra L Clark ◽  
Alexandra J Weigand ◽  
Katherine J Bangen ◽  
Victoria C Merritt ◽  
Mark W Bondi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Risk Factor ◽  
Cerebral Blood Flow ◽  
Cortical Thickness ◽  
Regression Analyses ◽  
Brain Scans ◽  
Age Related ◽  
Cerebrovascular Dysfunction ◽  
Parietal Cortices

Mild traumatic brain injury (mTBI) is a risk factor for Alzheimer’s disease (AD), and evidence suggests cerebrovascular dysregulation initiates deleterious neurodegenerative cascades. We examined whether mTBI history alters cerebral blood flow (CBF) and cortical thickness in regions vulnerable to early AD-related changes. Seventy-four young to middle-aged Veterans (mean age = 34, range = 23–48) underwent brain scans. Participants were divided into: (1) Veteran Controls ( n =  27), (2) 1–2 mTBIs ( n =  26), and (2) 3+ mTBIs ( n =  21) groups. Resting CBF was measured using MP-PCASL. T1 structural scans were processed with FreeSurfer. CBF and cortical thickness estimates were extracted from nine AD-vulnerable regions. Regression analyses examined whether mTBI moderated the association between age, CBF, and cortical thickness. Regressions adjusting for sex and posttraumatic stress revealed mTBI moderated the association between age and CBF of the precuneus as well as superior and inferior parietal cortices ( p’s < .05); increasing age was associated with lower CBF in the 3+ mTBIs group, but not in the VCs or 1–2 mTBIs groups. mTBI did not moderate associations between age and cortical thickness ( p’s >.05). Repetitive mTBI is associated with cerebrovascular dysfunction in AD-vulnerable regions and may accelerate pathological aging trajectories.

Major Predictive Factors for Progression of Early to Late Age-Related Macular Degeneration

2020 ◽  
Vol 243 (6) ◽  
pp. 444-452 ◽  
Author(s):  
Vasilena Sitnilska ◽  
Eveline Kersten ◽  
Lebriz Altay ◽  
Tina Schick ◽  
Philip Enders ◽  
...  
Keyword(s):  
Prediction Model ◽  
Macular Degeneration ◽  
Area Under The Curve ◽  
Age Related Macular Degeneration ◽  
Advanced Age ◽  
Fundus Photography ◽  
Imaging Biomarkers ◽  
Nucleotide Polymorphisms ◽  
Phenotypic Profile ◽  
Age Related

<b><i>Introduction:</i></b> We present a prediction model for progression from early/intermediate to advanced age-related macular degeneration (AMD) within 5.9 years. <b><i>Objectives:</i></b> To evaluate the combined role of genetic, nongenetic, and phenotypic risk factors for conversion from early to late AMD over ≥5 years. <b><i>Methods:</i></b> Baseline phenotypic characteristics were evaluated based on color fundus photography, spectral-domain optical coherence tomography, and infrared images. Genotyping for 36 single-nucleotide polymorphisms as well as systemic lipid and complement measurements were performed. Multivariable backward logistic regression resulted in a final prediction model. <b><i>Results and Conclusions:</i></b> During a mean of 5.9 years of follow-up, 22.4% (<i>n</i> = 52) of the patients (<i>n</i> = 232) showed progression to late AMD. The multivariable prediction model included age, <i>CFH</i> variant rs1061170, pigment abnormalities, drusenoid pigment epithelial detachment (DPED), and hyperreflective foci (HRF). The model showed an area under the curve of 0.969 (95% confidence interval 0.948–0.990) and adequate calibration (Hosmer-Lemeshow test, <i>p</i> = 0.797). In addition to advanced age and carrying a <i>CFH</i> variant, pigment abnormalities, DPED, and HRF are relevant imaging biomarkers for conversion to late AMD. In clinical routine, an intensified monitoring of patients with a high-risk phenotypic profile may be suitable for the early detection of conversion to late AMD.

scholarly journals A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Richard A. I. Bethlehem ◽  
Jakob Seidlitz ◽  
Rafael Romero-Garcia ◽  
Stavros Trakoshis ◽  
Guillaume Dumas ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Autism Spectrum ◽  
Case Control ◽  
Small Subset ◽  
Typically Developing ◽  
Average Case ◽  
Age Related ◽  
Small Subgroup ◽  
Individualized Approach ◽  
Age Range

AbstractUnderstanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). We examined how cortical thickness (CT) in ASD can be parameterized as an individualized metric of atypicality relative to typically-developing (TD) age-related norms. Across a large sample (n = 870 per group) and wide age range (5–40 years), we applied normative modelling resulting in individualized whole-brain maps of age-related CT atypicality in ASD and isolating a small subgroup with highly age-atypical CT. Age-normed CT scores also highlights on-average differentiation, and associations with behavioural symptomatology that is separate from insights gleaned from traditional case-control approaches. This work showcases an individualized approach for understanding ASD heterogeneity that could potentially further prioritize work on a subset of individuals with cortical pathophysiology represented in age-related CT atypicality. Only a small subset of ASD individuals are actually highly atypical relative to age-norms. driving small on-average case-control differences.

scholarly journals The Role of Selected Bioactive Compounds in the Prevention of Alzheimer’s Disease

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 229 ◽  
Author(s):  
Wojciech Grodzicki ◽  
Katarzyna Dziendzikowska
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Bioactive Compounds ◽  
Molecular Mechanisms ◽  
Neuroprotective Effect ◽  
Health Concern ◽  
Elderly Persons ◽  
Global Public Health ◽  
Age Related ◽  
In Vivo Animal Model

Neurodegeneration is a feature of many debilitating, incurable age-dependent diseases that affect the nervous system and represent a major threat to the health of elderly persons. Because of the ongoing process of aging experienced by modern societies, the increasing prevalence of neurodegenerative diseases is becoming a global public health concern. A major cause of age-related dementia is Alzheimer’s disease (AD). Currently, there are no effective therapies to slow, stop, or reverse the progression of this disease. However, many studies have suggested that modification of lifestyle factors, such as the introduction of an appropriate diet, can delay or prevent the onset of this disorder. Diet is currently considered to be a crucial factor in controlling health and protecting oneself against oxidative stress and chronic inflammation, and thus against chronic degenerative diseases. A large number of bioactive food compounds may influence the pathological mechanisms underlying AD. Among them, phenolic compounds, omega-3 fatty acids, fat-soluble vitamins, isothiocyanates, and carotenoids seem to be promising. They act not only as antioxidant and anti-inflammatory agents, but also as active modulators of the pathological molecular mechanisms that play a role in AD development, including the formation of amyloid plaques and tau tangles, the main hallmarks of AD pathology. In vivo animal model studies as well as clinical and epidemiological research suggest that nutritional intervention has a positive effect on the health of older people and may prevent age-related cognitive decline, especially when the diet contains more than one bioactive nutrient. The Mediterranean diet and in particular its combination with Dietary Approaches to Stop Hypertension, which is called the MIND diet, are nutritional patterns based on many products rich in bioactive compounds that appear to be the most effective in preventing neurodegeneration. The present review gathers evidence that supports the neuroprotective effect of bioactive substances.

P2-429: PRESERVED CORTICAL THICKNESS IN ALZHEIMER SIGNATURE REGIONS: RESISTANCE TO AMYLOID ACCUMULATION IN NORMAL AGING

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P876-P876
Author(s):  
Catherine Veilleux ◽  
Sven Joubert ◽  
Michaël Bernier ◽  
Pénélope Sévigny-Dupont ◽  
Marie-Maxime Lavallée ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Normal Aging ◽  
Amyloid Accumulation

scholarly journals NIA HEALTH DISPARITIES RESEARCH NETWORK: APPROACHES AND FINDINGS FROM GERIATRICS AND CLINICAL GERONTOLOGY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S13-S13
Author(s):  
Lyndon Joseph ◽  
CarlV Hill
Keyword(s):  
Health Disparities ◽  
Life Expectancy ◽  
Research Network ◽  
Imaging Biomarkers ◽  
Sociocultural Factors ◽  
Multiple Chronic Conditions ◽  
Structural Level ◽  
Biological Mechanisms ◽  
Age Related ◽  
Reduce Life Expectancy

Abstract Health disparities are differences in the incidence, prevalence and burden of diseases, mortality rates and causes of death that exist among population groups. Health disparities are associated with a broad, complex, and interrelated array of factors that influence health, accelerate aging and reduce life expectancy. NIA’s health disparities research goals are to understand environmental and sociocultural factors and related behavioral and biological mechanisms that diminish health and reduce life expectancy for vulnerable populations, explore the biological mechanisms through which disparities influence age-related change, and identify where disparities emerge in diagnosis, prognosis or treatment in geriatric conditions. Presentations will focus on whether structural-level discrimination may be a key factor in potentiating well known race-related health disparities especially those with an accelerated onset and may be associated with MRI-indicators of subclinical brain pathology; identifying biomarkers for early detection of cognitive and functional decline in high risk subpopulations and how ethnicity influences cerebral spinal fluid and imaging biomarkers link to early identification of cognitive and functional impairment ; effects of medication management and deprescribing among African American and Hispanic older adults with Alzheimer’s disease and related dementias and multiple chronic conditions; examine the use of multi-level factors and technology to overcome the barriers to urban-rural health disparities in managing many chronic diseases such as hepatitis C virus infection and delivery of appropriate medical services; and understanding the racial and ethnic differences in the link between environmental exposures and auto-immune comorbid asthma.

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