scholarly journals A comparative perspective on lung and gill regeneration

2020 ◽  
Vol 223 (19) ◽  
pp. jeb226076
Author(s):  
Laura Cadiz ◽  
Michael G. Jonz
Keyword(s):  
Model Organisms ◽  
Comparative Approach ◽  
The Past ◽  
Tissue Replacement ◽  
Signaling Mechanisms ◽  
Aquatic Vertebrates ◽  
Mammalian Lung ◽  
The Common ◽  
Underlying Mechanisms ◽  
Lung Regeneration

ABSTRACTThe ability to continuously grow and regenerate the gills throughout life is a remarkable property of fish and amphibians. Considering that gill regeneration was first described over one century ago, it is surprising that the underlying mechanisms of cell and tissue replacement in the gills remain poorly understood. By contrast, the mammalian lung is a largely quiescent organ in adults but is capable of facultative regeneration following injury. In the course of the past decade, it has been recognized that lungs contain a population of stem or progenitor cells with an extensive ability to restore tissue; however, despite recent advances in regenerative biology of the lung, the signaling pathways that underlie regeneration are poorly understood. In this Review, we discuss the common evolutionary and embryological origins shared by gills and mammalian lungs. These are evident in homologies in tissue structure, cell populations, cellular function and genetic pathways. An integration of the literature on gill and lung regeneration in vertebrates is presented using a comparative approach in order to outline the challenges that remain in these areas, and to highlight the importance of using aquatic vertebrates as model organisms. The study of gill regeneration in fish and amphibians, which have a high regenerative potential and for which genetic tools are widely available, represents a unique opportunity to uncover common signaling mechanisms that may be important for regeneration of respiratory organs in all vertebrates. This may lead to new advances in tissue repair following lung disease.

scholarly journals Future In The Past: The Problem Of Values In Transatlantic Relations

2006 ◽  
Vol 11 ◽  
pp. 9-29
Author(s):  
Ana-Maria Stoian
Keyword(s):  
Transatlantic Relations ◽  
Second World War ◽  
Comparative Approach ◽  
World War ◽  
The Past ◽  
Norms And Values ◽  
The Us ◽  
The Common ◽  
Second World ◽  
The Eu

This paper discusses the importance of norms and values in the transatlantic relations. Beginning with the values that shaped the transatlantic partnership at the end of the Second World War, the analysis questions the redefinition of transatlantic values at the beginning of the 21st century, emphasizing patterns of convergence and divergence. Using a comparative approach, the article presents values, norms and principles explaining the domestic and international behaviour of the US and the EU. The main argument of the paper is that there are not two different sets of values, a European and an American one, but a single transatlantic set of values (a Western one), with some distinct elements and approaches. There is not a great departure from the common matrix of values so that to endanger the US-European relationship indefinitely.

Beyond Promoter: The Role of Macrophage in Invasion and Progression of Renal Cell Carcinoma

2020 ◽  
Vol 15 (7) ◽  
pp. 588-596
Author(s):  
Haibao Zhang ◽  
Guodong Zhu
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Formation ◽  
Biological Behavior ◽  
Tumor Stem Cell ◽  
The Past ◽  
The Common

Renal cell carcinoma (RCC) is one of the common urologic neoplasms, and its incidence has been increasing over the past several decades; however, its pathogenesis is still unknown up to now. Recent studies have found that in addition to tumor cells, other cells in the tumor microenvironment also affect the biological behavior of the tumor. Among them, macrophages exist in a large amount in tumor microenvironment, and they are generally considered to play a key role in promoting tumorigenesis. Therefore, we summarized the recent researches on macrophage in the invasiveness and progression of RCC in latest years, and we also introduced and discussed many studies about macrophage in RCC to promote angiogenesis by changing tumor microenvironment and inhibit immune response in order to activate tumor progression. Moreover, macrophage interactes with various cytokines to promote tumor proliferation, invasion and metastasis, and it also promotes tumor stem cell formation and induces drug resistance in the progression of RCC. The highlight of this review is to make a summary of the roles of macrophage in the invasion and progression of RCC; at the same time to raise some potential and possible targets for future RCC therapy.

Novel Findings of Anti-cancer Property of Propofol

2018 ◽  
Vol 18 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Jiaqiang Wang ◽  
Chien-shan Cheng ◽  
Yan Lu ◽  
Xiaowei Ding ◽  
Minmin Zhu ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Intravenous Anesthetic ◽  
The Past ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
Recent Attention

Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.

Searching for Political Parties in the Past

2017 ◽  
Author(s):  
Piero Ignazi
Keyword(s):  
Eighteenth Century ◽  
Political Parties ◽  
Political Party ◽  
Ancient Greece ◽  
Political Community ◽  
Democratic Politics ◽  
The Political ◽  
The Past ◽  
The Common

Chapter 1 introduces the long and difficult process of the theoretical legitimation of the political party as such. The analysis of the meaning and acceptance of ‘parties’ as tools of expressing contrasting visions moves forward from ancient Greece and Rome where (democratic) politics had first become a matter of speculation and practice, and ends up with the first cautious acceptance of parties by eighteenth-century British thinkers. The chapter explores how parties or factions have been constantly considered tools of division of the ‘common wealth’ and the ‘good society’. The holist and monist vision of a harmonious and compounded society, stigmatized parties and factions as an ultimate danger for the political community. Only when a new way of thinking, that is liberalism, emerged, was room for the acceptance of parties set.

The Oxford History of Historical Writing

2018 ◽  
Keyword(s):  
Early Modern ◽  
Korean Peninsula ◽  
Comparative Approach ◽  
Modern World ◽  
Historical Writing ◽  
North West ◽  
The Past ◽  
History Of

How was history written in Europe and Asia between 400–1400? How was the past understood in religious, social, and political terms? And in what ways does the diversity of historical writing in this period mask underlying commonalities in narrating the past? The volume tackles these and other questions. Part I provides comprehensive overviews of the development of historical writing in societies that range from the Korean Peninsula to north-west Europe, which together highlight regional and cultural distinctiveness. Part II complements the first part by taking a thematic and comparative approach; it includes chapters on genre, warfare, and religion (amongst others) which address common concerns of historians working in this liminal period before the globalizing forces of the early modern world.

Can Groups Assert That P?

2019 ◽  
pp. 326-344
Author(s):  
Deborah Tollefsen
Keyword(s):  
Common Ground ◽  
Speech Act ◽  
Single Individual ◽  
Constitutive Rule ◽  
The Past ◽  
Group Members ◽  
The Common ◽  
Declarative Statement ◽  
John Macfarlane

When a group or institution issues a declarative statement, what sort of speech act is this? Is it the assertion of a single individual (perhaps the group’s spokesperson or leader) or the assertion of all or most of the group members? Or is there a sense in which the group itself asserts that p? If assertion is a speech act, then who is the actor in the case of group assertion? These are the questions this chapter aims to address. Whether groups themselves can make assertions or whether a group of individuals can jointly assert that p depends, in part, on what sort of speech act assertion is. The literature on assertion has burgeoned over the past few years, and there is a great deal of debate regarding the nature of assertion. John MacFarlane has helpfully identified four theories of assertion. Following Sandy Goldberg, we can call these the attitudinal account, the constitutive rule account, the common-ground account, and the commitment account. I shall consider what group assertion might look like under each of these accounts and doing so will help us to examine some of the accounts of group assertion (often presented as theories of group testimony) on offer. I shall argue that, of the four accounts, the commitment account can best be extended to make sense of group assertion in all its various forms.

scholarly journals A Theoretical Framework on the Determinants of Food Purchasing Behavior of the Elderly: A Bibliometric Review with Scientific Mapping in Web of Science

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 688
Author(s):  
Khaled Alhammadi ◽  
Luna Santos-Roldán ◽  
Luis Javier Cabeza-Ramírez
Keyword(s):  
Elderly Population ◽  
Web Of Science ◽  
The Elderly ◽  
Purchasing Behavior ◽  
Food Purchasing ◽  
The Past ◽  
Bibliometric Review ◽  
Food Market ◽  
The Common ◽  
Elderly Consumers

The past few years have seen significant demographic changes in most regions, including an increased elderly population. Subsequently, elderly citizens comprise an important market segment of consumers, with the food industry one of the most affected areas in this context. However, food market managers previously believed that elderly consumers’ needs were stereotyped in nature. The lack of focus on this sector, therefore, left elderly consumers as an untapped market, without realizing the financial independence of this segment regarding their nutrition. This research will attempt to provide the key determinant factors on elderly consumers’ behavior related to food. For that purpose, a complete literature review of more than 123 papers regarding these concepts has been carried out. Once analyzed, we highlight the common insights to give clear guidance for supermarket managers and food manufacturers to have a better knowledge of the reasons behind elderly people’s food acquisitions.

scholarly journals B.05 Hemi-laryngopharyngeal spasm (HELPS) syndrome: The discovery, cure, and characterization of a new neurological condition

2017 ◽  
Vol 44 (S2) ◽  
pp. S11-S11
Author(s):  
C Honey ◽  
M Morrison
Keyword(s):  
Surgical Care ◽  
Review Of The Literature ◽  
The Past ◽  
First Case ◽  
Patient Reported ◽  
Operative Outcome ◽  
Small Cohort ◽  
The Common ◽  
Similar Motor

Background: We published the world’s first case of hemi-laryngpharyngeal spasm (HELPS) syndrome cured by microvascular decompression (MVD) of the Xth cranial nerve in 2016. We now present a small cohort of patients (n=3) successfully treated with surgery in order to better delineate the common characteristics of this syndrome, diagnostic tests of choice, nuances of their surgical care and outcomes of their treatment. Methods: The history and physical examination of three patients with HELPS syndrome are presented. Pre-operative laryngoscopy, neuroimaging, response to botox and intra-operative videos are detailed. Post-operative outcome and complications are presented. Results: Each patient reported similar motor (choking) and sensory (coughing) features in their history. Episodic choking relentlessly progressed over the years until it occurred while sleeping and with frightening severity prompting tracheostomy in one patient and intubation in another. A “tickling” sensation deep in the throat triggered episodic coughing that worsened over the years until it occurred while sleeping and with frightening severity (syncope and incontinence). Conclusions: A review of the literature suggests that patients with similar symptoms, often called episodic laryngospasm in the past, have been treated with psychotherapy or antacids. With the recognition that a clearly defined subset of these patients have HELPS syndrome, we can offer them the potential of a neurosurgical cure.

Expanding Evolutionary Psychology: toward a Better Understanding of Violence and Aggression

2003 ◽  
Vol 42 (1) ◽  
pp. 5-50 ◽  
Author(s):  
Iver Mysterud ◽  
Dag Viljen Poleszynski
Keyword(s):  
Evolutionary Psychology ◽  
Food Allergies ◽  
Sociocultural Factors ◽  
The Past ◽  
Physical Chemical ◽  
Reactive Hypoglycemia ◽  
Proximate Factors ◽  
Survival And Reproduction ◽  
The Common ◽  
Habitual Intake

The “mainstream” evolutionary psychology model is currently under criticism from scientists of other persuasions wanting to expand the model or to make it more realistic in various ways. We argue that focusing on the environment as if it consisted only of social (or sociocultural) factors gives too limited a perspective if evolutionary approaches are to understand the behavior of modern humans. Taking the case of violence, we argue that numerous novel environmental factors of nutritional and physical-chemical origin should be considered as relevant proximate factors. The common thesis presented here is that several aspects of the biotic or abiotic environment are able to change brain chemistry, thus predisposing individuals to violence and aggression in given contexts. In the past, aggressive behavior has had a number of useful functions that were of particular importance to our ancestors' survival and reproduction. However, some of the conditions in our novel environment, which either lowered the threshold for aggression or released such behavior in contexts which were adaptive in our evolutionary past, no longer apply. It is high time evolutionary approaches to violence are expanded to include the possibilities that violence may be triggered by nutritionally depleted foods, reactive hypoglycemia caused by habitual intake of foods with a high glycemic index (GI), food allergies/intolerances and exposure to new environmental toxins (heavy metals, synthetic poisons).

Communication Theory and Training Approaches for Multiculturally Diverse Organizations: Have Academics and Practitioners Missed the Connection?

2001 ◽  
Vol 30 (4) ◽  
pp. 445-455 ◽  
Author(s):  
Marguerite Arai ◽  
Maryanne Wanca-Thibault ◽  
Pamela Shockley-Zalabak
Keyword(s):  
Communication Theory ◽  
Diversity Training ◽  
Multicultural Training ◽  
Theory And Practice ◽  
Important Research ◽  
Human Communication ◽  
The Past ◽  
The Common ◽  
Multiculturally Diverse ◽  
And Training

While a number of articles have looked at the importance of multicultural training in the workplace over the past 30 years, there is little concrete agreement that documents the common fundamental elements of a “successful” diversity initiative. A review of the training literature suggests the importance of human communication theory and practice without including important research, methodologies, and practice from the communication discipline. This article examines formal diversity approaches, provides examples from the literature of several successful diversity initiatives in larger organizations, identifies the limited use of communication-based approaches in diversity training, and discusses the importance of integrating communication theory and practice in future training efforts.

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