THE RELATIONSHIP BETWEEN INSULIN SENSITIVITY, FAT DISTRIBUTION AND SKELETAL MUSCLE CHARACTERISTICS IS MUSCLE GROUP-SPECIFIC

1995 ◽  
Vol 27 (Supplement) ◽  
pp. S38
Author(s):  
M. S. Hickey ◽  
M. D. Weidner ◽  
K. E. Gavigan ◽  
D. Zheng ◽  
G. L. Tyndall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Fat Distribution ◽  
Muscle Group ◽  
The Relationship

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Metabolism ◽  
2010 ◽  
Vol 59 (11) ◽  
pp. 1556-1561 ◽  
Author(s):  
Darren C. Henstridge ◽  
Josephine M. Forbes ◽  
Sally A. Penfold ◽  
Melissa F. Formosa ◽  
Sonia Dougherty ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 72 ◽  
The Relationship

scholarly journals Insulin Sensitivity Is Correlated with Subcutaneous but Not Visceral Body Fat in Overweight and Obese Prepubertal Children

2008 ◽  
Vol 93 (6) ◽  
pp. 2122-2128 ◽  
Author(s):  
Claudio Maffeis ◽  
Riccardo Manfredi ◽  
Maddalena Trombetta ◽  
Silvia Sordelli ◽  
Monica Storti ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Body Fat ◽  
Fat Distribution ◽  
Fat Content ◽  
Liver Fat ◽  
P Value ◽  
Inflammation Markers ◽  
Liver Fat Content ◽  
Prepubertal Children

Abstract Aim: Our aim was to explore the relationship between insulin sensitivity, body fat distribution, ectopic (liver and skeletal muscle) fat deposition, adipokines (leptin and adiponectin), and inflammation markers (highly sensitive C-reactive protein, IL-6, IL-10, and TNF-α) in prepubertal children. Subjects and Methods: Thirty overweight and obese children (16 males and 14 females with body mass index z-score range of 1.1–3.2) were recruited. Body fat distribution and fat accumulation in liver and skeletal muscle were measured using magnetic resonance imaging. Insulin sensitivity was assessed by iv glucose tolerance test. Results: Insulin sensitivity was associated with sc abdominal adipose tissue (SAT) (r = −0.52; P < 0.01) and liver fat content (r = −0.44; P < 0.02) but not with visceral abdominal adipose tissue (VAT) (r = −0.193; P value not significant) and fat accumulation in skeletal muscle (r = −0.210; P value not significant). Adipokines, but not inflammation markers, were significantly correlated to insulin sensitivity. VAT correlated with C-reactive protein (r = 0.55; P < 0.01) as well as adiponectin (r = −0.53; P <0.01). Multiple regression analysis showed that only SAT and liver fat content were independently correlated to insulin sensitivity (P < 0.01; 20 and 16% of explained variance, respectively). Conclusions: In overweight and moderately obese prepubertal children, insulin sensitivity was negatively correlated with SAT and liver fat content. Furthermore, contrary to adults, VAT and inflammation markers were not correlated with insulin sensitivity in children.

Behavioral, metabolic, and molecular correlates of lower insulin sensitivity in Mexican-Americans

2002 ◽  
Vol 283 (4) ◽  
pp. E799-E808 ◽  
Author(s):  
Richard C. Ho ◽  
Kevin P. Davy ◽  
Matthew S. Hickey ◽  
Scott A. Summers ◽  
Christopher L. Melby
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Dietary Intake ◽  
Mexican Americans ◽  
Muscle Protein ◽  
Fat Distribution ◽  
Abdominal Fat ◽  
Protein Abundance ◽  
Model Assessment ◽  
Skeletal Muscle Protein

We determined whether lower insulin sensitivity persists in young, nonobese, nondiabetic Mexican-American [MA; n = 13, 27.0 ± 2.0 yr, body mass index (BMI) 23.0 ± 0.7] compared with non-Hispanic white (NHW; n = 13, 24.8 ± 1.5 yr, BMI 22.8 ± 0.6) males and females after accounting for cardiorespiratory fitness (maximal O2 uptake), abdominal fat distribution (computed tomography scans), dietary intake (4-day records), and skeletal muscle insulin-signaling protein abundance from muscle biopsies (Western blot analysis). MA were significantly less insulin sensitive compared with their NHW counterparts when estimated by homeostatic model assessment of insulin resistance (MA: 1.53 ± 0.22 vs. NHW: 0.87 ± 0.16, P < 0.05) and the revised quantitative insulin sensitivity check index (MA: 0.45 ± 0.08 vs. NHW: 0.58 ± 0.19, P = 0.05). However, skeletal muscle protein abundance of insulin receptor-β (IRβ), phosphatidylinositol 3-kinase p85 subunit, Akt1, Akt2, and GLUT4 were not significantly different. Differences in indexes of insulin sensitivity lost significance after percent dietary intake of palmitic acid, palmitoleic acid, and skeletal muscle protein abundance of IRβ were accounted for. We conclude that differences in insulin sensitivity between nonobese, nondiabetic MA and NHW persist after effects of chronic and acute exercise and total and abdominal fat distribution are accounted for. These differences may be mediated, in part, by dietary fat intake.

The relationship between insulin sensitivity and skeletal muscle enzyme activities in hepatic cirrhosis

Hepatology ◽  
1988 ◽  
Vol 8 (6) ◽  
pp. 1615-1619 ◽  
Author(s):  
Yolanta Kruszynska ◽  
Nicholas Williams ◽  
Michael Perry ◽  
Philip Home
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Enzyme Activities ◽  
Hepatic Cirrhosis ◽  
Muscle Enzyme ◽  
The Relationship ◽  
Muscle Enzyme Activities

Epigenetic and Metabolic Changes in Skeletal Muscle Underlying the Improvement of Insulin Sensitivity after Bariatric Surgery in Humans

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 156-OR
Author(s):  
SOFIYA GANCHEVA ◽  
MERIEM OUNI ◽  
CHRYSI KOLIAKI ◽  
TOMAS JELENIK ◽  
DANIEL F. MARKGRAF ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Metabolic Changes

scholarly journals Morphological Evidence of Telocytes in Skeletal Muscle Interstitium of Exercised and Sedentary Rodents

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 807
Author(s):  
Silvia Ravalli ◽  
Concetta Federico ◽  
Giovanni Lauretta ◽  
Salvatore Saccone ◽  
Elisabetta Pricoco ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Stromal Cells ◽  
Tibialis Anterior Muscle ◽  
Skeletal Muscle Atrophy ◽  
Morphological Evidence ◽  
Double Positive ◽  
Functional Changes ◽  
Cell Niche ◽  
The Relationship

Skeletal muscle atrophy, resulting from states of hypokinesis or immobilization, leads to morphological, metabolic, and functional changes within the muscle tissue, a large variety of which are supported by the stromal cells populating the interstitium. Telocytes represent a recently discovered population of stromal cells, which has been increasingly identified in several human organs and appears to participate in sustaining cross-talk, promoting regenerative mechanisms and supporting differentiation of local stem cell niche. The aim of this morphologic study was to investigate the presence of Telocytes in the tibialis anterior muscle of healthy rats undergoing an endurance training protocol for either 4 weeks or 16 weeks compared to sedentary rats. Histomorphometric analysis of muscle fibers diameter revealed muscle atrophy in sedentary rats. Telocytes were identified by double-positive immunofluorescence staining for CD34/CD117 and CD34/vimentin. The results showed that Telocytes were significantly reduced in sedentary rats at 16 weeks, while rats subjected to regular exercise maintained a stable Telocytes population after 16 weeks. Understanding of the relationship between Telocytes and exercise offers new chances in the field of regenerative medicine, suggesting possible triggers for Telocytes in sarcopenia and other musculoskeletal disorders, promoting adapted physical activity and rehabilitation programmes in clinical practice.

Effect of training on insulin binding to rat skeletal muscle sarcolemmal vesicles

1986 ◽  
Vol 250 (5) ◽  
pp. E570-E575
Author(s):  
G. K. Grimditch ◽  
R. J. Barnard ◽  
S. A. Kaplan ◽  
E. Sternlicht
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Insulin Binding ◽  
Whole Body ◽  
Rat Skeletal Muscle ◽  
Binding Studies ◽  
Muscle Enzyme ◽  
Intravenous Glucose ◽  
High Affinity

We examined the hypothesis that the exercise training-induced increase in skeletal muscle insulin sensitivity is mediated by adaptations in insulin binding to sarcolemmal (SL) insulin receptors. Insulin binding studies were performed on rat skeletal muscle SL isolated from control and trained rats. No significant differences were noted between groups in body weight or fat. An intravenous glucose tolerance test showed an increase in whole-body insulin sensitivity with training, and specific D-glucose transport studies on isolated SL vesicles indicated that this was due in part to adaptations in skeletal muscle. Enzyme marker analyses revealed no differences in yield, purity, or contamination of SL membranes between the two groups. Scatchard analyses indicated no significant differences in the number of insulin binding sites per milligram SL protein on the high-affinity (15.0 +/- 4.1 vs. 18.1 +/- 6.4 X 10(9)) or on the low-affinity portions (925 +/- 80 vs. 884 +/- 106 X 10(9)) of the curves. The association constants of the high-affinity (0.764 +/- 0.154 vs. 0.685 +/- 0.264 X 10(9) M-1) and of the low affinity sites (0.0096 +/- 0.0012 vs. 0.0102 +/- 0.0012 X 10(9) M-1) also were similar. These results do not support the hypothesis that the increased sensitivity to insulin after exercise training is due to changes in SL insulin receptor binding.

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