Inspiratory Flow Resistive Loaded Breathing and Inspiratory Muscle Induced Systemic Oxidative Stress

We examined whether the respiratory muscles of humans contribute to systemic oxidative stress following inspiratory flow-resistive breathing, whether the amount of oxidative stress is influenced by the level of resistive load, and whether the amount of oxidative stress is related to the degree of diaphragm fatigue incurred. It is only when sufficiently strenuous that inspiratory flow-resistive breathing elevates plasma F2-isoprostanes, and our novel data show that this is not related to a reduction in transdiaphragmatic twitch pressure.

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P2990 Sulfhydryl angiotensin-converting enzyme inhibition induces a sustained reduction of low-density lipoprotein oxidazibility and systemic oxidative stress in patients with essential hypertension

European Heart Journal ◽

10.1016/s0195-668x(03)95768-x ◽

2003 ◽

Vol 24 (5) ◽

pp. 582

Author(s):

A LIGUORI

Keyword(s):

Oxidative Stress ◽

Essential Hypertension ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Angiotensin Converting Enzyme Inhibition ◽

Low Density ◽

Converting Enzyme ◽

Systemic Oxidative Stress ◽

Sustained Reduction ◽

Converting Enzyme Inhibition

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Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings

Antioxidants ◽

10.3390/antiox10071126 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1126

Author(s):

Tijana Kosanovic ◽

Dragan Sagic ◽

Vladimir Djukic ◽

Marija Pljesa-Ercegovac ◽

Ana Savic-Radojevic ◽

...

Keyword(s):

Oxidative Stress ◽

Time Course ◽

Redox Homeostasis ◽

Original Data ◽

Advanced Oxidation Protein Products ◽

Oxidative Stress Parameters ◽

Systemic Oxidative Stress ◽

Dependent Relation ◽

Organ Tissue ◽

Insight Into

Although the original data on systemic oxidative stress in COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes in patients’ redox homeostasis. We aimed to assess the extent of oxidative damage of proteins, lipids and DNA during the course of acute disease, as well as their association with CT pulmonary patterns. In order to obtain more insight into the origin of the systemic oxidative stress, the observed parameters were correlated with inflammatory biomarkers and biomarkers of multiorgan impairment. In this prospective study, we included 58 patients admitted between July and October 2020 with COVID-19 pneumonia. Significant changes in malondialdehyde, 8-hydroxy-2’-deoxyguanosine and advanced oxidation protein products levels exist during the course of COVID-19. Special emphasis should be placed on the fact that the pattern of changes differs between non-hospitalized and hospitalized individuals. Our results point to the time-dependent relation of oxidative stress parameters with inflammatory and multiorgan impairment biomarkers, as well as pulmonary patterns in COVID-19 pneumonia patients. Correlation between redox biomarkers and immunological or multiorgan impairment biomarkers, as well as pulmonary CT pattern, confirms the suggested involvement of neutrophils networks, IL-6 production, along with different organ/tissue involvement in systemic oxidative stress in COVID-19.

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Patients with Gaucher disease display systemic oxidative stress dependent on therapy status

Molecular Genetics and Metabolism Reports ◽

10.1016/j.ymgmr.2020.100667 ◽

2020 ◽

Vol 25 ◽

pp. 100667

Author(s):

Reena V. Kartha ◽

Marcia R. Terluk ◽

Roland Brown ◽

Abigail Travis ◽

Usha R. Mishra ◽

...

Keyword(s):

Oxidative Stress ◽

Gaucher Disease ◽

Systemic Oxidative Stress ◽

Stress Dependent

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Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Scientific Reports ◽

10.1038/s41598-021-81736-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Takashi Yokota ◽

Shintaro Kinugawa ◽

Kagami Hirabayashi ◽

Mayumi Yamato ◽

Shingo Takada ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Skeletal Muscle ◽

Energy Metabolism ◽

Aerobic Capacity ◽

Plantar Flexion ◽

Exercise Intolerance ◽

Whole Body ◽

Resonance Spectroscopy ◽

Systemic Oxidative Stress

AbstractOxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p < 0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2 ± 7.1 vs. 29.4 ± 9.7 units/L, p < 0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.

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Serum Albumin Redox States: More than Oxidative Stress Biomarker

Antioxidants ◽

10.3390/antiox10040503 ◽

2021 ◽

Vol 10 (4) ◽

pp. 503

Author(s):

Fuka Tabata ◽

Yasuaki Wada ◽

Satomi Kawakami ◽

Kazuhiro Miyaji

Keyword(s):

Oxidative Stress ◽

Serum Albumin ◽

Animal Studies ◽

Redox State ◽

Ex Vivo ◽

Pathological Condition ◽

Analytical Techniques ◽

Cysteine Residue ◽

Research Field ◽

Systemic Oxidative Stress

Serum albumin is the most abundant circulating protein in mammals including humans. It has three isoforms according to the redox state of the free cysteine residue at position 34, named as mercaptalbumin (reduced albumin), non-mercaptalbumin-1 and -2 (oxidized albumin), respectively. The serum albumin redox state has long been viewed as a biomarker of systemic oxidative stress, as the redox state shifts to a more oxidized state in response to the severity of the pathological condition in various diseases such as liver diseases and renal failures. However, recent ex vivo studies revealed oxidized albumin per se could aggravate the pathological conditions. Furthermore, the possibility of the serum albumin redox state as a sensitive protein nutrition biomarker has also been demonstrated in a series of animal studies. A paradigm shift is thus ongoing in the research field of the serum albumin. This article provides an updated overview of analytical techniques for serum albumin redox state and its association with human health, focusing on recent findings.

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Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry

Antioxidants ◽

10.3390/antiox10040622 ◽

2021 ◽

Vol 10 (4) ◽

pp. 622

Author(s):

Pamela A. Nono Nankam ◽

Télesphore B. Nguelefack ◽

Julia H. Goedecke ◽

Matthias Blüher

Keyword(s):

Oxidative Stress ◽

Adipose Tissue ◽

Metabolic Diseases ◽

African Ancestry ◽

Fat Distribution ◽

African Women ◽

European Ancestry ◽

Whole Body ◽

Redox Equilibrium ◽

Systemic Oxidative Stress

Adipose tissue (AT) storage capacity is central in the maintenance of whole-body homeostasis, especially in obesity states. However, sustained nutrients overflow may dysregulate this function resulting in adipocytes hypertrophy, AT hypoxia, inflammation and oxidative stress. Systemic inflammation may also contribute to the disruption of AT redox equilibrium. AT and systemic oxidative stress have been involved in the development of obesity-associated insulin resistance (IR) and type 2 diabetes (T2D) through several mechanisms. Interestingly, fat accumulation, body fat distribution and the degree of how adiposity translates into cardio-metabolic diseases differ between ethnicities. Populations of African ancestry have a higher prevalence of obesity and higher T2D risk than populations of European ancestry, mainly driven by higher rates among African women. Considering the reported ethnic-specific differences in AT distribution and function and higher levels of systemic oxidative stress markers, oxidative stress is a potential contributor to the higher susceptibility for metabolic diseases in African women. This review summarizes existing evidence supporting this hypothesis while acknowledging a lack of data on AT oxidative stress in relation to IR in Africans, and the potential influence of other ethnicity-related modulators (e.g., genetic-environment interplay, socioeconomic factors) for consideration in future studies with different ethnicities.

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Task failure from inspiratory resistive loaded breathing: a role for inspiratory muscle fatigue?

European Journal of Applied Physiology ◽

10.1007/s00421-003-0871-x ◽

2003 ◽

Vol 90 (3-4) ◽

pp. 405-410 ◽

Cited By ~ 19

Author(s):

Markus Rohrbach ◽

Claudio Perret ◽

Bengt Kayser ◽

Urs Boutellier ◽

Christina M. Spengler

Keyword(s):

Muscle Fatigue ◽

Inspiratory Muscle ◽

Task Failure ◽

Loaded Breathing ◽

Inspiratory Muscle Fatigue

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Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00522.2005 ◽

2006 ◽

Vol 290 (5) ◽

pp. G847-G851 ◽

Cited By ~ 204

Author(s):

Jinah Choi ◽

J.-H. James Ou

Keyword(s):

Oxidative Stress ◽

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Liver Injury ◽

Iron Overload ◽

Antioxidant Defense ◽

Hcv Infection ◽

Nitrogen Species ◽

Systemic Oxidative Stress

Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. The increased generation of reactive oxygen and nitrogen species, together with the decreased antioxidant defense, promotes the development and progression of hepatic and extrahepatic complications of HCV infection. This review discusses the possible mechanisms of HCV-induced oxidative stress and its role in HCV pathogenesis.

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