Influence of High Intensity Body-Weight Circuit Training in Adults with Type II Diabetes.

Obesity and Type II diabetes are complex diseases in the human population. The existence of a large number of contributing loci and gene-gene as well as gene-environment interactions make it difficult to identify the disease genes underlying these complex traits. In mouse models of obesity and Type II diabetes such as the murine fat mutation, genetic crosses can be used to dissect the genetic complexity influencing the observed phenotypes. The underlying defect in the fat mutant is a Ser202Pro change in carboxypeptidase E (CPE), an enzyme responsible for the final proteolytic processing step of prohormone intermediates. On the HRS/J (HRS) inbred strain background, mice homozygous for the fat mutation exhibit early onset hyperinsulinemia followed by postpubertal moderate obesity without hyperglycemia. In contrast, on the C57BLKS/J (BKS) genetic background, fat/fat mice become severely obese, hyperinsulinemic, and hyperglycemic. Therefore, in the Cpefatgenetic model, the fat mutation is necessary but not sufficient for the development of obesity, Type II diabetes, and related metabolic disorders. To dissect the susceptibility loci responsible for modifying obesity- and diabetes-associated traits, we characterized, both genetically and phenotypically, fat/fat male progeny from a large intercross between BKS. HRS- fat/fat and HRS- +/+ mice. Four major loci were mapped, including a locus for body weight (body weight 1) on chromosome 14; a locus for hyperglycemia (fat-induced diabetes 1) on chromosome 19; a locus for hyperglycemia, hyperinsulinemia, and hypercholesterolemia (fat-induced diabetes 2) on chromosome 5; and a locus for adiposity and body weight (fat-induced adiposity 1) on chromosome 11. The identification of these interacting genetic determinants for obesity and Type II diabetes may allow better definition of the obesity/diabetes-related hormone signaling pathways and ultimately may provide new insights into the pathogenesis of these complex diseases.

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Effects of Adding High Intensity of Effort Resistance Training to Routine Care in Persons With Type II Diabetes

10.51224/srxiv.13 ◽

2021 ◽

Author(s):

Jürgen Giessing ◽

Björn Eichmann ◽

Wolfgang Kemmler ◽

Wayne Westcott ◽

Richard Winett ◽

...

Keyword(s):

Resistance Training ◽

High Intensity ◽

Type Ii Diabetes ◽

Routine Care ◽

Type Ii

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The Effectiveness of Alpha Mangostin on Kidney Physiology and Histopathology in Type II Diabetes Mellitus

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.83358342 ◽

2021 ◽

Vol 12 (6) ◽

pp. 8335-8342

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Uric Acid ◽

Type Ii Diabetes ◽

Kidney Tissue ◽

Type Ii Diabetes Mellitus ◽

Control Group ◽

Type Ii ◽

Garcinia Mangostana ◽

Significant Difference

The compound isolate alpha Mangostin was the most dominant compound found in the rind and trunk of the mangosteen fruit tree (Garcinia mangostana L.). Alpha Mangostin compounds have pharmacological activities, including antibacterial, antifungal, anticancer, antidiabetic, and other bioactivities. This study aims to determine the bioactivity of alpha Mangostin on kidney function and histopathology in type II diabetes mellitus. This study used an experimental research design with posttest only control group; this study used 36 rats consisting of 6 groups, namely negative control group, positive control group, standard medicine, and the treatment of lecturers alpha Mangostin 10 mg/kg body weight, 30 mg/kg body weight, and 50 mg/kg BW. Parameters measured in this study were uric acid, BUN, creatinine, and renal histopathological evaluation. The results showed that there was a significant difference (p < 0.05) in the examination of creatinine levels, but the BUN and uric acid did not show significant results (p > 0.05) in each group. Observations on renal histopathology showed that alpha Mangostin could normalize damaged kidney tissue compared to positive controls. So it can be concluded that alpha Mangostin isolates in mangosteen has the potential as kidney bioactivity in type II diabetes.

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Single Session of High Intensity Exercises on Random Blood Sugar on Type II Diabetes Subject on Insulin Therapy

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i1.28 ◽

2018 ◽

Vol 6 (1) ◽

Author(s):

Dr S.S. Subramanian ◽

Keyword(s):

Insulin Therapy ◽

Blood Sugar ◽

High Intensity ◽

Type Ii Diabetes ◽

Type Ii ◽

Single Session ◽

Random Blood Sugar

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Renoprotective Effects of Xanthone Derivatives from Garcinia mangostana Against High Fat Diet and Streptozotocin-Induced Type II Diabetes in Mice

Walailak Journal of Science and Technology (WJST) ◽

10.48048/wjst.2018.2632 ◽

2016 ◽

Vol 15 (2) ◽

pp. 107-116 ◽

Cited By ~ 1

Author(s):

Naymul KARIM ◽

Nutjaree JEENDUANG ◽

Jitbanjong TANGPONG

Keyword(s):

Body Weight ◽

Mouse Model ◽

High Fat Diet ◽

Type Ii Diabetes ◽

Phenolic Content ◽

Kidney Tissue ◽

Total Phenolic ◽

Type Ii ◽

Garcinia Mangostana ◽

Total Antioxidant

Diabetes mellitus is described as a metabolic disorder with multiple etiology, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolisms. Recently, obesity has been identified as a risk factor of developing type II diabetes, at about 80 - 85 %. 1 out of 3 people with type II diabetes develop kidney disease. Garcinia mangostana is used as a traditional medicine in various types of disease, such as abdominal pain, dysentery, wound infections, suppuration, and chronic ulcers. Previous studies have revealed that G. mangostana has good antioxidant, antitumoral, antiallergic, anti-inflammatory, antibacterial, and antiviral activities. In this study, an aqueous extract of xanthone derivative from G. mangostana was used, and the total phenolic content and total antioxidant capacity was assessed. Mice body weight, plasma glucose level, kidney hypertrophy (KI, kidney damage indicator), kidney function test (BUN, CREA), plasma, and kidney tissue melondialdehyde level (MDA, as oxidative damage marker) were evaluated in a high fat diet/streptozotocin (HFD/STZ)-induced type II diabetes mouse model. The results showed that the total phenolic compound in xanthone was 272.62±2.26 µg GAE/mg extract and, in the case of the total antioxidant capacity, % of inhibition of xanthone was 88.40±0.25 µmol TEAC/mg extract, respectively. This has significant correlation (R2 = 0.9777) to the total phenolic content. In the in vivo study, increased body weight, plasma glucose level, kidney hypertrophy, plasma kidney profile, plasma, and kidney tissue melondialdehyde levels were significantly increased (P < 0.05) in the HFD/STZ-induced type II diabetes mouse model. Co-treatment with xanthone significantly (P < 0.05) improved all of the biochemical parameters and body weight in the mouse model. Taken together, the results indicate that xanthone possesses a potent renoprotective effect in type II diabetes mice.

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Cytoprotective Effects of Lepidium sativum Seed Extract on Liver and Pancreas of HFD/STZ Induced Type 2 Diabetic Mice

International Journal of Pharmacognosy and Phytochemical Research ◽

10.25258/phyto.v9i4.8121 ◽

2017 ◽

Vol 9 (4) ◽

Cited By ~ 1

Author(s):

Desai S. S. ◽

Walvekar M. V. ◽

Shaikh N. H.

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Seed Extract ◽

Lepidium Sativum ◽

Type Ii ◽

Diabetic Mice ◽

Liver And Pancreas

Type II diabetes mellitus (TIIDM) is the world’s largest endocrine disorder. Obesity is one of the leading causes for type II diabetes. In the present study antihyperglycemic and cytoprotective role of Lepidium sativum seed extract (LSE) for obesity associated diabetes in normal and high fat diet (HFD)-streptozotocin induced mice was investigated. Blood glucose, histology of liver and pancreas and body weight in obese diabetic mice was evaluated. Administration of LSE for 28 days significantly lowered blood glucose while increased body weight and recovered degenerative changes in liver and pancreas. These findings suggest that LSE possess antihyperglycemic and cytoprotective action and might be a good candidate for obesity associated diabetes.

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Expounding the Role of Exercise in the Management of Type II Diabetes

Asian Journal of Physical Education & Recreation ◽

10.24112/ajper.81275 ◽

2002 ◽

Vol 8 (2) ◽

pp. 80-82

Author(s):

Michael CHIA ◽

Jin Jong QUEK

Keyword(s):

Physical Activity ◽

Body Weight ◽

Light Intensity ◽

Exercise Training ◽

Body Fat ◽

Type Ii Diabetes ◽

Weight Training ◽

Adult Population ◽

Type Ii

LANGUAGE NOTE | Document text in English; abstract also in Chinese.The association between the urbanization of cultures and the concomitant decreased levels of exercise and physical activity and the prevalence of type II diabetes has been established. The incidence of type II diabetes in Singapore is about six percent in the adult population but the disease is unequally distributed among the ethnic cultures. Type II diabetes is also linked with an increase in age, body weight and body fat, but a regimen of regular aerobic-type or light intensity weight-training has 'insulin-like' effect and is beneficial in the amelioration and management of type II diabetes. However, the 'insulin-like' are quickly lost within 14 days after the cessation of the exercise training or physical activity.現已確認城市的都市化伴隨著體育活動的水平下降，並與II型糖尿病的流行之間有著相互的聯系。II型糖尿病在新加坡成年人中的發病率約為6%，但疾病的分佈在不同的種族之間是不均衡的。II型糖尿病也與年齡的增長，體重和體脂的增加有關。規律性和系統性的有氧或健身運動可產生"胰島素樣"作用，這有利于改善糖尿病病人的狀況。然而，運動訓練或體育活動一旦停止，此"胰島素樣"作用即在14天內消失。

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