scholarly journals Acute Heavy Resistance Exercise Protocol Induces Significant Physiological Stress Elevating Extracellular Heat Shock Protein

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 799
Author(s):  
Jacob Bowie ◽  
Adam J. Sterczala ◽  
William J. Kraemer ◽  
Carl M. Maresh ◽  
Brett A. Comstock ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Resistance Exercise ◽  
Physiological Stress ◽  
Exercise Protocol ◽  
Heavy Resistance Exercise

scholarly journals Effects ofβ-Hydroxy-β-methylbutyrate Free Acid Ingestion and Resistance Exercise on the Acute Endocrine Response

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Jeremy R. Townsend ◽  
Jay R. Hoffman ◽  
Adam M. Gonzalez ◽  
Adam R. Jajtner ◽  
Carleigh H. Boone ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Repeated Measures ◽  
Free Acid ◽  
Area Under The Curve ◽  
High Volume ◽  
Endocrine Response ◽  
Exercise Protocol ◽  
Volume Resistance ◽  
Heavy Resistance Exercise ◽  
Plasma Gh

Objective. To examine the endocrine response to a bout of heavy resistance exercise following acuteβ-hydroxy-β-methylbutyrate free acid (HMB-FA) ingestion.Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule.Results. The resistance exercise protocol resulted in significant elevations from PRE in testosteroneP<0.01, GHP<0.01, and insulinP=0.05at IP, with GHP<0.01and insulinP<0.01remaining elevated at 30P. A significant interaction was noted between groups in the plasma GH response at IP, which was significantly higher following HMB-FA compared to PLP<0.01. AUC analysis revealed an elevated GH and IGF-1 response in the HMB-FA group compared to PL.Conclusion. HMB-FA prior to resistance exercise augments the GH response to high volume resistance exercise compared to PL. These findings provide further support for the potential anabolic benefits associated with HMB supplementation.

Transcription regulation of alpha B-crystallin in astrocytes: analysis of HSF and AP1 activation by different types of physiological stress

1996 ◽  
Vol 109 (5) ◽  
pp. 1029-1039
Author(s):  
M.W. Head ◽  
L. Hurwitz ◽  
J.E. Goldman
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Physiological Stress ◽  
Heat Shock Protein 27 ◽  
Heat Shock Factor ◽  
Transcriptional Level ◽  
Heat Shock Factor 1 ◽  
Hypertonic Stress ◽  
Transcriptional Activator Protein ◽  
Different Types

The coordinated cellular responses to physiological stress are known to be effected in part by the activation of heat-shock factor 1, a transcriptional activator protein capable of binding to, and inducing transcription from genes containing heat shock elements. Other stress responsive signal transduction pathways also exist including the stress activated protein kinase cascade that regulates the activity of the transcription factor AP1. We have examined the expression of the low molecular stress proteins, heat shock protein 27 and alpha B-crystallin in astrocytes in response to physiological stress of different types and asked what component of this induction is effected at the transcriptional level and whether activation of heat shock factor 1 and AP1 might account for these events. We have found that stress regulated induction of alpha B-crystallin has a strong transcriptional component and that it may be effected by at least two different transcriptional mechanisms. In one set of phenomena, represented here by cadmium exposure, alpha B-crystallin and heat shock protein 27 are coordinately regulated and this occurs in the presence of activated heat shock factor 1. In the second series of phenomena, represented here by hypertonic stress, alpha B-crystallin is induced in the absence of heat shock factor activation and in the absence of any corresponding change in heat shock protein 27 expression. Although hypertonic stress does activate an AP1-like binding activity, the AP1 consensus binding site in the alpha B-crystallin promoter does not appear to be a target for this hypertonic stress inducible activity. These data suggest that the hypertonic stress response is effected through a heat shock factor independent mechanism and that hypertonic stress regulated induction of alpha B-crystallin does not directly depend on the SAPK pathway and AP1 activity.

Responses of IGF-I to endogenous increases in growth hormone after heavy-resistance exercise

1995 ◽  
Vol 79 (4) ◽  
pp. 1310-1315 ◽  
Author(s):  
W. J. Kraemer ◽  
B. A. Aguilera ◽  
M. Terada ◽  
R. U. Newton ◽  
J. M. Lynch ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Creatine Kinase ◽  
Resistance Exercise ◽  
Acute Exercise ◽  
Recovery Period ◽  
Exercise Protocol ◽  
Significant Relationships ◽  
Igf I ◽  
Heavy Resistance Exercise ◽  
And Control

The purpose of this study was to examine the effects of a heavy-resistance exercise protocol known to dramatically elevate immunoreactive growth hormone (GH) on circulating insulin-like growth factor I (IGF-I) after the exercise stimulus. Seven men (23.1 +/- 2.4 yr) volunteered to participate in this study. Each subject was asked to perform an eight-station heavy-resistance exercise protocol consisting of 3 sets of 10 repetition maximum resistances with 1-min rest between sets and exercises followed by a recovery day. In addition, a control day followed a nonexercise day to provide baseline data. Pre- and postexercise (0, 15, and 30 min) blood samples were obtained and analyzed for lactate, creatinine kinase, GH, and IGF-I. Postexercise values for lactate and GH were significantly (P < 0.05) elevated above preexercise and resting baseline values. The highest mean GH concentration after the heavy-resistance exercise protocol was 23.8 +/- 11.8 micrograms/l, observed at the immediate postexercise time point. Significant increases in creatine kinase were observed after the exercise protocol and during the recovery day. No significant relationships were observed between creatine kinase and IGF-I concentrations. No significant changes in serum IGF-I concentrations were observed with acute exercise or between the recovery and control days. Thus, these data demonstrate that a high-intensity bout of heavy-resistance exercise that increases circulating GH did not appear to affect IGF-I concentrations over a 24-h recovery period in recreationally strength-trained and healthy young men.

scholarly journals Effects of Post-Activation Potentiation induced by a plyometric protocol on deceleration performance

2019 ◽  
Author(s):  
Gianmarco Ciocca ◽  
Harald Tschan ◽  
Antonio Tessitore
Keyword(s):  
Resistance Exercise ◽  
Performance Characteristics ◽  
Soccer Players ◽  
Exercise Protocol ◽  
Running Performance ◽  
Muscular Performance ◽  
Plyometric Exercise ◽  
Key Factor ◽  
Heavy Resistance Exercise ◽  
Condition C

AbstractPost-Activation Potentiation is a phenomenon by which muscular performance characteristics are acutely enhanced as a result of their previous contractile actions. It has been shown how Post-Activation Potentiation, which is usually evoked through heavy resistance exercise, has the potential to improve many different power performances, such as sprinting and jumping. Due to an easier applicability, some studies explored the potential of plyometric muscular actions to evoke the effects of Post-Activation Potentiation. Despite some findings on acceleration running performance, to the authors’ best knowledge, no studies investigated the effects of Post-Activation Potentiation on deceleration performance, which is a key factor in sports involving change of directions. Therefore, the aim of this study is to investigate the influence of a plyometric exercise protocol to a subsequent deceleration running performance. University soccer players (n = 18) performed 7 deceleration trials: at baseline and after ∼ 15 seconds, 2, 4, 8, 12 and 16 minutes a walking control condition (C) or 3 sets of 10 repetitions of alternate-leg bounding (plyometric, P). Results show that no significant differences were found at any of the trials of the control condition (C) in comparison to the relative baseline. In the plyometric condition (P), the deceleration performance executed 2 minutes after the plyometric activity resulted significantly faster compared to the relative baseline (p = 0.042; ES = 0.86, large effect; % of improvement = 4.13 %). Therefore, the main findings of this study showed that a plyometric exercise has the potential to improve a subsequent running deceleration performance in soccer players, if an adequate recovery between these activities is provided to the players. These findings encourage further future investigations about the possible potentiating effects of plyometric activities on more complex actions like changes of direction and agility.

Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise

2001 ◽  
Vol 90 (4) ◽  
pp. 1319-1326 ◽  
Author(s):  
Bradley C. Nindl ◽  
William J. Kraemer ◽  
James O. Marx ◽  
Paul J. Arciero ◽  
Kei Dohi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Resistance Exercise ◽  
High Volume ◽  
Systemic Circulation ◽  
Insulin Like Growth Factor ◽  
Exercise Protocol ◽  
Igf I ◽  
Heavy Resistance Exercise ◽  
The Impact ◽  
Igfbp 3

This study evaluated the individual components of the insulin-like growth factor I (IGF-I) system [i.e., total and free IGF-I, insulin-like growth factor binding protein (IGFBP)-2 and -3, and the acid-labile subunit (ALS)] in 10 young, healthy men (age: 22 ± 1 yr, height: 177 ± 2 cm, weight: 79 ± 3 kg, body fat: 11 ± 1%) overnight for 13 h after two conditions: a resting control (Con) and an acute, heavy-resistance exercise protocol (Ex). The Ex was a high-volume, multiset exercise protocol that alternated between 10- and 5-repetition maximum sets with 90-s rest periods between sets. The Ex was performed from 1500 to 1700; blood was obtained immediately postexercise and sampled throughout the night (every 10 min for the first hour and every hour thereafter) until 0600 the next morning. For the first hour, significant differences ( P ≤ 0.05) were only observed for IGFBP-3 (Ex: 3,801 > Con: 3,531 ng/ml). For the overnight responses, no differences were observed for total or free IGF-I or IGFBP-3, whereas IGFBP-2 increased (Ex: 561 > Con: 500 ng/ml) and ALS decreased (Ex: 35 < Con: 39 μg/ml) after exercise. The results from this study suggest that the impact that resistance exercise exerts on the circulating IGF-I system is not in the alteration of the amount of IGF-I but rather of the manner in which IGF-I is partitioned among its family of binding proteins. Thus acute, heavy-resistance exercise can lead to alterations in the IGF-I system that can be detected in the systemic circulation.

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