scholarly journals Montmorency Tart Cherries Influence The Urinary Metabolome But Not Vascular Function In Healthy Individuals

2020 ◽  
Vol 52 (7S) ◽  
pp. 1073-1073
Author(s):  
Rachel Kimble ◽  
Lucy Murray ◽  
Karen M. Keane ◽  
Karen Haggerty ◽  
Glyn Howatson ◽  
...  
Keyword(s):  
Vascular Function ◽  
Healthy Individuals ◽  
Tart Cherries

scholarly journals The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study

2021 ◽  
Vol 10 ◽  
Author(s):  
Rachel Kimble ◽  
Lucy Murray ◽  
Karen M. Keane ◽  
Karen Haggerty ◽  
Glyn Howatson ◽  
...  
Keyword(s):  
Vascular Function ◽  
Prunus Cerasus ◽  
Whole Body ◽  
Healthy Individuals ◽  
Double Blind ◽  
Randomised Study ◽  
Spot Urine ◽  
Chronic Effects ◽  
Preliminary Study ◽  
Tart Cherries

Abstract Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes (P < 0⋅001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms.

scholarly journals Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mahmoud A. Alomari ◽  
Esraa F. Keewan ◽  
Rania A. Shammaa ◽  
Khaldoon Alawneh ◽  
Said Y. Khatib ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Blood Flow ◽  
Vascular Function ◽  
Forearm Blood Flow ◽  
Handgrip Strength ◽  
Muscle Dysfunction ◽  
Healthy Individuals ◽  
Healthy Control ◽  
Relationship Of ◽  
The Relationship

Objective. To examine the relationship of handgrip strength with forearm blood flow (BF) and vascular resistance (VR) in rheumatoid arthritis (RA) patients.Methods. Forearm BF at rest (RBF) and after upper arm occlusion (RHBF), and handgrip strength were examined in 78 individuals (RA=42and controls (CT)=36). Subsequently, VR at rest (RVR) and after occlusion (RHVR) were calculated.Results. The patients’ RBF (P=0.02) and RHBF (P=0.0001) were less, whereas RVR (P=0.002) and RHVR (P=0.0001) were greater as compared to the CTs. Similarly, handgrip strength was lower in the RAs (P=0.0001). Finally, handgrip strength was directly associated with RBF (r=0.43;P=0.0001), and RHBF (r=0.5;P=0.0001), and inversely related to RVR (r=-0.3;P=0.009) and RHVR (r=-0.3;P=0.007).Conclusion. The present study uniquely identifies an association between regional measures of forearm blood flow and handgrip strength in patients and healthy control. In addition, this study confirms the presence of vascular and muscle dysfunction in patients with rheumatoid arthritis, as evidenced by lower forearm blood flow indices, at rest and following occlusion, and lower handgrip strength as compared to healthy individuals.

Acute effect of fish protein hydrolysate supplementation on vascular function in healthy individuals

2018 ◽  
Vol 46 ◽  
pp. 250-255 ◽  
Author(s):  
Thiago Silveira Alvares ◽  
Carlos Adam Conte-Junior ◽  
Anna Paola Pierucci ◽  
Gustavo Vieira de Oliveira ◽  
Elisaldo Mendes Cordeiro
Keyword(s):  
Vascular Function ◽  
Protein Hydrolysate ◽  
Acute Effect ◽  
Fish Protein ◽  
Healthy Individuals ◽  
Fish Protein Hydrolysate

Natural antioxidant ice cream acutely reduces oxidative stress and improves vascular function and physical performance in healthy individuals

Nutrition ◽  
2017 ◽  
Vol 33 ◽  
pp. 225-233 ◽  
Author(s):  
Valerio Sanguigni ◽  
Melania Manco ◽  
Roberto Sorge ◽  
Lucio Gnessi ◽  
Davide Francomano
Keyword(s):  
Oxidative Stress ◽  
Physical Performance ◽  
Vascular Function ◽  
Ice Cream ◽  
Natural Antioxidant ◽  
Healthy Individuals

scholarly journals Exercise and vascular function: how much is too much?

2014 ◽  
Vol 92 (7) ◽  
pp. 551-557 ◽  
Author(s):  
Matthew J. Durand ◽  
David D. Gutterman
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Cardiovascular Disease ◽  
Vascular Function ◽  
Reactive Oxygen ◽  
Causative Role ◽  
Oxygen Species ◽  
Healthy Individuals ◽  
Intense Exercise ◽  
Nitric Oxide Bioavailability

Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular disease, less is known about how exercise, especially intense exercise, affects vascular function in healthy individuals. This review highlights examples of how vascular function can paradoxically be impaired in otherwise healthy individuals by extreme levels of exercise, with a focus on the causative role that reactive oxygen species play in this impairment.

Association between exercise hemodynamics and changes in local vascular function following acute exercise

2011 ◽  
Vol 36 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Joaquin U. Gonzales ◽  
Benjamin C. Thompson ◽  
John R. Thistlethwaite ◽  
Barry W. Scheuermann
Keyword(s):  
Blood Pressure ◽  
Shear Rate ◽  
Brachial Artery ◽  
Vascular Function ◽  
Acute Exercise ◽  
Contractile Activity ◽  
Healthy Individuals ◽  
Physical Stimuli ◽  
Exercise Hemodynamics ◽  
Artery Flow

Skeletal muscle contractions are associated with physical stimuli that act upon muscle vasculature, including increased shear stress and blood pressure. It is unclear if acute dynamic exercise alters local vascular function. The purpose of this study was to examine the role of exercise hemodynamics on the effects of acute exercise on vascular function, as evaluated by brachial artery flow-mediated dilation (FMD). Healthy individuals (n = 14; age, 18–34 years) performed 30 min of handgrip exercise at fast and slow contractions. Blood pressure during exercise was measured using a Vasotrac system (Medwave Inc.), while shear rate during exercise and FMD at rest and after 30 min of recovery from exercise were measured in the brachial artery of the active arm using Doppler ultrasound. Estimated contractile work was correlated with blood pressure (r = 0.61, p < 0.01) and retrograde shear rate (r = –0.78, p < 0.01). As a result, blood pressure was higher (p < 0.05) and oscillatory shear index was lower (p < 0.05) during slow as compared with fast contractions. On average, FMD was unchanged following fast contractions (5.4 ± 3.4%dilation to 6.1 ± 3.8%dilation; p = 0.19), but significantly reduced following slow contractions (6.9 ± 4.2%dilation to 3.6 ± 2.5%dilation; p = 0.01). Within slow contractions, subgroup analysis revealed blood pressure to associate with the change in FMD; such that individuals with mean blood pressure >100 mm Hg (range, 102–139 mm Hg) during exercise had larger decreases in FMD than individuals with lower exercise blood pressure. These results indicate that impaired local vascular function following acute exercise with high contractile activity is associated with blood pressure stimuli in healthy individuals

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