Use of impedance ratios to assess hand swelling in lymphoedema

2014 ◽  
Vol 29 (2) ◽  
pp. 83-89 ◽  
Author(s):  
E S Dylke ◽  
H Alsobayel ◽  
L C Ward ◽  
M Liu ◽  
E Webb ◽  
...  
Keyword(s):  
Dominant Hand ◽  
Bioimpedance Spectroscopy ◽  
Postural Change ◽  
Promising Tool ◽  
Volume Measurements ◽  
History Of ◽  
Hand Volume ◽  
Change Position ◽  
Head Height ◽  
Device Interaction

Objectives To determine whether bioimpedance spectroscopy was suitable for detection of hand lymphoedema. Methods The hands of 50 participants without a history of lymphoedema were measured with perometry and bioimpedance spectroscopy after positioning two ways for three minutes: (a) both hands rested at heart height and (b) the dominant hand at heart height and the non-dominant hand at head height. In addition, 10 women with secondary hand lymphoedema were also measured. Results Impedance and volume measurements were found to be strongly related (dominant hand r = −0.794). Both measurements were reliable (ICC2,1 = 0.900–0.967 and 0.988–0.996, respectively). Impedance was more sensitive to small changes in hand volume due to the postural change (position × device interaction: F = 23.9, P < 0.001). Finally, impedance measurements had better discrimination of women with lymphoedema than volume measurements. Conclusions Bioimpedance spectroscopy is a promising tool for the detection of secondary hand lymphoedema.

scholarly journals 532. Can Saccharomyces boulardii Therapy Be Effective in Decolonizing Rectal Carbapenem-Resistant Enterobacteriaceae (CRE) Colonization?

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S255-S256
Author(s):  
Oguz Resat Sipahi ◽  
Gunel Quliyeva ◽  
Feriha Cilli ◽  
Nilgun Deniz Kucukler ◽  
Demet Dikis ◽  
...  
Keyword(s):  
Susceptibility Testing ◽  
Rectal Swab ◽  
Saccharomyces Boulardii ◽  
Inclusion Criteria ◽  
Randomized Controlled ◽  
Promising Tool ◽  
Carbapenem Resistant ◽  
History Of ◽  
Vitek 2 ◽  
Carbapenem Resistant Enterobacteriaceae

Abstract Background CRE are globally important pathogens associated with significant morbidity and mortality. The problem of carrying CRE may continue to create a problem in discharged cases in the community. Saccharomyces boulardii sachet therapy (SBST) is reported to cause decolonization in several MDR bacteria carriers. Herein, it is aimed to present the decolonizing rates of rectal CRE colonized cases after SBST treatment. Methods The study period was August 2018–March 2019. Inclusion criteria were: (i) age >18, (ii) receiving Saccharomyces boulardii 250 mg sachets q12h for 7 days, (iii) being proven CRE carrier on rectal swab culture (RSC) up to 5 days period before SBST. The first repeated RSC was performed 3–5 days after the end of SBST. Data were retrieved from the hospital electronic database. Cases with three consecutive weekly performed negative RSC were considered to be decolonized. RSC were processed according to CDC protocol; briefly, the swab was inoculated into 10 mL of trypticase soy broth (bioMérieux Inc., Marcy-l’Étoile, France) with the addition of one 10-μg ertapenem disk (Oxoid, Altrincham, UK) and incubated at 35°C for 18–20 h. The next day, after vortexing, 100 μL of the inoculum was subcultured (8) onto chromID CARBA agar plates (bioMérieux) and incubated at 35°C for 18–20 h. Suspected CRE colonies on chromID CARBA (blue/green to blue/gray in color) were identified by the VITEK MS system (bioMérieux). Susceptibility testing of the isolates was performed with the VITEK 2 system (bioMérieux). Isolates were tested for their resistance phenotypes to imipenem, ertapenem, and meropenem by E-test (bioMérieux). The results were interpreted according to the EUCAST criteria. Results Fifteen cases [2 women, mean age 60.6 ± 18.3 (min. 18–max. 83)] fulfilled the inclusion criteria. All had a history of carbapenem usage. Five cases (33%) had three consequent negative RSC after SBST and were considered to be decolonized. Twelve cases were receiving concomitant antibiotic during SBST (10 carbapenem based regimens). Three cases who received no concomitant antibiotic were decolonized. Conclusion SBST may be a promising tool for decolonizing CRE carriers. These data need to be validated in larger cohorts preferably via randomized-controlled trials. Disclosures All authors: No reported disclosures.

scholarly journals Using resting-state intrinsic network connectivity to identify suicide risk in mood disorders

2019 ◽  
Vol 50 (14) ◽  
pp. 2324-2334 ◽  
Author(s):  
Jonathan P. Stange ◽  
Lisanne M. Jenkins ◽  
Stephanie Pocius ◽  
Kayla Kreutzer ◽  
Katie L. Bessette ◽  
...  
Keyword(s):  
Mood Disorder ◽  
Mood Disorders ◽  
Resting State ◽  
Suicide Risk ◽  
Network Connectivity ◽  
Resting State Fmri ◽  
Neural Substrates ◽  
Resting State Functional Connectivity ◽  
Promising Tool ◽  
History Of

AbstractBackgroundLittle is known about the neural substrates of suicide risk in mood disorders. Improving the identification of biomarkers of suicide risk, as indicated by a history of suicide-related behavior (SB), could lead to more targeted treatments to reduce risk.MethodsParticipants were 18 young adults with a mood disorder with a history of SB (as indicated by endorsing a past suicide attempt), 60 with a mood disorder with a history of suicidal ideation (SI) but not SB, 52 with a mood disorder with no history of SI or SB (MD), and 82 healthy comparison participants (HC). Resting-state functional connectivity within and between intrinsic neural networks, including cognitive control network (CCN), salience and emotion network (SEN), and default mode network (DMN), was compared between groups.ResultsSeveral fronto-parietal regions (k > 57, p < 0.005) were identified in which individuals with SB demonstrated distinct patterns of connectivity within (in the CCN) and across networks (CCN-SEN and CCN-DMN). Connectivity with some of these same regions also distinguished the SB group when participants were re-scanned after 1–4 months. Extracted data defined SB group membership with good accuracy, sensitivity, and specificity (79–88%).ConclusionsThese results suggest that individuals with a history of SB in the context of mood disorders may show reliably distinct patterns of intrinsic network connectivity, even when compared to those with mood disorders without SB. Resting-state fMRI is a promising tool for identifying subtypes of patients with mood disorders who may be at risk for suicidal behavior.

scholarly journals The Flaws and Future of Islet Volume Measurements

2018 ◽  
Vol 27 (7) ◽  
pp. 1017-1026 ◽  
Author(s):  
Han-Hung Huang ◽  
Stephen Harrington ◽  
Lisa Stehno-Bittel
Keyword(s):  
Large Range ◽  
Therapeutic Option ◽  
Lessons Learned ◽  
Volume Estimation ◽  
Improved Method ◽  
Islet Volume ◽  
Volume Measurements ◽  
History Of ◽  
Advance Research ◽  
Islet Transplants

When working with isolated islet preparations, measuring the volume of tissue is not a trivial matter. Islets come in a large range of sizes and are often contaminated with exocrine tissue. Many factors complicate the procedure, and yet knowledge of the islet volume is essential for predicting the success of an islet transplant or comparing experimental groups in the laboratory. In 1990, Ricordi presented the islet equivalency (IEQ), defined as one IEQ equaling a single spherical islet of 150 μm in diameter. The method for estimating IEQ was developed by visualizing islets in a microscope, estimating their diameter in 50 μm categories and calculating a total volume for the preparation. Shortly after its introduction, the IEQ was adopted as the standard method for islet volume measurements. It has helped to advance research in the field by providing a useful tool improving the reproducibility of islet research and eventually the success of clinical islet transplants. However, the accuracy of the IEQ method has been questioned for years and many alternatives have been proposed, but none have been able to replace the widespread use of the IEQ. This article reviews the history of the IEQ, and discusses the benefits and failings of the measurement. A thorough evaluation of alternatives for estimating islet volume is provided along with the steps needed to uniformly move to an improved method of islet volume estimation. The lessons learned from islet researchers may serve as a guide for other fields of regenerative medicine as cell clusters become a more attractive therapeutic option.

scholarly journals Hand Pain in a Golfer

2016 ◽  
Vol 9 (1) ◽  
pp. 84-86
Author(s):  
Cortie J. Rolison ◽  
Milton Kyle Smoot
Keyword(s):  
Stress Fracture ◽  
Return To Play ◽  
Dominant Hand ◽  
Hand Pain ◽  
History Of

A 19-year-old golfer presented to the sports clinic with a 2-week history of dominant-hand pain after several months of daily golf. He had a metacarpal stress fracture. This case discusses the athlete’s return-to-play timeline as well as reviews the current limited literature guiding return to play in grip athletes.

Intracortical motor conduction is associated with hand dexterity in progressive multiple sclerosis

2020 ◽  
pp. 135245852096037
Author(s):  
Marco Pisa ◽  
Raffaella Chieffo ◽  
Martina Congiu ◽  
Gloria Dalla Costa ◽  
Federica Esposito ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Primary Motor Cortex ◽  
Motor Evoked Potentials ◽  
Progressive Multiple Sclerosis ◽  
Dominant Hand ◽  
Motor Pathways ◽  
Promising Tool ◽  
Hand Dexterity ◽  
Hand Impairment ◽  
Nine Hole Peg Test

Background: Hand dexterity dysfunction is a key feature of disability in people with progressive multiple sclerosis (PMS). It underlies corticospinal tract (CST) and cerebellar integrity, as well as disruption of cortical networks, which are hardly assessed by standard techniques. Transcranial magnetic stimulation is a promising tool for evaluating the integrity of intracortical motor pathways. Objective: To investigate neurophysiological correlates of motor hand impairment in PMS. Methods: Antero-posterior (AP) stimulation of the primary motor cortex activates the CST indirectly through polysynaptic pathways, while a direct CST activation occurs with latero-medial (LM) directed current. Thirty PMS and 15 healthy controls underwent dominant hand motor evoked potentials (MEP) using AP and LM-directed stimulation, and a clinical assessment of dexterity (nine-hole peg test) and strength (MRC scale, grip and pinch). Results: PMS with AP-LM latency difference 2.5 standard deviation above the mean of controls (33%) showed worse dexterity but no difference in upper limb strength. Accordingly, AP-LM latency shortening predicted dexterity (R2 = 0.538, p < 0.001), but not strength impairment. On the contrary, absolute MEP latencies only correlated with strength (grip: R2 = 0.381, p = 0.014; MRC: R2 = 0.184, p = 0.041). Conclusion: AP-LM latency shortening may be used to assess the integrity polysynaptic intracortical networks implicated in dexterity impairment.

scholarly journals A study of second to fourth digit ratio in relation to verbal and numerical intelligence among medical students

Biomedicine ◽  
2021 ◽  
Vol 41 (3) ◽  
pp. 678-681
Author(s):  
G .Yuvarani ◽  
Jibi Paul ◽  
M. Manoj Abraham ◽  
N. Harikrishnan
Keyword(s):  
Shoulder Pain ◽  
Prospective Observational Study ◽  
External Rotation ◽  
Dominant Hand ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Female Population ◽  
Female Age ◽  
History Of ◽  
Severity Of The Disease

Introduction and Aim:Periarthritis shoulder is generally defined as a self - limiting disorder that affects mostly the diabetic persons. Periarthritis shoulder affects the older population with females at its peak.This study was intended to find out whether all the shoulder pain subjects were victims of periarthritis shoulder and to analyse the prevalence of periarthritis among subjects who were suffering from shoulder.   Materials and Methods:This study was a prospective, observational study conducted on the patients who visited the outpatient Physiotherapy Departments. Nearly 300 patients who came with shoulder pain were taken as samples. A detailed explanation about the purpose of the study was given to the subjects. The subjects included were based on the inclusion criteria pain more than 1 month, both male and female, age group of 40-60 years, both dominant and non-dominant hand, history of shoulder pain at night, progressive limitation of shoulder movement, particularly a reduction of at least half the normal range of abduction and external rotation.   Results:Based on the inclusion and exclusion criteria nearly 300 participants were selected and they were asked to fill the SPADI questionnaire. Out of 300 participants nearly 127 subjects were concluded with positive signs of periarthritis shoulder.   Conclusion: The result obtained from our study states that the severity of the disease is more among the female population. The subjects who are suffering from shoulder pain must be taken into anticipation that in future they may develop shoulder periarthritis.

Paroxysmal finger haematoma - a benign acrosyndrome occurring in middle-aged women

VASA ◽  
2016 ◽  
Vol 45 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Patrick H. Carpentier ◽  
Hildegard R. Maricq ◽  
Christine Biro ◽  
Myriam Jiguet ◽  
Christophe Seinturier
Keyword(s):  
Risk Factors ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sudden Onset ◽  
Dominant Hand ◽  
Middle Aged ◽  
Cross Sectional ◽  
Lifestyle Risk Factors ◽  
Medical Evaluation ◽  
History Of

Abstract. Background: Paroxysmal finger haematoma (PFH) is an under-recognised vascular acrosyndrome with no epidemiological description to date. The aim of this work was to evaluate the prevalence, risk factors and clinical correlates of PFH in a population-based sample of subjects and to describe their semiological characteristics. Patients and methods: This cross-sectional study of random samples of the general population in three geographic areas of France involved 802 subjects, 548 women and 254 men, aged 18 to 84 years. The diagnosis of PFH was made from a report by the subject of a history of recurrent haematoma in the fingers with a sudden, painful and unexpected occurrence. Diagnosis of associated conditions and evaluation of lifestyle variables were obtained through standardised medical interview and examination. Results: A history of PFH was detected in 71 subjects, with a prevalence of 1.2 % in men and 12.4 % in women; there was no significant regional variation. Onset before 40 years of age was rare. Besides female sex and age, no socio-economical nor lifestyle risk factors were detected. PFH was associated with Raynaud phenomenon and a history of chilblains, but no link with any health threatening disease was found. In addition to the sudden onset of pain and hematoma, the main clinical features were a frequent digital swelling during the painful attack, and their predominant location on the volar side of the first and second phalanges of the third or second fingers of the dominant hand. Conclusions: PFH is a benign phenomenon, frequently found in middle-aged women, to be classified among the vascular acrosyndromes. Patients seeking medical evaluation for this disorder should be reassured.

scholarly journals 1008 Brain Age Based on Sleep Encephalography is Elevated in HIV+ Adults on ART

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A383-A383
Author(s):  
M J Leone ◽  
H Sun ◽  
C Boutros ◽  
L Sullivan ◽  
R J Thomas ◽  
...  
Keyword(s):  
Brain Aging ◽  
Sleep Eeg ◽  
Delta Power ◽  
Promising Tool ◽  
Stage 2 Sleep ◽  
History Of ◽  
The Difference ◽  
Inference Methods ◽  
Brain Age ◽  
Eeg Features

Abstract Introduction Sleep EEG is a promising tool to measure brain aging in vulnerable populations such as people with HIV, who are high risk of brain aging due to co-morbidities, increased inflammation, and antiretroviral neurotoxicity. Our lab previously developed a machine learning model that estimates age from sleep EEG (brain age, BA), which reliably predicts chronological age (CA) in healthy adults. The difference between BA and CA, the brain age index (BAI), independently predicts mortality, and is increased by cardiovascular co-morbidities. Here, we assessed BAI in HIV+ compared to matched HIV- adults. Methods Sleep EEGs from 43 treated HIV+ adults were gathered and matched to controls (HIV-, n=284) by age, gender, race, alcoholism, smoking and substance use history. We compared BAI between groups and used additional causal interference methods to ensure robustness. Individual EEG features that underlie BA prediction were also compared. We performed a sub-analysis of BAI between HIV+ with or without a history of AIDS. Results After matching, mean CA of HIV+ vs HIV- adults were 49 and 48 years, respectively (n.s.). The mean HIV+ BAI was 3.04 years higher than HIV- (4.4 vs 1.4 yr; p=0.048). We found consistent and significant results with alternative causal inference methods. Several EEG features predictive of BA were different in the HIV+ and HIV- cohorts. Most notably, non-REM stage 2 sleep (N2) delta power (1-4Hz) was decreased in HIV+ vs. HIV- adults, while theta (4-8Hz) and alpha (8-12Hz) power were increased. Those with AIDS (n=19, BAI=4.40) did not have significantly different BAI than HIV+ without AIDS (n=23, BAI=5.22). HIV+ subjects had higher rates of insomnia (56% vs 29%, p&lt;0.001), obstructive apnea (47% vs 30%, p=0.03), depression (49% vs 23%, p&lt;0.001), and bipolar disorder (19% vs 4%, p&lt;0.001). Conclusion HIV+ individuals on ART have excess sleep-EEG based brain age compared to matched controls. This excess brain age is partially due to reduction in delta power during N2, suggesting decreased sleep depth. These results suggest sleep EEG could be a valuable brain aging biomarker for the HIV population. Support This research is supported by the Harvard Center for AIDS Research HU CFAR NIH/NIAID 5P30AI060354-16.

Sign in / Sign up

Export Citation Format

Share Document