scholarly journals Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Saima Ejaz ◽  
Anwar Ali ◽  
Sumaira Riffat ◽  
Kamran Azim ◽  
Atif Mahmood
Keyword(s):  
Risk Factor ◽  
Genetic Polymorphism ◽  
Creative Commons ◽  
Pregnant Females ◽  
Hypertension In Pregnancy ◽  
Significant Difference ◽  
Polymerase Chain ◽  
Control Study ◽  
Open Access Article ◽  
In Pregnancy

Objective: The study was performed to investigate the association of hypertension in pregnancy with prostasin gene polymorphism in Pakistani females. Methods: This case-control study was performed at University of Karachi, Pakistan from April 2018 to May 2019. A total of 160 females, including 90 hypertensives and 70 healthy pregnant females, were recruited by purposive sampling after obtaining informed written consent. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: The frequencies of the TC and CC genotypes were higher in hypertensive pregnant females compared to healthy controls. A significant difference was evident for CC (P=0.012) genotype; however, no significant difference was observed for TC (P=0.49) and TT genotypes (P=0.06) between control and hypertensive groups. The adjusted odds ratio for CC genotype was 6.2 (P=0.025) and 1.48 (P=0.44) for TC genotype compared to the TT genotype. There was a significantly higher prevalence of the C allele of the prostasin gene at rs12597511 in the hypertensive group, suggesting that this allele is a risk factor for hypertension and cardiovascular diseases. Conclusion: C allele at rs12597511 of prostasin gene demonstrate as a risk factor for having hypertension in pregnancy. doi: https://doi.org/10.12669/pjms.37.1.3666 How to cite this:Ejaz S, Ali A, Riffat S, Azim K, Mahmood A. Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females. Pak J Med Sci. 2021;37(1):109-113. doi: https://doi.org/10.12669/pjms.37.1.3666 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Hypertension in pregnancy as a risk factor for cardiovascular disease later in life

2010 ◽  
Vol 28 (4) ◽  
pp. 826-833 ◽  
Author(s):  
Vesna D Garovic ◽  
Kent R Bailey ◽  
Eric Boerwinkle ◽  
Steven C Hunt ◽  
Alan B Weder ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

The Egogram Is a Potent, Independent Risk Factor for Hypertension in Pregnancy

2005 ◽  
Vol 31 (03) ◽  
pp. 302-306 ◽  
Author(s):  
Gen Kobashi ◽  
Kaori Ohta ◽  
Koichi Shido ◽  
Akira Hata ◽  
Hideto Yamada ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

Hypertension in pregnancy and endothelial activation: An emerging risk factor for cardiovascular disease

2012 ◽  
Vol 2 (4) ◽  
pp. 393-397 ◽  
Author(s):  
Natalia Lazzarin ◽  
Giovambattista Desideri ◽  
Claudio Ferri ◽  
Herbert Valensise ◽  
Giulia Gagliardi ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Endothelial Activation ◽  
Hypertension In Pregnancy ◽  
Emerging Risk ◽  
In Pregnancy

The Effect of Interleukin-1 Allele 2 Genotype (IL-1a−889 and IL-1b+3954) on the Individual's Susceptibility to Peri-Implantitis: Case-Control Study

2011 ◽  
Vol 37 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Ahmed Abd El-Meguid Mostafa Hamdy ◽  
Mohamed Abd El-Moniem Ebrahem
Keyword(s):  
Interleukin 1 ◽  
Response To Treatment ◽  
Clinical Parameters ◽  
Tissue Destruction ◽  
Maintenance Program ◽  
Group I ◽  
Significant Difference ◽  
Polymerase Chain ◽  
Group Ii ◽  
Control Study

Abstract Individuals bearing the combination of interleukin (IL)-1 allele 2 at IL-1A−889 and IL-1B+3954 are referred to as being genotype positive and are susceptible to increased periodontal tissue destruction. The aim of this study was to assess the possible association of IL-1 allele 2 (IL-1A−889 and IL-B+3954) genotypes with the severity of peri-implantitis progression and the effect of this combination on treatment outcomes. Fifty patients with International Team for Implantology implants were studied; patients ranged in age from 35–55 years, and each patient had 1 implant. According to peri-implant tissue status, patients were divided into 2 groups: group I consisted of 25 patients with peri-implantitis, and group II comprised 25 patients with healthy peri-implant tissue. Clinical parameters were assessed at baseline and after 3 and 6 months. Epithelial cells were collected from the oral mucosa by plastic spatula and were used for IL-1 genotyping by the polymerase chain reaction technique. Group I patients were subjected to a peri-implantitis treatment and maintenance program. In all, 17 patients from group I and 5 patients from group II were genotype positive, with a statistically significant difference noted between the 2 groups. Group I genotype-positive patients presented with higher scores and measurements of clinical parameters with increased suppuration from peri-implant tissues compared with group II; differences were statistically significant (P < .05). In terms of response to treatment, genotype-negative patients demonstrated better response than genotype-positive patients. The combination of IL-1 allele 2 (IL-1A−889 and IL-1B+3954) in patients with inflamed periodontal or peri-implant tissues acts as a risk factor that leads to greater tissue destruction. IL-1 gene polymorphism at IL-1A−889 and IL-1B+3954 may affect outcomes of treatment for peri-implantitis in genotype-positive individuals.

Headache is a risk factor for the onset of hypertension in pregnancy

2005 ◽  
Vol 193 (6) ◽  
pp. S178
Author(s):  
Fabio Facchinetti ◽  
Rossella E. Nappi ◽  
Luca Marozio ◽  
Roberto D'Amico ◽  
Lorena Bertozzi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

Hypertension in pregnancy: a risk factor for the whole family?

2017 ◽  
Vol 13 (6) ◽  
pp. 326-327 ◽  
Author(s):  
Grace Z. Yu ◽  
Paul Leeson
Keyword(s):  
Risk Factor ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

scholarly journals High frequency of simultaneous presence of ESBL and carbapenemase producers among nosocomial  coliform isolates in Faisalabad, Pakistan

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Sofia Irfan ◽  
Aysha Azhar ◽  
Asad Bashir Awan ◽  
Salman Ahmad ◽  
Abdul Haque
Keyword(s):  
High Frequency ◽  
Original Work ◽  
Carbapenem Resistance ◽  
Simultaneous Presence ◽  
Chain Reaction ◽  
E Coli ◽  
Creative Commons ◽  
Polymerase Chain ◽  
Open Access Article ◽  
Phenotypic Susceptibility

Objectives: The objective of the current study was to find prevalence of relevant ESBL and carbapenemase producing genes in nosocomial E. coli and K. pneumoniae isolates and to check phenotypic susceptibility of all ESBL positive isolates to carbapenems. Methods: Forty ESBL producing clinical isolates of Escherichia coli (n=33) and Klebsiella pneumoniae (n=7) were examined for the presence of β-lactamase genes (CTX-M, CTX-M-1, 2, 3, 4 and TEM). Carbapenem resistance was checked phenotypically and by presence of blaNDM-1 gene. Results: Nine (27%) were positive for CTX-M genes, and 10 (30%) for TEM among E. coli isolates. Importantly, six isolates showed co-existence of CTX-M and TEM genes. In K. pneumoniae, two (28%) isolates were positive for CTX-M and one (14%) for TEM genes. Eight (24%) E. coli and one (14%) K. pneumoniae isolates were positive for CTX-M-1. Respective figures for CTX-M-4 were three (10%) and one (14%). CTX-M-2 and CTX-M-3 groups were not represented. Twenty (50%) isolates were resistant to both imipenem and meropenem out of which only four isolates expressed blaNDM-1 gene. Conclusions: The significant presence of both ESBL and carbapenemase producers and co-existence of ESBL and carbapenemases in the same isolates is worrisome. Abbreviations: ESBL: Extended spectrum β-lactamase. MBL: Metallo-betlactamase. PCR: Polymerase chain reaction. doi: https://doi.org/10.12669/pjms.37.1.3192 How to cite this:Irfan S, Azhar A, Bashir A, Ahmed S, Haque A. High frequency of simultaneous presence of ESBL and carbapenemase producers among nosocomial coliform isolates in Faisalabad, Pakistan. Pak J Med Sci. 2021;37(1):34-39.  doi: https://doi.org/10.12669/pjms.37.1.3192 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Frequency, clinical characteristics, risks, and outcomes of Paradoxical upgrading reactions during anti-tuberculosis treatment in tuberculous lymphadenitis

2019 ◽  
Vol 36 (ICON-Suppl) ◽  
Author(s):  
Samreen Sarfaraz ◽  
Sundus Iftikhar ◽  
Naseem Salahuddin
Keyword(s):  
Clinical Characteristics ◽  
Case Control Study ◽  
Case Control ◽  
Tuberculosis Treatment ◽  
Tuberculous Lymphadenitis ◽  
Creative Commons ◽  
Special Supplement ◽  
Nested Case Control ◽  
Control Study ◽  
Open Access Article

Objectives: To investigate the clinical characteristics, risks and outcomes of Paradoxical upgrading reactions (PUR) during anti-tuberculosis treatment (ATT) in superficial tuberculous lymphadenitis (TBLA). Methods: In this nested case-control study, all patients diagnosed with TBLA based on combinations of histopathology, acid-fast bacilli (AFB) microscopy, AFB culture, and GeneXpert, between February 2013 and April 2016, were enrolled. Standard ATT was given. Demographics, clinical characteristics, occurrence of PUR and outcome were recorded. Results: TBLA was diagnosed and treated in 189 patients. PUR developed in 33 (17%), of which 77% developed new inflamed glands, 20.6% had increased size and inflammation of pre-existing glands and 5.9% had superficial chest wall abscesses requiring aspiration. All responded to regular NSAIDs except one, where a steroid course was effective. No change in dose or duration of ATT was required. Presence of anorexia (OR; 95%CI: 2.6; 1.003-6.74), bilateral extensive lymphadenopathy (OR; 95%CI: 2.9; 1.1-7.5) and lymph node specimen positive for AFB (OR; 95%CI: 3.2; 1.04-10.1) were significantly associated with PUR. Conclusion: PUR is common in TBLA. It responded to NSAIDS and does not need any modification in ATT. doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1711 How to cite this:Sarfaraz S, Iftikhar S, Salahuddin N. Frequency, clinical characteristics, risks, and outcomes of Paradoxical upgrading reactions during anti-tuberculosis treatment in tuberculous lymphadenitis. Pak J Med Sci. Special Supplement ICON 2020. 2020;36(1):S27-S32.  doi: https://doi.org/10.12669/pjms.36.ICON-Suppl.1711 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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