scholarly journals Efficacy of hyperbaric oxygen combined with escitalopram in depression and its effect on cognitive function

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Kun Mi ◽  
Qiang Guo ◽  
Bao-yan Xu ◽  
Man Wang ◽  
Hao Bi
Keyword(s):  
Cognitive Function ◽  
Hyperbaric Oxygen ◽  
Depression Scale ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Observation Group ◽  
Creative Commons ◽  
Significant Difference ◽  
Hamd Score ◽  
Icd 10

Objective: To investigate the efficacy of hyperbaric oxygen (HBO) combined with escitalopram in patients with depression and its effect on cognitive function. Methods: From 2016 to 2018, seventy patients with depression aged 18-65 years treated in Affiliated Hospital of Hebei University were selected. Seventy patients with depression meeting the diagnostic criteria of ICD-10 were selected and randomly divided into control group and observation group using a random number table, with 35 patients in each group. The control group was treated with escitalopram, while the observation group was additionally treated with HBO on this basis. The patients were assessed using the Hamilton Depression Scale (HAMD) and Montreal Cognitive Assessment Scale (MoCA) before treatment and two, four and six weeks after treatment. Results: Two weeks after treatment, HAMD score showed a statistically significant difference between the two groups (P < 0.05). No statistically significant differences were found in HAMD score between the two groups four and six weeks after treatment (P > 0.05). Four and six weeks after treatment, MoCA score presented statistically significant differences between the two groups (P < 0.05). Conclusion: Escitalopram combined with HBO in the treatment of depression presents rapid efficacy and a certain effect in improving cognitive function. doi: https://doi.org/10.12669/pjms.37.4.3993 How to cite this:Mi K, Guo Q, Xu BY, Wang M, Bi H. Efficacy of hyperbaric oxygen combined with escitalopram in depression and its effect on cognitive function. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3993 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Paroxetine combined with olanzapine in the treatment of schizophrenia

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Ning Wang ◽  
Na Zheng ◽  
Mei Dong ◽  
Jin He
Keyword(s):  
Negative Symptoms ◽  
Adverse Reactions ◽  
Statistical Significance ◽  
Depression Scale ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Observation Group ◽  
Research Subjects ◽  
Significant Difference ◽  
Hamd Score

Objective: To investigate the clinical efficacy of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression. Methods: Eighty-four elderly schizophrenic patients with depression who were admitted to our hospital from August 2016 to February 2018 were selected as research subjects and randomly divided into observation group and control group using random number table, 42 cases in each group. The control group was treated with olanzapine orally, while the observation group was treated with olanzapine and paroxetine orally. The level of homocysteine (Hcy) in the two groups was analyzed before and after treatment. The efficacy was evaluated by the Positive and Negative Symptoms Scale (PANSS) score and Hamilton Depression Scale (HAMD) score. The adverse reactions of the two groups were compared. Results: After treatment, the level of serum Hcy in the observation group was significantly lower than that in the control group (P<0.05), and it was close to the normal level. There was no significant difference in PANSS score between the two groups before treatment (P>0.05). After treatment, the negative factor score and PANSS score in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The HAMD score of the two groups had no significant difference before treatment (P>0.05). After treatment, the HAMD score of the observation group was significantly lower than that of the control group (P<0.05). The difference of incidence of adverse reactions between the two groups had no statistical significance (P>0.05). Conclusion: Paroxetine combined with olanzapine has a definite clinical effect in the treatment of senile schizophrenia with depression. It can effectively reduce the level of serum Hcy, relieve the symptoms of schizophrenia, and alleviate the depressive symptoms of patients, with high safety. It is worth promoting. doi: https://doi.org/10.12669/pjms.36.3.846 How to cite this:Wang N, Zheng N, Dong M, He J. Paroxetine combined with olanzapine in the treatment of schizophrenia. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.846 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effect of olanzapine combined with risperidone in the treatment of schizophrenia and its influence on cognitive function

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Lujie Yang ◽  
Xia Qi
Keyword(s):  
Cognitive Function ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Wisconsin Card Sorting Test ◽  
Control Group ◽  
Observation Group ◽  
Card Sorting ◽  
Significant Treatment ◽  
Creative Commons ◽  
Significant Difference

Objective: To explore the effect of risperidone combined with olanzapine in the treatment of schizophrenia and its influence on cognitive function. Methods: Ninety-eight schizophrenic patients in our hospital who were admitted and treated between June 2018 and December 2019 were selected. The study group was treated with risperidone combined with olanzapine, and the control group was treated with risperidone. The clinical efficacy, Positive and Negative Syndrome Scale (PANSS) score, Wisconsin Card Sorting Test (WCST) result and adverse reactions of the two groups were compared. Results: After treatment, the scores of classification completion number and correct times of the observation group were higher than those of the control group, and the scores of the random error number and continuous error number were higher than those of the control group; the differences were statistically significant (P<0.05). The total effective rate of the observation group was 95.56%, which was higher than 77.78% of the control group (P<0.05). After treatment, the PANSS scores of the observation group were significantly lower than those of the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 9.30% and 6.98%, respectively, and there was no significant difference between the two groups (P>0.05). Conclusion: Risperidone combined with olanzapine in the treatment of schizophrenia can effectively reduce symptoms of patients and induce fewer adverse reactions, showing high safety and significant treatment effect. doi: https://doi.org/10.12669/pjms.37.3.3348 How to cite this:Yang L, Qi X. Effect of olanzapine combined with risperidone in the treatment of schizophrenia and its influence on cognitive function. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3348 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Correlation of Catecholamine Content and Clinical Influencing Factors in Depression among Psoriasis Patients: A Case-Control Study

2020 ◽  
Author(s):  
Hui-Ling Shu ◽  
Jing Fang ◽  
Deng-Mei Xia ◽  
Zheng-Qun Wang ◽  
Wen-Yao Mi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Influencing Factors ◽  
Psoriasis Vulgaris ◽  
Depression Scale ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Dermatology Department ◽  
Dopamine Content ◽  
Significant Difference ◽  
The Mean

Abstract Backgroud: This study sought to investigate the clinical influencing factors of patients with psoriasis vulgaris complicated with depression, and to analyze whether the content of monoamine neurotransmitters in plasma was correlated with depression incidence among psoriasis patients. Methods Ninety patients aged 18-60 years with psoriasis vulgaris referred to the dermatology department and 40 healthy volunteers aged 18-60 years referred to the physical examination center of the Affiliated Hospital of Southwest Medical University were included. Questionnaires were administered in both groups to obtain basic patient information, Hamilton Depression Scale(HAMD), and Athens Insomnia Scale(AIS) scores. The questionnaire only for patients with psoriasis vulgaris included the course of disease, Psoriasis Area and Severity Index (PASI), and Dermatology Life Quality Index (DLQI). The catecholamine in plasma from the two groups was analyzed by radioimmunoassay. The data were analyzed by SPSS statistical software. Results: The mean HAMD (P=0.034) and mean AIS scores (P=0.001) of the psoriasis patients were higher than those of the control group, while the mean content of dopamine (P=0.004) and adrenaline in the plasma (P=0.007) of the psoriasis group were lower than those of the control group. Dopamine content in the plasma was lower (comparing psoriasis patients without depression and the control group: P<0.001), and was negatively correlated with HAMD, (P<0.05), AIS (P<0.05), and PASI scores (P<0.05) in the psoriasis patients with depression. There was no significant difference in the epinephrine and norepinephrine contents in all groups. PASI scores were positively correlated with HAMD scores in patients with psoriasis vulgaris, and the mean dopamine content in the patients with depression (P=0.001) was significantly lower than in those without depression. The low dopamine content and high PASI and DLQI scores were the risk factors for depression among the patient population. Conclusion: Psoriasis patients have a significantly higher risk of depression than healthy people, and higher PASI scores were linked to a higher incidence of depression. The dopamine levels of patients were influenced by both psoriasis and depression. The risk factors for depression in psoriasis patients are low dopamine levels in the plasma, severe skin lesions, and lower quality of life.

scholarly journals Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Patients with Vascular Dementia

2019 ◽  
Vol 28 (8) ◽  
pp. 1071-1075 ◽  
Author(s):  
Yuzhen Xu ◽  
Qian Wang ◽  
Zhongsen Qu ◽  
Jiajun Yang ◽  
Xinping Zhang ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Vascular Dementia ◽  
Hyperbaric Oxygen ◽  
Conventional Treatment ◽  
Elevated Serum ◽  
Control Group ◽  
Protective Effects ◽  
Significant Difference ◽  
Before And After ◽  
Baseline Characteristics

Recent studies have shown that hyperbaric oxygen (HBO) has a therapeutic effect on vascular dementia (VD); however, the exact mechanism remains unclear. This article aims to reveal the protective effects and underlying mechanisms of HBO on VD. A total of 158 patients with VD were prospectively included in the study and were randomly divided into control group and HBO group. The control group was given conventional treatment and the HBO group was treated with HBO in addition to conventional treatment. The following HBO protocol was practiced: 5 days per week, 60 min each, 100% oxygen at 2 standard atmospheric pressures for 12 weeks. The Mini-Mental State Examination (MMSE) scores and serum Humanin levels were detected before and after treatments in both groups. The baseline characteristics were not different dramatically between groups ( p > 0.05). There was no significant difference in MMSE scores and serum Humanin levels between the two groups before treatment ( p > 0.05). After treatment, compared with the control group, the MMSE scores and serum Humanin levels in the HBO group were significantly increased ( p < 0.05). Spearman correlation analysis showed that the serum Humanin levels were positively correlated with MMSE scores ( r = 0.409, p < 0.05) and this correlation was independent of baseline characteristics (β = 0.312, p < 0.05). HBO therapy can improve cognitive function in patients with VD, and its mechanism may be related to elevated serum Humanin levels.

Effect of eCASH Nursing Model on Life Self-care Ability, Physical Function, Psychological Function and Cognitive Function of Critical Patients in EICU

2021 ◽  
Vol 7 (5) ◽  
pp. 3243-3250
Author(s):  
Lili Lin ◽  
Danhong Pan
Keyword(s):  
Cognitive Function ◽  
Physical Function ◽  
Self Care ◽  
Nursing Intervention ◽  
Control Group ◽  
Observation Group ◽  
Psychological Function ◽  
Significant Difference ◽  
Critical Patients ◽  
The Impact

To explore and analyze the impact of Emergency Intensive Care Unit (EICU) critical care patients using eCASH nursing mode intervention on patients’ cognitive function, psychological function, physical function and life self-care ability. Randomly selected 142 critically ill patients in our hospital’s EICU ward from January 2018 to October 2019 as study subjects, and grouped them according to the time of admission. 71 patients in the observation group were intervened by the eCASH nursing model, and 71 patients in the control group received regular nursing intervention. Recording the cognitive, psychological, physical and other functions and self-care ability of the two groups of patients. Before nursing, the Bl score of critical patients in the observation group was compared with the control group (P> 0.05). After the intervention of the observation group patients accepted eCASH nursing model, the Bl score was obviously higher than the control group (P <0.05). According to the SCL-90 table scores, there is no significant difference in the scores of each dimension between the two groups before nursing (P> 0.05). Compare before and after nursing and score except for obsessive compulsive disorder and psychosis (P> 0.05). According to the SCL-90 scale score, there is no significant difference in the scores of each dimension between the two groups before nursing (P <0.05). According to the comparison of the two groups of data after nursing, somatization, anxiety, depression, fear, hostility, paranoia and SCL-90 total score in the observation group were significantly lower than that of control group (P <0.05). Before nursing, the cognitive level of the two groups was compared (P> 0.05). After nursing, the HDS score of the observation group was higher than that of the control group (P <0.05). The CM-PPT score was compared, and the data of the two groups before nursing was compared (P> 0.05). The score of observation group after receiving eCASH nursing was higher than that of control group (P <0.05). The study confirmed that eCASH nursing model for EICU critical patients as early as possible has a significant effect on improving patients ’cognitive function, mental state, physical function, etc. At the same time, it can improve patients’ self-care ability in life and is worthy of promotion.

scholarly journals Efficacy of Acupuncture On Cognitive Function In Poststroke Depression: Study Protocol For A Randomized, Placebo-Controlled Trial

2021 ◽  
Author(s):  
Ling Chen ◽  
Yi Chen ◽  
Lihua Wu ◽  
Wen Fu ◽  
Luanmian Wu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Acupuncture Treatment ◽  
Negative Emotion ◽  
Intervention Group ◽  
Depression Scale ◽  
Event Related Potentials ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Poststroke Depression ◽  
Related Potentials

Abstract Introduction: Poststroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes and quality of life. Antidepressants are the first-line treatment for PSD, but many reported side effects remain. Clinical research has shown that acupuncture has a positive effect on PSD. This trial aims to study the efficacy and safety of acupuncture for PSD and to explore its effect on cognitive function. It is hypothesized that acupuncture treatment improves depressive symptom, cognitive behavior and negative emotion processing bias in PSD.Methods: In this randomized, placebo-controlled, single-blinded trial, fifty-six people with PSD will be randomly allocated into the intervention (n=28) or control (n=28) groups. The intervention group will receive acupuncture treatment, and the control group will receive sham acupuncture treatment, in 20 sessions over 4 weeks. The primary outcome is the change from baseline in the Hamilton Depression Scale-17 (HAMD-17) scores at week 4. Secondary outcomes include the Wisconsin Card Sorting Test (WCST) and latency and amplitude of P1, N170 and P3 of the event-related potentials (ERPs) components to assess the changes in cognitive function and electroencephalography. Outcomes are assessed at baseline and post intervention.Discussion: Acupuncture therapy could become an alternative treatment for PSD, and it is expected that this trial will provide reliable clinical evidence for the future use of acupuncture for the treatment of PSD.Trial registration: Chinese Clinical Trial Registry: ChiCTR1900026948. Registered on 27 October 2019.

scholarly journals HospicNursing of Patients with Advanced Tumor

1970 ◽  
Vol 1 (2) ◽  
Author(s):  
Jiaxin Li
Keyword(s):  
Life Quality ◽  
Depression Scale ◽  
Nursing Intervention ◽  
Psychological Status ◽  
Control Group ◽  
Observation Group ◽  
Satisfaction Rate ◽  
Advanced Tumor ◽  
Significant Difference ◽  
The Difference

Purpose: Analyzing the nursing methods of patients with advanced tumor. Method: Choose 108 patients with advanced tumor from the patients of the hospital. according to the nursing 109 methods, each 54 patients are brought into the control group and the observation group respectively, which are given general nursing and hospic comprehensive nursing intervention measures, and use Self-rating depression scale (SDS) and Self-Rating Anxiety Scale (SAS) to evaluate the psychological situations of the two groups before and after nursing, and to compare the life quality situations and nursing satisfaction rate of the two group patients after nursing. Results: there is no significant difference in psychological status between the two groups before nursing (P > 0.05), but after nursing, the scores of SAS and SDS in the observation group were lower than those in the control group, and the difference is significant (P<0.05), which is statistically significant. For the scores of the life quality, the observation group is higher than that of the control group, the difference is significant (P < 0.05), which is statistically significant. The nursing satisfaction rate of the observation group is 96.30% (52/54), higher than that of the control group (74.07% (40/54)), and the difference is significant (P < 0.05), which is statistically significant. Conclusion: the comprehensive clinical nursing intervention method applying in nursing of patients with advanced tumors plays an important role to improve the psychological status of patients and enhance the life quality of patients and nursing satisfaction rate, which should be widely popularized in nursing practice.

scholarly journals Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Rui Han ◽  
Qianqian Yu ◽  
Guohui Zhang ◽  
Baoqiang Li ◽  
Shuzhen Han ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Research Subjects ◽  
Creative Commons ◽  
Significant Difference ◽  
Mycoplasma Pneumonia ◽  
The Difference

Objective: To study and compare the clinical effects of azithromycin and erythromycin on children with mycoplasma pneumonia. Methods: Total 132 children with mycoplasma pneumonia who were admitted to our hospital between November 2017 and September 2018 were selected as the research subjects. All the children were divided into an observation group and a control group according to random number table, 66 each. The observation group was treated with azithromycin, while the control group was treated with erythromycin. The therapeutic effect, incidence of adverse reactions and disappearance time of clinical symptoms were compared between the two groups. Results: The total efficacy of the observation group was 98.04%, and that of the control group was 74.51%; there was a significant difference (X2=7.184, P=0.007). The incidence of adverse reactions in the observation group was 15.69%, significantly lower than that in the control group (41.18%) (X2=6.376, P=0.002). The disappearance of fever, cough, rale and X ray shadow of the observation group was significantly earlier than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with erythromycin, azithromycin is more effective in the treatment of mycoplasma pneumonia in children. Azithromycin can further shorten the improvement time of clinical symptoms and signs and has few adverse reactions and high safety. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.2.1441 How to cite this:Han R, Yu Q, Zhang G, Li B, Han S, Li G. Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1441 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Evaluation of the online-based self-help programme “Selfapy” in patients with unipolar depression: study protocol for a randomized, blinded parallel group dismantling study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rico Krämer ◽  
Stephan Köhler
Keyword(s):  
Depressive Symptoms ◽  
Depression Scale ◽  
Drop Out ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Online Interventions ◽  
Phone Calls ◽  
Self Help ◽  
Low Threshold ◽  
The Impact

Abstract Background Patients with mild to moderate depressive symptoms can have limited access to regular treatment; to ensure appropriate care, low-threshold treatment is needed. Effective online interventions could increase the supply of low-threshold treatment. Further research is needed to evaluate the effectiveness of online interventions. This study aims to evaluate the online-based self-help programme “Selfapy” on a sample of depressive subjects and compares the impact of the programme’s unaccompanied version with its therapeutic accompanied version. Methods A sample of 400 subjects that have a mild to severe depressive episode (Becks Depression Inventory - II and Hamilton Depression Scale) will be used. Subjects are randomly assigned to immediate access to an unaccompanied course (no support from psychologist via weekly phone calls), immediate access to an accompanied course (support from a psychologist via weekly phone calls) or a waiting list control group (access to the intervention after 24 weeks). The intervention will last for a period of 12 weeks. Depressive symptoms as a primary parameter, as well as various secondary parameters, such as life satisfaction, therapeutic relationships, social activation, self-esteem, attitudes towards Internet interventions and drop-out rates, are recorded at four different points in time: at baseline (T1), 6 weeks after the start of the intervention (T2), 12 weeks after the start of the intervention (T3) and 3 months after completion of the treatment follow-up (T4). Conclusion This randomized and controlled, blinded study will make use of a “dismantled” approach to adequately compare the accompanied and unaccompanied versions of the intervention. Positive and meaningful results are expected that could influence the acceptance and implementation of online interventions. Trial registration German Clinical Trials Register DRKS00017191. Registered on 14 June 2019

Effectiveness of neurobic exercise program on memory and depression among elderly residing at old age home

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Divya Raj ◽  
Subramaniam Santhi ◽  
G. J. Sara Sapharina
Keyword(s):  
Old Age ◽  
Depression Scale ◽  
Exercise Program ◽  
The Elderly ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
The Mean ◽  
Interventional Group ◽  
Old Age Homes

AbstractObjectivesThis study finds out the effectiveness of neurobic exercise program on memory and depression among elderly residing in old age homes.MethodsThe non-probability purposive sampling technique was used for sample selection. Wechsler's memory scale (WMS-IV) and Geriatric depression scale (GDS) were the instruments used to assess the memory and depression among elderly during the pretest and posttest, respectively and the researcher had developed data sheet to collect information about the background variables using interview technique.ResultsThe neurobic exercise program was found to be effective in reducing depression among elderly residing in old age homes. There was a significant difference (p<0.001) in the level of depression had been found during the pretest and posttest in the interventional group. There was a statistically significant difference (p<0.001) found between the study group and in the control group. There was significant correlation (r=0.417, p<0.05) found between the memory and depression during the pretest in the study group among the elderly. A statistically significant association (p<0.05) found in the mean scores of depression and marital status of the elderly during the pretest in the study group and there was a significant association (p<0.01) found in the mean scores of depression and the gender of the elderly during the pretest and posttest in the non interventional group were found.ConclusionsThe findings suggested that neurobic exercise program is an effective intervention in improving memory and reducing depression.

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