scholarly journals Efficacy of Acupuncture On Cognitive Function In Poststroke Depression: Study Protocol For A Randomized, Placebo-Controlled Trial

2021 ◽  
Author(s):  
Ling Chen ◽  
Yi Chen ◽  
Lihua Wu ◽  
Wen Fu ◽  
Luanmian Wu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Acupuncture Treatment ◽  
Negative Emotion ◽  
Intervention Group ◽  
Depression Scale ◽  
Event Related Potentials ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Poststroke Depression ◽  
Related Potentials

Abstract Introduction: Poststroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes and quality of life. Antidepressants are the first-line treatment for PSD, but many reported side effects remain. Clinical research has shown that acupuncture has a positive effect on PSD. This trial aims to study the efficacy and safety of acupuncture for PSD and to explore its effect on cognitive function. It is hypothesized that acupuncture treatment improves depressive symptom, cognitive behavior and negative emotion processing bias in PSD.Methods: In this randomized, placebo-controlled, single-blinded trial, fifty-six people with PSD will be randomly allocated into the intervention (n=28) or control (n=28) groups. The intervention group will receive acupuncture treatment, and the control group will receive sham acupuncture treatment, in 20 sessions over 4 weeks. The primary outcome is the change from baseline in the Hamilton Depression Scale-17 (HAMD-17) scores at week 4. Secondary outcomes include the Wisconsin Card Sorting Test (WCST) and latency and amplitude of P1, N170 and P3 of the event-related potentials (ERPs) components to assess the changes in cognitive function and electroencephalography. Outcomes are assessed at baseline and post intervention.Discussion: Acupuncture therapy could become an alternative treatment for PSD, and it is expected that this trial will provide reliable clinical evidence for the future use of acupuncture for the treatment of PSD.Trial registration: Chinese Clinical Trial Registry: ChiCTR1900026948. Registered on 27 October 2019.

scholarly journals Efficacy of hyperbaric oxygen combined with escitalopram in depression and its effect on cognitive function

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Kun Mi ◽  
Qiang Guo ◽  
Bao-yan Xu ◽  
Man Wang ◽  
Hao Bi
Keyword(s):  
Cognitive Function ◽  
Hyperbaric Oxygen ◽  
Depression Scale ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Observation Group ◽  
Creative Commons ◽  
Significant Difference ◽  
Hamd Score ◽  
Icd 10

Objective: To investigate the efficacy of hyperbaric oxygen (HBO) combined with escitalopram in patients with depression and its effect on cognitive function. Methods: From 2016 to 2018, seventy patients with depression aged 18-65 years treated in Affiliated Hospital of Hebei University were selected. Seventy patients with depression meeting the diagnostic criteria of ICD-10 were selected and randomly divided into control group and observation group using a random number table, with 35 patients in each group. The control group was treated with escitalopram, while the observation group was additionally treated with HBO on this basis. The patients were assessed using the Hamilton Depression Scale (HAMD) and Montreal Cognitive Assessment Scale (MoCA) before treatment and two, four and six weeks after treatment. Results: Two weeks after treatment, HAMD score showed a statistically significant difference between the two groups (P < 0.05). No statistically significant differences were found in HAMD score between the two groups four and six weeks after treatment (P > 0.05). Four and six weeks after treatment, MoCA score presented statistically significant differences between the two groups (P < 0.05). Conclusion: Escitalopram combined with HBO in the treatment of depression presents rapid efficacy and a certain effect in improving cognitive function. doi: https://doi.org/10.12669/pjms.37.4.3993 How to cite this:Mi K, Guo Q, Xu BY, Wang M, Bi H. Efficacy of hyperbaric oxygen combined with escitalopram in depression and its effect on cognitive function. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.3993 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effectiveness of Melodic Intonation Therapy in Chinese Mandarin on Non-fluent Aphasia in Patients After Stroke: A Randomized Control Trial

2021 ◽  
Vol 15 ◽  
Author(s):  
Xiao-Ying Zhang ◽  
Wei-Yong Yu ◽  
Wen-Jia Teng ◽  
Meng-Yang Lu ◽  
Xiao-Li Wu ◽  
...  
Keyword(s):  
Music Therapy ◽  
Speech Therapy ◽  
Intervention Group ◽  
Depression Scale ◽  
Target Language ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Music Therapists ◽  
Melodic Intonation Therapy ◽  
Fluent Aphasia

Melodic intonation therapy (MIT) positively impacts the speech function of patients suffering from aphasia and strokes. Fixed-pitch melodies and phrases formulated in MIT provide the key to the target language to open the language pathway. This randomized controlled trial compared the effects of music therapy-based MIT and speech therapy on patients with non-fluent aphasia. The former is more effective in the recovery of language function in patients with aphasia. Forty-two participants were enrolled in the study, and 40 patients were registered. The participants were randomly assigned to two groups: the intervention group (n = 20; 16 males, 4 females; 52.90 ± 9.08 years), which received MIT, and the control group (n = 20; 15 males, 5 females; 54.05 ± 10.81 years), which received speech therapy. The intervention group received MIT treatment for 30 min/day, five times a week for 8 weeks, and the control group received identical sessions of speech therapy for 30 min/day, five times a week for 8 weeks. Each participant of the group was assessed by a Boston Diagnostic Aphasia Examination (BDAE) at the baseline (t1, before the start of the experiment), and after 8 weeks (t2, the experiment was finished). The Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were also measured on the time points. The best medical care of the two groups is the same. Two-way ANOVA analysis of variance was used only for data detection. In the spontaneous speech (information), the listening comprehension (right or wrong, word recognition, and sequential order) and repetitions of the intervention group were significantly higher than the control group in terms of the cumulative effect of time and the difference between groups after 8 weeks. The intervention group has a significant time effect in fluency, but the results after 8 weeks were not significantly different from those in the control group. In terms of naming, the intervention group was much better than the control group in spontaneous naming. Regarding object naming, reaction naming, and sentence completing, the intervention group showed a strong time accumulation effect. Still, the results after 8 weeks were not significantly different from those in the control group. These results indicate that, compared with speech therapy, MIT based on music therapy is a more effective musical activity and is effective and valuable for the recovery of speech function in patients with non-fluent aphasia. As a more professional non-traumatic treatment method, MIT conducted by qualified music therapists requires deeper cooperation between doctors and music therapists to improve rehabilitating patients with aphasia. The Ethics Committee of the China Rehabilitation Research Center approved this study (Approval No. 2020-013-1 on April 1, 2020) and was registered with the Chinese Clinical Trial Registry (Registration number: Clinical Trials ChiCTR2000037871) on September 3, 2020.

scholarly journals Auditory Cognitive Function Assessment during Pregnancy: An Event-Related Potential and Neuropsychological Study

2021 ◽  
Vol 20 (3) ◽  
pp. 608-617
Author(s):  
Tahamina Begum ◽  
Faruque Reza
Keyword(s):  
Cognitive Function ◽  
Medical Science ◽  
Event Related Potentials ◽  
Positive Influence ◽  
Event Related Potential ◽  
Oddball Paradigm ◽  
Control Group ◽  
Hormonal Changes ◽  
Related Potentials ◽  
Function Assessment

Objectives: We investigated the auditory cognitive and behavioral functions during 2nd and 3rd trimesters of pregnancy using event-related potentials (ERPs) and different neuropsychology tests, respectively. Methods: The ERPs were studied by using a 128-sensor net, and PAS/COWA, WCST, ZCT, RAVLTIM/RAVLTDR/RAVLTTS, and BDI were tested for neuropsychology assessment. Total 39 subjects were recruited for control group (G1, n=15, non-pregnant), 2nd trimester group (G2, n=12, 13-26 weeks gestation), and 3rd trimester group (G3, n=12, 26- 40 weeks gestation). Auditory oddball paradigm was used during ERP study. Subjects silently counted only the target stimuli with attention by ignoring standard stimuli. Value of the mean differences of the target and standard stimuli were measured across groups in 10-20 electrode systems. Results: The P50, N100, and P300 ERP components were analyzed. The G3 (at F7 and C3) and G2 (at T4) groups evoked the highest significant amplitudes in P50, and G3 (at Cz and Pz) and G1 (at F8 and T4) evoked the highest significant amplitudes of N100 with significantly prolonged latencies at Cz and O1 (in G1) and F8 (in G2). However, significantly higher amplitudes of P300 were found at Fz (in G3) and FP1 (G2) (G2>G3). On the other hand, neuropsychology tests revealed that G2 possessed the highest significant score in WCST and G1 in ZCT. The G3 performed poorly in all tests. Conclusion: We concluded that pregnant groups performed better in auditory (attention/memory) and executive function assessment. Moreover, the 2nd trimester group has better auditory cognitive function compared to the 3rd trimester group due to the effect of hormonal changes during pregnancy, which might be a positive influence during the pregnancy period. Bangladesh Journal of Medical Science Vol.20(3) 2021 p.608-617

scholarly journals Impaired impulse inhibition of emotional stimuli in patients with borderline personality disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huihui Yang ◽  
Qian Liu ◽  
Wanrong Peng ◽  
Zhaoxia Liu ◽  
Jun Chu ◽  
...  
Keyword(s):  
Psychiatric Symptoms ◽  
Negative Emotion ◽  
Event Related Potentials ◽  
Stop Signal Task ◽  
Group Differences ◽  
Control Group ◽  
Emotional Stimuli ◽  
Significant Group ◽  
Behavioral Variables ◽  
Related Potentials

AbstractThis study was aimed to investigate whether BPD patients showed impaired impulse inhibition of emotional and non-emotional stimuli and to explore relevant neuroelectrophysiological mechanisms. A total of 32 BPD patients and 32 matched healthy controls were recruited. Self-reported scales were used to measure psychiatric symptoms. The event-related potentials (ERPs) were recorded when subjects were performing neutral and emotional Stop Signal Task (SST). Group differences in self-reported scores, behavioral variables and ERPs were compared. The BPD group scored significantly higher on impulsivity, severity of BPD symptoms, levels of depression and anxiety than the control group. In neutral SST, no significant group differences were detected in the amplitude and latency of ERPs components induced. In emotional SST, the P2 amplitude of negative emotion was significantly larger than that of neutral emotion in Go trials. In Stop trials, the P2 amplitude of BPD group was significantly smaller than that of control group, and the N2 amplitude of BPD group was significantly greater than that of control group. BPD patients showed impaired inhibition of emotional stimuli rather than non-emotional stimuli. The deficits of emotional impulse control mainly exhibit at the early attention, stimulus evaluation and conflict detection stages.

EEG Measurement of Emotion Processing in Children with Daytime Urinary Incontinence

2018 ◽  
Vol 46 (4) ◽  
pp. 336-341
Author(s):  
Justine Niemczyk ◽  
Monika Equit ◽  
Katja Rieck ◽  
Mathias Rubly ◽  
Catharina Wagner ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Patient Group ◽  
Imaging Techniques ◽  
Emotion Processing ◽  
Event Related Potentials ◽  
Oddball Paradigm ◽  
Control Group ◽  
Central Processing ◽  
Daytime Urinary Incontinence ◽  
Related Potentials

Abstract. Objective: Daytime urinary incontinence (DUI) is common in childhood. The aim of the study was to neurophysiologically analyse the central emotion processing in children with DUI. Method: In 20 children with DUI (mean age 8.1 years, 55 % male) and 20 controls (mean age 9.1 years, 75 % male) visual event-related potentials (ERPs) were recorded after presenting emotionally valent (80 neutral, 40 positive, and 40 negative) pictures from the International Affective Picture System (IAPS) as an oddball-paradigm. All children received a full organic and psychiatric assessment. Results: Children with DUI did not differ significantly from controls regarding responses to emotional pictures in the frontal, central, and parietal regions and in the time intervals 250–450 ms, 450–650 ms, and 650–850 ms after stimulus onset. The patient group had more psychological symptoms and psychiatric comorbidities than the control group. Conclusions: EEG responses to emotional stimuli are not altered in children with DUI. Central emotion processing does not play a major role in DUI. Further research, including a larger sample size, a more homogeneous patient group (regarding subtype of DUI) or brain imaging techniques, could reveal more about the central processing in DUI.

scholarly journals Evaluation of the online-based self-help programme “Selfapy” in patients with unipolar depression: study protocol for a randomized, blinded parallel group dismantling study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rico Krämer ◽  
Stephan Köhler
Keyword(s):  
Depressive Symptoms ◽  
Depression Scale ◽  
Drop Out ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Online Interventions ◽  
Phone Calls ◽  
Self Help ◽  
Low Threshold ◽  
The Impact

Abstract Background Patients with mild to moderate depressive symptoms can have limited access to regular treatment; to ensure appropriate care, low-threshold treatment is needed. Effective online interventions could increase the supply of low-threshold treatment. Further research is needed to evaluate the effectiveness of online interventions. This study aims to evaluate the online-based self-help programme “Selfapy” on a sample of depressive subjects and compares the impact of the programme’s unaccompanied version with its therapeutic accompanied version. Methods A sample of 400 subjects that have a mild to severe depressive episode (Becks Depression Inventory - II and Hamilton Depression Scale) will be used. Subjects are randomly assigned to immediate access to an unaccompanied course (no support from psychologist via weekly phone calls), immediate access to an accompanied course (support from a psychologist via weekly phone calls) or a waiting list control group (access to the intervention after 24 weeks). The intervention will last for a period of 12 weeks. Depressive symptoms as a primary parameter, as well as various secondary parameters, such as life satisfaction, therapeutic relationships, social activation, self-esteem, attitudes towards Internet interventions and drop-out rates, are recorded at four different points in time: at baseline (T1), 6 weeks after the start of the intervention (T2), 12 weeks after the start of the intervention (T3) and 3 months after completion of the treatment follow-up (T4). Conclusion This randomized and controlled, blinded study will make use of a “dismantled” approach to adequately compare the accompanied and unaccompanied versions of the intervention. Positive and meaningful results are expected that could influence the acceptance and implementation of online interventions. Trial registration German Clinical Trials Register DRKS00017191. Registered on 14 June 2019

Effect of Communication Skills Training Program for Oncologists Based on Patient Preferences for Communication When Receiving Bad News: A Randomized Controlled Trial

2014 ◽  
Vol 32 (20) ◽  
pp. 2166-2172 ◽  
Author(s):  
Maiko Fujimori ◽  
Yuki Shirai ◽  
Mariko Asai ◽  
Kaoru Kubota ◽  
Noriyuki Katsumata ◽  
...  
Keyword(s):  
Communication Skills ◽  
Patient Preferences ◽  
Controlled Trial ◽  
Intervention Group ◽  
Depression Scale ◽  
Skills Training ◽  
Control Group ◽  
Communication Skills Training ◽  
Communication Performance

Purpose The aim of this study was to identify the effects of a communication skills training (CST) program for oncologists, developed based on patient preferences regarding oncologists' communication. Participants and Methods Thirty oncologists were randomly assigned to either an intervention group (IG; 2-day CST workshop) or control group (CG). Participants were assessed on their communication performance during simulated consultation and their confidence in communicating with patients at baseline and follow-up. A total of 1,192 patients (response rate, 84.6%) who had consultations with the participating oncologists at baseline and/or follow-up were assessed regarding their distress using the Hospital Anxiety and Depression Scale, satisfaction with the consultation, and trust in their oncologist after the consultation. Results At the follow-up survey, the performance scores of the IG had improved significantly, in terms of their emotional support (P = .011), setting up a supportive environment (P = .002), and ability to deliver information (P = .001), compared with those of the CG. Oncologists in the IG were rated higher at follow-up than those in the CG in terms of their confidence in themselves (P = .001). Patients who met with oncologists after they had undergone the CST were significantly less depressed than those who met with oncologists in the CG (P = .027). However, the CST program did not affect patient satisfaction with oncologists' style of communication. Conclusion A CST program based on patient preferences is effective for both oncologists and patients with cancer. Oncologists should consider CST as an approach to enhancing their communication skills.

scholarly journals The evaluation of Hashimoto's thyroiditis with event-related potentials and magnetic resonance spectroscopy and its relation to cognitive function

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marta Waliszewska-Prosół ◽  
Joanna Bladowska ◽  
Sławomir Budrewicz ◽  
Marek Sąsiadek ◽  
Edyta Dziadkowiak ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Hashimoto’S Thyroiditis ◽  
Event Related Potentials ◽  
Brain Dysfunction ◽  
P300 Amplitude ◽  
Hashimoto's Thyroiditis ◽  
Resonance Spectroscopy ◽  
Related Potentials

AbstractThyroid dysfunction is very often accompanied by cognitive and affective disorders. The frequency of these disorders in patients with compensated Hashimoto’s thyroiditis (HT) is unknown. The aim of the present study was to evaluate brain dysfunction in euthyroid HT patients by means of event-related potentials (ERP) and magnetic resonance spectroscopy (MRS) and to correlate it with cognitive function. 68 patients with HT (59 female, 9 male) and 45 healthy controls were included in the study. All the patients underwent ERP including an analysis of N200 and P300 response parameters. MRS voxels were located in the posterior cingulate gyrus (PCG) and the left parietal white matter (PWM). The NAA/Cr, mI/Cr, and Cho/Cr ratios were analysed. The ERP parameters, MRS metabolite ratios and hormonal concentrations (TSH, fT3, fT4) as well as TGAb and TPOAb titer were also correlated. There was a significant prolongation of the latencies of N200 and P300 potentials and a significant decrease of P300 amplitude in HT patients than in the control group. There was a significant positive correlation between the mI/Cr ratio in the PCG area and P300 latencies. NAA/Cr ratio in the PCG region showed significant negative correlations with all N200 latencies. The results may suggest brain dysfunction in neurologically asymptomatic HT patients. ERPs undergo significant changes in patients with HT and may, in combination with MRS, constitute an important element in the recognition and monitoring of cognitive functions in this group of patients.

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