Dynamic Monitoring of Vitamin D Levels in Extremely Premature Infants and Its Effect on Pulmonary Diseases

2021 ◽  
Vol 11 (07) ◽  
pp. 3097-3107
Author(s):  
丽娟 杨
Keyword(s):  
Vitamin D ◽  
Premature Infants ◽  
Pulmonary Diseases ◽  
Dynamic Monitoring ◽  
Vitamin D Levels

Response of vitamin D binding protein and free vitamin D concentrations to vitamin D supplementation in hospitalized premature infants

2015 ◽  
Vol 28 (9-10) ◽  
Author(s):  
Corrine Hanson ◽  
Elizabeth Lyden ◽  
Amy Nelson ◽  
Melissa Thoene ◽  
Julie Wagner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Premature Infants ◽  
Vitamin D3 ◽  
Mineral Content ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Vitamin D Levels ◽  
Free Vitamin D

AbstractThe objective of this study was to evaluate the relationship between 25(OH)D, Vitamin D Binding Protein (DBP), and free vitamin D in premature infants.Thirty-two infants <32 weeks’ gestation were randomized to two different levels of vitamin D3 supplementation (400 vs. 800 IU/day). 25(OH)D levels were measured by LC-MS/MS; DBP was measured by validated ELISA. Free vitamin D was calculated using molar ratios of 25(OH)D and DBP. The Wilcoxon signed rank test was used to compare DBP, free D and 25(OH)D levels; Spearman’s correlation coefficients were used to assess correlations.The mean gestational age at birth was 30.5 weeks; mean birth weight was 1405 g. Mean 25(OH)D levels at birth were 17.3 ng/mL; DBP levels were 297 mg/L, and estimated free vitamin D levels were 18.9. There was a statistically significant change in 25(OH)D levels after 8 weeks (24.6 vs. 39.1 ng/mL in the 400 vs. 800 group, respectively, p=0.02). DBP levels from birth to 8 weeks showed a statistically significant decrease (267 vs. 208, p=0.04). Estimated free 25(OH)D concentrations increased over the study period, from 18.9 at birth to 64.7 at 8 weeks of age (p=0.0001). Free vitamin D levels at birth were associated with global DEXA bone mineral content at discharge from the NICU (r=0.58, p=0.05).Supplementation with vitamin D3 increased the free portion of the vitamin D metabolite, providing increased bioavailable substrate. Improved free vitamin D levels may improve measurable outcomes such as bone mineral content and deserve further evaluation.

scholarly journals Increased Levels of Umbilical Cord Blood Interleukin-6 (IL-6) and Serum C-Reactive Protein (CRP) in Premature Infants of Vitamin D Deficient Mothers

2021 ◽  
pp. 21-25
Author(s):  
Lisnawati Yuyun ◽  
Marianna Yesy ◽  
Rinawati Rohsiswatmo
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Premature Infants ◽  
Umbilical Cord Blood ◽  
Serum Vitamin ◽  
C Reactive Protein ◽  
Serum Vitamin D ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Serum Crp

Objective: Increased levels of inflammatory factors in newborns are often associated with lower maternal vitamin D levels. This study aimed to find out the relationship between maternal and umbilical cord vitamin D serum levels on umbilical cord Interleukin-6 (IL-6) and serum C-Reactive Protein (CRP) levels in premature infants.Methods: The study was an observational analytic, cross-sectional design in mothers who underwent preterm birth at 28-34 weeks' gestation due to premature rupture of membranes (PROM) and their infants at Dr. Cipto Mangunkusumo General Hospital (RSCM), Jakarta and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Levels of serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6 and serum CRP in premature infants were recorded. Vitamin D level was divided into deficiency (<10 ng/mL), insufficiency (10–29 ng/mL), and normal (>30 ng/mL) groups. The relationship of vitamin D levels with IL-6 and CRP was carried out using Kruskal Wallis test.Results: A total of 70 subjects met the research criteria. Umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers were higher (20.31 pg/mL and 0.50 mg/L) compared to insufficient (3.34 pg/mL and 0.45 mg/L) and  normal  mothers (3.29 pg/mL and 0.30 mg/L), although  not  statistically  significant (IL-6 p = 0.665, CRP p = 0.89). Referring to the umbilical cord blood vitamin D levels, the results were different and not as expected, in which the umbilical cord IL-6 and serum CRP levels of preterm infants in the deficiency (3.76 pg/mL and 0.35 mg/L) and insufficiency (3.37 pg/mL and 0.40 mg/L) groups were lower (IL-6) and not different (CRP) than the normal group (9.41 pg/mL and 0.40 mg/L).Conclusion: There were an increasing tendency for umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers although these were not statistically significant. Based on the levels of vitamin D umbilical cord blood, the CRP levels in the serum of premature infants were not different, while the IL-6 levels in the deficiency and insufficiency group were lower than in the normal group.Keywords: CRP, IL-6, maternal vitamin D, umbilical cord vitamin D.   Abstrak Tujuan: Peningkatan kadar faktor inflamasi pada  bayi baru lahir sering dikaitkan dengan rendahnya kadar vitamin D ibu. Penelitian ini bertujuan untuk mengetahui hubungan kadar serum vitamin D ibu dan tali pusat, dengan kadar IL-6 tali pusat dan serum C-Reactive Protein (CRP) bayi prematur.Metode: Studi observasional analitik dengan desain potong lintang pada  subjek  ibu yang mengalami kelahiran prematur di usia 28–34 minggu kehamilan disebabkan ketuban pecah dan bayi yang dilahirkannya, di  Rumah   Sakit  Umum  Pusat  Nasional dr. Cipto Mangunkusumo (RSCM) dan Rumah Sakit Umum Pusat Persahabatan, Jakarta, pada bulan Januari 2017 sampai Agustus 2018.  Variabel data adalah kadar serum vitamin D ibu dan tali pusat, kadar serum IL-6 tali pusat dan  kadar  CRP  darah  bayi.  Kadar vitamin D (25(OH)D) dibagi menjadi defisiensi (<10 ng/mL), insufisiensi (10–29 ng/mL) dan normal (>30 ng/mL) dan dicari hubungannya dengan kadar IL-6 tali pusat dan serum CRP bayi prematur, menggunakan uji Kruskal Wallis. Hasil: Sebanyak  70  subjek  telah memenuhi kriteria penelitian.  Kadar IL-6 tali pusat dan serum CRP bayi prematur dari kelompok ibu defisiensi vitamin D (20,31 pg/ml dan 0,50 mg/L) lebih tinggi dibandingkan kelompok ibu insufisiensi vitamin D (3,34 pg/mL dan 0,45 mg/L) maupun kelompok ibu normal vitamin D (3,29 pg/mL dan 0,30 mg/L) tetapi perbedaan tersebut tidak bermakna (IL-6 p=0,665 dan CRP p = 0,899).   Mengacu pada kadar vitamin D darah tali pusat didapatkan hasil yang berbeda dan tidak sesuai harapan, dimana tali pusat IL-6 dan serum CRP bayi prematur mengalami defisiensi (3,76 pg / mL dan 0,35 mg / L) dan insufisiensi. (3,37 pg / mL dan 0,40 mg / L) kelompok lebih rendah (IL-6) dan tidak berbeda (CRP) dibandingkan kelompok normal (9,41 pg / mL dan 0,40 mg / L).Kesimpulan: Didapat kecenderungan peningkatan kadar IL-6 darah tali pusat dan serum CRP bayi prematur dari ibu dengan defisiensi kadar vitamin D walaupun secara statistik tidak signifikan. Berdasarkan kelompok vitamin D darah tali pusat, kadar CRP serum bayi prematur tidak berbeda, sedangkan kadar IL-6 pada kelompok defisiensi dan insufisiensi lebih rendah dibandingkan pada kelompok normal.Kata kunci: CRP, IL-6, vitamin D ibu, vitamin D tali pusat.  

Evaluation of Maternal and Infantile Levels of Vitamin D in Preterm Infants

2021 ◽  
Vol 17 ◽  
Author(s):  
Hassan Boskabadi ◽  
Ali Moradi ◽  
Maryam Zakerihamidi
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Preterm Infants ◽  
Premature Infants ◽  
Serum Levels ◽  
Severe Deficiency ◽  
Vitamin D Levels ◽  
The Difference ◽  
D 20 ◽  
D Values

Introduction: Vitamin D deficiency is highly prevalent during pregnancy and in premature infants. This study was done to investigate the maternal and infantile levels of vitamin D in preterm infants. Methods: Using available sampling during 2018-2020 the maternal and umbilical cord serum levels of vitamin D were measured in 294 premature infants in Ghaem Hospital, Mashhad, Iran. A researcher-made questionnaire containing neonatal demographic and clinical characteristics was used as data collection tool. Both maternal and placental vitamin D levels were categorized into four classes: severe deficiency (vitamin D<10 ng/ml), moderate deficiency (10.1≤vitamin D≤20 ng/ml), mild deficiency (20.1≤vitamin D≤30 ng/ml) and normal (vitamin D >30.1ng ml). Results: Vitamin D deficiency was seen in 89% of premature infants (46.6% severe, 30.6% moderate, and 11.9% mild). Serum levels of vitamin D were 18.28±13.94 ng/ml and 14.10±9.70 ng/ml in mothers and infants, respectively. The infants below and above 32 weeks had vitamin D values of: 10.97±6.31 ng/ml and 18.05±11.64 ng/ml, respectively. The difference in vitamin D levels between boys (12.59±8.40 ng/ml) and girls (16.05±11.45 ng/ml) was significant (P=0.009). Moderate and severe vitamin D deficiency were more common at earlier pregnancy ages (P=0.001). Conclusion: Vitamin D deficiency is more common and severe in preterm infants and their mothers. Controlling vitamin D level during pregnancy, especially in women at risk of preterm labor and preterm infants may help reduce prematurity problems.

scholarly journals Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants

2017 ◽  
Vol 60 (8) ◽  
pp. 248 ◽  
Author(s):  
Birgul Say ◽  
Nurdan Uras ◽  
Suzan Sahin ◽  
Halil Degirmencioglu ◽  
Serife Suna Oguz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Premature Infants ◽  
Neonatal Sepsis ◽  
Vitamin D Levels

scholarly journals Vitamin D and antimicrobial peptides in congenital pneumonia of premature newborns

2021 ◽  
pp. 13-19
Author(s):  
L. Zhuravleva. ◽  
V. Novikova
Keyword(s):  
Vitamin D ◽  
Respiratory Tract ◽  
Antimicrobial Peptides ◽  
Premature Infants ◽  
Premature Newborns ◽  
Leading Role ◽  
Vitamin D Levels ◽  
Duration Of Hospitalization ◽  
The Relationship ◽  
Lower Vitamin

Introduction. One of the leading causes of morbidity in newborns is the pathology of the respiratory tract. Among this group of patients, and especially premature newborns, congenital pneumonia takes the leading role among diseases of the respiratory system. The aim of the work was to identify the relationship between the level of vitamin D and endogenous antimicrobial peptides in congenital pneumonia of premature infants. Material and methods. We observed 2 groups of premature newborns: 32 newborns with congenital pneumonia, and the comparison group consisted of 20 "almost healthy" newborns without respiratory tract pathology. Results. In patients with pneumonia, the level of vitamin D was significantly lower (9,57 [6,57-17,25]) when compared with conventionally healthy newborns (21,1 [9,2-32,02]), p<0.01. However, in the group with congenital pneumonia, the levels of cathelicidin LL-37 and HBD-2 were significantly higher (2,87 [2,3-4,43] and 240,4 [132,4-406,7]) compared with another group (1,6 [0,8-2,5] and 156,7 [82,4-208,7]), p<0,01. Moreover, patients with severe congenital pneumonia had significantly lower concentration of vitamin D (7,6 [5,7-13,2]) and higher cathelicidin LL-37 (3,75 [2,8-4,26]) compared with patients with moderate pneumonia (13,7 [9,7-16,5] and 2,5 [2,1-3,7], respectively). But we did not observe such a relationship with HBD-2 (in severe congenital pneumonia, there was a decrease in HBD-2 (220,4 [142,6-401,6] and 278,2 [154,6-378,6], respectively). Conclusion. Lower vitamin D concentrations in serum may be have significant associatiation with congenital pneumonia. Also, vitamin D levels can predict the need for mechanical ventilation and the duration of hospitalization for congenital pneumonia in premature infants.

Abstract #421 Association of Vitamin D Levels with the Severity of Fibrosis in NAFLD Patients with Type 2 Diabetes

2019 ◽  
Vol 25 ◽  
pp. 199-200
Author(s):  
Prathyusha Chitrapu ◽  
Shilpa Jain ◽  
Aaron Thrift ◽  
Maya Balakrishnan ◽  
Ruchi Gaba
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Levels

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

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