scholarly journals Case Report: A rare case of prosthetic valve infective endocarditis caused by Aerococcus urinae

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1998
Author(s):  
Muhammad Adeel ◽  
Saman Tariq ◽  
Hisham Akthar ◽  
Ahmed Zaghloul ◽  
Corina Iorgoveanu ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Fatal Outcome ◽  
The Elderly ◽  
High Morbidity ◽  
Elderly Male ◽  
Male Population ◽  
Aerococcus Urinae ◽  
Cardiac Condition ◽  
Life Threatening ◽  
Tract Infections

Infective endocarditis (IE) is a serious and life threatening cardiac condition, most commonly caused by staphylococci, streptococci, enterococci and rarely by HACEK organisms (Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella corrodens and Kingella). Here, we present a case of IE caused by Aerococcus urinae in a 75-year-old man with a bioprosthetic aortic valve.  Aerococcus urinae is a gram-positive, catalase negative microorganism, and is usually an isolate of complicated urinary tract infections in the elderly male population. It is associated with high morbidity and mortality. Awareness of this organism as a cause of IE is important, since failure to recognize the condition may lead to adverse clinical outcomes and significant complications with even fatal outcome, as in this case.

scholarly journals Case Report: A rare case of prosthetic valve infective endocarditis caused by Aerococcus urinae

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 1998
Author(s):  
Muhammad Adeel ◽  
Saman Tariq ◽  
Hisham Akthar ◽  
Ahmed Zaghloul ◽  
Corina Iorgoveanu ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Diagnostic Testing ◽  
The Elderly ◽  
Elderly Male ◽  
Male Population ◽  
Flight Mass Spectrometry ◽  
Aerococcus Urinae ◽  
Cardiac Condition ◽  
Life Threatening ◽  
Tract Infections

Infective endocarditis (IE) is a serious and life-threatening cardiac condition, most commonly caused by staphylococci, Streptococcus viridans, and enterococci. However, in special settings, IE can be caused by rare organisms. Here we present a case of IE caused by Aerococcus urinae in a 75-year-old man with a bioprosthetic aortic valve.  Aerococcus urinae is a gram-positive, catalase-negative microorganism and is usually an isolate of complicated urinary tract infections in the elderly male population.  Improvements in diagnostic testing including use of matrix-assisted laser desorption ionization– a time of flight mass spectrometry (MALDI-TOF MS) have played an important role in recognition of Aerococcus urinae.

scholarly journals Case Report: A rare case of prosthetic valve infective endocarditis caused by Aerococcus urinae

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 1998
Author(s):  
Muhammad Adeel ◽  
Saman Tariq ◽  
Hisham Akthar ◽  
Ahmed Zaghloul ◽  
Corina Iorgoveanu ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Diagnostic Testing ◽  
The Elderly ◽  
Elderly Male ◽  
Male Population ◽  
Flight Mass Spectrometry ◽  
Aerococcus Urinae ◽  
Cardiac Condition ◽  
Life Threatening ◽  
Tract Infections

Infective endocarditis (IE) is a serious and life-threatening cardiac condition, most commonly caused by staphylococci, Streptococcus viridans, and enterococci. However, in special settings, IE can be caused by rare organisms. Here we present a case of IE caused by Aerococcus urinae in a 75-year-old man with a bioprosthetic aortic valve.  Aerococcus urinae is a gram-positive, catalase-negative microorganism and is usually an isolate of complicated urinary tract infections in the elderly male population.  . Improvements in diagnostic testing including use of matrix-assisted laser desorption ionization– a time of flight mass spectrometry (MALDI-TOF MS) have played an important role in isolating Aerococcus.

scholarly journals Clinical spectrum of obstructive jaundice: a descriptive crosssectional study

2021 ◽  
Vol 6 (1) ◽  
pp. 53-57
Author(s):  
R. Naveena MS
Keyword(s):  
Obstructive Jaundice ◽  
The Elderly ◽  
Stone Disease ◽  
Clinical Spectrum ◽  
Bile Duct Stricture ◽  
Elderly Male ◽  
Male Population ◽  
Pancreas Head ◽  
Duodenal Carcinoma ◽  
Duct Stricture

Objective. The objective of this study was to evaluate the clinical spectrum of obstructive jaundice in inflammation, stone disease, and malignancy. Methods. A descriptive observational study was done among 50 patients with the diagnosis of obstructive jaundice during the period 2012 to 2013. A detailed history and clinical examinations and radiological confirmation were done. Results. Among the participants, 74% participants had jaundice, 58% with vomiting as presenting complaints. Among benign cases, 60% were choledocholithiasis, 25% were common bile duct stricture, and 15% were choledochal cyst. Among malignant cases, 26.67% were periampullary carcinoma, 23.33% had carcinoma of the pancreas head, and 13.33% had D2 duodenal carcinoma. Conclusions. The etiology of obstructive jaundice was malignancy in the elderly male population. The most common presenting features were yellowish discoloration of skin and mucosa followed by vomiting and abdominal pain.

scholarly journals 1583. The Utility of the Immunodeficiency Scoring Index (ISI) to Predict Outcomes of Coronavirus (HCoV) Infections in Hematopietic Cell Transplant (HCT) Recipients

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S495-S495
Author(s):  
Fareed Khawaja ◽  
Terri Lynn Shigle ◽  
Shashank S Ghantoji ◽  
Marjorie Batista ◽  
Ella Ariza-Heredia ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Tract ◽  
Viral Infections ◽  
Fatal Outcome ◽  
High Morbidity ◽  
Cell Transplant ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections ◽  
Overall Mortality

Abstract Background Respiratory viral infections in HCT recipients are associated with high morbidity and mortality, especially after progression from upper respiratory tract infection (URI) to lower respiratory tract infections (LRI). Data on risk factors (RF) for LRI and mortality is lacking for HCoV infections after HCT. We aimed to validate our ISI in HCoV infections. Methods All adult HCT recipients with HCoV infection from 2015 to 2017 were evaluated. An ISI based on RF was used to classify patients as low (0–2), moderate (3–6), or high (7 or higher) risk for progression to LRI or death. We defined LRI as HCoV detected in nasal wash and/or bronchoalveolar lavage and new lung infiltrates on diagnostic imaging. Clinical parameters were collected and ISI were calculated for comparison. Results A total of 144 adult HCT recipients with 166 episodes of HCoV infections were analyzed. The most common HCoV serotype for LRI and URI was 229E (42.4%) and OC43 (37.6%), respectively, and most patients were infected between November and March each year (Figures 1 and 2). When compared with URI, patients with LRI were more likely in the pre-engraftment period, had multiple respiratory viruses infections, had nosocomially acquired HCoV, required hospitalization, ICU transfer, and mechanical ventilation (all, P < 0.05). Overall mortality rate was 4% at Day 30 from diagnosis and all patients who died had LRI with an 18% mortality. Among those who died, 33% had nosocomial infection, 67% were co-infected with another respiratory virus and 67% required mechanical ventilation. Using an ISI cut off of <4, the negative predictive value (NPV) for progression to LRI was 86% with a specificity of 76%. Conclusion HCT recipients with HCoV LRI were more likely to have a fatal outcome. The NPV of the ISI for progression to LRI was high and could be used as a prognostic tool for future studies and for therapeutic clinical trials. Disclosures All authors: No reported disclosures.

scholarly journals Bibliometric analysis on infective endocarditis

2021 ◽  
Vol 3 (4) ◽  
pp. 350-355
Author(s):  
Uğur Küçük ◽  
◽  
Sevil Alkan ◽  
Cemile Uyar ◽  
◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Bibliometric Analysis ◽  
The Elderly ◽  
Developed Countries ◽  
The United States ◽  
High Morbidity ◽  
Scientific Publications ◽  
Mortality And Morbidity ◽  
Type Data ◽  
Medical Advances

Introduction: Although infective endocarditis (IE) is rare disease, this disease has importance due to its high morbidity and mortality rates. The exact incidence is not known as it is not a reportable disease. Unlike developed countries, the disease affects the young more than the elderly in developing countries. Most of the time, the diagnosis cannot be made at the first examination and the disease is often overlooked. In order to reduce the mortality and morbidity of this disease, it is important to quickly recognize the disease by following current diagnosis and treatment methods, to identify the causative agent and to treat accordingly. Both the epidemiology and the management of IE are changing due to medical advances. This situation may also be reflected in scientific publications. We aimed to analyze the global researches on IE. Material and methods: The Scopus database was searched for bibliometric analysis without selecting document type. Data were retrieved for the time period January 1, 1940 and Semptember 26, 2021, containing the keywords " Infective’’ and’’endocarditis " in their title. Results: 7911 publications were included in the study. The first publication was made in the year 1891. Most of the publications were research articles [n=5784 (73.11%)] and were from the United States of America (USA) [n =1622 (20.50%)]. Japan, France, United Kingdom and Spain were also in the top 5 publishing countries on IE. Conclusions: Infective endocarditis is still an important reason of mortality, and there are many unanswered questions about the managament and preventation of this disease. This situation reflected the scientific publications. Since this is a global problem, not just some developed countries involved in the IE research, also more countries should be encouraged to participate the studies on IE.

scholarly journals Outcomes of and Satisfaction with the Inflatable Penile Prosthesis in the Elderly Male

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Humberto G. Villarreal ◽  
LeRoy Jones
Keyword(s):  
Penile Prosthesis ◽  
The Elderly ◽  
Artificial Urinary Sphincter ◽  
Ease Of Use ◽  
Elderly Male ◽  
Male Population ◽  
Inflatable Penile Prosthesis ◽  
Postoperative Hematoma ◽  
Degree Of Satisfaction ◽  
Age Range

Objective. To determine the outcomes of and satisfaction with the multi-component inflatable penile prosthesis (IPP) in the elderly male (age >71).Methods. Using a chart review and telephone survey, we retrospectively assessed patients who underwent IPP or combined IPP/artificial urinary sphincter (AUS) from 2004–2006.Results. We identified 56 patients that underwent IPP (48) or IPP/AUS (8). The age range was 71–86 (mean 74.3) at the time of surgery, with a follow-up range of 0.5–2.4 years (mean 1.5). The overall complication rate was 3.8% (2 of 56) with one device removed for infection and a second patient requiring exploration for a postoperative hematoma. The telephone interview was conducted with 35 of 56 patients. Patients rated ease of use (a scale from 1–5, 5 meaning very easy) and overall satisfaction (a scale of 1–5, 5 meaning very satisfied) at an average of 4.1 and 4.3, respectively. IPP usage varied from 0–7 times per month (mean 3.3). 32 of 35 patients (91%) said they would undergo the procedure again.Conclusion. Our review demonstrates that the IPP is well tolerated in the elderly male population, who report a high degree of satisfaction and ease of use with this device.

scholarly journals Elderly Male With Cardiovascular-Related Comorbidities Has a Higher Rate of Fatal Outcomes: A Retrospective Study in 602 Patients With Coronavirus Disease 2019

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiao-Yong Zhan ◽  
Liang Li ◽  
Yuhai Hu ◽  
Qiang Li ◽  
Huimin Kong ◽  
...  
Keyword(s):  
Neutrophil Count ◽  
Lymphocyte Count ◽  
Fatal Outcome ◽  
The Elderly ◽  
C Reactive Protein ◽  
Elderly Male ◽  
Cox Regression Analysis ◽  
Protein Levels ◽  
Reactive Protein ◽  
D Dimer

Elderly with comorbidities have shown a higher rate of fatal outcomes when suffering coronavirus disease 2019 (COVID-19). However, a delineation of clinical significances of hematologic indices and underlying comorbidities in the progression and outcome of COVID-19 remains undefined. Six hundred two COVID-19 patients with established clinical outcomes (discharged or deceased) from Hankou Hospital of Wuhan, China between January 14, 2020 and February 29, 2020 were retrospectively analyzed. Of the 602 patients with COVID-19, 539 were discharged and 63 died in the hospital. The deceased group showed higher leukocyte and neutrophil counts but lower lymphocyte and platelet counts. Longer activated partial thromboplastin time (APTT) and prothrombin time (PT), as well as higher D-dimer and C-reactive protein levels, were found in non-survivors. Our observations suggest that these parameters could serve as potential predictors for the fatal outcome and in the discharged group. A higher neutrophil count and D-dimer level but lower lymphocyte were associated with a longer duration of hospitalization. A multivariable Cox regression analysis showed that higher neutrophil count, prolonged PT, and low lymphocyte count were risk factors for patients with COVID-19. Also, we found an association of lower lymphocyte count and higher C-reactive protein levels with the elderly group and those with cardiovascular-related comorbidities. The significantly different hematologic profiles between survivors and non-survivors support that distinct hematologic signatures in COVID-19 patients will dictate different outcomes as a prognostic marker for recovery or fatality. Lymphopenia and aggressive inflammatory response might be major causes for fatal outcomes in the elderly male and especially those with cardiovascular-related comorbidities.

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