scholarly journals Recent advances in understanding and treating ARDS

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 725 ◽  
Author(s):  
Rebecca M. Baron ◽  
Bruce D. Levy
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Clinical Care ◽  
Treatment Strategies ◽  
Preventive Strategies ◽  
Recent Advances ◽  
Improved Outcomes ◽  
Considerable Morbidity

Acute respiratory distress syndrome represents a complex syndrome with considerable morbidity and mortality, for which there exist no targeted treatment strategies. However, recent advances in clinical care have improved outcomes, and we will review a number of these approaches here, as well as explore the mechanisms underlying the benefit of intervention that might point us in the direction toward future treatment and preventive strategies for this devastating syndrome.

Acute Respiratory Distress Syndrome: Etiology, Pathogenesis, and Summary on Management

2019 ◽  
Vol 35 (8) ◽  
pp. 723-737 ◽  
Author(s):  
Shawn Kaku ◽  
Christopher D. Nguyen ◽  
Natalie N. Htet ◽  
Dominic Tutera ◽  
Juliana Barr ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Management Strategies ◽  
Treatment Strategies ◽  
Acute Lung Inflammation ◽  
Hypoxemic Respiratory Failure ◽  
Pulmonary Vascular Permeability ◽  
Current State

The acute respiratory distress syndrome (ARDS) has multiple causes and is characterized by acute lung inflammation and increased pulmonary vascular permeability, leading to hypoxemic respiratory failure and bilateral pulmonary radiographic opacities. The acute respiratory distress syndrome is associated with substantial morbidity and mortality, and effective treatment strategies are limited. This review presents the current state of the literature regarding the etiology, pathogenesis, and management strategies for ARDS.

scholarly journals Gene Therapy for Acute Respiratory Distress Syndrome

2022 ◽  
Vol 12 ◽  
Author(s):  
Jing Liu ◽  
David A. Dean
Keyword(s):  
Gene Therapy ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Single Gene ◽  
Treatment Strategies ◽  
The United States ◽  
Clinical Syndrome ◽  
Underlying Mechanisms

Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome that leads to acute respiratory failure and accounts for over 70,000 deaths per year in the United States alone, even prior to the COVID-19 pandemic. While its molecular details have been teased apart and its pathophysiology largely established over the past 30 years, relatively few pharmacological advances in treatment have been made based on this knowledge. Indeed, mortality remains very close to what it was 30 years ago. As an alternative to traditional pharmacological approaches, gene therapy offers a highly controlled and targeted strategy to treat the disease at the molecular level. Although there is no single gene or combination of genes responsible for ARDS, there are a number of genes that can be targeted for upregulation or downregulation that could alleviate many of the symptoms and address the underlying mechanisms of this syndrome. This review will focus on the pathophysiology of ARDS and how gene therapy has been used for prevention and treatment. Strategies for gene delivery to the lung, such as barriers encountered during gene transfer, specific classes of genes that have been targeted, and the outcomes of these approaches on ARDS pathogenesis and resolution will be discussed.

scholarly journals Acute respiratory distress syndrome in COVID-19: possible mechanisms and therapeutic management

Pneumonia ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Anolin Aslan ◽  
Cynthia Aslan ◽  
Naime Majidi Zolbanin ◽  
Reza Jafari
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Lung Diseases ◽  
Distress Syndrome ◽  
Treatment Strategies ◽  
Current Treatment ◽  
New Era ◽  
Experimental Drugs ◽  
Lung Failure

AbstractCOVID-19 pandemic is a serious concern in the new era. Acute respiratory distress syndrome (ARDS), and lung failure are the main lung diseases in COVID-19 patients. Even though COVID-19 vaccinations are available now, there is still an urgent need to find potential treatments to ease the effects of COVID-19 on already sick patients. Multiple experimental drugs have been approved by the FDA with unknown efficacy and possible adverse effects. Probably the increasing number of studies worldwide examining the potential COVID-19 related therapies will help to identification of effective ARDS treatment. In this review article, we first provide a summary on immunopathology of ARDS next we will give an overview of management of patients with COVID-19 requiring intensive care unit (ICU), while focusing on the current treatment strategies being evaluated in the clinical trials in COVID-19-induced ARDS patients.

scholarly journals The Features of Pathobiology and Clinical translation of Approved treatments for Coronavirus Disease 2019 (COVID-19)

Intervirology ◽  
2021 ◽  
Author(s):  
Hamidreza Abbasi ◽  
Hadi Razavi Nikoo ◽  
Ali Fallah ◽  
Azadeh Mohammad-Hasani ◽  
Abasalt Hosseinzadeh Colagar ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Transmission Rate ◽  
Treatment Strategies ◽  
Etiological Agent ◽  
Behavioral Factors ◽  
Cellular Mechanisms

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last two years worldwide. Several reasons and parameters are responsible for the difficult management of coronavirus disease-2019 (COVID-19) patients; the first is virus behavioral factors such as high transmission rate, and the different molecular and cellular mechanisms of pathogenesis remain a matter of controversy, is another factor. Summary: In the present review, we attempted to explain about features of SARS-COV-2, particularly focusing on the various aspects of pathogenesis and treatment strategies. Key Messages: We note evidence for the understanding of the precise molecular and cellular mechanisms of SARS-CoV-2 pathogenesis, which can help design the appropriate drug or vaccine. Additionally, and importantly, we reported the updated issues associated with the history and development of treatment strategies such as, drugs, vaccines, and other medications that have been approved or under consideration in clinics and markets worldwide.

scholarly journals Severe COVID-19 acute respiratory distress syndrome in an adult with single-ventricle physiology: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Götz Schmidt ◽  
Christian Koch ◽  
Matthias Wolff ◽  
Michael Sander
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Single Ventricle ◽  
Treatment Strategies ◽  
Prone Positioning ◽  
Case Presentation ◽  
Single Ventricle Physiology ◽  
First Case

Abstract Background COVID-19 can induce acute respiratory distress syndrome (ARDS). In patients with congenital heart disease, established treatment strategies are often limited due to their unique cardiovascular anatomy and passive pulmonary perfusion. Case presentation We report the first case of an adult with single-ventricle physiology and bidirectional cavopulmonary shunt who suffered from severe COVID-19 ARDS. Treatment strategies were successfully adopted, and pulmonary vascular resistance was reduced, both medically and through prone positioning, leading to a favorable outcome. Conclusion ARDS treatment strategies including ventilatory settings, prone positioning therapy and cannulation techniques for extracorporeal oxygenation must be adopted carefully considering the passive venous return in patients with single-ventricle physiology.

scholarly journals Manejo del Síndrome de Distrés Respiratorio Agudo (SDRA). ¿Qué hay de nuevo? Artículo original: Papazian L, Aubron C, Brochard L, Chiche JD, Combes A, Dreyfuss D et al. Formal guidelines: management of acute respiratory distress syndrome. Ann. Intensive Care. 2019 Jun 13;9(1):69. doi: 10.1186/s13613-019-0540-9.

2020 ◽  
Vol 12 (8) ◽  
pp. 3
Author(s):  
Rocío López Herrero ◽  
Belén Sánchez Quirós ◽  
Mario Lorenzo López
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Scientific Evidence ◽  
Treatment Strategies ◽  
Lung Compliance ◽  
Diffuse Lung Disease ◽  
Therapeutic Algorithm ◽  
Diffuse Lung

El síndrome de Distrés respiratorio es una enfermedad pulmonar aguda y difusa que produce hipoxemia, disminución de la compliance pulmonar y aumento del espacio muerto. Existe disparidad de opiniones sobre el manejo de esta patología, por lo que es necesario disponer de guías de práctica clínica  donde se organicen las estrategias de tratamiento de acuerdo a la mejor evidencia científica. En esta guía se proponen quince recomendaciones y un algoritmo terapéutico sobre el manejo del síndrome de Distrés respiratorio agudo. ABSTRACT Acute respiratory distress syndrome (ARDS) management. Anything new? Acute respiratory distress syndrome (ARDS) it is an acute and diffuse lung disease. The consequences are hypoxemia, decreased lung compliance and increased intrapulmonary shunt and dead space. There are different opinions about the treatment of this disease. It is necessary to have clinical practice guidelines where treatment strategies are organized according to the best scientific evidence. Fifteen recommendations and a therapeutic algorithm regarding the management of acute respiratory distress syndrome are proposed in these guidelines.

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