Dynamics of correlations of the immune and hormonal status and the optimization efficiency of rehabilitation of the treatment of patients with osteoarthritis as result of local therapy by essential oils applications

2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Крикорова ◽  
S. Krikorova ◽  
Бобкова ◽  
A. Bobkova ◽  
Деревнина ◽  
...  
Keyword(s):  
Immune System ◽  
Essential Oils ◽  
Endocrine System ◽  
Local Therapy ◽  
Hormonal Status ◽  
Cd4 Cells ◽  
Low Level ◽  
Dynamics Of Correlations ◽  
Low Levels ◽  
Optimization Efficiency

Purpose of this research is to study the effects of a essential oils mixture applications on the dynamics of the correlation of the immune and hormonal status, and the treatment efficiency of osteoarthritis. Materials and methods. 30 women with OA were treated with applications of 5% mix EO: lavender, gin-ger, peppermint, rosemary, pine, clove, nutmeg, eucalyptus, thyme, anise. Dynamics of the correlation of immu-nological status indicators: total number of cells; absolute and % of number of total lympho-cytes,CD3,CD4+,CD8+, To cells, indicators immune-regulatory index CD4+/CD8+, absolute and % indicators CD19, IgG, IgA, IgM was studied. Dynamics of the correlation of endocrine system: STH, PL, cortisol, , TTH, fT4, fT3, PTH, CT, osteocalcin, LH, FSH, ED and TS, DHEA, AS, PG, INS, С-P, index HOMA-IR was also studied. Results. Before treatment - immunodeficiency CD3, CD4, increase CD8+ (cytotoxic cells), low level in-dicators index CD4+ /CD8+ were revealed. Low level indicators CD3, CD4 according to the correlation analysis resulted in reducing the formation of IgM, IgG, IgA was noted. Before treatment low levels of sex steroids ED, TS were revealed. The main hormones support the immune system before treatment, were ED, PTH, CT. After treatment – there were increase in CD3, CD4-cells, index indicators CD4+ /CD8+, reduced CD8, a statistically significant increase in TS (p<0.05), reducing INS and glucose (p<0.05), index HOMA-IR (p<0.05).The main hormones support the immune system after treatment began INS (p<0.05) and thyroid hormones, PTH. The dynamics of the correlation of the immune and hormonal status is associated with a decrease in pain, improved joint function, according to index Lekena (p<0.05).

The study of effect of local therapy by essential oils applications on the dynamics of the immune and hormonal indicators and the optimization efficiency of rehabilitation treatment of patients with osteoarthritis

2015 ◽  
Vol 9 (1) ◽  
pp. 0-0
Author(s):  
Бобкова ◽  
A. Bobkova ◽  
Деревнина ◽  
N. Derevnina ◽  
Дашина ◽  
...  
Keyword(s):  
Essential Oils ◽  
Local Therapy ◽  
Thyroid Stimulating Hormone ◽  
Total Testosterone ◽  
Functional Index ◽  
Free Triiodothyronine ◽  
Cytotoxic Cells ◽  
Immunological Status ◽  
Optimization Efficiency ◽  
Stimulating Hormone

Purpose of this research is to study the effects of essential oils applications on the dynamics of the immune and hormonal indicators and clinical picture of osteoarthritis. Materials and methods. 30 women with osteoarthritis were treated by applications of mixture of essential oils: lavender, ginger, peppermint, rosemary, pine, clove, nutmeg, eucalyptus, thyme, anise. The dynamics of the immunological status: the total number of leucocytes; absolute and % of number of total lymphocytes, CD3,CD4+,CD8+, То cells, the indicators of immune-regulatory index CD4+/CD8+, absolute and % indicators CD19, IgG, IgA, IgM was studied. The dynamics of indicators of endocrine systems: somatotropic hormone, prolactin, cortisol, thyroid-stimulating hormone, free thyroxine, free triiodothyronine, paratiritis hormone, calci-tonin, osteocalcin, luteinizing hormone, follicle-stimulating hormone, estradiol and total testosterone, dehydroe-piandrosterone, aldosterone, progesterone, insulin , C-peptide, index HOMA-IR was examined. Results. Before treatment - immunodeficiency CD3, CD4, То cells, increasing CD8 cytotoxic cells, re-ducing the index CD4+ /CD8+ were revealed. After therapy – it was noted increasing CD4, То cells, reducing CD8, increasing the index CD4+ /CD8+. There were a statistically significant increase in testosterone (p<0.05), reduced levels of insulin and glucose (p<0.05), index, HOMA-IR (p<0.05). Against the background of im-provement of immune and hormonal status, the decrease in pain and improvement of function of the joints, according to algo-functional index Lekena (p<0.05), are marked.

The essential oils of some medicinal plants on the immune system of rainbow trout (Oncorhynchus mykiss)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Ghasemi Pirbalouti ◽  
E Pirali ◽  
G Pishkar ◽  
S Mohammadali Jalali ◽  
M Reyesi ◽  
...  
Keyword(s):  
Immune System ◽  
Rainbow Trout ◽  
Medicinal Plants ◽  
Oncorhynchus Mykiss ◽  
Essential Oils ◽  
Rainbow Trout Oncorhynchus Mykiss

scholarly journals Chronic low-level cadmium exposure in rats affects cytokine production by activated T cells

2019 ◽  
Vol 8 (2) ◽  
pp. 227-237 ◽  
Author(s):  
Alexandra E. Turley ◽  
Joseph W. Zagorski ◽  
Rebekah C. Kennedy ◽  
Robert A. Freeborn ◽  
Jenna K. Bursley ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
Low Dose ◽  
Cytokine Production ◽  
Ex Vivo ◽  
Cadmium Exposure ◽  
Activated T Cells ◽  
Low Level

The purpose of this study was to determine the effect of subchronic, oral, low-dose cadmium exposure (32 ppm over 10 weeks) on the rat immune system. We found that cadmium exposure increased the induction of IFNγ and IL-10 in T cells activated ex vivo after cadmium exposure.

scholarly journals Prevalencia, causas y tratamiento de la depresión mayor

2017 ◽  
Vol 28 (2) ◽  
Author(s):  
Elsy Arlene Pérez-Padilla ◽  
Víctor Manuel Cervantes-Ramírez ◽  
Nayeli Alejandra Hijuelos-García ◽  
Juan Carlos Pineda-Cortes ◽  
Humberto Salgado-Burgos
Keyword(s):  
Immune System ◽  
Major Depression ◽  
Endocrine System ◽  
Public Health Problem ◽  
Stressful Event ◽  
Structural Level ◽  
Biological Factors ◽  
Major Depressive ◽  
Brain Physiology ◽  
El Sistema

ResumenLa depresión mayor representa un problema de salud pública debido a su alta prevalencia. La etiología de la depresión es compleja, en ella intervienen factores psicosociales, genéticos, y biológicos. Entre los factores psicosociales, se ha observado que los primeros episodios depresivos aparecen después de algún evento estresante, y el estrés que acompaña al primer episodio produce cambios a largo plazo en la fisiología cerebral. Estos cambios de larga duración pueden producir variaciones a nivel estructural y en el funcionamiento de diferentes áreas cerebrales. Entre los factores genéticos que intervienen en la enfermedad depresiva, se ha reportado que alrededor de 200 genes están relacionados con el trastorno depresivo mayor. Dentro de los factores biológicos, existen evidencias de alteraciones a nivel de neurotransmisores, citosinas y hormonas, cuyas acciones inducen modificaciones estructurales y funcionales en el sistema nervioso central, en el sistema inmunológico y en el sistema endocrino, que incrementan el riesgo de padecer la depresión mayor. A pesar de años de estudio, las bases biológicas de la depresión mayor y el mecanismo preciso de la eficacia antidepresiva siguen siendo poco claras. Los objetivos de la presente revisión son el resumir las principales conclusiones de la literatura clínica y experimental en relación con la etiología del trastorno depresivo mayor.Palabras claveDepresión mayor, neurotransmisores, neuroplasticidad, serotonina, norepinefrina, sistema inmune. AbstractMajor depression represents a public health problem due to its high prevalence. The etiology of major depression is complex because involves psychosocial, genetic, and biological factors. Among psychosocial factors, different studies report that the first depressive episode appear after some stressful event and produces long-term changes in brain physiology. These long-lasting changes produce variations at the structural level and in the functioning of different brain areas. Among the genetic factors involved in depressive illness, it has been reported that about 200 genes are related to major depressive disorder. Within the biological factors, there is an evidence of alterations in the level of neurotransmitters, cytosine’s and hormones, whose actions induces structural and functional modifications in the central nervous system, the immune system and the endocrine system, which increases the risk of suffering major depression. Despite years of study, the biological basis of major depression and precise mechanisms of antidepressant efficacy remain unclear. The objective of the present review is to summarize the main conclusions of the clinical and experimental literature regarding to the etiology of major depressive disorder.Key wordsMajor depression, neurotransmitters, neuroplasticity, serotonin, norepinephrine, immune system.

scholarly journals Do overweight/obesity and low levels of leisure-time vigorous physical activity moderate the effect of occupational physical activity on self-rated health of construction workers?

2021 ◽  
Author(s):  
M. Van den Berge ◽  
S. H. Van Oostrom ◽  
H. F. Van der Molen ◽  
S. J. W. Robroek ◽  
C. T. J. Hulshof ◽  
...  
Keyword(s):  
Physical Activity ◽  
Material Handling ◽  
Vigorous Physical Activity ◽  
Construction Workers ◽  
Low Level ◽  
Self Rated Health ◽  
Manual Material Handling ◽  
Strenuous Work ◽  
Low Levels

Abstract Purpose To investigate the combined effects of occupational physical activity (OPA) and either overweight/obesity or low levels of leisure-time vigorous physical activity (LTVPA) on self-rated health. Methods A longitudinal study was performed among 29,987 construction workers with complete data on 2 Workers’ Health Surveillance Programs during 2010–2018. Self-reported OPA involved strenuous work postures and manual material handling. Low level of LTVPA was defined as self-reported vigorous activity for less than three times per week lasting at least 20 min per session. Overweight and obesity were based on Body Mass Index (BMI) (25.0 ≤ BMI < 30.0 kg/m2 and BMI ≥ 30.0 kg/m2, respectively) using measured body height and weight. Self-rated health was measured using a single item question. Logistic regression analysis was used to investigate the associations between the separate risk factors at baseline and self-rated health at follow-up. The combined effects of demanding OPA and either overweight/obesity or low level of LTVPA on self-rated health were analyzed using the relative excess risk due to interaction (RERI). Results Mean follow-up duration was 31.7 (SD = 14.9) months. Construction workers with strenuous work postures (OR 1.35 95% CI 1.25–1.46), manual material handling (OR 1.29 95% CI 1.19–1.40), obesity (OR 1.31 95% CI 1.17–1.47) and low LTVPA (OR 1.13 95% CI 1.01–1.25) were more likely to report poor self-rated health at follow-up. No statistically significant interaction effects were found for OPA and obesity or low LTVPA. Conclusions OPA, obesity and low level of LTVPA were separate risk factors for poor self-rated health, but did not appear to have a synergistic effect.

scholarly journals Olfactory perception in women with physiologically altered hormonal status (during pregnancy and postmenopause)

2002 ◽  
Vol 55 (9-10) ◽  
pp. 380-383 ◽  
Author(s):  
Slobodan Savovic ◽  
Dejan Nincic ◽  
Slobodanka Lemajic ◽  
Vladimir Pilija ◽  
Aljosa Mandic ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Endocrine System ◽  
Premenopausal Women ◽  
First Trimester ◽  
Olfactory Function ◽  
Hormonal Status ◽  
Emotional States ◽  
Olfactory Ability ◽  
Novi Sad ◽  
In Pregnancy

Introduction Olfaction is considered to be the ability to: perceive, conduct and recognize scents and odors. With its numerous connections to the limbic system and reticular formation, the olfactory system affects regulation of numerous vegetative functions, visceral functions and sexual behavior. Since estrogen and progesterone protect the olfactory function, changes in their levels in particular physiological states in women (in pregnancy and postmenopause) exert an influence on the ability to feel and recognize smells. It has its role in creating emotions and adjustment of visceral and vegetative response to particular emotional states. Also, it represents the connection between higher cortical functions and the endocrine system. Material and methods Our investigation was performed at the Ear, Nose and Throat Clinic in Novi Sad. The research included 80 healthy women classified into 4 groups; 20 women aged between 20 and 30; 20 women in the first trimester of pregnancy aged between 20 and 30; 20 premenopausal women aged between 41 and 50; and 20 women at least 3 years in postmenopause, aged between 41 and 50. For our research we used an olfactometer and the Fortunato-Niccolini method. Results and discussion In pregnancy the thresholds of perception (TP) and identification (TI) of examined substances were slightly lower in comparison to nonpregnant women of the same ages, but without any statistical significance (p>0.05). In climacteric-postmenopausal women there was a significant decrease of olfactory ability in comparison to nonmenopausal women of the same ages (p<0.01). Conclusion All changes of the olfactory function in pregnancy are explained by mental changes of pregnant women as well as their hormonal status. Significant decrease of olfactory ability in postmenopause is explained by decline in sexual hormone levels.

scholarly journals Cytotoxic Effect of Progesterone, Tamoxifen and Their Combination in Experimental Cell Models of Human Adrenocortical Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Elisa Rossini ◽  
Mariangela Tamburello ◽  
Andrea Abate ◽  
Silvia Beretta ◽  
Martina Fragni ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Cytotoxic Effect ◽  
Clinical Approach ◽  
Cell Models ◽  
Adrenocortical Cancer ◽  
Experimental Cell ◽  
Low Level ◽  
H295r Cells ◽  
Low Levels ◽  
Protein Reduction

Progesterone (Pg) and estrogen (E) receptors (PgRs and ERs) are expressed in normal and neoplastic adrenal cortex, but their role is not fully understood. In literature, Pg demonstrated cytotoxic activity on AdrenoCortical Carcinoma (ACC) cells, while tamoxifen is cytotoxic in NCI-H295R cells. Here, we demonstrated that in ACC cell models, ERs were expressed in NCI-H295R cells with a prevalence of ER-β over the ER-α.Metastasis-derived MUC-1 and ACC115m cells displayed a very weak ER-α/β signal, while PgR cells were expressed, although at low level. Accordingly, these latter were resistant to the SERM tamoxifen and scarcely sensitive to Pg, as we observed a lower potency compared to NCI-H295R cells in cytotoxicity (IC50: MUC-1 cells: 67.58 µM (95%CI: 63.22–73.04), ACC115m cells: 51.76 µM (95%CI: 46.45–57.67) and cell proliferation rate. Exposure of NCI-H295R cells to tamoxifen induced cytotoxicity (IC50: 5.43 µM (95%CI: 5.18–5.69 µM) mainly involving ER-β, as their nuclear localization increased after tamoxifen: Δ A.U. treated vs untreated: 12 h: +27.04% (p &lt; 0.01); 24 h: +36.46% (p &lt; 0.0001). This effect involved the SF-1 protein reduction: Pg: −36.34 ± 9.26%; tamoxifen: −46.25 ± 15.68% (p &lt; 0.01). Finally, in a cohort of 36 ACC samples, immunohistochemistry showed undetectable/low level of ERs, while PgR demonstrated a higher expression. In conclusion, ACC experimental cell models expressed PgR and low levels of ER in line with data obtained in patient tissues, thus limiting the possibility of a clinical approach targeting ER. Interestingly, Pg exerted cytotoxicity also in metastatic ACC cells, although with low potency.

scholarly journals Evaluation of Distributed Collaborative Adaptive Sensing for Detection of Low-Level Circulations and Implications for Severe Weather Warning Operations

2010 ◽  
Vol 25 (1) ◽  
pp. 173-189 ◽  
Author(s):  
J. Brotzge ◽  
K. Hondl ◽  
B. Philips ◽  
L. Lemon ◽  
E. J. Bass ◽  
...  
Keyword(s):  
Severe Weather ◽  
Special Focus ◽  
Test Bed ◽  
Scanning Strategy ◽  
Engineering Research ◽  
Low Level ◽  
Adaptive Sensing ◽  
Low Levels ◽  
Casa System ◽  
Better Than

Abstract The Center for Collaborative Adaptive Sensing of the Atmosphere (CASA) is a multiyear engineering research center established by the National Science Foundation for the development of small, inexpensive, low-power radars designed to improve the scanning of the lowest levels (&lt;3 km AGL) of the atmosphere. Instead of sensing autonomously, CASA radars are designed to operate as a network, collectively adapting to the changing needs of end users and the environment; this network approach to scanning is known as distributed collaborative adaptive sensing (DCAS). DCAS optimizes the low-level volume coverage scanning and maximizes the utility of each scanning cycle. A test bed of four prototype CASA radars was deployed in southwestern Oklahoma in 2006 and operated continuously while in DCAS mode from March through June of 2007. This paper analyzes three convective events observed during April–May 2007, during CASA’s intense operation period (IOP), with a special focus on evaluating the benefits and weaknesses of CASA radar system deployment and DCAS scanning strategy of detecting and tracking low-level circulations. Data collected from nearby Weather Surveillance Radar-1988 Doppler (WSR-88D) and CASA radars are compared for mesoscyclones, misocyclones, and low-level vortices. Initial results indicate that the dense, overlapping coverage at low levels provided by the CASA radars and the high temporal (60 s) resolution provided by DCAS give forecasters more detailed feature continuity and tracking. Moreover, the CASA system is able to resolve a whole class of circulations—misocyclones—far better than the WSR-88Ds. In fact, many of these are probably missed completely by the WSR-88D. The impacts of this increased detail on severe weather warnings are under investigation. Ongoing efforts include enhancing the DCAS data quality and scanning strategy, improving the DCAS data visualization, and developing a robust infrastructure to better support forecast and warning operations.

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