Ion-Molecular Memory Model. Physical Media Delivery and Storage of Information

10.12737/2755 ◽  
2013 ◽  
Vol 20 (4) ◽  
pp. 171-176 ◽  
Author(s):  
Герасимов ◽  
I. Gerasimov ◽  
Яшин ◽  
A. Yashin
Keyword(s):  
Memory Performance ◽  
Brain Cell ◽  
Elementary Particles ◽  
Memory Model ◽  
Cell Physiology ◽  
Topographic Map ◽  
Molecular Memory ◽  
Media Delivery ◽  
And Storage ◽  
The Brain

То develop the theme of creation of ion-molecular memory model, the physical media delivery and storage of information as a basic subject of memory from the positions of bio-physics-chemistry are considered. The purpose of this paper is to present the rationale and definition of the material basis of information processes memory that are implemented in solving the identified problems, namely: a study of the topology of memory in the brain, cell physiology memory, molecular biochemistry memory, the role of elementary particles in the formation of memory, including thermodynamic hypothesis of N.I. Kobozev, the principle of Prigogine - Onsager and other concepts. It is shown that the brain develops, topographic map of memory, which gives an idea about the localization of the structures of memory. In the part of cellular physiology memory these relevant processes take place with the participation of neurons, their electrical activity is varied in the processes of production and the extraction of information, i.e. the neurons are receivers and transmitters of information; their functions analyzers and selectors are not excluded. The electrical processes in neurons are the result of bio-physical and chemical reactions, in which DNA-RNA and protein molecules form: enzymes and neuro-peptides are dominant. It is shown that research of material media is the most promising in the sphere of the effectiveness of elementary particles, providing energy (electromagnetic) standard memory performance.

Ion-Molecular Memory Model. Mechanisms of Information Search in the Library Memory

10.12737/7287 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 137-142 ◽  
Author(s):  
Герасимов ◽  
I. Gerasimov ◽  
Яшин ◽  
A. Yashin
Keyword(s):  
Fractal Dimension ◽  
Information Search ◽  
Memory Model ◽  
Hydrogen Ions ◽  
Time Axis ◽  
Molecular Memory ◽  
Memory Functions ◽  
Mechanisms Of Memory ◽  
The Brain

In the context of developed by the authors of the memory model, the mechanism of information search in the library memory were studied. The authors proposed consistent variants of such mechanisms from the positions of biophysics, chemistry and mathematical logic. As in the previous articles, the role of the spectrum of the activity of hydrogen ions was highlighted. Events (facts) are placed in the library memory on the time axis - stratigraphy memory (according to V.V. Nabokov) and are subject to internal chronotype (according to A.A. Ukhtomsky). The authors touched a question upon vectorization time in biological systems in relation to the functioning of mechanisms of information search in the library memory. The authors note that the vectorization time in biosystems is the basis of the "speed" work of all mechanisms of memory. The mechanism of memory functions; for example, sleep, even deep - its essence is the work of the subconscious, i.e. the reference to the images and content of memory. Even taking into account the principle of anthropomorphism in the design of technical devices memory by individual, don’t associate characteristic for these devices "compression" of information from the brain work: here the information is not "shrinks" and recoded, contributing to lower power consumption of the process and reducing the overall entropy. The authors argue that the geometry of the drive with inherent spectra of the activity of hydrogen ions it is logically to consider the characteristics of similarity. This characteristic has fractal dimension that gives some level of comfort to compare patterns, which were discussed in this work. Identical and similar items patterns contribute equally to the formation of fractal dimension.

Biological response of the organism to the introduction of metal nanocomposites

2020 ◽  
pp. 761-762
Author(s):  
L. M. Sosedova ◽  
V. S. Rukavishnikov ◽  
E. A. Titov
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Biological Response ◽  
Brain Cell ◽  
Metal Nanocomposites ◽  
The Brain

The results of a study on rats toxicity of nanoparticles of metals bismuth, gadolinium and silver encapsulated in a natural biopolymer matrix arabinogalactan are presented. When intake of nanocomposite of silver revealed the readiness of the brain cell to apoptosis. The effect of bismuth and gadolinium nanocomposites did not cause an increase in the process of programmed cell death.

scholarly journals Genomic Mosaicism Formed by Somatic Variation in the Aging and Diseased Brain

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1071
Author(s):  
Isabel Costantino ◽  
Juliet Nicodemus ◽  
Jerold Chun
Keyword(s):  
Dna Sequence ◽  
Technology Development ◽  
Copy Number Variations ◽  
Brain Cell ◽  
Brain Diseases ◽  
Multiple Forms ◽  
Somatic Variation ◽  
Dna Content Variation ◽  
Effects Of Aging ◽  
The Brain

Over the past 20 years, analyses of single brain cell genomes have revealed that the brain is composed of cells with myriad distinct genomes: the brain is a genomic mosaic, generated by a host of DNA sequence-altering processes that occur somatically and do not affect the germline. As such, these sequence changes are not heritable. Some processes appear to occur during neurogenesis, when cells are mitotic, whereas others may also function in post-mitotic cells. Here, we review multiple forms of DNA sequence alterations that have now been documented: aneuploidies and aneusomies, smaller copy number variations (CNVs), somatic repeat expansions, retrotransposons, genomic cDNAs (gencDNAs) associated with somatic gene recombination (SGR), and single nucleotide variations (SNVs). A catch-all term of DNA content variation (DCV) has also been used to describe the overall phenomenon, which can include multiple forms within a single cell’s genome. A requisite step in the analyses of genomic mosaicism is ongoing technology development, which is also discussed. Genomic mosaicism alters one of the most stable biological molecules, DNA, which may have many repercussions, ranging from normal functions including effects of aging, to creating dysfunction that occurs in neurodegenerative and other brain diseases, most of which show sporadic presentation, unlinked to causal, heritable genes.

scholarly journals Effect of Water and Ethanol Extracts from Hericium erinaceus Solid-State Fermented Wheat Product on the Protection and Repair of Brain Cells in Zebrafish Embryos

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3297
Author(s):  
Shun-Kuo Sun ◽  
Chun-Yi Ho ◽  
Wei-Yang Yen ◽  
Su-Der Chen
Keyword(s):  
Solid State ◽  
Brain Cell ◽  
Hot Water ◽  
Raw Material ◽  
Brain Cells ◽  
Zebrafish Embryos ◽  
Hericium Erinaceus ◽  
Water Extracts ◽  
The Brain ◽  
Wheat Product

Extracts from Hericium erinaceus can cause neural cells to produce nerve growth factor (NGF) and protect against neuron death. The objective of this study was to evaluate the effects of ethanol and hot water extracts from H. erinaceus solid-state fermented wheat product on the brain cells of zebrafish embryos in both pre-dosing protection mode and post-dosing repair mode. The results showed that 1% ethanol could effectively promote zebrafish embryo brain cell death. Both 200 ppm of ethanol and water extracts from H. erinaceus solid-state fermented wheat product protected brain cells and significantly reduced the death of brain cells caused by 1% ethanol treatment in zebrafish. Moreover, the zebrafish embryos were immersed in 1% ethanol for 4 h to cause brain cell damage and were then transferred and soaked in the 200 ppm of ethanol and water extracts from H. erinaceus solid-state fermented wheat product to restore the brain cells damaged by the 1% ethanol. However, the 200 ppm extracts from the unfermented wheat medium had no protective and repairing effects. Moreover, 200 ppm of ethanol and water extracts from H. erinaceus fruiting body had less significant protective and restorative effects on the brain cells of zebrafish embryos. Both the ethanol and hot water extracts from H. erinaceus solid-state fermented wheat product could protect and repair the brain cells of zebrafish embryos damaged by 1% ethanol. Therefore, it has great potential as a raw material for neuroprotective health product.

Information Processing and Storage in the Brain

2019 ◽  
pp. 1-39
Author(s):  
Manfred Fahle
Keyword(s):  
Information Processing ◽  
Processing And Storage ◽  
And Storage ◽  
The Brain

Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells

2009 ◽  
Vol 367 (1908) ◽  
pp. 4699-4716 ◽  
Author(s):  
Taïssia Lelekov-Boissard ◽  
Guillemette Chapuisat ◽  
Jean-Pierre Boissel ◽  
Emmanuel Grenier ◽  
Marie-Aimée Dronne
Keyword(s):  
Immune Cells ◽  
Blood Cells ◽  
Inflammatory Process ◽  
Living Cells ◽  
Therapeutic Strategies ◽  
Brain Parenchyma ◽  
Brain Cell ◽  
Cytokines And Chemokines ◽  
The Brain

The inflammatory process during stroke consists of activation of resident brain microglia and recruitment of leucocytes, namely neutrophils and monocytes/macrophages. During inflammation, microglial cells, neutrophils and macrophages secrete inflammatory cytokines and chemokines, and phagocytize dead cells. The recruitment of blood cells (neutrophils and macrophages) is mediated by the leucocyte–endothelium interactions and more specifically by cell adhesion molecules. A mathematical model is proposed to represent the dynamics of various brain cells and of immune cells (neutrophils and macrophages). This model is based on a set of six ordinary differential equations and explores the beneficial and deleterious effects of inflammation, respectively phagocytosis by immune cells and the release of pro-inflammatory mediators and nitric oxide (NO). The results of our simulations are qualitatively consistent with those observed in experiments in vivo and would suggest that the increase of phagocytosis could contribute to the increase of the percentage of living cells. The inhibition of the production of cytokines and NO and the blocking of neutrophil and macrophage infiltration into the brain parenchyma led also to the improvement of brain cell survival. This approach may help to explore the respective contributions of the beneficial and deleterious roles of the inflammatory process in stroke, and to study various therapeutic strategies in order to reduce stroke damage.

Enkephalin, Drug Addiction and Acupuncture

1977 ◽  
Vol 05 (01) ◽  
pp. 25-30 ◽  
Author(s):  
Gregory S. Chen
Keyword(s):  
Nervous System ◽  
Opiate Receptors ◽  
Basic Research ◽  
Brain Cell ◽  
Withdrawal Symptoms ◽  
Opiate Withdrawal ◽  
Acupuncture Analgesia ◽  
Acupuncture Stimulation ◽  
Natural Ligand ◽  
The Brain

From the results of clinical and basic research, there is clear evidence the acupuncture analgesia is closely associated with the nervous system, especially the central nervous system. Stimulation of certain acupuncture loci which have been used for analgesia during operations aslo can calm the withdrawal symptoms of morphine and heroin addicts. Acupuncture analgesia can be antagonized by the specific narcotic antagonist, naloxone. These findings suggest the factor or factors produced by acupuncture stimulation would also have agonist activity on opiate receptors. Moreover, the morphine receptors are most concentrated in those parts of the brain concerned with preception of pain and the pathway of acupuncture stimulation. Since the opiate receptors are associated with the synaptic fraction of brain cell membrane preparations, the natural ligand of these receptors may be a neuro-transmitter. Enkephalin has stronger binding affinity to opiate receptors than morphine, which suggests that it is the natural ligand for these receptors. In other words, enkephalin might be the natural "pain killer" produced in the brain to suppress pain. If we summate all the information available now, it is possible to suggest that enkephalin may be the product of the nervous system released by acupuncture stimulation to create an analgesic effect as well as suppress opiate withdrawal symptoms.

scholarly journals Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory

2018 ◽  
Vol 115 (43) ◽  
pp. E10187-E10196 ◽  
Author(s):  
Michael A. van der Kooij ◽  
Tanja Jene ◽  
Giulia Treccani ◽  
Isabelle Miederer ◽  
Annika Hasch ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Spatial Memory ◽  
Chronic Stress ◽  
High Glucose ◽  
Social Stress ◽  
Cognitive Impairments ◽  
Memory Performance ◽  
Dietary Treatment ◽  
Metabolic Phenotype ◽  
The Brain

Stringent glucose demands render the brain susceptible to disturbances in the supply of this main source of energy, and chronic stress may constitute such a disruption. However, whether stress-associated cognitive impairments may arise from disturbed glucose regulation remains unclear. Here we show that chronic social defeat (CSD) stress in adult male mice induces hyperglycemia and directly affects spatial memory performance. Stressed mice developed hyperglycemia and impaired glucose metabolism peripherally as well as in the brain (demonstrated by PET and induced metabolic bioluminescence imaging), which was accompanied by hippocampus-related spatial memory impairments. Importantly, the cognitive and metabolic phenotype pertained to a subset of stressed mice and could be linked to early hyperglycemia 2 days post-CSD. Based on this criterion, ∼40% of the stressed mice had a high-glucose (glucose >150 mg/dL), stress-susceptible phenotype. The relevance of this biomarker emerges from the effects of the glucose-lowering sodium glucose cotransporter 2 inhibitor empagliflozin, because upon dietary treatment, mice identified as having high glucose demonstrated restored spatial memory and normalized glucose metabolism. Conversely, reducing glucose levels by empagliflozin in mice that did not display stress-induced hyperglycemia (resilient mice) impaired their default-intact spatial memory performance. We conclude that hyperglycemia developing early after chronic stress threatens long-term glucose homeostasis and causes spatial memory dysfunction. Our findings may explain the comorbidity between stress-related and metabolic disorders, such as depression and diabetes, and suggest that cognitive impairments in both types of disorders could originate from excessive cerebral glucose accumulation.

Regional MR Perfusion Topographic Map of the Brain Using Arterial Spin Labeling at 3 Tesla

2010 ◽  
pp. 241-253
Author(s):  
Shuichi Higano ◽  
Takaki Murata
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
3 Tesla ◽  
Mr Perfusion ◽  
Topographic Map ◽  
The Brain

Visuospatial Working Memory Capacity in the Brain After Working Memory Training in College Students With ADHD: A Randomized Controlled Trial

2019 ◽  
pp. 108705471987948 ◽  
Author(s):  
Steven Woltering ◽  
Chao Gu ◽  
Zhong-Xu Liu ◽  
Rosemary Tannock
Keyword(s):  
College Students ◽  
Working Memory ◽  
Controlled Trial ◽  
Memory Performance ◽  
Working Memory Capacity ◽  
Memory Training ◽  
Treatment Groups ◽  
Before And After ◽  
Students With Adhd ◽  
The Brain

Objective: ADHD has been associated with persistent problems of working memory. This study investigated the efficacy of an intensive and adaptive computerized working memory treatment (CWMT) at behavioral and neural levels. Method: College students ( n = 89; 40 females) with ADHD were randomized into a standard-length CWMT (45 min/session, 25 sessions, n = 29), shortened-length CWMT (15 min/session, 25 sessions, n = 32), and a waitlist group ( n = 28). Both CWMT groups received treatment for 5 days a week for 5 weeks. Lab sessions before and after CWMT assessed electroencephalography (EEG) indicators of working memory, behavioral indicators of working memory performance, and ADHD symptomatology. Results: No evidence was found for neural or any other behavioral transfer effects of improvement for the CWMT treatment groups over the active control or waitlist group. Conclusion: Our study does not provide evidence for the benefits of CWMT at neural or behavioral levels.

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