scholarly journals Prolonged Detection of SARS-CoV-2 RNA in An Asymptomatic Individual in Thailand: A Case Study

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Chidchamai Kewcharoenwong ◽  
Woottichai Khamduang ◽  
Sirintra Kwunchoo ◽  
Kesinee Chantawiang ◽  
Piyapong Pinta ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Additional Data ◽  
Clinical Symptoms ◽  
Throat Swab ◽  
Asymptomatic Individual ◽  
Molecular Monitoring ◽  
Igg Antibody ◽  
Asymptomatic Case ◽  
First Time

Clinical characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) have been reported in Thailand, but there is still no asymptomatic case with prolonged persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA has been described. Here, we report, for the first time, the detection of SARS-CoV-2 RNA from nasopharyngeal and throat swab specimens for at least 110 days in a 30-year-old Thai female with no clinical symptoms. The COVID-19 IgG antibody was also observed in her blood sample. However, her husband was negative for both SARS-CoV-2 RNA and IgM/IgG antibody, implying no transmission of SARS-CoV-2 to her husband throughout the 110 days. As far as we know, this is the very first asymptomatic case to show the longest prolonged persistence of SARS-CoV-2 RNA from nasopharyngeal and throat swab specimens in Thailand. In most cases of COVID-19 infection, molecular monitoring for SARS-CoV-2 may be discontinued, and asymptomatic cases may be underestimated. Thus, the information in this report could be combined with additional data sources to raise public health awareness with regard to clinical management. Keywords: Asymptomatic individual, COVID-19, Prolonged detection, SARS-CoV-2

Epileptic Spikes in EEG and Migraine Attacks in the Course of Cannabis Withdrawal: A Case Report

2019 ◽  
Vol 51 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Kristina Adorjan ◽  
Agnieszka I. Chrobok ◽  
Gabi Koller ◽  
Susanne Karch ◽  
Oliver Pogarell
Keyword(s):  
Clinical Symptoms ◽  
Clinical Correlates ◽  
Cannabis Abuse ◽  
Dsm 5 ◽  
Cannabis Withdrawal ◽  
Epileptic Discharges ◽  
History Of ◽  
Epileptic Spikes ◽  
First Time

In psychiatry, routine EEGs are often abnormal and not very specific, raising questions about the clinical relevance and consequences of potential anomalies. One such question is whether the administration of anticonvulsants would be useful if epileptic discharges are detected in patients without any clinical correlates. With regard to this question, we present a case study in which abnormal EEG patterns were observed in a patient with chronic migraine and cannabis addiction. The patient was a 34-year-old woman with a 14-year history of cannabis abuse who, during withdrawal, showed epileptic spikes, without any corresponding clinical symptoms, and migraine attacks of increasing intensity and frequency. This case study is in line with the new DSM-5 diagnostic tool that for the first time includes the diagnosis of cannabis withdrawal.

Islamic and Jewish Religious Feminists Tackle Islamic and Jewish Oral Law: Maintenance and Rebellion of Wives

2017 ◽  
Vol 11 (1) ◽  
pp. 35-63
Author(s):  
Ruth Roded
Keyword(s):  
State Policy ◽  
Political System ◽  
Daily Life ◽  
The State ◽  
The Political ◽  
Jewish Law ◽  
Modern Times ◽  
Parallel Case ◽  
First Time

Beginning in the early 1970s, Jewish and Muslim feminists, tackled “oral law”—Mishna and Talmud, in Judaism, and the parallel Hadith and Fiqh in Islam, and several analogous methodologies were devised. A parallel case study of maintenance and rebellion of wives —mezonoteha, moredet al ba?ala; nafaqa al-mar?a and nush?z—in classical Jewish and Islamic oral law demonstrates similarities in content and discourse. Differences between the two, however, were found in the application of oral law to daily life, as reflected in “responsa”—piskei halacha and fatwas. In modern times, as the state became more involved in regulating maintenance and disobedience, and Jewish law was backed for the first time in history by a state, state policy and implementation were influenced by the political system and socioeconomic circumstances of the country. Despite their similar origin in oral law, maintenance and rebellion have divergent relevance to modern Jews and Muslims.

scholarly journals Variable clinical characteristics and laboratory results in five patients with Chinese Good's syndrome (thymoma and hypogammaglobulinemia): an 8-year retrospective analysis in a university hospital in China

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jinyao Ni ◽  
Junwu Zhang ◽  
Yanxia Chen ◽  
Weizhong Wang ◽  
Jinlin Liu
Keyword(s):  
Information System ◽  
Lichen Planus ◽  
Hospital Information System ◽  
Clinical Characteristics ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Ivig Treatment ◽  
Good’S Syndrome ◽  
Laboratory Results

Abstract Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.

scholarly journals Clinical characteristics and outcomes of COVID-19 long-term nucleic acid positive patients

2021 ◽  
pp. 1-10
Author(s):  
Xuan Zhu ◽  
Xinxin Zhu ◽  
Min Wang ◽  
Fang Yang ◽  
Zhibing Sun ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Control Group ◽  
Viral Shedding ◽  
Imaging Characteristics ◽  
And Gender ◽  
Acid Test ◽  
Pulmonary Ct

OBJECTIVE: This study aimed to investigate the clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) long-term nucleic acid positive patients (hereinafter referred to as CLTAPs). METHODS: Patients were recruited from the Xiaogan Central Hospital between 16 January 2020 and 28 March 2020. Among the 562 cases of patients with laboratory-identified COVID-19 infection by real-time polymerase chain reaction (qtPCR), 19 cases of COVID-19 patients with more than 41 days from the first to the last time of nucleic acid test were selected as the study group, and 76 cases of age- and gender-matched COVID-19 patients were selected as the control group (hereinafter referred to as C-CLTAPs). Demographic characteristics, clinical symptoms, laboratory examination and computed tomography (CT) imaging characteristics were retrospectively analyzed. RESULTS: On admission, among the 562 cases of patients with COVID-19, there were 398 cases of ordinary COVID-19 patients, 99 cases of severe COVID-19 patients and 99 cases of critical COVID-19 patients. CLTAPs had milder clinical symptoms and longer viral shedding time in comparison to C-CLTAPs. Compared to C-CLTAPs, CLTAPs had a lower infection index at admission. CLTAPs used less oxygen therapy and a higher proportion of hydroxychloroquine treatment in comparison to C-CLTAPs. In comparison to C-CLTAPs, CLTAPs showed slower pulmonary CT progression and faster pulmonary CT absorption. CONCLUSION: In this study, out of the 562 cases, we found 19 CLTAPs. The clinical differences between CLTAPs and C-CLTAPs were compared and analyzed. We hope that these finding can provide a theoretical basis for the treatment of CLTAPs.

scholarly journals Erratum: Gravrok, J., et al. Beyond the Benefits of Assistance Dogs: Exploring Challenges Experienced by First-Time Handlers. Animals 2019, 9, 203

Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 237
Author(s):  
Jennifer Gravrok ◽  
Dan Bendrups ◽  
Tiffani Howell ◽  
Pauleen Bennett
Keyword(s):  
Assistance Dogs ◽  
First Time

The authors wish to make the following corrections [1]:In Table 1, under case study 4, the code was originally labeled as H8, P8 and ADI 8; these labels should be H4, P4 and ADI 4, respectively [...]

scholarly journals Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA

2021 ◽  
Author(s):  
Yoshinori Taniguchi ◽  
Hirofumi Nishikawa ◽  
Takeshi Yoshida ◽  
Yoshio Terada ◽  
Kurisu Tada ◽  
...  
Keyword(s):  
Reactive Arthritis ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Intravesical Instillation ◽  
Group Classification ◽  
Pathogenic Mechanism ◽  
Hla B27 ◽  
Bacillus Calmette Guerin ◽  
Poncet’S Disease ◽  
Streptococcal Tonsillitis

AbstractReactive arthritis (ReA) is a form of sterile arthritis that occurs secondary to an extra-articular infection in genetically predisposed individuals. The extra-articular infection is typically an infection of the gastrointestinal tract or genitourinary tract. Infection-related arthritis is a sterile arthritis associated with streptococcal tonsillitis, extra-articular tuberculosis, or intravesical instillation of bacillus Calmette–Guérin (iBCG) therapy for bladder cancer. These infection-related arthritis diagnoses are often grouped with ReA based on the pathogenic mechanism. However, the unique characteristics of these entities may be masked by a group classification. Therefore, we reviewed the clinical characteristics of classic ReA, poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA. Considering the diversity in triggering microbes, infection sites, and frequency of HLA-B27, these are different disorders. However, the clinical symptoms and intracellular parasitism pathogenic mechanism among classic ReA and infection-related arthritis entities are similar. Therefore, poststreptococcal ReA, Poncet’s disease, and iBCG-induced ReA could be included in the expanding spectrum of ReA, especially based on the pathogenic mechanism.

scholarly journals Investigating the Concerns of First-Time Distance Education Instructors

2019 ◽  
Vol 20 (5) ◽  
Author(s):  
Halil Kayaduman ◽  
Turgay Demirel
Keyword(s):  
Distance Education ◽  
Content Knowledge ◽  
Stages Of Concern ◽  
Concerns Based Adoption Model ◽  
Descriptive Case Study ◽  
Time Distance ◽  
Adaptation Processes ◽  
First Time ◽  
Ongoing Concern

The purpose of the study is to investigate the concern developments of first-time distance education instructors using the concerns-based adoption model (CBAM). This study used stages of concern (SoC), a component of CBAM, as its theoretical framework. A descriptive case study was implemented, which focused on the adaptation processes of nine instructors lecturing for the first time via distance education. The instructors attended a two-day training, which was designed based on their initial concerns. Then instructors implemented their courses for four weeks via distance education. While the informational and personal stages (self-concerns) decreased compared to the initial findings, the consequence stage increased in intensity. However, self-concerns remained predominant in the process despite the reduction in self-concerns and increase in the consequence stage. Based on the findings, the implications for distance education and recommendations for addressing the instructors’ concerns are discussed. Recommendations for alleviating the concerns of first-time distance education instructors include: the provision of ongoing concern-based interventions that incorporate technological, pedagogical, and content knowledge; providing working examples related to distance education from which instructors can learn vicariously; and encouraging collaboration among instructors.

scholarly journals Clinical characteristics and surgical treatments of primary hepatic angiosarcoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lei Jiang ◽  
Lijun Xie ◽  
Ge Li ◽  
Hang Xie ◽  
Zhao Fang ◽  
...  
Keyword(s):  
Malignant Tumor ◽  
Transarterial Chemoembolization ◽  
Clinical Characteristics ◽  
Clinical Symptoms ◽  
Past History ◽  
Hepatic Lobectomy ◽  
Hepatic Angiosarcoma ◽  
Mri Features ◽  
Primary Hepatic Angiosarcoma ◽  
Surgical Treatments

Abstract Purpose Primary hepatic angiosarcoma is a very rare and highly malignant tumor with poor prognosis. It is difficult to diagnose because of the lack of typical clinical features, and the treatment protocols for PHA are also not clear. Therefore, this study wants to find out the clinical characteristics and surgical treatments of primary hepatic angiosarcoma. Methods Among 8990 patients diagnosed with primary malignant tumor of the liver from January 2000 to December 2019 in our hospital, only four patients were diagnosed with primary hepatic angiosarcoma. The demographics, clinical manifestation, past history, serology test results, MRI features, pathology, treatment modality and prognosis of four patients were collected and analyzed. Results Three of four patients had no clinical symptoms, while one patient's symptom was abdominal pain. The levels of tumor markers of all four patients were within the normal reference range and serological tests were negative for hepatitis B and C virus. The MRI imaging findings of all four patients were mixed mass with highly disordered vascular characteristics. All four patients were misdiagnosed preoperatively. One patient who underwent hepatic lobectomy was still alive for about 18 months after surgery. One patient who underwent hepatic lobectomy has survived for only 6 months due to severe pneumonia. The other two patients who received transarterial chemoembolization survived 16 months and 11 months respectively. Conclusion The clinical symptoms of primary hepatic angiosarcoma are not typical, and primary hepatic angiosarcoma is easily misdiagnosed. The typical imaging manifestations are structural disorder and heterogeneous tumor. Hepatic lobectomy and transarterial chemoembolization may be important surgical treatments to improve the prognosis of patients.

scholarly journals Bearing Severity Fault Evaluation Using Contour Maps—Case Study

2021 ◽  
Vol 11 (14) ◽  
pp. 6452
Author(s):  
César Ricardo Soto-Ocampo ◽  
Juan David Cano-Moreno ◽  
José Manuel Mera ◽  
Joaquín Maroto
Keyword(s):  
Health Indicators ◽  
Bearing Faults ◽  
Contour Maps ◽  
Initial Stage ◽  
Critical Components ◽  
Bearing Damage ◽  
First Time ◽  
Current Operating

Increasing industrial competitiveness has led to an increased global interest in condition monitoring. In this sector, rotating machinery plays an important role, where the bearing is one of the most critical components. Many vibration-based signal treatments are already being used to identify features associated with bearing faults. The information embedded in such features are employed in the construction of health indicators, which allow for evaluation of the current operating status of the machine. In this work, the use of contour maps to represent the diagnosis map of a bearing, used as a health map, is presented for the first time. The results show that the proposed method is promising, allowing for the satisfactory detection and evaluation of the severity of bearing damage. In this initial stage of the research, our results suggest that this method can improve the classification of bearing faults and, therefore, optimise maintenance processes.

Are seasonal lakes as productive as permanent lakes? A case study from Ireland

2010 ◽  
Vol 67 (8) ◽  
pp. 1291-1302 ◽  
Author(s):  
Helder Cunha Pereira ◽  
Norman Allott ◽  
Catherine Coxon
Keyword(s):  
Seasonal Variation ◽  
Linear Regression ◽  
Chlorophyll A ◽  
Algal Biomass ◽  
P Limitation ◽  
Underlying Causes ◽  
Western Ireland ◽  
Log Linear ◽  
First Time

This paper compares, for the first time, nutrient levels and chlorophyll a measured in a set of seasonal lakes with those reported for permanent lakes in the literature. Twenty-two turloughs (karstic seasonal lakes) in western Ireland were sampled monthly from the onset of flooding (October) until they dried out (6 to 9 months). The turloughs showed similar levels of nutrients and chlorophyll a to those reported for Irish and international lakes. Chlorophyll a peaked between November and February in the majority of turloughs, sometimes with values higher than those measured in mesotrophic lakes in summer. A significant log-linear regression was found between total phosphorus and chlorophyll a, which suggests P limitation of algal biomass in the majority of the turloughs. The regression characteristics were not significantly different than those described in similar studies of permanent lakes. Patterns in seasonal variation of nutrients are also presented, their underlying causes being discussed in relation to their transport within catchments. Our results show that despite being predominantly winter phenomena, turloughs can be as productive as permanent lakes.

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