scholarly journals High Rate of Per Oral Mecillinam Treatment Failure in Community-Acquired Urinary Tract Infections Caused by ESBL-Producing Escherichia coli

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85889 ◽  
Author(s):  
Arne Søraas ◽  
Arnfinn Sundsfjord ◽  
Silje Bakken Jørgensen ◽  
Knut Liestøl ◽  
Pål A. Jenum
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Treatment Failure ◽  
Urinary Tract Infections ◽  
High Rate ◽  
Tract Infections ◽  
Per Oral

scholarly journals Microbial risk factors for treatment failure of pivmecillinam in community‐acquired urinary tract infections caused by ESBL‐producing Escherichia coli

Apmis ◽  
2020 ◽  
Vol 128 (3) ◽  
pp. 232-241 ◽  
Author(s):  
Heidi Syre ◽  
Marit Andrea Klokkhammer Hetland ◽  
Eva Bernhoff ◽  
Marianne Bollestad ◽  
Nils Grude ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Urinary Tract ◽  
Treatment Failure ◽  
Urinary Tract Infections ◽  
Microbial Risk ◽  
Tract Infections

Treatment duration of pivmecillinam in men, non-pregnant and pregnant women for community-acquired urinary tract infections caused by Escherichia coli: a retrospective Danish cohort study

2019 ◽  
Vol 74 (9) ◽  
pp. 2767-2773 ◽  
Author(s):  
Jonas Bredtoft Boel ◽  
Filip Jansåker ◽  
Frederik Boëtius Hertz ◽  
Katrine Hartung Hansen ◽  
Sara Thønnings ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Cohort Study ◽  
Urinary Tract ◽  
Treatment Failure ◽  
Pregnant Women ◽  
Urinary Tract Infections ◽  
Treatment Duration ◽  
E Coli ◽  
Tract Infections ◽  
Risk Of Treatment

Abstract Objectives To evaluate the importance of treatment duration for therapeutic efficacy of pivmecillinam for community-acquired urinary tract infections (UTIs) caused by Escherichia coli. Methods A retrospective cohort study was conducted between 1 January 2010 and 30 September 2016 in adults with community-acquired E. coli bacteriuria, treated empirically with pivmecillinam. Regimens of 3, 5 and 7 days were compared using clinical treatment failure (i.e. redemption of a new antibiotic or hospitalization due to UTI) within 14 and 30 days as outcome. HR and risk difference with 95% CI were estimated for treatment failure. Results were stratified by age (18–50, 51–70, >70 years) and sex. Results Of the 21864 cases of E. coli UTI that were analysed, 2524 (11.5%) were in men. In 954 cases (4.4%) E. coli produced ESBL and 125 (13.1%) of the cases were in men. The 3 day regimen increased the risk of treatment failure for all groups. The risk differences between the 3 and 5 day regimens were <10% for women, but >10% for men. Comparing the 7 day and 5 day regimens, only women aged >50 years demonstrated an increased risk of treatment failure within 14 days with the 5 day regimen, but not within 30 days. Conclusions With the current data, where data on clinical classification of the E. coli UTI were missing, a 5 day treatment with pivmecillinam at 400 mg three times daily seems to be the rational recommendation for lower UTI in men, pregnant women and women >50 years old. A 3 day regimen seems sufficient for non-pregnant women <50 years old.

scholarly journals Emerging Escherichia coli O25b/ST131 Clone Predicts Treatment Failure in Urinary Tract Infections

2014 ◽  
Vol 60 (4) ◽  
pp. 523-527 ◽  
Author(s):  
F. Can ◽  
O. K. Azap ◽  
C. Seref ◽  
P. Ispir ◽  
H. Arslan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Treatment Failure ◽  
Urinary Tract Infections ◽  
Tract Infections ◽  
St131 Clone

scholarly journals Complicated Catheter-Associated Urinary Tract Infections Due to Escherichia coli and Proteus mirabilis

2008 ◽  
Vol 21 (1) ◽  
pp. 26-59 ◽  
Author(s):  
S. M. Jacobsen ◽  
D. J. Stickler ◽  
H. L. T. Mobley ◽  
M. E. Shirtliff
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Proteus Mirabilis ◽  
Health Care Professionals ◽  
Bacterial Species ◽  
Disease Process ◽  
High Rate ◽  
Health Concern ◽  
Tract Infections

SUMMARY Catheter-associated urinary tract infections (CAUTIs) represent the most common type of nosocomial infection and are a major health concern due to the complications and frequent recurrence. These infections are often caused by Escherichia coli and Proteus mirabilis. Gram-negative bacterial species that cause CAUTIs express a number of virulence factors associated with adhesion, motility, biofilm formation, immunoavoidance, and nutrient acquisition as well as factors that cause damage to the host. These infections can be reduced by limiting catheter usage and ensuring that health care professionals correctly use closed-system Foley catheters. A number of novel approaches such as condom and suprapubic catheters, intermittent catheterization, new surfaces, catheters with antimicrobial agents, and probiotics have thus far met with limited success. While the diagnosis of symptomatic versus asymptomatic CAUTIs may be a contentious issue, it is generally agreed that once a catheterized patient is believed to have a symptomatic urinary tract infection, the catheter is removed if possible due to the high rate of relapse. Research focusing on the pathogenesis of CAUTIs will lead to a better understanding of the disease process and will subsequently lead to the development of new diagnosis, prevention, and treatment options.

scholarly journals Treatment Failure in Urinary Tract Infections: A Warning Witness for Virulent Multi-Drug Resistant ESBL- Producing Escherichia coli

2020 ◽  
Vol Volume 13 ◽  
pp. 1839-1850
Author(s):  
Zahra Naziri ◽  
Abdollah Derakhshandeh ◽  
Arash Soltani Borchaloee ◽  
Meisam Poormaleknia ◽  
Negar Azimzadeh
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Treatment Failure ◽  
Urinary Tract Infections ◽  
Drug Resistant ◽  
Tract Infections

Molecular Analysis of Uropathogenic E.coli Isolates from Urinary Tract Infections

2019 ◽  
Vol 19 (3) ◽  
pp. 322-326 ◽  
Author(s):  
Hassan Valadbeigi ◽  
Elham Esmaeeli ◽  
Sobhan Ghafourian ◽  
Abbas Maleki ◽  
Nourkhoda Sadeghifard
Keyword(s):  
Escherichia Coli ◽  
Polymerase Chain Reaction ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Multiplex Polymerase Chain Reaction ◽  
Virulence Genes ◽  
Uropathogenic Escherichia Coli ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Tract Infections

Introduction: The aim of the current study was to investigate the prevalence of virulence genes in uropathogenic Escherichia coli (UPEC) isolates in Ilam. Materials and Methods: For this purpose, a total of 80 UPEC isolates were collected for patients with UTIs during a 6 months period. The multiplex polymerase chain reaction (multiplex PCR) was used to detect the papEF, fimH, iucD, hlyA, fyuA, and ompT genes. Results: The prevalence of fimH, papEF, iucD, fyuA, hlyA, hlyA, and ompT genes were 87.5%, 47.5%, 60%, 67.5%, 27.5%, 47.5% and 71.2%, respectively. Among all of the isolates, 27 profiles were obtained. Conclusion: Our findings demonstrated that the most prevalence was found for fimH, and different distribution of virulence genes suggested different ability of pathogenicity.

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