scholarly journals Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150924 ◽  
Author(s):  
Hana Malínská ◽  
Olena Oliyarnyk ◽  
Vojtěch Škop ◽  
Jan Šilhavý ◽  
Vladimír Landa ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
C Reactive Protein ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Reactive Protein

scholarly journals P98Cardiac ischemic tolerance of spontaneously hypertensive rats with increased expression of C-reactive protein

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S26-S26
Author(s):  
J Neckar ◽  
F Papousek ◽  
V Farkasova ◽  
T Ravingerova ◽  
M Vecka ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Ischemic Tolerance ◽  
C Reactive Protein ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Reactive Protein

scholarly journals Hepatotoxic Effects of Fenofibrate in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

2016 ◽  
pp. 891-899 ◽  
Author(s):  
V. ŠKOP ◽  
J. TRNOVSKÁ ◽  
O. OLIYARNYK ◽  
I. MARKOVÁ ◽  
H. MALÍNSKÁ ◽  
...  
Keyword(s):  
Body Weight ◽  
Spontaneously Hypertensive Rats ◽  
Hdl Cholesterol ◽  
Metabolic Effects ◽  
C Reactive Protein ◽  
Hypertensive Rats ◽  
Serum Triglycerides ◽  
Spontaneously Hypertensive ◽  
Reactive Protein ◽  
Anti Inflammatory

Dyslipidemia and inflammation play an important role in the pathogenesis of cardiovascular and liver disease. Fenofibrate has a well-known efficacy to reduce cholesterol and triglycerides. Combination with statins can ameliorate hypolipidemic and anti-inflammatory effects of fibrates. In the current study, we tested the anti-inflammatory and metabolic effects of fenofibrate alone and in combination with rosuvastatin in a model of inflammation and metabolic syndrome, using spontaneously hypertensive rats expressing the human C-reactive protein transgene (SHR-CRP transgenic rats). SHR-CRP rats treated with fenofibrate alone (100 mg/kg body weight) or in combination with rosuvastatin (20 mg/kg body weight) vs. SHR-CRP untreated controls showed increased levels of proinflammatory marker IL6, increased concentrations of ALT, AST and ALP, increased oxidative stress in the liver and necrotic changes of the liver. In addition, SHR-CRP rats treated with fenofibrate, or with fenofibrate combined with rosuvastatin vs. untreated controls, exhibited increased serum triglycerides and reduced HDL cholesterol, as well as reduced hepatic triglyceride, cholesterol and glycogen concentrations. These findings suggest that in the presence of high levels of human CRP, fenofibrate can induce liver damage even in combination with rosuvastatin. Accordingly, these results caution against the possible hepatotoxic effects of fenofibrate in patients with high levels of CRP.

scholarly journals Moringa oleiferaSeeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Joseph Iharinjaka Randriamboavonjy ◽  
Marc Rio ◽  
Pierre Pacaud ◽  
Gervaise Loirand ◽  
Angela Tesse
Keyword(s):  
Traditional Medicine ◽  
Spontaneously Hypertensive Rats ◽  
Protective Role ◽  
Protective Effects ◽  
Resistance Arteries ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Functional Studies ◽  
Reactive Protein ◽  
Wistar Kyoto

Moringa oleifera(MOI) is a tree currently used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including arterial hypertension. We previously described a cardiac protective role of a treatment with MOI seeds in spontaneously hypertensive rats (SHR). Here, we investigated the effects of this treatment on oxidative and nitrosative vascular stresses in SHR, with normotensive Wistar Kyoto rats used as controls. Oxidative and nitrosative stresses detected in SHR aortas using the fluorescent dye dihydroethidine and protein nitrotyrosine staining were reduced in MOI-treated SHR aortas. This was associated with a decrease of free 8-isoprostane circulating level, vascular p22phoxand p47phoxexpressions, and SOD2 upregulation. Moreover, circulating nitrites and C-reactive protein, increased in SHR, were both reduced in SHR receiving MOI. This was associated to decrease iNOS and NF-κB protein expressions after MOI treatment. In functional studies, the endothelium-dependent carbachol-induced relaxation was improved in MOI-treated SHR resistance arteries. Oral administration of MOI seeds demonstrates vascular antioxidant, anti-inflammatory, and endothelial protective effects in SHR. Our data support the use of MOI seeds in diet against cardiovascular disorders associated with oxidative stress and inflammation such as hypertension, scientifically validating the use of these seeds in Malagasy traditional medicine.

scholarly journals Rosuvastatin Ameliorates Inflammation, Renal Fat Accumulation, and Kidney Injury in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

2015 ◽  
pp. 295-301 ◽  
Author(s):  
J. ŠILHAVÝ ◽  
V. ZÍDEK ◽  
V. LANDA ◽  
M. ŠIMÁKOVÁ ◽  
P. MLEJNEK ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Kidney Injury ◽  
Organ Injury ◽  
Hypertensive Rats ◽  
Transgenic Rats ◽  
Fat Accumulation ◽  
Transgenic Expression ◽  
Spontaneously Hypertensive ◽  
Cardiac Inflammation ◽  
Reactive Protein

Recently, we derived “humanized” spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress, several features of metabolic syndrome and target organ injury. In addition, we found that rosuvastatin treatment of SHR-CRP transgenic rats can protect against pro-inflammatory effects of human CRP and also reduce cardiac inflammation and oxidative damage. In the current study, we tested the effects of rosuvastatin (5 mg/kg) on kidney injury in SHR-CRP males versus untreated SHR-CRP and SHR controls. All rats were fed a high sucrose diet. In SHR-CRP transgenic rats, treatment with rosuvastatin for 10 weeks, compared to untreated transgenic rats and SHR controls, was associated with significantly reduced systemic inflammation which was accompanied with activation of antioxidative enzymes in the kidney, lower renal fat accumulation, and with amelioration of histopathological changes in the kidney. These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects.

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