Acute hypoxia diminishes the relationship between blood pressure and subarachnoid space width oscillations at the human cardiac frequency

The precise mechanisms connecting the cardiovascular system and the cerebrospinal fluid (CSF) are not well understood in detail. This paper investigates the couplings between the cardiac and respiratory components, as extracted from blood pressure (BP) signals and oscillations of the subarachnoid space width (SAS), collected during slow ventilation and ventilation against inspiration resistance. The experiment was performed on a group of 20 healthy volunteers (12 females and 8 males; BMI =22.1±3.2 kg/m2; age 25.3±7.9 years). We analysed the recorded signals with a wavelet transform. For the first time, a method based on dynamical Bayesian inference was used to detect the effective phase connectivity and the underlying coupling functions between the SAS and BP signals. There are several new findings. Slow breathing with or without resistance increases the strength of the coupling between the respiratory and cardiac components of both measured signals. We also observed increases in the strength of the coupling between the respiratory component of the BP and the cardiac component of the SAS and vice versa. Slow breathing synchronises the SAS oscillations, between the brain hemispheres. It also diminishes the similarity of the coupling between all analysed pairs of oscillators, while inspiratory resistance partially reverses this phenomenon. BP–SAS and SAS–BP interactions may reflect changes in the overall biomechanical characteristics of the brain.

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Increased inspiratory resistance affects the dynamic relationship between blood pressure changes and subarachnoid space width oscillations

PLoS ONE ◽

10.1371/journal.pone.0179503 ◽

2017 ◽

Vol 12 (6) ◽

pp. e0179503 ◽

Cited By ~ 6

Author(s):

Magdalena Wszedybyl-Winklewska ◽

Jacek Wolf ◽

Ewa Swierblewska ◽

Katarzyna Kunicka ◽

Kamila Mazur ◽

...

Keyword(s):

Blood Pressure ◽

Subarachnoid Space ◽

Dynamic Relationship ◽

Inspiratory Resistance ◽

Pressure Changes ◽

Space Width

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The relationship of peripheral sympathetic neural discharge to arterial blood pressure levels in pregnancy induced hypertens on

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86476-3 ◽

1998 ◽

Vol 5 (1) ◽

pp. 136A-136A

Author(s):

J GREENWOOD ◽

I STOKER ◽

J WALKER ◽

D MARY

Keyword(s):

Blood Pressure ◽

Arterial Blood Pressure ◽

Arterial Blood ◽

Neural Discharge ◽

Relationship Of ◽

The Relationship ◽

In Pregnancy

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Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648811 ◽

1994 ◽

Vol 72 (01) ◽

pp. 058-064 ◽

Cited By ~ 14

Author(s):

Goya Wannamethee ◽

A Gerald Shaper

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Alcohol Intake ◽

Blood Lipids ◽

The Other ◽

The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

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Family-Supportive Supervisory Behaviors as a Moderator of the Relationship between Job Strain and Workers' Blood Pressure

10.15760/etd.198 ◽

2000 ◽

Author(s):

Christopher Harper

Keyword(s):

Blood Pressure ◽

Job Strain ◽

The Relationship

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Risk assessment of occupational and occupationally conditioned diseases connection to noise when exceeding maximum permissible levels

Russian Journal of Occupational Health and Industrial Ecology ◽

10.31089/1026-9428-2018-10-17-19 ◽

2019 ◽

pp. 17-19

Author(s):

Vladimir A. Fokin ◽

Dmitrii M. Shlyapnikov ◽

Svetlana V. Red’ko

Keyword(s):

Blood Pressure ◽

Nervous System ◽

Autonomic Nervous System ◽

High Blood Pressure ◽

Noise Exposure ◽

Physical Factors ◽

Autonomic Nervous ◽

Permissible Levels ◽

The Relationship ◽

Perm Region

In accordance with the requirements of paragraph 3.2.6 of sanitary rules and norms «Sanitary and epidemiological requirements for physical factors at workplace», in the event of exceeding noise level at workplace above 80 dBA, an employer is obliged to assess the health risk of workers and confirm an acceptable risk to their health. The connection between the incidence of occupational and occupationally conditioned diseases with noise exposure exceeding the maximum permissible levels (80 dBA) was estimated. The assessment was carried out at a food industry enterprise of Perm Region. Assessing the relationship between morbidity and noise exposure is the first step in evaluation of occupational health risks for workers exposed to noise exceeding MAL. If a reliable relationship between morbidity and noise exposure is established, an assessment of occupational risk is conducted. The odds ratio (OR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1 (confidence interval CI=0.11–1.61 and CI=0.08–2.78, respectively). The relative risk (RR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1. The received data testify absence of connection of morbidity with exposure to industrial noise, calculation of etiological share of responses and levels of risk is not required.

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