scholarly journals The impact of the method of extracting metabolic signal from 1H-NMR data on the classification of samples: A case study of binning and BATMAN in lung cancer

PLoS ONE ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. e0211854 ◽  
Author(s):  
Trishanta Padayachee ◽  
Tatsiana Khamiakova ◽  
Evelyne Louis ◽  
Peter Adriaensens ◽  
Tomasz Burzykowski
Author(s):  
Tatiana Kaletová ◽  
Luis Loures ◽  
Rui Alexandre Castanho ◽  
Elena Aydin ◽  
José Telo da Gama ◽  
...  

Ecosystem services (ES), as an interconnection of the landscape mosaic pieces, along with temporal rivers (IRES) are an object of research for environmental planners and ecological economists, among other specialists. This study presents (i) a review on the importance of IRES and the services they can provide to agricultural landscapes; (ii) a classification tool to assess the impact of IRES to provide ES by agricultural landscapes; (iii) the application of the proposed classification to the Caia River in order to identify the importance of this intermittent river for its surrounding agricultural landscape. The classification of the ES follows the Common International Classification of Ecosystem (CICES) classification that was adapted for the purposes of this study. Firstly, the list of ES provided by agricultural landscape was elaborated. In the next step, we assessed the potential of IRES to provide ES. Next, IRES impacts to ES within the agricultural landscape were evaluated according to observations from the conducted field monitoring in the study area. This study focuses on the relevance of the intermittent Caia River—a transboundary river in Spain and Portugal—and its ephemeral tributaries in the agricultural landscape. Our study estimates that each hydrological phase of IRES increases the ES provided by the agricultural landscape. However, the dry phase can potentially have negative impacts on several services. The intensification of the agricultural sector is the main provision of the water resource within the Caia River basin, but we were able to identify several other ES that were positively impacted. The present study is in line with the conclusions of other authors who state that IRES constitute a valuable resource which should not be underestimated by society.


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 575-575
Author(s):  
Lorraine Brennan ◽  
Claire Conolly

Abstract Objectives Milk and dairy products are a major component of dietary intake, with milk consumption estimated at 6 billion people globally. Adults are reported to consume two or more portions of dairy daily. Cow's milk is composed of a variety of micro and macro nutrients, which is impacted by a range of factors, including lactation stage, and feeding system (indoor vs. pasture). Application of Metabolomics provides in depth analysis of the metabolite composition of milk. The objective was to examine the impact of lactation on bovine milk metabolite levels. Methods Metabolomic analysis of bovine milk powder samples across lactation (N = 18), was performed using 1H-NMR. Metabolites were quantified using Chenomx software (7.7). One-way repeated measures of analysis variance (ANOVA) with Tukeys post hoc test, was preformed on NMR data using SPSS (version 24.0), to assess the impact of lactation stages. P-values were corrected for multiple comparisons using Benjamini and Hochberg false discovery rate (FDR) procedure. Multivariate statistical analysis of the 1H-NMR data was carried out using SIMCA 13 (SIMCA Version 13.0.3.0 Umetrics, AB). Results 42 metabolites were identified and quantified in the 1H-NMR spectra. Statistical analysis revealed that 17 metabolites were significantly different across lactation stages (FDR < 0.05). Of these 17 metabolites, the majority had higher concentrations in early lactation. Examples of metabolites that changed with lactation stage include the tricarboxylic acid cycle intermediates citrate and 2-oxoglutarate, amino acids, choline and phosphocholine. Interestingly choline and phosphocholine levels changed in opposite directions. Conclusions Our results demonstrate significant differences in metabolites across the stages of lactation, with early lactation having a distinct metabolic profile. Future work will explore these compositional differences further, encompassing animal feeding practice. Funding Sources Food for Health Ireland and Enterprise Ireland.


2020 ◽  
Vol nr specjalny 1(2020) ◽  
pp. 311-334
Author(s):  
Arkadiusz Luboń ◽  

The article discusses the conventional models and translation techniques, which are most common among the Polish translators of the weird fiction by Howard Phillips Lovecraft. The proposed classification of such models, aimed at either “popularisation,” “stereotypisation” or “revision” of Lovecraft’s short stories, presents the impact of extra-textual factors (vision of the writer, target group of readers, cultural and political influences) on the content, language and style of translated works by the American author. The comparative analysis takes into consideration one of the early short stories by Lovecraft, “Dagon” (1917), and its Polish versions by Arnold Mostowicz (1973), Robert Lipski (1994) and Maciej Płaza (2012).


2020 ◽  
Author(s):  
Yori Qalbi Khairi ◽  
Ratna Widayati

This study aims to determine the level of bank health at PT. BPR Raga Dana Sejahtera in the Padang branch by using non-pefoming loan standards in 2015-2017, the impact of non-performing loans on company profits in 2015-2017, efforts made to overcome non-performing loans at PT. BPR Raga Dana Sejahtera Padang branch in 2015-2017. Data was collected using interviews and documentation. Data were analyzed using case study analysis with a quantitative approach. The results showed that the classification of the Bank's health level there are four categories, namely: healthy, healthy enough, less healthy, and unhealthy. the impact of non-performing loans to the Bank is the decline in profits, disruption of cash turnover, reduced level of bank soundness, reduced bank capital, and decreased public confidence. efforts made to overcome problem loans at PT. BPR Raga Dana Sejahtera Padang branch is a restructuring, rescheduling, foreclosure guarantee, and write off loans (write off receivables).


2010 ◽  
Vol 44-47 ◽  
pp. 13-17
Author(s):  
Hui Sun ◽  
Zhi Qing Fan ◽  
Ying Zhou

Combining with the characters of the practicing qualification personnel in construction market, probabilistic neural network is brought out trying to analyze the credit classification of the practicing qualification personnel. And the impact factor of the number of neurons on the credit classification of the practicing qualification personnel is studied. Then a probabilistic neural network is built. At last, a case study is conducted by taking practicing qualification personnel as an example. The research result reveals that the method can efficiently evaluate the credit of the practicing qualification personnel, thus it could provide scientific advice to the construction enterprise to prevent relevant discreditable behaviors of some practicing qualification personnel.


Author(s):  
Jan Paul Lindner ◽  
Ulrike Eberle ◽  
Eva Knuepffer ◽  
Carla R. V. Coelho

Abstract Purpose The impact of land use on biodiversity is a topic that has received considerable attention in life cycle assessment (LCA). The methodology to assess biodiversity in LCA has been improved in the past decades. This paper contributes to this progress by building on the concept of conditions for maintained biodiversity. It describes the theory for the development of mathematical functions representing the impact of land uses and management practices on biodiversity. Methods The method proposed here describes the impact of land use on biodiversity as a decrease in biodiversity potential, capturing the impact of management practices. The method can be applied with weighting between regions, such as ecoregions. The biodiversity potential is calculated through functions that describe not only parameters which are relevant to biodiversity, for example, deadwood in a forest, but also the relationships between those parameters. For example, maximum biodiversity would hypothetically occur when the nutrient balance is ideal and no pesticide is applied. As these relationships may not be readily quantified, we propose the use of fuzzy thinking for biodiversity assessment, using AND/OR operators. The method allows the inclusion of context parameters that represent neither the management nor the land use practice being investigated, but are nevertheless relevant to biodiversity. The parameters and relationships can be defined by either literature or expert interviews. We give recommendations on how to create the biodiversity potential functions by providing the reader with a set of questions that can help build the functions and find the relationship between parameters. Results and discussion We present a simplified case study of paper production in the Scandinavian and Russian Taiga to demonstrate the applicability of the method. We apply the method to two scenarios, one representing an intensive forestry practice, and another representing lower intensity forestry management. The results communicate the differences between the two scenarios quantitatively, but more importantly, are able to provide guidance on improved management. We discuss the advantages of this condition-based approach compared to pre-defined intensity classes. The potential drawbacks of defining potential functions from industry-derived studies are pointed out. This method also provides a less strict approach to a reference situation, consequently allowing the adequate assessment of cases in which the most beneficial biodiversity state is achieved through management practices. Conclusions The originality of using fuzzy thinking is that it enables land use management practices to be accounted for in LCA without requiring sub-categories for different intensities to be explicitly established, thus moving beyond the classification of land use practices. The proposed method is another LCIA step toward closing the gap between land use management practices and biodiversity conservation goals.


2019 ◽  
Vol 29 (2) ◽  
pp. 391-417 ◽  
Author(s):  
Alison Gibbons

Abstract Using Elena Ferrante’s Neapolitan novels as case study, this article presents a cognitive approach to fictionality and authorial intention using Text World Theory and Mind-Modelling. It investigates two forms of ontological distortion: readers’ (mis)classification of the novels’ genre (as autofiction or autobiography) and the problem posed by the author’s pseudonymic identity. The analysis has three parts: first, I conduct a Text World analysis of the novels’ syntactic/stylistic similarities to autobiography and, in doing so, reveal its ontological structure; second, I consider the ontological liminality of narration and the ways in which readers build an authorial mind-model of Ferrante; thirdly, I explore the assessment of critics and/as readers of the text’s fictionality and the impact of Ferrante’s pseudonym on perceptions of authorial intentionality and the authorial mind-model. Ultimately, I argue that a cognitive approach offers greatest insight into readers’ interpretations of authors and of fictionality.


2018 ◽  
Vol 17 (6) ◽  
pp. 387-405 ◽  
Author(s):  
Kelly R. Harris ◽  
Peter J. Norton

A recent shift in the conceptualization of both depressive and anxiety disorders supports the notion that these disorders may best fall under a single classification of “emotional disorders.” This understanding has resulted in the development of various transdiagnostic cognitive behavioral therapy (tCBT) protocols to address underlying core pathology shared by emotional disorders. While there is evidence to suggest tCBT is effective in reducing co-occurring depression, research into the efficacy of face-to-face tCBT has generally focused on the delivery of tCBT to individuals with predominantly anxiety diagnoses. The current case study aims to expand the research by examining the impact of group tCBT for individuals with a principal depressive diagnosis. A session-by-session explanation of a 12-week group tCBT protocol designed to treat a heterogeneous group of individuals diagnosed with an emotional disorder is provided in detail and accompanied by a quantitative case study of a recently delivered treatment group. The case study demonstrates the feasibility and pragmatic application of the group tCBT treatment approach. Data presented support the continued research of transdiagnostic interventions for the treatment of emotional disorders and justify future randomized controlled trials to further evaluate the presented intervention.


Author(s):  
Muhammad Taufiq Atsifa Razali ◽  
Zaim Akmal Zainal ◽  
Maulidiani Maulidiani ◽  
Khozirah Shaari ◽  
Zulkifli Zambri ◽  
...  

Background: The official standard for quality control of honey is currently based on physicochemical properties. However, this method is time-consuming, cost intensive, and do not lead to information on the originality of honey. This study aims to classify raw stingless bee honeys by bee species origins as a potential classifier using NMR-LCMS-based metabolomics approach. Methods: Raw stingless bee honeys were analysed and classified by bee species origins using proton nuclear magnetic resonance (1H NMR) spectroscopy and an ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-QTOF MS) in combination with chemometrics tools. Results: The honey samples were able to be classified into three different groups based on the bee species origins of Heterotrigona itama, Geniotrigona thoracica, and Tetrigona apicalis. D-Fructofuranose (H. itama honey), β-D-Glucose, D-Xylose, α-D-Glucose (G. thoracica honey), and L-Lactic acid, Acetic acid, L-Alanine (T. apicalis honey) identified via 1H NMR data and the diagnostic ions of UHPLC-QTOF MS were characterized as the discriminant metabolites or putative chemical markers. Conclusion: It could be suggested that the quality of honey in terms of originality and purity can be rapidly determined using classification technique by bee species origins via 1H NMR- and UHPLC-QTOF MS-based metabolomics approach.


Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2160 ◽  
Author(s):  
Muhammad Razali ◽  
Zaim Zainal ◽  
M. Maulidiani ◽  
Khozirah Shaari ◽  
Zulkifli Zamri ◽  
...  

The official standard for quality control of honey is currently based on physicochemical properties. However, this method is time-consuming, cost intensive, and does not lead to information on the originality of honey. This study aims to classify raw stingless bee honeys by bee species origins as a potential classifier using the NMR-LCMS-based metabolomics approach. Raw stingless bee honeys were analysed and classified by bee species origins using proton nuclear magnetic resonance (1H-NMR) spectroscopy and an ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UHPLC-QTOF MS) in combination with chemometrics tools. The honey samples were able to be classified into three different groups based on the bee species origins of Heterotrigona itama, Geniotrigona thoracica, and Tetrigona apicalis. d-Fructofuranose (H. itama honey), β-d-Glucose, d-Xylose, α-d-Glucose (G. thoracica honey), and l-Lactic acid, Acetic acid, l-Alanine (T. apicalis honey) ident d-Fructofuranose identified via 1H-NMR data and the diagnostic ions of UHPLC-QTOF MS were characterized as the discriminant metabolites or putative chemical markers. It could be suggested that the quality of honey in terms of originality and purity can be rapidly determined using the classification technique by bee species origins via the 1H-NMR- and UHPLC-QTOF MS-based metabolomics approach.


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