Abundances of placental imprinted genes CDKN1C, PHLDA2 and IGF-2 are related to low birth weight and early catch-up growth in full-term infants born small for gestational age

Introduction. The impact of prematurity on the functional state of the kidneys in infants has not yet been sufficiently studied. Aim. To determine the influence of birth weight and gestational age on the creatinine level in the blood and glomerular filtration rate (GFR) in early childhood. Materials and methods. A retrospective analysis was conducted on medical records of 316 children aged from 1 month to 1.5 years, hospitalized at the Department of Early Childhood Pathology (National Medical Research Center for Children’s Health, Moscow) from 2012 to 2020 due to consequences of perinatal CNS damage. Children without congenital kidney diseases, with normal urine values in medical history, without structural abnormalities on ultrasound were included in this study. Serum creatinine was determined by the enzymatic method, GFR - by the Schwartz’s formula using a coefficient of 0.413, as well as, previously proposed coefficients of 0.33 for premature and 0.44 for full-term infants. Results. In premature infants, notably born with extremely low birth weight and very low birth weight, at the age of 1 year, serum creatinine is reduced compared to full-term infants, GFR in deep-premature infants exceeds the level of GFR in full-term infants by the year. The results allow concluding the method of calculating GFR by formulas based on serum creatinine to be invalid. Due to possible hyperfiltration in preterm infants, they need regular monitoring urine tests, blood pressure, due to the risk of developing chronic kidney disease. Conclusions. It is necessary to search for other methods for determining GFR in extremely premature infants. The established indices of the blood creatinine content can be used as reference values for different periods of gestation and body weight at birth in institutions using the enzymatic method for determining blood creatinine. The obtained GFR indices as a reference can be recommended for full-term and premature babies born after 32 weeks of gestation and with a birth weight of more than 1500 g.

Download Full-text

Characteristics of Catch-Up Growth in Very Low Birth Weight Infants (<1500 g)

10.5772/intechopen.96933 ◽

2021 ◽

Author(s):

Teodoro Durá-Travé ◽

Isabel San Martín-García ◽

Fidel Gallinas-Victoriano ◽

María Malumbres-Chacón ◽

Paula Moreno-González ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Small For Gestational Age ◽

Very Low Birth Weight ◽

Control Group ◽

Low Birth Weight Infants ◽

Normal Height ◽

Appropriate For Gestational Age ◽

Catch Up

Features of catch-up growth are not well established in very low birth weight infants (VLBW). The aim of this study is to analyze the catch-up growth in height and some factors associated in a cohort of VLBW (<1500 g) from birth to age 14 years. Retrospective registration of weight and height at birth and ages 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 14 years in a cohort of 170 VLBW have been recorded Anthropometric variables were compared with those from a control group. Sixty-nine (40.6%) were small for gestational age (SGA subgroup) and 101 (59.4%) were appropriate for gestational age (AGA subgroup). Thirty-seven (21.8%) were extremely low birth weight (ELBW), and 32 (18.8%) extremely preterm (EPT). At age 2, 4 and 10 years, 49.4%, 78.9% and 87.1% VLBW, respectively, did reach normal height. Between 4 and 10 years of age, only 8.2% of VLBW reached normal height. At 10 years of age, 7% of VLBW (1000–1500 g) and 35% of ELBW (<1500 g) showed short stature (p = 0.001). Almost the entire sample of VLBW with normal height at age 2, 4 and 10 have reached an adequate catch-up growth in weight in the previous evaluations. ELBW, SGA and EPT were found to be independent predictors for inadequate catch-up growth in height at 2, 4, and 10 years of age. The growth pattern of children born preterm has particular features: they have a lower rate and/or slowness in the catch-up growth in height with respect to that described in full-term small-for-gestational-age infants. Catch-up in weight appears to be a decisive factor for catch-up in height, and, on this basis, we recommend a rigorous nutritional follow-up in these individuals. If these measures do not help improve catch-up in height, they may be eligible for the establishment of rhGH therapy.

Download Full-text

Management of the Child Born Small for Gestational Age through to Adulthood: A Consensus Statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-2017 ◽

2007 ◽

Vol 92 (3) ◽

pp. 804-810 ◽

Cited By ~ 319

Author(s):

P. E. Clayton ◽

S. Cianfarani ◽

P. Czernichow ◽

G. Johannsson ◽

R. Rapaport ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Small For Gestational Age ◽

Consensus Statement ◽

Published Data ◽

Increased Risk ◽

Catch Up

Abstract Objective: Low birth weight remains a major cause of morbidity and mortality in early infancy and childhood. It is associated with an increased risk of health problems later in life, particularly coronary heart disease and stroke. A meeting was convened to identify the key health issues facing a child born small for gestational age (SGA) and to propose management strategies. Participants: There were 42 participants chosen for their expertise in obstetrics, peri- and neonatal medicine, pediatrics, pediatric and adult endocrinology, epidemiology, and pharmacology. Evidence: Written materials were exchanged, reviewed, revised, and then made available to all. This formed the basis for discussions at the meeting. Where published data were not available or adequate, discussion was based on expert clinical opinions. Consensus Process: Each set of questions was considered by all and then discussed in plenary sessions with consensus and unresolved issues identified. The consensus statement was prepared in plenary sessions and then edited by the group chairs and shared with all participants. Conclusions: The diagnosis of SGA should be based on accurate anthropometry at birth including weight, length, and head circumference. We recommend early surveillance in a growth clinic for those without catch-up. Early neurodevelopment evaluation and interventions are warranted in at-risk children. Endocrine and metabolic disturbances in the SGA child are recognized but infrequent. For the 10% who lack catch-up, GH treatment can increase linear growth. Early intervention with GH for those with severe growth retardation (height sd score, <−2.5; age, 2–4 yr) should be considered at a dose of 35–70 μg/kg·d. Long-term surveillance of treated patients is essential. The associations at a population level between low birth weight, including SGA, and coronary heart disease and stroke in later life are recognized, but there is inadequate evidence to recommend routine health surveillance of all adults born SGA outside of normal clinical practice.

Download Full-text

Catch-up Growth of Supine Length/Height of Very Low Birth Weight, Small for Gestational Age Preterm Infants to Adulthood

The Journal of Pediatrics ◽

10.1016/j.jpeds.2005.06.034 ◽

2005 ◽

Vol 147 (5) ◽

pp. 662-668 ◽

Cited By ~ 47

Author(s):

Ingeborg Brandt ◽

Elisabeth J. Sticker ◽

Ruth Gausche ◽

Michael J. Lentze

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Small For Gestational Age ◽

Very Low Birth Weight ◽

Catch Up

Download Full-text

Kinematic Analysis of Kicking Movements in Preterm Infants With Very Low Birth Weight and Full-Term Infants

Physical Therapy ◽

10.1093/ptj/82.2.148 ◽

2002 ◽

Vol 82 (2) ◽

pp. 148-159 ◽

Cited By ~ 44

Author(s):

Suh-Fang Jeng ◽

Li-Chiou Chen ◽

Kuo-Inn Tsou Yau

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Gestational Age ◽

Kinematic Analysis ◽

Very Low Birth Weight ◽

Full Term ◽

Coordination Pattern ◽

Term Infants ◽

Spontaneous Movements

Abstract Background and Purpose. Study of kicking development provides important information to understand how early spontaneous movements change in infants as they acquire voluntary control. Researchers have investigated the kicking movements of preterm infants; however, the movement patterns that they have described were inconsistent. The purpose of this study, therefore, was to examine the development of kicking movements with kinematic analysis in preterm infants with very low birth weight (VLBW) and full-term infants. Subjects and Methods. Twenty-two infants with VLBW who were divided into low gestational age (gestational age of <30 weeks, n=9) and high gestational age (gestational age of ≥30 weeks, n=13) classes and 22 full-term infants were evaluated during kicking movements using 4 synchronized cameras and 3-dimensional kinematic analysis when the infants were 2 and 4 months of corrected age. Results. The infants with VLBW and a high gestational age showed similar kicking movements compared with the full-term infants. In contrast, the infants with VLBW and a low gestational age exhibited a higher kick frequency and a shorter flexion phase at 4 months of corrected age. They also exhibited a higher hip-knee correlation and lower variability in the interlimb coordination pattern at 2 and 4 months of corrected age. Discussion and Conclusion. The findings indicate that infants with VLBW, particularly those with a low gestational age, have age-related differences in movement organization and coordination of kicking compared with full-term infants.

Download Full-text

A LONGITUDINAL STUDY OF THE GROWTH OF LOW BIRTH WEIGHT INFANTS

PEDIATRICS ◽

10.1542/peds.51.4.620 ◽

1973 ◽

Vol 51 (4) ◽

pp. 620-628

Author(s):

Mary O. Cruise

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Study Groups ◽

Full Term ◽

Normal Velocity ◽

Low Birth Weight Infants ◽

Term Infants ◽

Actual Length ◽

Growth Measurement

Physicians may need to consider the growth of children–especially those of unusual size for age–from two different viewpoints. Most pediatricians are used to thinking of what may be called distance growth: how "normal" is a child's actual length at 2 years? The other aspect, velocity growth, expresses the rate or speed at which the child has grown. This may be equal for children of corresponding ages, whereas their distance growth may vary greatly. Failure of growth at a normal rate in one child should be investigated whereas another child with horizontal growth measurement outside ± 2 SD, but with normal velocity growth may require no investigation. Data from this study provide not only mean measurements for weight, length, and head circumference of low birth weight infants who are grouped by sex and gestational age, but also provide velocity growth from birth through 3 years of age. Preterm infants (gestational age < 37 weeks) had greater velocity growth rates than small-for-date infants (full-term, low birth weight). At 1, 2, and 3 years the SFD infants had the smallest mean measurements of all the study groups of low birth weight infants. Comparative full-term infants were larger than low birth weight infants from birth through 3 years of age.

Download Full-text

Diet Quality Is Associated with a High Newborn Size and Reduction in the Risk of Low Birth Weight and Small for Gestational Age in a Group of Mexican Pregnant Women: An Observational Study

Nutrients ◽

10.3390/nu13061853 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1853

Author(s):

María A. Reyes-López. ◽

Carla P. González-Leyva ◽

Ameyalli M. Rodríguez-Cano ◽

Carolina Rodríguez-Hernández ◽

Eloisa Colin-Ramírez ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Nutritional Status ◽

Diet Quality ◽

Gestational Age ◽

Small For Gestational Age ◽

Mexican Women ◽

High Quality ◽

Quality Diet ◽

Newborn Size

A high-quality diet during pregnancy may have positive effects on fetal growth and nutritional status at birth, and it may modify the risk of developing chronic diseases later in life. The aim of this study was to evaluate the association between diet quality and newborn nutritional status in a group of pregnant Mexican women. As part of the ongoing Mexican prospective cohort study, OBESO, we studied 226 healthy pregnant women. We adapted the Alternated Healthy Eating Index-2010 for pregnancy (AHEI-10P). The association between maternal diet and newborn nutritional status was investigated by multiple linear regression and logistic regression models. We applied three 24-h recalls during the second half of gestation. As the AHEI-10P score improved by 5 units, the birth weight and length increased (β = 74.8 ± 35.0 g and β = 0.3 ± 0.4 cm, respectively, p < 0.05). Similarly, the risk of low birth weight (LBW) and small for gestational age (SGA) decreased (OR: 0.47, 95%CI: 0.27–0.82 and OR: 0.55, 95%CI: 0.36–0.85, respectively). In women without preeclampsia and/or GDM, the risk of stunting decreased as the diet quality score increased (+5 units) (OR: 0.62, 95%IC: 0.40–0.96). A high-quality diet during pregnancy was associated with a higher newborn size and a reduced risk of LBW and SGA in this group of pregnant Mexican women.

Download Full-text