scholarly journals Changes in salivary oxytocin levels and bonding disorder in women from late pregnancy to early postpartum: A pilot study

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0221821 ◽  
Author(s):  
Eri Shishido ◽  
Takuya Shuo ◽  
Kaori Takahata ◽  
Shigeko Horiuchi
Keyword(s):  
Pilot Study ◽  
Late Pregnancy ◽  
Early Postpartum

747 Suicidal Ideation Associated with Cognitive Hyperarousal, Rumination and Insomnia in Depressed Perinatal Women

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A291-A292
Author(s):  
Lily Arnett ◽  
David Kalmbach ◽  
Brian Ahmedani ◽  
Bizu Gelaye ◽  
Christopher Drake ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Cognitive Activity ◽  
Late Pregnancy ◽  
Future Research ◽  
Blood Institute ◽  
Cognitive Arousal ◽  
Early Postpartum ◽  
National Heart Lung ◽  
Perseverative Thinking ◽  
Perinatal Women

Abstract Introduction This prospective study explored associations among clinical insomnia, nocturnal cognitive hyperarousal, and nocturnal perinatal-focused rumination with suicidal ideation (SI) in perinatal women with mild-to-moderate depression. Methods From late pregnancy through early postpartum, 39 women with depression completed 17 weekly surveys assessing insomnia, depression, suicidal ideation, perceived stress, and three cognitive arousal indices. Results Women with nocturnal cognitive hyperarousal at baseline, relative to those with low nocturnal cognitive arousal, were at greater risk for developing new onset SI in late pregnancy or early postpartum (33% vs 1%). Moreover, nocturnal perinatal-focused rumination was independently associated with SI. SI-risk was highest when women reported clinical insomnia combined with nocturnal cognitive hyperarousal (OR=5.66, p=.037) or perinatal-focused rumination (OR=11.63, p=.018). Daytime perseverative thinking was not uniquely associated with SI. Conclusion Cognitive hyperarousal and perinatal-focused rumination at night are uniquely associated with SI among perinatal women with depression. Moreover, insomnia augments the suicidogenicity of nighttime cognitive activity. Future research should determine whether alleviating nocturnal cognitive arousal, pregnancy- and fetal/infant-related concerns, and insomnia with psychotherapy reduces SI for women with perinatal depression. Support (if any) This study was funded by the American Academy of Sleep Medicine (198-FP-18, PI: Kalmbach). Dr. Cheng’s effort was supported by the National Heart, Lung, and Blood Institute (K23-HL13866, PI: Cheng).

Hemostatic profile during late pregnancy and early postpartum period in mares

2014 ◽  
Vol 81 (4) ◽  
pp. 639-643 ◽  
Author(s):  
M. Bazzano ◽  
C. Giannetto ◽  
F. Fazio ◽  
S. Marafioti ◽  
E. Giudice ◽  
...  
Keyword(s):  
Postpartum Period ◽  
Late Pregnancy ◽  
Early Postpartum Period ◽  
Early Postpartum

scholarly journals Secretion of inhibin A and inhibin B throughout pregnancy and the early postpartum period in chimpanzees

2001 ◽  
Vol 168 (2) ◽  
pp. 257-262 ◽  
Author(s):  
M Kondo ◽  
M Kondo ◽  
T Udono ◽  
WZ Jin ◽  
WZ Jin ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Postpartum Period ◽  
Plasma Concentrations ◽  
Late Pregnancy ◽  
Inhibin B ◽  
Enzyme Linked Immunosorbent Assay ◽  
Inhibin A ◽  
Early Postpartum Period ◽  
Early Postpartum ◽  
Normal Menstrual Cycle

Plasma concentrations of inhibin A and inhibin B during pregnancy and early lactation in chimpanzees were determined by enzyme-linked immunosorbent assay (ELISA). Plasma samples were taken from five pregnant chimpanzees at 6-9, 10, 20 and 25 weeks of pregnancy, and following parturition. Throughout pregnancy and the early postpartum period, circulating inhibin A and inhibin B concentrations remained low, at similar levels to those during the normal menstrual cycle in chimpanzees. Concentrations of inhibin A in the placental homogenate were high enough to be measured by the ELISA and by bioassay, whereas circulating inhibin bioactivities in late pregnancy were too low to be measured. Plasma concentrations of FSH remained low with no significant changes throughout pregnancy and the postpartum period. Plasma concentrations of oestradiol-17beta and progesterone at 25 weeks of pregnancy were much higher than normal menstrual cycle levels. It was concluded that in chimpanzees the levels of circulating inhibin A and inhibin B remained low throughout pregnancy and the early postpartum period, and that the concentrations of bioactive dimeric inhibin did not increase towards the end of pregnancy. The suppression of circulating FSH levels during pregnancy is suggested to be controlled by steroid hormones that increased significantly in late pregnancy, and the present findings further suggest that the secretory pattern and role of inhibin during pregnancy in chimpanzees may be different from that in human and other primates.

Adverse Psychological Impact of Operative Obstetric Interventions: A Prospective Longitudinal Study

1997 ◽  
Vol 31 (5) ◽  
pp. 728-738 ◽  
Author(s):  
Jane Fisher ◽  
Jill Astbury ◽  
Anthony Smith
Keyword(s):  
Longitudinal Study ◽  
Mode Of Delivery ◽  
Psychological Impact ◽  
Late Pregnancy ◽  
Self Esteem ◽  
Structured Interviews ◽  
Prospective Longitudinal Study ◽  
Early Postpartum ◽  
Vaginal Deliveries ◽  
Prospective Longitudinal

Objective: This paper reports the findings of a prospective longitudinal study of 272 nulliparous pregnant women, which investigated as one of its objectives the psychological sequelae of obstetric procedures. Method: Participants completed structured interviews and standardised, published psychometric questionnaires, including the Rosenberg Self-Esteem Scale and the Profile of Mood States late in pregnancy and again early in the postpartum period. Results: Little evidence was found to support the notion that the total number of obstetric interventions was linked to a deterioration in postpartum mood. Significant adverse psychological effects were associated with the mode of delivery. Those women who had spontaneous vaginal deliveries were most likely to experience a marked improvement in mood and an elevation in self-esteem across the late pregnancy to early postpartum interval. In contrast, women who had Caesarean deliveries were significantly more likely to experience a deterioration in mood and a diminution in self-esteem. The group who experienced instrumental intervention in vaginal deliveries fell midway between the other two groups, reporting neither an improvement nor a deterioration in mood and self-esteem. Conclusions: The findings of this study suggest that operative intervention in first childbirth carries significant psychological risks rendering those who experience these procedures vulnerable to a grief reaction or to posttraumatic distress and depression.

scholarly journals Do Maternal Quality of Life and Breastfeeding Difficulties Influence the Continuation of Exclusive Breastfeeding?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Forough Mortazavi ◽  
Seyed Abbas Mousavi ◽  
Reza Chaman ◽  
Ahmad Khosravi
Keyword(s):  
Quality Of Life ◽  
Exclusive Breastfeeding ◽  
Late Pregnancy ◽  
Life Questionnaire ◽  
Third Trimester ◽  
Early Postpartum ◽  
Maternal Quality Of Life ◽  
Postpartum Mothers ◽  
Maternal Quality

Objectives.This study was conducted to determine whether maternal quality of life (QOL) and breastfeeding difficulties influence the continuation of exclusive breastfeeding (EBF).Methods.In a survey, 358 consecutive pregnant women filled out a quality of life questionnaire in the third trimester of pregnancy and the breastfeeding experience scale at 4 weeks postpartum. We assessed breastfeeding practices every month up to 6 months postpartum.Results.Only 11.8% of women continued EBF at six months. Mothers who continued EBF at 2 and 4 months postpartum had better QOL in late pregnancy than mothers who discontinued it (P<0.05). There were no significant differences between the two groups in QOL scores at 6 months postpartum. Mothers who continued EBF at 2 months postpartum experienced less breastfeeding difficultties during one month postpartum than mothers who discontinued it (P<0.05).Conclusion.In attempts to promote EBF, mothers with poor QOL or breastfeeding difficulties in early postpartum should be identified and helped.

scholarly journals Megakaryocytopoiesis and platelet production are stimulated during late pregnancy and early postpartum in the rat

Blood ◽  
1992 ◽  
Vol 79 (7) ◽  
pp. 1672-1678
Author(s):  
CW Jackson ◽  
SA Steward ◽  
RA Ashmun ◽  
TP McDonald
Keyword(s):  
Platelet Count ◽  
Dna Content ◽  
Late Pregnancy ◽  
Late Gestation ◽  
Platelet Volume ◽  
Pregnant Rats ◽  
Platelet Production ◽  
Platelet Counts ◽  
Platelet Survival ◽  
Early Postpartum

Platelet count during uncomplicated pregnancy shows considerable patient variation. To gain a better understanding of thrombocytopoiesis during pregnancy, megakaryocytes and platelets were examined during gestation and the early postpartum period, using as a model the rat. Platelet counts and megakaryocyte concentrations and DNA content distributions of timed-pregnant rats were examined at intervals from day 10 of gestation through parturition on day 22 and days 1 through 7 postpartum. Platelet survival was studied in late gestation and the early postpartum. Platelet volume was measured on gestation day 21. Platelet counts were moderately increased on gestation days 17 and 19 through 22, and on days 2 to 3 postpartum. However, the actual rate of platelet production was much higher than the platelet count suggests because the blood volume increased in late gestation to 1.5 times the nonpregnant level. Mean platelet volume and platelet volume distribution width of day 21 gestation rats were not significantly altered. Platelet survival in pregnant rats was not significantly different from that in nonpregnant females. In contrast, megakaryocyte concentration was significantly increased on gestation days 12, 17, and 19 through 21, and 2 to 3 days postpartum. In addition, in late gestation, megakaryocyte DNA content distributions displayed a marked increase in the proportion of high ploidy cells, which peaked 1 day before parturition. At that time, the proportions of 32N (43%) and 64N cells (3%) were, respectively, three and four times nonpregnant values. In contrast to megakaryocyte concentration, megakaryocyte DNA content distributions had returned to the nonpregnant pattern by day 1 postpartum. The changes in megakaryocyte DNA content distribution were accompanied by changes in megakaryocyte size. These data indicate that thrombopoiesis is substantially increased during late pregnancy, and that this increase is accomplished through an increase in megakaryocyte DNA content and size, as well as megakaryocyte number. The more rapid return of megakaryocyte DNA content than of megakaryocyte concentration to nonpregnant levels postpartum suggests that pregnancy-associated hormonal changes which produce an increase in megakaryocyte DNA content and size differ from those which cause an increase in megakaryocyte number.

scholarly journals Megakaryocytopoiesis and platelet production are stimulated during late pregnancy and early postpartum in the rat

Blood ◽  
1992 ◽  
Vol 79 (7) ◽  
pp. 1672-1678 ◽  
Author(s):  
CW Jackson ◽  
SA Steward ◽  
RA Ashmun ◽  
TP McDonald
Keyword(s):  
Platelet Count ◽  
Dna Content ◽  
Late Pregnancy ◽  
Late Gestation ◽  
Platelet Volume ◽  
Pregnant Rats ◽  
Platelet Production ◽  
Platelet Counts ◽  
Platelet Survival ◽  
Early Postpartum

Abstract Platelet count during uncomplicated pregnancy shows considerable patient variation. To gain a better understanding of thrombocytopoiesis during pregnancy, megakaryocytes and platelets were examined during gestation and the early postpartum period, using as a model the rat. Platelet counts and megakaryocyte concentrations and DNA content distributions of timed-pregnant rats were examined at intervals from day 10 of gestation through parturition on day 22 and days 1 through 7 postpartum. Platelet survival was studied in late gestation and the early postpartum. Platelet volume was measured on gestation day 21. Platelet counts were moderately increased on gestation days 17 and 19 through 22, and on days 2 to 3 postpartum. However, the actual rate of platelet production was much higher than the platelet count suggests because the blood volume increased in late gestation to 1.5 times the nonpregnant level. Mean platelet volume and platelet volume distribution width of day 21 gestation rats were not significantly altered. Platelet survival in pregnant rats was not significantly different from that in nonpregnant females. In contrast, megakaryocyte concentration was significantly increased on gestation days 12, 17, and 19 through 21, and 2 to 3 days postpartum. In addition, in late gestation, megakaryocyte DNA content distributions displayed a marked increase in the proportion of high ploidy cells, which peaked 1 day before parturition. At that time, the proportions of 32N (43%) and 64N cells (3%) were, respectively, three and four times nonpregnant values. In contrast to megakaryocyte concentration, megakaryocyte DNA content distributions had returned to the nonpregnant pattern by day 1 postpartum. The changes in megakaryocyte DNA content distribution were accompanied by changes in megakaryocyte size. These data indicate that thrombopoiesis is substantially increased during late pregnancy, and that this increase is accomplished through an increase in megakaryocyte DNA content and size, as well as megakaryocyte number. The more rapid return of megakaryocyte DNA content than of megakaryocyte concentration to nonpregnant levels postpartum suggests that pregnancy-associated hormonal changes which produce an increase in megakaryocyte DNA content and size differ from those which cause an increase in megakaryocyte number.

scholarly journals Peripartum cardiomyopathy

BMJ ◽  
2019 ◽  
pp. k5287 ◽  
Author(s):  
Michael C Honigberg ◽  
Michael M Givertz
Keyword(s):  
Systolic Function ◽  
Systolic Dysfunction ◽  
Specific Treatment ◽  
Late Pregnancy ◽  
Peripartum Cardiomyopathy ◽  
Future Research ◽  
Multiple Gestation ◽  
Reduced Ejection Fraction ◽  
Early Postpartum ◽  
Future Research Directions

AbstractPeripartum cardiomyopathy (PPCM) is a rare, often dilated, cardiomyopathy with systolic dysfunction that presents in late pregnancy or, more commonly, the early postpartum period. Although the condition is prevalent worldwide, women with black ancestry seem to be at greatest risk, and the condition has a particularly high incidence in Nigeria and Haiti. Other risk factors include pre-eclampsia, advanced maternal age, and multiple gestation pregnancy. Although the complete pathophysiology of peripartum cardiomyopathy remains unclear, research over the past decade suggests the importance of vasculo-hormonal pathways in women with underlying susceptibility. At least some women with the condition harbor an underlying sarcomere gene mutation. More than half of affected women recover systolic function, although some are left with a chronic cardiomyopathy, and a minority requires mechanical support or cardiac transplantation (or both). Other potential complications include thromboembolism and arrhythmia. Currently, management entails standard treatments for heart failure with reduced ejection fraction, with attention to minimizing potential adverse effects on the fetus in women who are still pregnant. Bromocriptine is one potential disease specific treatment under investigation. In this review, we summarize the current literature on peripartum cardiomyopathy, as well as gaps in the understanding of this condition and future research directions.

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