scholarly journals The incidence of HIV and associated risk factors among pregnant women in Kabarole District, Uganda

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234174
Author(s):  
Hannah Schumann ◽  
Kenyonyozi Rubagumya ◽  
John Rubaihayo ◽  
Gundel Harms ◽  
Rhoda K. Wanyenze ◽  
...  
2020 ◽  
pp. sextrans-2020-054631
Author(s):  
Dorothy Chiwoniso Nyemba ◽  
Andrew Medina-Marino ◽  
Remco P H Peters ◽  
Jeffrey D Klausner ◽  
Phuti Ngwepe ◽  
...  

ObjectiveSTIs during pregnancy increase adverse pregnancy and birth outcomes and may increase HIV risk. STI syndromic management is standard of care in South Africa. Our study evaluated the prevalence and incidence of STIs in pregnant women and the associated risk factors.MethodsWe combined data from two prospective observational studies of pregnant women enrolled while attending their first antenatal clinic (ANC) visit in Tshwane District and Cape Town. Women ≥18 years were tested at first ANC visit and at their first postpartum visit for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis using Xpert assays (Cepheid, USA). We evaluated the prevalence and incidence of STI and the associated risk factors using multivariable regression models.ResultsWe enrolled 669 pregnant women, 64% (n=427) from Tshwane District and 36% (n=242) from Cape Town; 80% (n=534) were women living with HIV (WLHIV) and 20% (n=135) without HIV. At enrolment, 37% (n=250) were diagnosed with at least one STI, of which 76% (n=190) were asymptomatic. STI prevalence was 40% (n=213) in WLHIV and 27% (n=37) in women without HIV (p=0.01). Baseline STI infection was associated with younger age (OR=0.95 per year, 95% CI 0.92 to 0.98), higher gestational age (adjusted OR (aOR)=1.03 per week, 95% CI 1.00 to 1.05), single relationship status (aOR=1.53, 95% CI 1.09 to 2.15) and HIV status (aOR=1.86, 95% CI 1.17 to 2.95). Of 419 participants with no STI at baseline, 21 had an incident STI during follow-up, with a mean follow-up time of 140 days. The incidence rate of STI during pregnancy and early post partum was 15 infections per 100 women-years (95% CI 9 to 23). Younger age was associated with STI incidence.ConclusionOur study shows high prevalence and incidence of STIs in pregnancy, especially in WLHIV, demonstrating the need for STI screening in ANC to prevent adverse pregnancy and birth outcomes. Most STI cases were asymptomatic and would have gone untreated with syndromic management. Aetiological STI screening is urgently needed to reduce the burden of STIs in pregnancy.


2019 ◽  
Vol 45 (1) ◽  
pp. 76-82
Author(s):  
Beril Gürlek ◽  
Ülkü Mete Ural ◽  
Sibel Tuğcugil ◽  
Medeni Arpa ◽  
Özgür Önal

Abstract Objective Striae gravidarum (SG) is the most common dermatological defect in pregnancy leading to cosmetic anxiety with unknown etiopathogenesis. The aim of the study was to analyze the relation between serum elastin levels and striae and identify possible independent associated risk factors. Materials and methods This was a prospective observational study. In total, 138 primipara pregnant women were examined before delivery. Participants were separated into two groups according to the presence of SG. Striae assessment was performed according to Davey score. Before the active phase of labor patients were physically examined and blood samples were collected. Personal characteristics, features of birth, skin findings and serum elastin levels were compared between groups. Results Term pregnant women with SG had significantly higher serum elastin levels than those without SG (99.46 ± 32.92 vs. 88.36 ± 19.12, respectively; p = 0.018). Conclusions Serum elastin levels were increased in women with SG. However, the newly synthesized elastin may not be functional as it is thin and disorganized. Therefore, increased elastin production may not prevent the formation of striae. This finding may provide an impetus to explore the pathomechanisms of striae. Further controlled trials are warranted to determine the clinical significance of serum elastin levels in the formation of SG.


Author(s):  
S Lestari ◽  
I I Fujiati ◽  
D Keumalasari ◽  
M Daulay ◽  
S J Martina ◽  
...  

2013 ◽  
Vol 10 (1) ◽  
pp. 47-54
Author(s):  
A.M. Ashshi ◽  
H. S. Faidah ◽  
A.A. Saati ◽  
G.A.A. El-Ella ◽  
Ahmad K. Al-Ghamdi ◽  
...  

2017 ◽  
Vol 41 (S1) ◽  
pp. S419-S419
Author(s):  
G. Chorwe-Sungani ◽  
J. Chipps

IntroductionDepression is one of major health problems affecting pregnant women in low resource settings. It can lead to poor uptake of antenatal services. Data about prevalence of antenatal depression and associated risk factors remain scanty in Malawi. The study settings were eight selected antenatal clinics in Blantyre district, Malawi. The aim of this study was to assess prevalence of antenatal depression and associated risk factors among pregnant women attending antenatal clinics in Blantyre district, Malawi.MethodsThis was a quantitative study which used a random sample of 97 pregnant women. Ethical approval was granted by relevant bodies. Descriptive and inferential statistics were used to analyse data.ResultsPrevalence of antenatal depression in Blantyre district was 25.8% (n = 25). Risk factors associated with antenatal depression included: “being distressed by anxiety or depression for more than two weeks during this pregnancy”; “feeling that pregnancy has been a positive experience”; “having a history of feeling miserable or depressed for two weeks or more before this pregnancy”; “relationship with partner is an emotionally supportive one”; “experiencing major stresses, changes or losses in the course of this pregnancy”; “having history of physical abuse when growing up”, and “having concerns about being or becoming a mother”.ConclusionThis study has shown that antenatal depression is prevalent in Malawi. It suggests that psychosocial interventions targeting pregnant women may be necessary to reduce antenatal depression and associated risk factors. However, further research regarding ways for assisting pregnant women to build and strengthen their psychosocial support structures is needed.Disclosure of interestThe authors have not supplied their declaration of competing interest.


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