Dietary quality score is positively associated with serum adiponectin level in Indonesian preschool-age children living in the urban area of Jakarta

An unhealthy diet during childhood directly impacts the risk of developing noncommunicable diseases (NCDs) later on in life. However, well-documented information on this issue is lacking. We investigated the dietary quality of young Indonesian children and assessed the relationship to serum adiponectin levels as an early marker of NCDs. Eighty-five (44 girls and 41 boys) Indonesian preschool-age children in East Jakarta were included in this study. Dietary intake data were gathered by collecting repeated 24-hour recalls for one weekday and one day during the weekend, which were then further converted into participants’ Healthy Eating Index (HEI) 2015 scores. Meanwhile, an enzyme-linked immunosorbent assay was performed to determine the serum adiponectin level. A multiple regression analysis was performed to assess the association between the HEI 2015 score and serum adiponectin, adjusting for potential confounders. The mean HEI 2015 score was 33.2 ± 8.3 points, which was far below the recommended score of ≥ 80 points, while the mean serum adiponectin was 10.3 ± 4.1 μg/mL. Multiple linear regression testing showed that a one-point increase in the HEI 2015 score was significantly associated with an increase in the serum adiponectin level by 0.115 μg/mL after adjusting for exclusive breastfeeding history (β = 0.115; 95% CI = 0.010–0.221; p = 0.032). In conclusion, better adherence of young children to a healthy diet has a positive association with their adiponectin level. This result suggests that strengthening children’s dietary quality from an early age by involving all parties in the children’s environment (e.g., parents, teachers at school, policymakers) may help to reduce the risk of NCDs later on in childhood and during adult life.

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Association between serum adiponectin levels with gestational diabetes mellitus and postpartum metabolic syndrome:A case control study

Endocrine Regulations ◽

10.2478/enr-2020-0014 ◽

2020 ◽

Vol 54 (2) ◽

pp. 119-125

Author(s):

Zoleikha Atarod ◽

Mostafa Ebrahemian ◽

Hamed Jafarpour ◽

Mahta Moraghebi ◽

Elham Sharafkhani

Keyword(s):

Metabolic Syndrome ◽

Gestational Diabetes ◽

Pregnant Women ◽

Case Control Study ◽

Adiponectin Level ◽

Diabetic Group ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

The Mean ◽

Control Study

AbstractObjective. Pregnancy can cause diabetic conditions and gestational diabetes is the most common metabolic disorder of the era. Scientific evidence suggests that obesity increases the incidence and severity of gestational diabetes. Adipokines are proteins secreted from adipose tissue in response to extracellular stimuli and altered metabolism. These hormones are involved in regulating the energy balance, lipid metabolism, and insulin sensitivity. One of the types of adipokines is called adiponectin, which has anti-diabetic, anti-inflammatory, and anti-atherogenic effects. Accordingly, this study is aimed to investigate the correlation between the serum adiponectin level with the gestational diabetes and the postpartum metabolic syndrome.Methods. This case-control study was carried out on 37 pregnant women (in Sari, Iran) with gestational diabetes and 37 non-diabetic pregnant women who were matched regarding age and body mass index (BMI). Serum adiponectin and glucose levels were measured. Finally, six weeks after termination of pregnancy, women in both groups were evaluated for metabolic syndrome. All statistical analyses of this study were performed using IBM SPSS software version 21 and, in all cases, the two-way p value less than 0.05 was considered statistically significant.Results. The mean age of pregnant women was 28.46±4.11 years in the non-diabetic group and 30.03±4.71 in the diabetic group. There was no statistically significant difference found between the mean age (p=0.123) and BMI (p=0.727) in two groups. Serum adiponectin levels in the diabetic group (5.51±3.15 µg/ml) were significantly lower than in the non-diabetic group (8.35±4.54 µg/ml) (p=0.003). In the diabetic group, serum adiponectin level did not correlate with the maternal age, maternal BMI, and postpartum metabolic syndrome (p>0.005).Conclusions. The results of the present study indicate a correlation of low adiponectin concentrations with gestational diabetes, but this association with postpartum metabolic syndrome is uncertain. However, to elucidate the mechanism of adiponectin in predicting gestational diabetes and postpartum metabolic syndrome further studies are required.

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Serum Adiponectin Level in Diabetic Patients with and withoutHelicobacter pyloriInfection: Is There Any Difference?

The Scientific World JOURNAL ◽

10.1155/2014/402685 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Jamshid Vafaeimanesh ◽

Akram Heidari ◽

Marzieh Effatpanah ◽

Mahmoud Parham

Keyword(s):

Insulin Resistance ◽

Adiponectin Level ◽

Serum Levels ◽

Serum Adiponectin ◽

Diabetic Patients ◽

Serum Adiponectin Level ◽

Igg Antibody ◽

Cross Sectional ◽

Significant Difference ◽

The Mean

Background.Increased insulin resistance is an extragastrointestinal manifestation ofHelicobacter pylori(HP) infection. HP changes the level of inflammatory markers and cytokines and changes the adipocyte function by altering the adiponectin level. Given the high prevalence of HP and diabetes in our society, we evaluated the association between HP and serum adiponectin level. In this cross-sectional study, 211 diabetic patients under treatment other than insulin were studied. These patients were divided into two groups of HP+ and HP− based on their HP IgG antibody serology and their blood adiponectin levels were measured. Data was analyzed using independentt-test, Chi-square test, and Fisher’s exact test.Results.Seventy-two patients with an average age of51.56±8.34years were HP− and 139 patients with an average age of50.35±9.01years were HP+. The mean serum adiponectin level in HP− and HP+ groups was4.54±5.43and5.64±3.88 ng/mL, respectively. Insulin resistance degree was significantly higher in HP+ group (HP− =3.160±3.327versus HP+ =4.484±3.781,P=0.013) but no significant difference was found between the mean serum adiponectin level in HP− and HP+ groups (P=0.140).Conclusions.Although the insulin resistance degree was significantly higher in HP+ diabetic patients, no significant relationship was found between HP infection and serum levels of adiponectin.

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Type 2 Diabetes Mellitus is Associated with Lower Serum Adiponectin Level in Bangladeshi Population

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v6i1.24978 ◽

2015 ◽

Vol 6 (1) ◽

pp. 10-13

Author(s):

Sohely Nazneen Eva ◽

Rahelee Zinnat ◽

Golam Morshed Molla ◽

Muneera Zahir ◽

Fatema Akter ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Adiponectin Level ◽

Serum Insulin ◽

Serum Adiponectin ◽

Enzyme Linked Immunosorbent Assay ◽

Serum Adiponectin Level ◽

Lower Serum ◽

Control Subjects

Background: The physiological role of adiponectin is not yet fully clear, but it is now generally accepted that it has a protective role against the development of lifestyle disorders, related to insulin resistance and atherosclerosis. Insulin resistance is one of the basic defects of type 2 diabetes (T2DM) and adiponectin is inversely associated with T2DM. As serum adiponectin level has not yet been investigated in Bangladeshi T2DM subjects,so that the present study has been under taken to find out the association of T2DM with serum adiponectin level in Bangladeshi population.Methodology: In this observational case control study, sixty six (66) T2DM subjects, seventy four (74) healthy control subjects were included. Diabetes was diagnosed and classified as per WHO criteria. Serum Adiponectin was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Serum glucose was measured by glucose-oxidase method; serum insulin was measured by chemiluminescence-based ELISA technique. The insulin secretory capacity (HOMA%B), insulin sensitivity (HOMA%S) & insulin resistance (HOMA IR) were assayed by homeostasis model assessment method.Results: The study subjects were BMI matched. BMI of the Control subjects and T2DM subjects (Mean±SD) were 25.02±3.55 and 25.85±3.62. Age (year) of the Control subjects and T2DM subjects (Mean±SD) were 42.46±9.24 and 48.49±8.09. Median (range) fasting serum insulin in the control and T2DM was 14.68 (1.86-45.92) and 18.09 (4.10-42.78) respectively which was not statistically significant (p=0.214). Median (range) HOMA%B values in the control and T2DM subjects was 160.10(33.40-493.40) and 100.45(17.70-349.30). Median HOMA%B in the T2DM group was significantly lower compared to the control (p=0.0001). Median (range) HOMA%S values in the control and T2DM subjects was 44.20(9.80- 339.40) and 32.80(14.30-154.70) respectively. Median HOMA%S in the T2DM group was significantly lower compared to the control (p=0.036). Median (range) serum adiponectin (?g/ml) of the control and T2DM subjects was 8.70 (0.76-15.96) and 6.19 (1.13-22.37). Serum adiponectin was significantly lower in T2DM compared to the control (p=0.0001).Conclusions: From this study it may be concluded that, T2DM subjects have both insulin secretory defects and insulin resistance and associated with lower serum adiponectin level in Bangladeshi population.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 10-13

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Relationship between serum adiponectin level and non-alcoholic fatty liver diseases

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2008.01201 ◽

2009 ◽

Vol 28 (10) ◽

pp. 1201-1203

Author(s):

Guang-xi SUN ◽

Yue-ju TAN ◽

Chao XU

Keyword(s):

Fatty Liver ◽

Liver Diseases ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Alcoholic Fatty Liver

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Decreased Serum Adiponectin Level Affected Clinical Pathological Characteristics of Patients with Gastric Cancer

Current Proteomics ◽

10.2174/1570164613666161128145508 ◽

2016 ◽

Vol 13 (4) ◽

pp. 305-312

Author(s):

Song-Guo Li ◽

Yi Gao ◽

Yan Zhang ◽

Xu-Shi Xie ◽

Hui Lv ◽

...

Keyword(s):

Gastric Cancer ◽

Adiponectin Level ◽

Serum Adiponectin ◽

Serum Adiponectin Level ◽

Pathological Characteristics

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Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

Journal of Egyptian Public Health Association ◽

10.1186/s42506-020-00060-z ◽

2020 ◽

Vol 95 (1) ◽

Author(s):

Walaa H. Foula ◽

Rana H. Emara ◽

Mona K. Eldeeb ◽

Samiha A. Mokhtar ◽

Fikrat A. El-Sahn

Keyword(s):

Public Health ◽

Insulin Resistance ◽

Weight Loss ◽

Adiponectin Level ◽

Normal Weight ◽

Weight Loss Program ◽

Serum Adiponectin ◽

Health Clinic ◽

Serum Adiponectin Level ◽

Health Crisis

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

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