scholarly journals The way of the pharmaceutical ingredients to the finished pharmaceutical form

2018 ◽  
Vol 12 (2) ◽  
pp. 24-31
Author(s):  
Bence Rafael ◽  
Nóra Kuruczleki ◽  
József Gál
Keyword(s):  
Material Handling ◽  
Raw Materials ◽  
Good Manufacturing Practice ◽  
Raw Material ◽  
No Production ◽  
Pharmaceutical Ingredients ◽  
Correct Execution ◽  
Pharmaceutical Form ◽  
Pharmaceutical Manufacture ◽  
Logistics Activity

The modern pharmaceutical industry is a strictly controlled area. Both national and international rules apply, but none of these deals with logistical issues arising from the manufacture of the product. Following the path of a drug, it is possible to get acquainted with the problems that arise and their solution. The drug is much more than a common product. The drug is a product of confidence, which is provided with information. It defines its quality as well, to comply with the relevant directives and standards in the manufacture of, and that the enclosed information is sent to the user. This requires the manufacturer, the distributor and the user to comply with it. There is no production without material handling, but GMP (Good Manufacturing Practice) does not yet have a chapter on logistics. References to handling raw materials and finished products can be found in the corresponding GMP chapters, the responsibility of the correct execution are borne by the manufacturer. In this case, the effect of the common sense prevails exponentially, keep the medicine in mind and it has to be done, that no loss, no quality deterioration is not caused by the transport, handling of such loads, storage. It is typical that the raw material and the finished product are going through the entire site during the pharmaceutical manufacture. Starting from the warehouse, it runs through the manufacturing facilities, on the packaging, and some units go to the lab, so that eventually, in medicine form returns to the warehouse, from where it goes further in the supply chain through the pharmacies to the patients. In our study we examine the logistics activity and problems of a small pharmaceutical company and tasks to be solved presented in the light of the theory.

Computer Vision-Based Non-Magnetic Object Detection on Moving Conveyors in Steel Industry through Differential Techniques and Performance Evaluation

2014 ◽  
pp. 247-261
Author(s):  
K. C. Manjunatha ◽  
H. S. Mohana ◽  
P. A. Vijaya
Keyword(s):  
Object Detection ◽  
Steel Industry ◽  
Material Handling ◽  
Raw Materials ◽  
Industrial Applications ◽  
Raw Material ◽  
Smart Control ◽  
Image Pixels ◽  
And Performance ◽  
Video Input

Intelligent process control technology in various manufacturing industries is important. Vision-based non-magnetic object detection on moving conveyor in the steel industry will play a vital role for intelligent processes and raw material handling. This chapter presents an approach for a vision-based system that performs the detection of non-magnetic objects on raw material moving conveyor in a secondary steel-making industry. At single camera level, a vision-based differential algorithm is applied to recognize an object. Image pixels-based differential techniques, optical flow, and motion-based segmentations are used for traffic parameters extraction; the proposed approach extends those futures into industrial applications. The authors implement a smart control system, since they can save the energy and control unnecessary breakdowns in a robust manner. The technique developed for non-magnetic object detection has a single static background. Establishing background and background subtraction from continuous video input frames forms the basis. Detection of non-magnetic materials, which are moving with raw materials, and taking immediate action at the same stage as the material handling system will avoid the breakdowns or power wastage. The authors achieve accuracy up to 95% with the computational time of not more than 1.5 seconds for complete system execution.

Computer Vision-Based Non-Magnetic Object Detection on Moving Conveyors in Steel Industry Through Differential Techniques and Performance Evaluation

2018 ◽  
pp. 1820-1837
Author(s):  
K. C. Manjunatha ◽  
H. S. Mohana ◽  
P. A. Vijaya
Keyword(s):  
Object Detection ◽  
Steel Industry ◽  
Material Handling ◽  
Raw Materials ◽  
Industrial Applications ◽  
Raw Material ◽  
Smart Control ◽  
Image Pixels ◽  
And Performance ◽  
Video Input

Intelligent process control technology in various manufacturing industries is important. Vision-based non-magnetic object detection on moving conveyor in the steel industry will play a vital role for intelligent processes and raw material handling. This chapter presents an approach for a vision-based system that performs the detection of non-magnetic objects on raw material moving conveyor in a secondary steel-making industry. At single camera level, a vision-based differential algorithm is applied to recognize an object. Image pixels-based differential techniques, optical flow, and motion-based segmentations are used for traffic parameters extraction; the proposed approach extends those futures into industrial applications. The authors implement a smart control system, since they can save the energy and control unnecessary breakdowns in a robust manner. The technique developed for non-magnetic object detection has a single static background. Establishing background and background subtraction from continuous video input frames forms the basis. Detection of non-magnetic materials, which are moving with raw materials, and taking immediate action at the same stage as the material handling system will avoid the breakdowns or power wastage. The authors achieve accuracy up to 95% with the computational time of not more than 1.5 seconds for complete system execution.

Machine Vision Based Non-Magnetic Object Detection and Removal on Moving Conveyors in Steel Industry through Differential Techniques

2012 ◽  
Vol 2 (3) ◽  
pp. 59-70
Author(s):  
K. C. Manjunatha ◽  
H. S. Mohana ◽  
P. A. Vijaya
Keyword(s):  
Object Detection ◽  
Steel Industry ◽  
Material Handling ◽  
Raw Materials ◽  
Industrial Applications ◽  
Vital Role ◽  
Raw Material ◽  
Computational Time ◽  
Video Input ◽  
Intelligent Process

Intelligent process control technology in various manufacturing industries is important. Vision based non-magnetic object detection on moving conveyor in the steel industry will play a vital role for intelligent process and raw material handling. This paper presents an approach for a vision based system which performs the detection of non-magnetic objects on raw material moving conveyor in a secondary steel making industry. At single camera level, a vision based differential algorithm is applied to recognize an object. Image pixels based differential techniques; optical flow and motion based segmentations are used for traffic parameters extraction, the proposed approach extends those futures into industrial applications. The authors can implement smart control system, since they can save the energy and control unnecessary breakdowns in a robust manner. The technique developed for non-magnetic object detection is having single static background. Establishing background and background subtraction from continuous video input frames forms the basis. Detection of non-magnetic materials which are moving with raw materials and taking immediate action at the same stage as material handling system will avoid the breakdowns or power wastage. The authors achieve accuracy up to 95% with the computational time of not more than 1.5 seconds for complete system execution.

scholarly journals Analisa Perbaikan Tata Letak Penempatan Bahan Bakudi Area Gudang Penyimpanan

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Beni Harma ◽  
Helga Ika Sudra
Keyword(s):  
Material Handling ◽  
Raw Materials ◽  
Layout Design ◽  
Raw Material ◽  
Storage Method ◽  
Handling Cost ◽  
Material Handling Cost ◽  
Method Class ◽  
Material Handling Costs ◽  
Initial Layout

Activities carried out in the warehouse include material handling. Generally, the costs involved in material handling activities are quite large. One method that can be used in managing the layout of raw material placement in raw material warehouses is the class based storage method. Class based storage is a policy that divides storage into three classes A, B and C based on Pareto law. Pareto law is the principle of putting items that have the greatest accessibility near the Input-Output point. The distance of material handling to the initial layout raw material warehouse is 3,513,337 meters / month and the material handling costs are Rp. 134,534,765 / month, because the initial layout of the raw material warehouse still uses random storage and the raw materials that are widely used are not placed close to the intake floor of the production, so that the distance to get raw materials for production needs is far. After the re-layout design was made based on the placement of raw materials in the class based storage method, the material handling transfer distance was reduced to 2,644,459 meters / month and the material handling cost for the repair raw material warehouse layout fell to Rp. 99,949,520 / month. In other words, there was a decrease in material handling distance by 25% and material handling costs by 26%.

scholarly journals Analisis Persediaan Material Jenis Botol Menggunakan Metode Economic Order Quantity (EOQ)

2018 ◽  
Vol 2 (3) ◽  
Author(s):  
Diana Khairani Sofyan ◽  
Sri Meutia
Keyword(s):  
Production Process ◽  
Raw Materials ◽  
Raw Material ◽  
Economic Order Quantity ◽  
Economic Order ◽  
No Production ◽  
Order Quantity ◽  
Safety Stock ◽  
Reorder Point ◽  
Production Department

Inventories have an important role in business operations. In fact, problems in controlling inventory is the most important thing we've come across in any company. Inventories have enormous influence for a smooth production process. PT Ima Montaz Sejahtera (PT IMS) is one of the companies engaged in the manufacture beverage Bottled Drinking Water. PT IMS is distributes its products throughout NAD. The main raw material used was water purchased from PT. PIM. The company ordered a bottle of the product medium, glass cup on products, lids, labels and cartons were booked from Medan which become relationship with them. But in reality, the bottle material is not always available because raw material ordering is not efficient, thus inhibiting the production process and increase the use of cost. In the years 2015-2016 from September to August happens 18 times a monthly ordered are ordering frequency from 1 to 2 orders with the amount of raw materials that different every month. Based on preliminary research shows that ordered data in September, October, November, December, January and February each performed two times ordered, while March, April, May, June, July and August each time is 1 ordered. Additionally in 2015 there were eight times the idle time in the production department Bottleline due to the absence of Safety Stock thus automatically no production activities in the production department Bottleline to incur losses for the company. Based on this it needs to be analyzed at the company's inventory control. The results showed that the frequency of the purchasing of raw materials by using the EOQ method which is 3 times the total cost of supply of raw materials companies amounted to Rp12,041,404. Where the company must hold safety stock to expedite the process of production by the number of 407.685 bottles, with reorder point of 362.961 bottles.Keywords: Inventory, Economic Order Quantity (EOQ), Reorder Point, Safety stock

scholarly journals In-Depth Understanding of Granule Compression Behavior under Variable Raw Material and Processing Conditions

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 177
Author(s):  
Tibor Casian ◽  
Sonia Iurian ◽  
Alexandru Gâvan ◽  
Alina Porfire ◽  
Anca Lucia Pop ◽  
...  
Keyword(s):  
Microcrystalline Cellulose ◽  
Raw Materials ◽  
Binding Capacity ◽  
Raw Material ◽  
Sensitivity Index ◽  
Processing Conditions ◽  
Water Binding ◽  
Pharmaceutical Ingredients ◽  
Compression Properties ◽  
Addition Rate

Tablet manufacturing involves the processing of raw materials through several unit operations. Thus, the mitigation of input-induced variability should also consider the downstream processability of intermediary products. The objective of the present work was to study the effect of variable raw materials and processing conditions on the compression properties of granules containing two active pharmaceutical ingredients (APIs) and microcrystalline cellulose. Differences in compressibility and tabletability of granules were highlighted in function of the initial particle size of the first API, granule polydispersity and fragmentation. Moreover, interactions were underlined with the atomizing pressure. Changing the supplier of the second API was efficiently controlled by adapting the binder addition rate and atomizing pressure during granulation, considering the starting crystal size. By fitting mathematical models on the available compression data, the influence of diluent source on granule compactibility and tabletability was identified. These differences resumed to the ease of compaction, tableting capacity and pressure sensitivity index due to variable water binding capacity of microcrystalline cellulose. Building the design space enabled the identification of suitable API types and the appropriate processing conditions (spray rate, atomizing pressure, compression force) required to ensure the desired tableting performance.

scholarly journals Indian Active Pharmaceutical Ingredient (API) Industry- An overview on Challenges, Opportunities & Regulatory prerequisites

2021 ◽  
Vol 9 (2) ◽  
pp. 66-76
Author(s):  
Shefali Singh ◽  
Harvinder Popli
Keyword(s):  
Raw Materials ◽  
Pharmaceutical Medicine ◽  
Active Pharmaceutical Ingredient ◽  
Point Of View ◽  
Raw Material ◽  
Manufacturing Cost ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Self Sufficiency ◽  
History Of

Active pharmaceutical ingredient is a chemical compound which is most important raw material to formulate a finished pharmaceutical medicine and has a pharmacological effect.  India has a long history of being heavily dependent for these raw materials on China due to one major reason i.e. Low manufacturing cost. But overdependence of APIs imports from China brought various liabilities to India including supply chain disruption and price hikes during pandemic, leading to shortage of various important APIs/KSMs. This COVID 19 widespread has solidly put the center of our country on being “Atma Nirbhar”. And this activity had brought out the strengths, market patterns and opportunities in five divisions counting Healthcare, which are basic from country’s point of view. In view of changing geo-political situation and recalibrated trade arrangement, it is crucial that India become self-reliant within the generation of APIs and KSMs, which is why decreasing the Import reliance for Active pharmaceutical ingredients (APIs) & Key starting materials (KSMs) particularly from china has been focused upon with the assistance of productive linked incentive scheme (PLIS) passed by Department of pharmaceuticals, Government of India to thrive Indian API industry. Hence, this review highlights the current state of Indian API industry, evaluates challenges, opportunities give suggestions for moving forward for self-sufficiency of APIs as well as centers on current regulatory prerequisites for Active pharmaceutical Ingredients.

RHEOLOGICAL PROPERTIES OF CERAMIC MASSES: IMPROVEMENT BY COMPLEX MATERIAL ACTIVATION

2019 ◽  
Vol 16 (3) ◽  
pp. 334-351
Author(s):  
A. S. Mavlyanov ◽  
E. K. Sardarbekova
Keyword(s):  
Rheological Properties ◽  
Raw Materials ◽  
Sensitivity Coefficient ◽  
Raw Material ◽  
Clay Material ◽  
Fibrous Materials ◽  
Chemical Production ◽  
Production Wastes ◽  
Pass Through ◽  
The Masses

Introduction. The objective of the research is to study the effect of the complex activation of the alumina raw material on the rheological properties of the ceramic mass. In addition, the authors investigate solutions for the application of optimal coagulation structures based on loams and ash together with plastic certificates.Materials and methods. The authors used the local forest like reserves of clay loams at the BashKarasu, ash fields of the Bishkek Central Heating Centre (BTEC) and plasticizer (sodium naphthenate obtained from alkaline chemical production wastes) as fibrous materials. Moreover, the authors defined technological properties of raw materials within standard laboratory methodology in accordance with current GOSTs.Results. The researchers tested plastic durability on variously prepared masses for the choice of optimal structures. The paper demonstrated the plastic durability of complexly activated compounds comparing with non-activated and mechanically activated compounds. The sensitivity coefficient increased the amount of clay loams by mechanically and complexly activated, which predetermined the possibility of intensifying the process of drying samples based on complexly activated masses.Discussion and conclusions. However, mechanical activation of clay material reduces the period of relaxation and increases the elasticity coefficient of ceramic masses by 1.8–3.4 times, meanwhile decreases elasticity, viscosity and the conventional power during molding, which generally worsens the molding properties of the masses. Сomplex activation of ash-clay material decreases the period of relaxation and provides an increase in elasticity, plasticity of ceramic masses by 46–47%, reduction in viscosity by 1.5–2 times, conventional power on molding by 37–122% in comparison with MA clay loams. Ceramic masses based on spacecraft alumina raw materials belong to the SMT with improved rheological properties; products based on them pass through the mouthpiece for 5–7 seconds.

ANALYSIS FOR POTENCY AND PRODUCTION OF GRANULE ORGANIC FERTILIZER BASED ON MANURE

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Firman L. Sahwan
Keyword(s):  
Organic Material ◽  
Organic Materials ◽  
Raw Materials ◽  
Organic Fertilizer ◽  
Raw Material ◽  
Cow Manure ◽  
Production Potential ◽  
Natural Organic Material ◽  
Very High

Organic materials that are generally used as raw material for organic fertilizer granules (POG) is a natural organic material that has been degrade, smooth and dry. One of the main raw materials are always used with a very high percentage of usage, is manure. Manure potential in Indonesia is very high, amounting to 113.6 million tons per year, or 64.7 million tons per year to the island of Java. From this amount, it will be generated numbers POG production potential of 17.5 million tons per year (total Indonesia) or 9.9 million tons per year for the island of Java. While the realistic POG production predictions figures made from raw manure is 2.5 million tons annually, a figure that has been unable to meet the number requirement of POG greater than 4 million tons per year. Therefore, in producing POG, it should be to maximize the using of the potential of other organic materials so that the use of manure can be saved. With the use of a small amount of manure (maximum 30% for cow manure), it would be useful also to avoid the production of POG with high Fe content.keywods: organic material, manure, granule organic fertilizer

Nutritional Value Research of Spelt Pasta with Vegetable Additives

Food Industry ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 61-70
Author(s):  
Oliya Fazullina ◽  
Stanislav Smirnov
Keyword(s):  
Dietary Fiber ◽  
Nutritional Value ◽  
Raw Materials ◽  
Health Indicators ◽  
Dietary Treatment ◽  
Raw Material ◽  
Whole Wheat ◽  
Healthy Nutrition ◽  
Physiologically Active Substances ◽  
Simple Carbohydrates

Health indicators of the population depend significantly on the food quality and nutritional value. Simple carbohydrates excess of and lack of protein, dietary fiber, vitamins, minerals, antioxidants and other physiologically active substances increase the risk of socially significant disease progress. The development and production of mass-consumed products with high nutritional and biological value, including affordable non-traditional raw materials use, are promising areas of the food industry development aimed at improving the nutritional status of the population. The article presents the research results on the developed Noodle products recipes from non-traditional raw materials that meet modern healthy nutrition requirements, intended for dietary treatment and dietary prevention of people with overweight / obesity. The research aimed at expanding the range of macaroni products with these characteristics. As the main raw material, a man selected whole-wheat flour – new spelt flour, and as additional raw materials – buckwheat flour, broccoli and celery powders. The researchers found that the introduction of macaroni products from buckwheat spelt, broccoli and celery powders into the recipe had a multidirectional effect, reducing or increasing various indicators of its nutritional value. The changes range did not affect the overall characteristics. The satisfaction degree of the average daily need for food substances and energy when consuming a portion of 100 g for each sample of developed Noodle products allows them to be classified as functional products that are protein and dietary fiber sources, according to the requirements of the TR CU 022/2011.

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