Synthesis of New Class of Functionalized Flavones/Isoxazole
Derivatives-Nitrile oxide 1,3-Dipolar Cycloaddition
A new series of functionalized flavone-isoxazole derivatives have been synthesized from alkyne tethered 3-hydroxy flavone by adopting facile synthetic method, intermolecular nitrile oxide 1,3-dipolar cycloaddition in the presence of eco-friendly sodium hypochloride oxidant under mild reaction conditions. Structures of all the synthesized compounds were established on the basis of 1H NMR, 13C NMR and ESI-mass.
2019 ◽