scholarly journals Blood glucose level during induction phase chemotherapy in childhood acute lymphoblastic leukemia

2020 ◽  
Vol 60 (4) ◽  
pp. 197-2
Author(s):  
Nunki Andria ◽  
Annang Giri Moelyo ◽  
Muhammad Reza
Keyword(s):  
Blood Glucose ◽  
Acute Lymphoblastic Leukemia ◽  
Nutritional Status ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Side Effect ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Remission Status

Background Steroids and L-asparaginase (L-Asp) are agents used in induction phase chemotherapy for childhood acute lymphoblastic leukemia (ALL). Both agents are often reported to have the side effect of hyperglycemia, and native L-Asp is also reported to cause hypoglycemia. In ALL patients, hyperglycemic events during chemotherapy can cause lower 5-year overall and relapse-free survival. Objective To investigate the incidence of abnormal blood glucose level (BG) as the side effect of prednisone and L-Asp during induction phase chemotherapy, its  predisposing factors, and its effect on remission status. Methods This cohort prospective study was conducted in 36 children aged 1-18 years who were newly diagnosed with childhood ALL at Dr. Moewardi Hospital, Surakarta, Central Java. Subjects’ nutritional status consist of wellnourished and undernourishment. Subjects underwent BG monitoring. At the end of induction phase chemotherapy, subjects underwent bone marrow puncture (BMP) evaluation to assess their response to chemotherapy and the effect of abnormal BG on remission status. Results Hypoglycemia, a combination of hypoglycemia and hyperglycemia, hyperglycemia, as well as euglycemia, were experienced by 9, 7, 6, and 14 subjects, respectively. Nutritional status was found to be a significant risk factor for abnormal BG. There was no significant difference in remission status at the end of induction phase chemotherapy between the euglycemic group and abnormal BG groups (P=0.533). Conclusion Abnormal BG during induction phase chemotherapy did not affect remission status at the end of induction phase.  Undernourishment is also found to be a predisposing factor in abnormal BG.

The incidence of hyperglycemia during the induction phase of chemotherapy in patients with acute lymphoblastic leukemia

2019 ◽  
Author(s):  
Ahmad Tamaddoni ◽  
Morteza Alijanpour ◽  
Hassan Mahmoodi ◽  
Beniamin Miladi ◽  
Ali Bijani ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Acute Lymphoblastic Leukemia ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Lymphoblastic Leukemia ◽  
Fasting Blood Glucose ◽  
Induction Phase ◽  
Fasting Blood Glucose Level ◽  
Chi Square ◽  
Cross Sectional

Background: Hyperglycemia is one of the most complications of corticosteroid and asparaginase during induction phase of chemotherapy in children suffering from acute lymphoblastic leukemia (ALL). This study was carried out to evaluate the incidence of hyperglycemia and associated risk factors during chemotherapy induction phase at Amirkola Children's Hospital. Materials and Methods: In this cross-sectional (retrospective) study, 150 children (mean age: 79.16±42.68 months) with ALL were evaluated (2000- 2011). Hyperglycemia was described as random blood glucose level more than 200mg/dl in patients less than 2 years old. In patients older than 2 years, fasting blood glucose level more than 110-125 mg/dl was considered as impaired glucose level and fasting blood glucose level more than 126 mg/dl was defined as diabetes mellitus. The data were analyzed using SPSS (version 18) and running chi square test, pearson Ccorrelation, and logistic regression. P-values less than0.05 was considered statistically significant. Results: Out of 150 children with ALL, 21 (14%) of them had hyperglycemia, but none of them had diabetic ketoacidosis. Hyperglycemia was significantly associated with gender (P=0.014) and age. (P=0.000) which was more likely in patients older than 10 years. The incidence of hyperglycemia was also related to BMI (P=0.000). Relapse rate for ALL was 14.7%, which was not significantly associated with hyperglycemia. Conclusion: Hyperglycemia was common and transient during induction phase of chemotherapy and it was correlated with age, sex, and weight.

scholarly journals Correlative Study Between Nutritional Status and Remission Outcome in Childhood Acute Lymphoblastic Leukemia in Dr. Soetomo General Hospital Surabaya

2019 ◽  
Vol 2 (1) ◽  
pp. 27
Author(s):  
Asma' Athifah ◽  
Siti Nurul Hidayati ◽  
Sulistiawati Sulistiawati
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Nutritional Status ◽  
General Hospital ◽  
Risk Group ◽  
Lymphoblastic Leukemia ◽  
High Risk Group ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Cross Sectional ◽  
Term Survival

Introduction: The most common malignancy that is diagnosed in children is acute lymphoblastic leukemia. Undernourished children tend to have poorer long term survival. This descriptive analytic study is aimed towards analyzing the correlation between nutritional status at diagnosis and outcomes of induction phase therapy in childhood acute lymphoblastic leukemia at the Department of Pediatrics Dr. Soetomo General Hospital Surabaya in 2014.Methods: A cross-sectional method using the medical records of patients is used in this study. The nutritional statuses of patients are calculated using weight for length/height trough curves of WHO 2006 or CDC 2000.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

Impact of anti‐oxidant status and apoptosis on the induction phase of chemotherapy in childhood acute lymphoblastic leukemia

Hematology ◽  
2011 ◽  
Vol 16 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Youssef Al‐Tonbary ◽  
Samir Abou Al‐Hasan ◽  
Maysaa Zaki ◽  
Ayman Hammad ◽  
Shaimaa Kandil ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Anti Oxidant ◽  
Oxidant Status

scholarly journals Causes of Death in Childhood Acute Lymphoblastic Leukemia at Hue Central Hospital for 10 Years (2008-2018)

2020 ◽  
Vol 7 ◽  
pp. 2333794X2090193
Author(s):  
Tran Kiem Hao ◽  
Pham Nhu Hiep ◽  
Nguyen Thi Kim Hoa ◽  
Chau Van Ha
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Maintenance Phase ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Induction Phase ◽  
Central Hospital ◽  
Female Ratio ◽  
Cancer Group ◽  
Almost All ◽  
And Control

Aim. To analyze the common cause of death in childhood acute lymphoblastic leukemia patients. Methods and Materials. A retrospective descriptive study on children with acute lymphoblastic leukemia who died at Hue Central Hospital between 2008 and 2018. All the patients were treated with the same protocol of modified Children’s Cancer Group 1882 and 1881. Results. A total of 238 children with acute lymphoblastic leukemia who were cared for at our center were enrolled. Of these, there were 74 deaths. Among the death group, the male-to-female ratio was 2.7:1. Twenty-six (35.1%) occurred in maintenance phase, 18 (24.3%) occurred in induction phase, and 9 (12.2%) occurred in delayed intensification. Infection was responsible for deaths in 32 of 74 (43.2%) cases. Pseudomonas aeruginosa was found in 3 of 32 infected cases (9.4%) and resistance to almost all antibiotics in our hospital. Relapse, abandonment, and bleeding were documented in 20 (27.0%), 7 (9.5%), and 6 (8.1%) cases, respectively. Twenty-seven (84.3%) patients had absolute neutrophil count <500/µL. Of 32 infectious deaths, pneumonia occurred in 40.6%. Regarding 20 relapse death, bone marrow was the major site of relapse and it occurred in 13 (65%) cases. And there were 65% patients with very early relapse. Conclusions. Infection is the major cause of mortality in acute lymphoblastic leukemia patients in our study. To improve outcome, we should improve supportive care, especially prevention and control infection.

scholarly journals Karakteristik dan Jumlah Leukosit pada Anak Penderita Leukemia Limfoblastik Akut yang Menjalani Kemoterapi Fase Induksi di Rumah Sakit Al Islam Bandung

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Fairuz Fakhri Luthfiyan ◽  
Lia Marlia Kurniawati ◽  
Ieva Baniasih Akbar
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Nutritional Status ◽  
Lymphoblastic Leukemia ◽  
Genetic Disorders ◽  
Current Therapy ◽  
Induction Phase ◽  
Cross Sectional ◽  
Leukocyte Counts ◽  
Cross Sectional Design

Leukemia limfoblastik akut (LLA) adalah kelompok keganasan heterogen dengan sejumlah kelainan genetik khas yang menghasilkan berbagai perilaku klinis dan respons terhadap terapi. Pasien LLA pada umumnya identik dengan jumlah leukosit yang tinggi,  terapi saat ini adalah dengan cara kemoterapi yang terdiri atas 3 fase, yaitu induksi, konsolidasi, dan pemeliharaan. Keberhasilan kemoterapi ditentukan banyak faktor antara lain adalah terjadi remisi setelah kemoterapi fase induksi. Penelitian ini bertujuan mengetahui karakteristik dan jumlah leukosit pada anak penderita LLA setelah fase induksi kemoterapi. Metode yang digunakan adalah deskriptif dengan rancangan potong lintang  yang menggunakan data rekam medik pasien LLA  periode tahun 2019 usia 0 - 15 tahun. Penelitian ini dilaksanakan selama bulan Oktober 2020, teknik pengambilan data menggunakan total sampling. Pada penelitian ini didapatkan 137 data rekam medik, data yang memenuhi kriteria inklusi sebanyak 74 data. Kasus LLA paling banyak terjadi pada usia 0 - 5 tahun pada 41 pasien (55%), jenis kelamin laki-laki 43 pasien (58%), status gizi baik 46 pasien (62%), morfologi sumsum tulang remisi 63 pasien (85%), dan jumlah leukosit 4500-13500/mm3 pada 52 pasien (70%), remisi sumsum tulang terbanyak pada jumlah leukosit 4 pada 45 pasien (61%). Simpulan,  karakteristik pasien LLA terba500-13500/mm3nyak laki-laki, usia 0 - 5 tahun status gizi baik dan morfologi sumsum tulang remisi.  Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital BandungAcute lymphoblastic leukemia (ALL) is a heterogeneous group of malignancies with a number of characteristic genetic disorders that produce a variety of clinical behaviors and responses to therapy. LLA patients are generally synonymous with high leukocyte counts. Current therapy is chemotherapy which consists of 3 phases, namely induction, consolidation, and maintenance. The success of chemotherapy is determined by many factors, including remission after induction phase chemotherapy. This study aims to determine the characteristics and number of leukocytes in children with LLA after the chemotherapy induction phase. The method used was descriptive with a cross-sectional design using medical records of LLA patients periode 2019 aged 0-15 years. study was held in October 2020. In this study, there were 137 medical record data, data that met the inclusion criteria were 74 data. LLA cases in this study mostly occurred at the age of 0 - 5 years, amounting to 41 patients (55%), male gender totaled 43 patients (58%), good nutritional status totaled 46 patients (62%). ), the morphology of bone marrow remission totaled 63 patients (85%), and for the number of leukocytes 4500 - 13500/mm3 as many as 52 patients (70%), the greatest occurrence of bone marrow remission was in the number of leukocytes 4500/mm3-13500/mm3 as many as 45 patients (61%). In conclusion, characteristics of most ALL patients are male, age of 0 - 5 years with good nutritional status and bone marrow morphology showing remission. Characteristics and Number of Leukocytes in Children with Acute Lymphoblastic Leukemia who Underwent Induction Phase Chemotherapy at Al Islam Hospital Bandung

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