scholarly journals Use of ozone therapy together to low power laser in osteonecrosis induced bisphosphonates - Clinical case

2016 ◽  
Vol 19 (1) ◽  
pp. 129
Author(s):  
Michelle Bianchi Moraes ◽  
Gabriel Da Silva Lopes ◽  
Rodrigo Dias Nascimento ◽  
Fernanda De Cássia Papaiz Gonçalves ◽  
Lucio Murilo dos Santos ◽  
...  
Keyword(s):  
Low Power ◽  
Bone Repair ◽  
Maxillofacial Surgery ◽  
Clinical Signs ◽  
Osteonecrosis Of The Jaw ◽  
The Body ◽  
Oral And Maxillofacial Surgery ◽  
Ozone Therapy ◽  
Power Laser ◽  
Disease Stabilization

Considering the probable causal association between the use of bisphosphonates and osteonecrosis of the jaw, as well as the high number of prescriptions and use these drugs every year, this paper aims to show different treatment. The combined use of ozone therapy and laser therapy in tissue regeneration  and bone repair in patients with osteonecrosis induced by bisphosphonates, held by the discipline of Oral and Maxillofacial Surgery and Traumatology, Paulista State University "Júlio de Mesquita Filho". Female patient, white, 53 years after a breast cancer had an evolution for bone metastases throughout the body, and start the chemotherapy treatment using intra-venous pamidronate 90 mg monthly from 2007 which has been used to the present day, due to disease stabilization. The patient sought the institution complaining of painful symptoms in the mandible and maxilla, and the clinical examination and CT were diagnosed initial sites suggestive of osteonecrosis induced by bisphosphonates. In seeking to reduce the symptoms and clinical signs, to prevent progress in the lesions, we recommend treatment by ozone therapy together to infrared low-power laser, which showed satisfactory reduction in bone necrosis sites. Although there are wide variations and difficulties in treatments for osteonecrosis induced by bisphosphonates, it was possible regression of the lesions through the joint processing applied, and the improvement in life expectancy of the patient.

Functional analysis of chondroitin 4 sulfate constituting osseointegration

Impact ◽  
2019 ◽  
Vol 2019 (8) ◽  
pp. 18-20
Author(s):  
Shuhei Tsuchiya
Keyword(s):  
Functional Analysis ◽  
Extracellular Matrix ◽  
Dental Implants ◽  
Maxillofacial Surgery ◽  
The Body ◽  
Oral And Maxillofacial Surgery ◽  
Direct Connection ◽  
Tooth Replacement ◽  
Living Bone ◽  
Natural Tooth

Osseointegration can be defined as a direct connection, both structural and functional, between living bone and the surface of an artificial implant. Indeed, the word comes from the Greek term for 'bone' and 'to make whole'. In dentistry, once dental implants are placed, the body will react with osseointegration, enabling the implants to become a permanent part of the jaw. There are many benefits to this type of implant, compared with traditional tooth replacement options, not least that dental implants mimic the strength and functionality of a natural tooth. Dr Shuhei Tsuchiya is a researcher based in the Division of Oral and Maxillofacial Surgery at Nagoya University, Japan, who is interested in a range of areas, including regenerative medicine and the extracellular matrix. One of his key preoccupations, though, is shedding light on osseointegration. He and his team are working to unravel the mysteries of the mechanism.

scholarly journals Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series

2021 ◽  
Vol 18 (3) ◽  
pp. 1018
Author(s):  
Guillermo Pardo-Zamora ◽  
Yanet Martínez ◽  
Jose Antonio Moreno ◽  
Antonio J. Ortiz-Ruíz
Keyword(s):  
Bone Structure ◽  
Negative Impact ◽  
Maxillofacial Surgery ◽  
Case Series ◽  
Osteonecrosis Of The Jaw ◽  
Oral And Maxillofacial Surgery ◽  
Minimally Invasive Surgical ◽  
Therapeutic Protocols ◽  
Serious Disease ◽  
The University

Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients’ quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the application of therapeutic protocols, the lesions were completely healed in all cases. Radiography showed slow but progressive healing with normal bone structure. Conservative treatment with antibiotics, chlorhexidine rinses and minimally invasive surgical intervention with necrotic bone resection is effective in treating stage 2 of MRONJ. In cases of refractory osteonecrosis, the application of platelet and leukocyte-rich fibrin (PRF-L) in the surgical approach improves the outcome in soft tissue healing and bone regeneration but further research is needed to confirm its effectiveness.

scholarly journals Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study

2020 ◽  
Vol 17 (23) ◽  
pp. 8801
Author(s):  
Na Rae Choi ◽  
Jung Han Lee ◽  
Jin Young Park ◽  
Dae Seok Hwang
Keyword(s):  
Retrospective Study ◽  
Surgical Treatment ◽  
Treatment Outcomes ◽  
Maxillofacial Surgery ◽  
Osteonecrosis Of The Jaw ◽  
Oral And Maxillofacial Surgery ◽  
Single Institution ◽  
Patient Factors ◽  
Surgical Success ◽  
Negative Impacts

The purpose of this study was to confirm the success rate of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) in patients at a single institution (Association of Oral and Maxillofacial Surgery (AAOMS) stages 1, 2, or 3), and to identify the factors that influence treatment outcomes. As a result of analyzing the outcomes of treatment, surgical “success” was achieved in 93.97% (109) of cases, and “failure” was observed at 6.03% (7) cases. Analysis of patient factors that potentially affect treatment outcomes showed that zoledronate dose (p = 0.005) and the IV (intravenous) injection of drugs (p = 0.044) had significant negative impacts.

scholarly journals Observational Study of the Bisphosphonate-Related Osteonecrosis of Jaws

2018 ◽  
Vol 91 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Andreea Elena Lungu ◽  
Madalina Anca Lazar ◽  
Andrada Tonea ◽  
Horatiu Rotaru ◽  
Rares Calin Roman ◽  
...  
Keyword(s):  
Oral Treatment ◽  
Maxillofacial Surgery ◽  
Osteonecrosis Of The Jaw ◽  
Postoperative Recovery ◽  
Oral And Maxillofacial Surgery ◽  
Necrotic Bone ◽  
Functional Rehabilitation ◽  
Maxillary Bone ◽  
Medical Background ◽  
Radiological Image

Introduction. The bisphosphonate-related osteonecrosis of the jaw was first referred to in 2003. Bisphosphonates action is focused on the osteoclasts. The drastic inhibition of the osteoclastic function is harmful for the jaws which are the only bones of the human skeleton in relative contact with the external environment. The adverse effects of the bisphosphonate-related therapy include the pathology for which they are prescribed, the atypical fractures in pathological bone.Method. The aim of this research was to analyze the risk factors and the treatment methods in case of osteonecrosis of the jaws. To achieve these goals, the author analyzed the observation sheets of the patients admitted to the Oral and Maxillofacial Surgery Clinic during the period 2010-2015. The inclusion criteria were as follows: treatment with bisphosphonates, current or previous; the lesions of the mucous gingiva of the maxillaries followed by exposed necrotic bone, older than 8 weeks, with no tendency of healing; specific radiological image showing extended osteolysis with diffuse outline or radiopacity surrounded by radio-transparence, representing the necrotic bone sequestered; no metastasis in the necrotic maxillary bone; patient with no medical background of cervical-facial radiations. The patients who met these criteria were admitted in the study after signing the informed consent. Afterwards, the information found in the notes of the observational sheet (anamnesis, general examination and the imagistic investigation, treatment, postoperative recovery, prescription, postoperative recommendations) were gathered and submitted for statistic analysisResults. Of the 20 patients in total, 13 were women and 7 men, of ages ranging from 43 to 83. The most numerous cases were registered in the seventh age decade. All patients included in the study had lesions of the gingival maxillary mucosal areas with exposure of the subjacent necrotic bone. 60% of them were under intravenous treatment with zoledronic acid (Zometa®). A single patient was under oral treatment with bisphosphonates. 19 of these 20 patients developed osteonecrosis following a dental extraction while one case was due to the instability of the mandibular mobile prosthesis. 61% of the patients included in the study developed a necrotic process in the mandibular bone, 80% of the localizations were in the posterior area. As first intention, the choice of treatment was represented by local lavages with antiseptic solutions, general antibiotics and sequestrectomy. Of these patients, a third had relapsed and needed radical surgery treatment.Conclusions. Prevention of the bisphosphonate-related osteonecrosis of the jaw represents the best method of treatment. The development of bone sequesters damages the volume of the maxillary bone as such, reducing the chances for prosthetic functional rehabilitation of the dento-maxillary system. An increase in the quality of life by oral restoration of these patients may represent a challenge.

scholarly journals Local Hemostatic Measures in Oral and Maxillofacial Surgery

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Platelet Aggregation ◽  
Continuous Process ◽  
Maxillofacial Surgery ◽  
Blood Gases ◽  
The Body ◽  
Oral And Maxillofacial Surgery ◽  
Hormone Signaling ◽  
Signaling System ◽  
Metabolic Products ◽  
Internal Body

Homeostasis is continuous process by which internal body system monitor and maintain constant internal environment. Blood is a connective tissue in fluid state closely connected to all tissues of the body. It has many roles including transport of nutrients, metabolic products, blood gases, thermal regulation hormone signaling system, heat conduction, immune response. Hemostasis is homeostasis of intravascular blood volume and is an important function of blood. It involves four major steps: vasoconstriction, platelet aggregation, coagulation and fibrinolysis [1]. The phase of vasoconstriction reduces the blood flow in preparation for platelet aggregation phase. However, the larger the size of the injured blood vessel the less possibility of vasoconstriction especially with high pressure.

scholarly journals The Role of Chemical Agents in the Microbial Flora with Major Risk of Interventios in Maxilo-facial Surgery

2019 ◽  
Vol 70 (6) ◽  
pp. 1988-1991
Author(s):  
Carmen Gabriela Stelea ◽  
Iulian Constantin ◽  
Cristian Budacu ◽  
Alexandra Lorina Platon ◽  
Mihail Balan ◽  
...  
Keyword(s):  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
The Body ◽  
Small Scale ◽  
Oral And Maxillofacial Surgery ◽  
Periodontal Surgery ◽  
Facial Surgery ◽  
Chemical Agents ◽  
Infectious Etiology

The pathology of the oro-maxilo-facial territory comprises a vast chapter of diseases with primary or secondary infectious etiology, the mouth being the natural cavity of the organism with the most varied and variable flora of bacterial contamination. By the continuity solutions created by the mechanical act of mastication, decubitus of defective prosthetic works, local dento-periodontal infectious processes, but especially of dental or small-scale interventions, open gates and possibilities of penetration into the blood circulation of the microorganisms, which cause the transient bacteria. The study included 243 randomly selected patients, with the address of the Oral and Maxillofacial Surgery Clinic in the period 2016-2018. The inoculation of microorganisms in the oral cavity in circulating blood as a result of oral surgery or dental care procedures is much more common than in other areas of the body. Aggressive dental maneuvers that create solutions of continuity of oral mucosa, gingiva, periodontal surgery, periodontal surgery techniques can cause bacteria.

Prevalence and pattern of oral and maxillofacial trauma in Chhattisgarh- A retrospective study

2021 ◽  
Vol 7 (3) ◽  
pp. 131-134
Author(s):  
Sushmita Batra ◽  
Surabhi Singhai ◽  
Pramod Krishna B ◽  
Rajdeep Singh ◽  
Sushant Soni
Keyword(s):  
Maxillofacial Surgery ◽  
The Body ◽  
Maxillofacial Trauma ◽  
Treatment Modalities ◽  
Oral And Maxillofacial Surgery ◽  
Mandibular Fractures ◽  
High Morbidity ◽  
Maxillofacial Injuries ◽  
Facial Region ◽  
Clinical Records

Maxillofacial trauma is any physical trauma to the facial region, commonly encountered by maxillofacial surgeons, and is often associated with high morbidity and so constitute quite a significant portion of the workload of the oral and maxillofacial surgeon. Maxillofacial injuries can occur as an isolated injury or may be associated with multiple injuries in other parts of the body. To assess the patterns, etiology, and treatment modalities of maxillofacial trauma in a teaching hospital in central India, over a 12-year period. Patients with maxillofacial trauma were identified using the department database and clinical records. 264 patients were identified with maxillofacial trauma in the department of oral and maxillofacial surgery between January 2006 and December 2018. The study showed that there was a male preponderance in all age groups over female. Of the 264 patients with maxillofacial injuries, 83,33% had isolated lower face (mandibular) fractures, followed by midface fractures (10.60%) and panfacial fractures (6.06%). Road traffic accidents (87.12%) were the most common form of etiology for trauma followed by assaults (10.98%). Most trauma were treated with open reduction internal fixation (89%) than closed reduction (11%). The etiology and pattern of maxillofacial injuries reflect the trauma patterns within the community and can thus provide a guide to help design programs toward prevention and treatment.

scholarly journals Practical Guidelines for the Prevention, Diagnosis, and Treatment of Osteonecrosis of the Jaw in Patients With Cancer

2006 ◽  
Vol 2 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Salvatore Ruggiero ◽  
Julie Gralow ◽  
Robert E. Marx ◽  
Ana O. Hoff ◽  
Mark M. Schubert ◽  
...  
Keyword(s):  
Risk Factors ◽  
Health Care Professionals ◽  
Multidisciplinary Treatment ◽  
Maxillofacial Surgery ◽  
Osteonecrosis Of The Jaw ◽  
Bisphosphonate Therapy ◽  
Oral And Maxillofacial Surgery ◽  
Patients With Cancer ◽  
Dental Procedures ◽  
Practical Guidelines

PurposeThis article discusses osteonecrosis of the jaw (ONJ) and offers health care professionals practical guidelines and recommendations for the prevention, diagnosis, and management of ONJ in cancer patients receiving bisphosphonate treatment.MethodsA panel of experts representing oral and maxillofacial surgery, oral medicine, endocrinology, and medical oncology was convened to review the literature and clinical evidence, identify risk factors for ONJ, and develop clinical guidelines for the prevention, early diagnosis, and multidisciplinary treatment of ONJ in patients with cancer. The guidelines are based on experience and have not been evaluated within the context of controlled clinical trials.ResultsONJ is a clinical entity with many possible etiologies; historically identified risk factors include corticosteroids, chemotherapy, radiotherapy, trauma, infection, and cancer. With emerging concern for potential development of ONJ in patients receiving bisphosphonates, the panel recommends a dental examination before patients begin therapy with intravenous bisphosphonates. Dental treatments and procedures that require bone healing should be completed before initiating intravenous bisphosphonate therapy. Patients should be instructed on the importance of maintaining good oral hygiene and having regular dental assessments. For patients currently receiving bisphosphonates who require dental procedures, there is no evidence to suggest that interrupting bisphosphonate therapy will prevent or lower the risk of ONJ. Frequent clinical assessments and conservative dental management are suggested for these patients. For treatment of patients who develop ONJ, a conservative, nonsurgical approach is strongly recommended.ConclusionAn increased awareness of the potential risk of ONJ in patients receiving bisphosphonate therapy is needed. Close coordination between the treating physician and oral surgeon and/or a dental specialist is strongly recommended in making treatment decisions.

scholarly journals Cell therapy for medication-related osteonecrosis of the jaw: update on treatment strategies

2021 ◽  
Vol 41 ◽  
pp. 31-39
Author(s):  
N Kaibuchi ◽  
◽  
T Iwata ◽  
T Okamoto ◽  
Y Kawase-Koga ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Large Scale ◽  
Case Reports ◽  
Autologous Transplantation ◽  
Maxillofacial Surgery ◽  
Treatment Strategies ◽  
Osteonecrosis Of The Jaw ◽  
Bone Diseases ◽  
Oral And Maxillofacial Surgery ◽  
Cell Therapies

Despite extensive research since the first report of medication-related osteonecrosis of the jaw (MRONJ) in 2003, the optimal treatment and preventive modalities for the condition are not clear. Therefore, its management has been a concern in dentistry, oral and maxillofacial surgery, as well as departments involved in the treatment of cancers and/or bone diseases worldwide. Several cases of MRONJ could not be cured by conventional treatment strategies, as per the recommendations in various position papers. Therefore, a number of studies, including randomized controlled trials, have been conducted to examine the efficacy of novel therapies. However, no definite treatment modality has been determined. Several types of cell therapies have been documented. 10 animal studies and 5 case reports have been documented, in which autologous transplantation of cells has been carried out in MRONJ patients. Although these reports showed the efficacy of cell therapy, they were not large-scale, statistically accurate clinical studies; hence, the efficacy of cell therapy for this condition is not certain. However, the efficacy of MRONJ treatment using mesenchymal stromal cell (MSC) sheets has been investigated since 2013. This has been confirmed through various experiments in which MSC sheets were transplanted into model rats and beagle dogs exhibiting MRONJ-like lesions. Based on these results, a clinical study of MRONJ treatment using periodontal ligament-derived MSC sheets is being currently planned.

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