scholarly journals Risk factors of disturbances in carbohydrate and lipid metabolism and some pleiotropic effects of antihypertensive therapy in pregnant women

2013 ◽  
Vol 10 (1) ◽  
pp. 9-13
Author(s):  
A V Padyganova

The any kind of hypertension developing during the pregnancy, associated with high cardiovascular risk in the future. At the pregnancy complicated by development by arterial hypertension, there are more expressed changes of a carbohydrate and lipide metabolism, than it is peculiar to normally proceeding pregnancy, were by important pathogenetic links of obesity, diabetes, cardiovascular complications. Identification of new mechanisms of action of antihypertensive means associated with positive influences on exchange processes, is represented very demanded, considering pandemic nature of prevalence of metabolic violations in modern population.

2019 ◽  
Vol 15 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Alberto Milan ◽  
Giulia Bruno ◽  
Ilaria Maffei ◽  
Andrea Iannaccone ◽  
Agnese Ravera ◽  
...  

The introduction of carfilzomib in the treatment of relapsing and refractory multiple myeloma has allowed a significant increase in survival. The most frequent adverse effect of Carfilzomib treatment is arterial hypertension, even though the exact physiopathological mechanism are still unclear. MM patients, on the other hand, often present significant cardiovascular risk factors and comorbidities. Uncontrolled hypertension is frequently the cause of cardiovascular complications. It has been estimated that up to 50% of subjects in the general population are unaware of their hypertensive condition and only half of those who are aware of this risk factor present good control of blood pressure. Although the management of arterial hypertension is clearly important in reducing the risk of cardiovascular events, and is well described by the current guidelines, no clear indications are provided on how to approach and treat specifically MM patients undergoing treatment with proteasome inhibitors. The aim of our work is to summarize a practical approach to the stratification of cardiovascular risk of hypertensive in patients who are candidates for or actively treated with carfilzomib for refractory multiple myeloma (MMR). MM patients eligible for carfilzomib treatment should preliminary undergo a careful cardiovascular risk stratification. Perspective studies will help to better identify the specific risk factors that should be considered and treated in these patients.


2013 ◽  
Vol 4 (4) ◽  
pp. 36-39
Author(s):  
D. S Kaskayeva ◽  
M. M Petrova ◽  
V. V Kostina ◽  
A. A Evsyukov ◽  
E. A Tepper

The article in comparative aspect presents results of rating of psychological profile of 142 patients (all are men, average age 46,5±0,35 years) with arterial hypertension of stage I–III with high risk of cardiovascular complications having been studied after 6 months of dynamic observation against the background of conducted antihypertensive therapy with inhibitors of angiotensin converting enzyme (ACE).


2019 ◽  
Vol 26 (1) ◽  
pp. 61-71
Author(s):  
G. S. Isayeva ◽  
L. A. Reznik ◽  
M. M. Vovchenko ◽  
O. O. Buryakovska ◽  
N. Yu. Emelyanova

The aim – to compare the effectiveness of group versus individual patients’ training of the medical basics to control the essential cardiovascular risk factors. Materials and methods. The study included 210 patients with high and very high cardiovascular risk. The first group comprised 75 patients who studied in Health Schools «Basics of Healthy Life Style». The second group comprised 75 patients who were offered individual consulting. 60 patients were representatives of the control group. Patients of both experimental groups were examined before the beginning and at the end of the training course. General clinical examination was carried out, anthropometric indicators were identified (body weight, height, body mass index, waist circumference, hip circumference, body build), blood pressure, glucose content, cholesterol and its fractions in blood. Results and discussion. In both groups of patients reliable reduction of blood pressure values was observed. For example, at the beginning of the study the number of patients with blood pressure target values was 31 persons (41.8 %) among the patients of the first group and 46 persons (60.9 %) among the patients of the second group. In the first group the average indicators of lipid metabolism did not show reliable change. However, in the second group the reliable reduction of total cholesterol by 21.1 % (р=0.031), low density lipoprotein cholesterol by 20.1 % (р=0.04) and the rise of the high-density lipoprotein cholesterol by 11 % (р=0.03) were found. Such behavioral risk factors as smoking, alcohol and table salt consumption did not reliably change in both groups of patients. Physical activities, assessed by the number of steps per day, did not reliably change in the first group 2311.6±1672.4 m steps per day and 2033.33±1980.27 steps per day (р=0.205), but it rose in the second group – from (2346.67±1845.54) m steps at the beginning of the study to 2654.67±1922.08 m at the end of the study (р=0.007). In the first group the life quality indicators, assessed by the data from questionnaires using SF-36 Health Status Survey, did not reliably change (58.66±16.21 and 62.54±16.39, р=0.062), in the second group it rose significantly – from 58.16±9.88 to 67.21±14.34 (р=0.008). Conclusions. The results of our research demonstrated higher effectiveness of the individual education compared to the group training. Group training of the patients with high and very high cardiovascular risk in the Health Schools «Basics of Healthy Life Style» encourages better control of blood pressure, but it does not significantly influence behavioral risk factors and lipid metabolism indicators in the patients with high and very high cardiovascular risk. Individual training of the patients with high and very high cardiovascular risk leads to significant reduction of blood pressure values, improves lipid metabolism indicators, increases physical activity and enhances life quality indicators.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1178-P ◽  
Author(s):  
RUBÉN SILVA-TINOCO ◽  
ENEDINA TERESA C. CUATECONTZI ◽  
VIRIDIANA DELATORRE-SALDAÑA ◽  
EILEEN B. GUZMAN ◽  
DOLORES CABRERA-GERARDO ◽  
...  

2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 205-209 ◽  
Author(s):  
Elvia García–López ◽  
Juan J. Carrero ◽  
Mohamed E. Suliman ◽  
Bengt Lindholm ◽  
Peter Stenvinkel

Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk. The present review discusses recent findings and therapy trends in cardiovascular research on the PD population, with emphasis on the roles of inflammation, insulin resistance, homocysteinemia, dyslipidemia, vascular calcification, and genetics/epigenetics.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Basilio Pintaudi ◽  
Alessia Scatena ◽  
Gabriella Piscitelli ◽  
Vera Frison ◽  
Salvatore Corrao ◽  
...  

Abstract Background The European Society of Cardiology (ESC) recently defined cardiovascular risk classes for subjects with diabetes. Aim of this study was to explore the distribution of subjects with type 2 diabetes (T2D) by cardiovascular risk groups according to the ESC classification and to describe the quality indicators of care, with particular regard to cardiovascular risk factors. Methods The study is based on data extracted from electronic medical records of patients treated at the 258 Italian diabetes centers participating in the AMD Annals initiative. Patients with T2D were stratified by cardiovascular risk. General descriptive indicators, measures of intermediate outcomes, intensity/appropriateness of pharmacological treatment for diabetes and cardiovascular risk factors, presence of other complications and overall quality of care were evaluated. Results Overall, 473,740 subjects with type 2 diabetes (78.5% at very high cardiovascular risk, 20.9% at high risk and 0.6% at moderate risk) were evaluated. Among people with T2D at very high risk: 26.4% had retinopathy, 39.5% had albuminuria, 18.7% had a previous major cardiovascular event, 39.0% had organ damage, 89.1% had three or more risk factors. The use of DPP4-i markedly increased as cardiovascular risk increased. The prescription of secretagogues also increased and that of GLP1-RAs tended to increase. The use of SGLT2-i was still limited, and only slightly higher in subjects with very high cardiovascular risk. The overall quality of care, as summarized by the Q score, tended to be lower as the level of cardiovascular risk increased. Conclusions A large proportion of subjects with T2D is at high or very high risk. Glucose-lowering drug therapies seem not to be adequately used with respect to their potential advantages in terms of cardiovascular risk reduction. Several actions are necessary to improve the quality of care.


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