scholarly journals Primenenie kombinirovannykh oral'nykh kontratseptivov u zhenshchin reproduktivnogo vozrasta s ozhireniem

2009 ◽  
Vol 6 (2) ◽  
pp. 3-6
Author(s):  
E N Andreeva ◽  
E A Karpova ◽  
E N Andreeva ◽  
E Karpova
Keyword(s):  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Integrated Treatment ◽  
Childbearing Age ◽  
Metabolic Complications ◽  
Pregnancy And Childbirth ◽  
High Prevalence ◽  
Ovary Function ◽  
Drug Interventions

This article assesses the problem of obesity as a risk factor for development of severe metabolic complications and different disorders of reproductive function in women of childbearing age. It is pointed that obesity is associated with high prevalence of hyperandrogenemic and hyperplastic disorders, polycystic ovary syndrome, infertility, complications of pregnancy and childbirth. Article discusses the questions of integrated treatment approach of this category of patients, which include non-drug interventions (rational nutrition, lifestyle modification) as well as the use of medications which lower the insulin resistance and hyperinsulinemia to restore ovary function and the possible use of combined oral contraceptives for correction of anovulation.

scholarly journals The conservative treatment in adolescents with the Polycystic ovary syndrome

2016 ◽  
Vol 11 (4) ◽  
pp. 337-341
Author(s):  
Adrian NEACȘU ◽  
◽  
Cătălina Diana STĂNICĂ ◽  
Constantin Dimitrie NANU ◽  
◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Metabolic Disturbances ◽  
Childbearing Age ◽  
Ovary Syndrome ◽  
Oral Antidiabetic Agents ◽  
Menstrual Cycles

Polycystic ovary syndrome (PCOS) is a common endocrine and heterogeneous dysfunction, characterized by chronic anovulation and androgen excess, affecting 6-10% of women of childbearing age. It is the most common cause of anovulatory infertility. It seems that the key element in the pathophysiology of PCOS is increased insulin resistance. The correction of infertility in teens is not a priority. They can receive treatment to normalize menstrual cycles, with the reduction of symptoms and improvement of metabolic disorders. Many overweight teens have increased insulinemia, which may play a role in the development of PCOS. Standard treatment is oral estroprogestative, used to perform regular menstrual cycles. Normalize menstrual cycles can be done with oral contraceptives or oral antidiabetic agents that improve metabolic dysfunctions. An adjuvant approach of the utmost importance for teens is lifestyle modification and diet. Teen treatment should be individualized depending on a number of peculiarities that have to be taken into account: menstruation disorders, mastopathies and ovarian dystrophies, hyperandrogenism syndrome, sexually transmitted diseases and other associated disorders. In obese women with PCOS, weight loss improves hyperandrogenism, reduces metabolic disturbances, reduces insulin resistance and insulinemia, improves fertility rate, stimulates ovulation.

Discussion of new approach to the management of polycystic ovary syndrome

2017 ◽  
pp. 45-48
Author(s):  
Z.M. Doubossarskaya ◽  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Lifestyle Modification ◽  
Polycystic Ovary ◽  
Critical Evaluation ◽  
Life Quality ◽  
Reproductive Function ◽  
Ovary Syndrome ◽  
Therapy Program ◽  
Life Style Changes ◽  
Complex Therapy

The objective: Critical evaluation of modern therapeutic methods for polycystic ovary syndrome (POS); depending of reproductive plans for infertility therapy needed or removing of cosmetic issues by including Protalis to complex therapy program. Patients and methods. 40 women in the age from 27 to 37; with confirmed diagnosis of POS according to criteria of Rotterdam consensus were examined. They were divided to 2 subgroups; first (30) got traditional therapy with individual variations: laparoscopic drilling of ovaries, Metphormin, lifestyle modification and Protalis. Second group got their therapy without Protalis. Every 3, 6, 9, 12 months clinical, hormonal manifestations of POS were controlled. Results. Usage of complex therapy of POS with Protalis facilitated statistically unreliable lowering of BMI; but number of women with irregular menstrual periods increased in 3.4 times; restoration of reproductive function were happened in 26.6 % cases (10% without Protalis). This therapy facilitated diminishing of cosmetic issues, better skin conditions. Diminishing of acne, lowering of hirsute number and with complex approach to reproductive health they got better life quality. Conclusions. Practicing gynecologists after the studies of several etiological hypotheses about POS, realized that syndrome is a defect of not only one gene but it is polygenic and it is explain phenotype of patients and all variations depending of a type of metabolic disorders. Life style changes (diet and exercises) are cornerstone of management of patients with POS with high body mass and obesity (particularly abdominal) and they can lower many symptoms of POS? considering effectiveness of usage of Protalis in the complex therapy of POS in our study and in documented foreign studies it can be recommended in usage in clinical practice. Key words: polycystic ovary syndrome, chronic anovulation, hyperandrogeny, Protalis.

scholarly journals Restoring Reproductive Function In Overweight And Obese Women Of Childbearing Age

2020 ◽  
Vol 2 (08) ◽  
pp. 77-81
Author(s):  
Hamdamova M. T. ◽  
Jurakulova Z. A
Keyword(s):  
Negative Impact ◽  
Reproductive Function ◽  
Diet Therapy ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Obese Women ◽  
Childbearing Age ◽  
Women Of Reproductive Age ◽  
Pregnancy And Childbirth ◽  
Group 2

The prevalence of overweight and obesity among women in Uzbekistan is 31.7 %. There is an annual increase in people with obesity. The facts of the negative impact of fat mass on the hormonal system and, as a result, a decrease in fertility in women are not in doubt. The purpose of this study was to evaluate the results of Metformin use in overweight and obese women of reproductive age. The study included 45 women of reproductive age who could not reduce weight with diet therapy. All patients were divided into three groups: group 1-planning pregnancy (n = 15), group 2 – having abnormal weight gain after childbirth (n = 15), group 3 – having overweight and obesity not related to pregnancy and childbirth (n = 15). Weight loss while taking Metformin increases fertility and should be performed in obese women as pre-gravidar training.

Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice

2019 ◽  
Vol 31 (10) ◽  
pp. 1597 ◽  
Author(s):  
Li-Feng Sun ◽  
Ya-Li Yang ◽  
Tian-Xia Xiao ◽  
Meng-Xia Li ◽  
Jian V. Zhang
Keyword(s):  
Gene Expression ◽  
Polycystic Ovary ◽  
Metabolic Abnormalities ◽  
Women Of Childbearing Age ◽  
Related Gene ◽  
Childbearing Age ◽  
Ovary Syndrome ◽  
Metabolic Markers ◽  
High Prevalence ◽  
Ovarian Morphology

Polycystic ovary syndrome (PCOS) is an endocrine disorder with a high prevalence in women of childbearing age. To date, there is no method of efficiently diagnosing PCOS and curing it completely because its pathomechanism remains unclear. Here, we investigated whether metabolic abnormalities maintain the hyperandrogenism and PCOS-like ovaries and whether the symptoms induced by excess androgen are treatable. We ceased the abnormal dihydrotestosterone (DHT) stimulation to determine changes in PCOS-like mice. After ceasing DHT stimulation, the ovarian morphology and gene expression recovered from the DHT-stimulated status. However, after cessation of DHT stimulation, the hypertrophy of adipose tissues and hepatic steatosis were not significantly restored, and fat accumulation-related gene expression and serum metabolic markers in the mice were altered. These findings showed that the reproductive dysfunction was obviously relieved, but because the metabolic abnormalities were not relieved after the cessation of excess androgen for 30 days, it appears that the latter may not maintain the former.

scholarly journals Pathogenesis and Consequences of Disordered Sleep in PCOS

2019 ◽  
Vol 13 ◽  
pp. 117955811987126 ◽  
Author(s):  
Susan Sam ◽  
David A Ehrmann
Keyword(s):  
Sleep Disturbances ◽  
Metabolic Disorders ◽  
Polycystic Ovary ◽  
Tertiary Care ◽  
Obese Women ◽  
Menstrual Irregularity ◽  
Ovary Syndrome ◽  
Metabolic Complications ◽  
Obstructive Sleep ◽  
High Prevalence

Polycystic ovary syndrome (PCOS) is a common hormonal disorder that is characterized by hyperandrogenism and menstrual irregularity. Affected women have a high prevalence of insulin resistance and related metabolic complications. The frequency of sleep disturbances appears to be increased in women with PCOS, although most studies so far have included more severely affected obese women with PCOS who are referred to tertiary care clinics and may not represent the general population of women with PCOS. This article provides an overview of sleep disturbances in PCOS with the focus on obstructive sleep apnea (OSA), the most commonly reported sleep disturbance among these women. The pathogenesis and risk factors for OSA in PCOS and its association with metabolic disorders is discussed in detail.

A CLINICAL CASE OF AN UNDEVELOPED PREGNANCY IN A UTERINE SCAR AFTER A CESAREAN SECTION

2021 ◽  
pp. 26-34
Author(s):  
Mikhail E. Shchepelev ◽  
Tatyana V. Deripasko ◽  
Anastasiya A. Sidorova ◽  
Elena G. Drandrova ◽  
Evgeny V. Moskvichev ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Clinical Case ◽  
Reproductive Function ◽  
Childbearing Age ◽  
Pregnancy And Childbirth ◽  
First Child ◽  
Anatomical Classification ◽  
Uterine Scar ◽  
Ectopic Pregnancies

Over the past twenty-five years, the average age of a woman giving birth to the first child has grown significantly around the world. So, in Russia, currently, women begin to bring their reproductive function into action on average at the age of 26-35. This leads to the fact that obstetricians and gynecologists in their practice increasingly face with pregnancy and childbirth complicated by a uterine scar after a previous cesarean section or myomectomy. The formation of a uterine scar after any intervention entails the likelihood of long-term complications, such as a rupture of the uterus along the scar and pregnancy in the uterine scar. According to the latest clinical recommendations for ectopic pregnancy, pregnancy in the uterine scar has been added to the anatomical classification of ectopic pregnancies. The article describes a clinical case of an undeveloped pregnancy in the uterine scar after a cesarean section, it shows the difficulty of timely diagnosis of such pregnancy, which often results in improper management of patients and loss of fertility by women of childbearing age. In the described case, late diagnosis of pregnancy in the uterine scar necessitated organ-resecting surgery – extirpation of the uterus with fallopian tubes.

scholarly journals Reproductive health of women with fat metabolism disorders

2020 ◽  
pp. 27-32
Author(s):  
E. R. Vedzizheva ◽  
I. V. Kuznetsova
Keyword(s):  
Reproductive Health ◽  
Polycystic Ovary ◽  
Hypogonadotropic Hypogonadism ◽  
Fat Metabolism ◽  
Normal Weight ◽  
Normal Body Mass Index ◽  
Obese Women ◽  
Childbearing Age ◽  
Menstrual Dysfunction ◽  
High Prevalence

Objective: to assess the reproductive health features of women with fat metabolism disorders and the safety of using combined oral contraception in them.Materials and methods. 150 women of childbearing age (mean age 29.8 ± 4.7 years) were examined, which were divided into three groups depending on the type of impaired fat metabolism: the first group included patients with obesity and dyslipidemia (n = 50); the second group – women with obesity without dyslipidemia (n = 46); the third group – patients with a normal body mass index and dyslipidemia (n = 54). All patients underwent clinical and laboratory examination with the assessment of biochemical, metabolic and hormonal blood parameters. At the second stage of the study, the safety assessment of the use of combined oral contraceptive with chlormadinone acetate (COC–CMA) in women in need of pregnancy protection was performed.Results. Women with fat metabolism disorders have a high prevalence of menstrual irregularities. The most commonly detected were polycystic ovary syndrome (PCOS), phenotypes A, C, D. In the absence of PCOS in obese women or patients with dyslipidemia at normal weight, the formation of endocrine pathology was observed, associated with hyperandrogenemia or a tendency to hypogonadotropic hypogonadism. Patients with obesity and dyslipidemia had the worst fertility profile and high prevalence of infertility and miscarriage. Taking COC–CMA did not have a significant effect on fat metabolism.Conclusion. Dyslipidemia and obesity are independent factors in reproductive health problems. Clinical portraits of gynecological endocrine pathology in patients with obesity, dyslipidemia and their combination are different. The assessment of carbohydrate and fat metabolism should be considered one of the important components of the examination of patients with menstrual dysfunction or impaired fertility. COC–CMA can be considered the drug of choice for contraception in women with impaired fat metabolism.

High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

2017 ◽  
Author(s):  
Hamidreza Mani ◽  
Yogini Chudasama ◽  
Danielle Bodicoat ◽  
Miles Levy ◽  
Laura Gray ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
High Prevalence

Appreciation of the importance of pregravid preparation and reproductive attitudes of women of childbearing age in the city of Omsk

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (6) ◽  
pp. 48-52
Author(s):  
E N Kravchenko ◽  
R A Morgunov
Keyword(s):  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Pregnancy And Childbirth ◽  
Perinatal Center ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Complicated Pregnancy ◽  
The Relationship ◽  
The City

The aim of the study. Assess the importance of pregravid preparation and outcomes of pregnancy and childbirth, depending on the reproductive attitudes of women in the city of Omsk. Materials and methods. The study included 92 women who were divided into groups: group A (n=43) - women whose pregnancy was planned; group B (n=49) - women whose pregnancy occurred accidentally. Each group was divided into subgroups depending on age: from 18 to 30 and from 31 to 49 years. For each patient included in the study, a specially designed map was filled out. These patients were interviewed at the City Clinical Perinatal Center. Results. Comparative analysis revealed the relationship between the reproductive settings of women of childbearing age and the peculiarity of the course of pregnancy and childbirth in these patients. Summary. The majority of women of fertile age are married: in subgroup AA - 25 (96.2%), AB - 13 (76.5%), BA - 25 (92.6%), BB - 20 (91.0%). The predominant number of women of fertile age have one or more abortions: in subgroup AA - 12 (46.2%), AB - 6 (35.3%), in subgroups of comparison BA - 8 (29.6%), BB - 6 (27.3%). More than half of the women of fertile age surveyed have a history of untreated cervical pathology (from 40.8% to 64.7%). The course of pregnancy in women planning pregnancy in most cases proceeded without complications: in subgroup AA - 13 (50.0%), AB - 11 (64.7%). The most common cause of complicated pregnancy in women whose pregnancy occurred accidentally is the threat of spontaneous miscarriage: in subgroup BA - 15 (55.6%), BB - 16 (72.7%). The uncomplicated course of labor more often [subgroup AA - 19 (73.0%), AB - 12 (70.6%)] was observed in women whose pregnancy was planned and they were motivated to give birth to a healthy child.

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