scholarly journals Clinicobiochemical correlations in patients with the predominance of high-molecular prolactin in the blood serum

1995 ◽  
Vol 41 (1) ◽  
pp. 19-22
Author(s):  
Ye. Ye. Makarovskaya ◽  
I. A. Ilovaiskaya ◽  
A. V. Martynov ◽  
Ye. I. Marova ◽  
G. A. Melnichenko ◽  
...  
Keyword(s):  
Blood Serum ◽  
Molecular Mass ◽  
Clinical Picture ◽  
Clinical Symptoms ◽  
Disease Course ◽  
Typical Symptom ◽  
Blood Disease ◽  
Symptom Complex ◽  
Large Groups

A new rapid method for assesment of the ratio of immunoreactive prolactin forms with high and low molecular mass has been developed, which permits screening of large groups of patients. It was used in examinations of 44 women with hyperprolactinemea of various origin and with normoprolactinemic galactorrhea. High-molecular immunoreactive prolactin predominated in the blood serum of 25% of patients. This predominance did not depend on the origin of hyperprolactinemia, clinical picture of the disease, or level of total immunoreactive prolactin in the blood. Heterogenous clinical symptoms of the disease were characteristic of these patients: a typical symptom complex was absent in moderate hyperprolactinemia, whereas in patients with manifest hyperprolactinemia of a tumorous origin a classical clinical picture of persistent galactorrhea-amenorrhea was observed. A follow-up showed the predominance of high-molecular prolactin irrespective of the changes in the level of total immunoreactive prolactin in the blood, disease course, onset of pregnancy and labor.

Diagnosing Conjunctivitis

2021 ◽  
pp. 71-74
Author(s):  
A.E. Babushkin ◽  
Keyword(s):  
Clinical Picture ◽  
Clinical Symptoms ◽  
Specific Treatment ◽  
Mucosal Inflammation ◽  
Laboratory Diagnostics ◽  
Medical Specialties ◽  
Follicular Hyperplasia ◽  
Gender And Age ◽  
Symptom Complex ◽  
Acute Conjunctivitis

Conjunctivitis accounts for a significant share in the structure of eye disease. The reasons for their occurrence are very diverse. At first glance, it seems that such a disease as conjunctivitis does not cause difficulties in making a diagnosis. However the wide variety of its clinical forms and the need for strictly specific treatment in some cases, in addition to modern laboratory diagnostics, requires careful collection of anamnesis, sufficient clinical experience, and knowledge of related medical specialties. In this case the probable etiology, mainly of acute conjunctivitis, can be established by anamnesis, a set of clinical symptoms observed in the dynamics of its development. In other words, each of the acute infectious or allergic lesions of the eyelid mucosa is characterized by its own symptom complex, while the effective treatment in such cases is specific therapy (antibacterial, antiviral, anti-allergic, etc.). Differentiation of various forms of conjunctivitis is usually based on the assessment of the nature of the discharge, the localization of follicular hyperplasia, and lymphadenopathy. At the same time, the patient's gender and age, living and working conditions, concomitant diseases, contact with an infectious patient, etc. are taken into account. As for chronic forms of mucosal inflammation, in contrast to acute conjunctivitis, they are characterized more by subjective complaints of patients than by objective changes. Since it is often not possible to establish their etiology from the biomicroscopic picture and other data due to the erased clinical picture, it is often necessary to resort to laboratory diagnostics to verify chronic conjunctival ophthalmic infections. Key words: conjunctivitis, clinical picture, diagnosis.

scholarly journals Rabson-Mendenhall syndrome in a 13 y.o. child (clinical case)

2015 ◽  
Vol 18 (1) ◽  
pp. 110-114
Author(s):  
Roza Arturovna Atanesyan ◽  
Leonid Yakovlevich Klimov ◽  
Tatiana Michailovna Vdovina ◽  
Tatiana Alexeevna Uglova ◽  
Victoria Alexandrovna Kuryaninova ◽  
...  
Keyword(s):  
Clinical Case ◽  
Prenatal Screening ◽  
Medical Literature ◽  
Clinical Symptoms ◽  
Subcutaneous Fat ◽  
Disease Prevalence ◽  
Disease Course ◽  
Skin Hyperpigmentation ◽  
Development Delay

We present a case of a teenage boy with a Rabson-Mendenhall syndrome. There are only few recent publications on the topic of Rabson-Mendenhall syndrome in medical literature. This syndrome appears with a same frequency in both sexes. The disease prevalence is still unknown due to many undiagnosed cases linked with high mortality in early childhood. There are no prenatal screening for this disease till now, but it is clear, that in case of positive diagnostic tests, abortion should be recommended. The typical clinical symptoms of Rabson-Mendenhall syndrome are the following: physical development delay, loss of subcutaneous fat, teeth and nails abnormalities (premature teeth eruption, teeth number doubling, nails thickening). The earliest signs of the syndrome are skin hyperpigmentation and hyperkeratosis at neck, armpits and groin, which are typical for insulin resistance. Children with Rabson-Mendenhall syndrome usually have early manifestation of diabetes mellitus, characterized by labile disease course and frequent ketoacidosis state. The present clinical case might be interesting regarding a long follow-up of the child.

Clinical picture, diagnosis and treatment of mitral valvular diseases

2021 ◽  
pp. 8-19
Author(s):  
Dmitriy Sergeevich Kovalev
Keyword(s):  
Heart Failure ◽  
Clinical Picture ◽  
Surgical Intervention ◽  
Clinical Symptoms ◽  
Heart Defects ◽  
Full Recovery ◽  
Diagnosis And Treatment ◽  
Pathological Changes ◽  
Valvular Diseases ◽  
Large Groups

Heart defects are pathological changes in the heart, during which the defects of the valve apparatus or its walls are observed, leading to heart failure. There are two large groups of heart defects: congenital and acquired. The diseases are chronic, slowly progressing; therapy only alleviates their course, but does not eliminate the cause of their occurrence; full recovery is possible only with surgical intervention. This article is devoted to the issues of classification, etiology, pathogenesis, clinical symptoms, approaches to the diagnosis and treatment of mitral valvular diseases.

scholarly journals On Two Cases with Autosomal Dominant Hyper IgE Syndrome: Importance of Immunological Parameters for Clinical Course and Follow-Up

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Snezhina Mihailova Kandilarova ◽  
Spaska Stoyneva Lesichkova ◽  
Nevena Todorova Gesheva ◽  
Petya Stefanova Yankova ◽  
Nedelcho Hristov Ivanov ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Dna Binding Domain ◽  
Disease Course ◽  
Immunological Parameters ◽  
Laboratory Findings ◽  
Hyper Ige Syndrome ◽  
Stat3 Mutation

Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare disease described in 1966. It is characterized by severe dermatitis, a peculiar face, frequent infections, extremely high levels of serum IgE and eosinophilia, all resulting from a defect in the STAT3 gene. A variety of mutations in the SH2 and DNA-binding domain have been described, and several studies have searched for associations between the severity of the clinical symptoms, laboratory findings, and the type of genetic alteration. We present two children with AD-HIES–a girl with the most common STAT3 mutation (R382W) and a boy with a rare variant (G617E) in the same gene, previously reported in only one other patient. Herein, we discuss the clinical and immunological findings in our patients, focusing on their importance on disease course and management.

Does Hospitalization Predict the Disease Course in Ulcerative Colitis? Prevalence and Predictors of Hospitalization and Re- Hospitalization in Ulcerative Colitis in a Population-based Inception Cohort (2000-2012)

2015 ◽  
Vol 24 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Petra A. Golovics ◽  
Laszlo Lakatos ◽  
Michael D. Mandel ◽  
Barbara D. Lovasz ◽  
Zsuzsanna Vegh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cox Regression ◽  
Diagnostic Procedures ◽  
Population Based ◽  
Disease Course ◽  
Inception Cohort ◽  
Disease Extent ◽  
Cox Regression Analysis ◽  
Hospitalization Rates

Background & Aims: Limited data are available on the hospitalization rates in population-based studies. Since this is a very important outcome measure, the aim of this study was to analyze prospectively if early hospitalization is associated with the later disease course as well as to determine the prevalence and predictors of hospitalization and re-hospitalization in the population-based ulcerative colitis (UC) inception cohort in the Veszprem province database between 2000 and 2012. Methods: Data of 347 incident UC patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (M/F: 200/147, median age at diagnosis: 36, IQR: 26-50 years, follow-up duration: 7, IQR 4-10 years). Both in- and outpatient records were collected and comprehensively reviewed. Results: Probabilities of first UC-related hospitalization were 28.6%, 53.7% and 66.2% and of first re-hospitalization were 23.7%, 55.8% and 74.6% after 1-, 5- and 10- years of follow-up, respectively. Main UC-related causes for first hospitalization were diagnostic procedures (26.7%), disease activity (22.4%) or UC-related surgery (4.8%), but a significant percentage was unrelated to IBD (44.8%). In Kaplan-Meier and Cox-regression analysis disease extent at diagnosis (HR extensive: 1.79, p=0.02) or at last follow-up (HR: 1.56, p=0.001), need for steroids (HR: 1.98, p<0.001), azathioprine (HR: 1.55, p=0.038) and anti-TNF (HR: 2.28, p<0.001) were associated with the risk of UC-related hospitalization. Early hospitalization was not associated with a specific disease phenotype or outcome; however, 46.2% of all colectomies were performed in the year of diagnosis. Conclusion: Hospitalization and re-hospitalization rates were relatively high in this population-based UC cohort. Early hospitalization was not predictive for the later disease course.

Scoring System for the Diagnosis of COVID-19

2020 ◽  
Vol 13 (1) ◽  
pp. 413-414 ◽  
Author(s):  
Mohamed Farouk Allam
Keyword(s):  
Scoring System ◽  
Clinical Symptoms ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Negative Results ◽  
False Negative Results ◽  
Symptoms And Signs

Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple, could be calculated in a few minutes, and incorporates the main possible data/findings of any patient.

scholarly journals Chinese Herbal Medicine Dingji Fumai Decoction for Ventricular Premature Contraction: A Real-World Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Bo Liang ◽  
Fei-Hu Zou ◽  
Ling Fu ◽  
Hui-Ling Liao
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Medication Compliance ◽  
Controlled Trial ◽  
Ventricular Premature Contraction ◽  
Traditional Chinese Medicine Syndrome ◽  
Chinese Herbal ◽  
Double Blinded

Background. Chinese herbal medicine Dingji Fumai Decoction (DFD) is widely clinically used for ventricular premature contraction (VPC). This real-word trial was designed to assess the safety and effectiveness of DFD for VPC. Methods. This was a double-blinded, randomized placebo-controlled trial. Patients with VPC were randomized (1 : 1) to treatment with DFD combined with metoprolol (DFD arm) or metoprolol combined with placebo (MET arm). A primary end point was a composite of clinical symptoms and signs determined by the traditionalChinese medicine syndrome score and the number of VPC determined by the Holter examination. Second outcomes were adverse events, medication compliance, and laboratory examination. Results. 144 patients were randomized to DFD arm (76 patients) or MET arm (68 patients), and 136 cases (71 in DFD arm and 65 in MET arm) finally completed this trial. After a 12-week follow-up, DFD arm significantly decreased traditional Chinese medicine syndrome score and the number of VPC compared with MET arm (P=0.003 and 0.034, respectively). There was no adverse drug effect and patient medication compliance was good. Conclusions. Superiority with DFD arm for VPC was demonstrated over MET arm for both the safety and effectiveness end points.

scholarly journals Treatment and therapeutic strategies for pituitary apoplexy in pregnancy: a case series

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yuya Kato ◽  
Yoshikazu Ogawa ◽  
Teiji Tominaga
Keyword(s):  
Pituitary Apoplexy ◽  
Clinical Symptoms ◽  
Case Series ◽  
Optimal Timing ◽  
Presenting Symptoms ◽  
Pathological Evaluation ◽  
Mother And Child ◽  
Life Threatening ◽  
In Pregnancy

Abstract Background Pregnancy is a known risk factor for pituitary apoplexy, which is life threatening for both mother and child. However, very few clinical interventions have been proposed for managing pituitary apoplexy in pregnancy. Case presentation We describe the management of three cases of pituitary apoplexy during pregnancy and review available literature. Presenting symptoms in our case series were headache and/or visual disturbances, and the etiology in all cases was hemorrhage. Conservative therapy was followed until 34 weeks of gestation, after which babies were delivered by cesarean section with prophylactic bolus hydrocortisone supplementation. Tumor removal was only electively performed after delivery using the transsphenoidal approach. All three patients and their babies had a good clinical course, and postoperative pathological evaluation revealed that all tumors were functional and that they secreted prolactin. Conclusions Although the mechanism of pituitary apoplexy occurrence remains unknown, the most important treatment strategy for pituitary apoplexy in pregnancy remains adequate hydrocortisone supplementation and frequent hormonal investigation. Radiological follow-up should be performed only if clinical symptoms deteriorate, and optimal timing for surgical resection should be discussed by a multidisciplinary team that includes obstetricians and neonatologists.

scholarly journals Non-Invasive Dengue Diagnostics—The Use of Saliva and Urine for Different Stages of the Illness

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1345
Author(s):  
Mahathir Humaidi ◽  
Wei Ping Tien ◽  
Grace Yap ◽  
Choon Rong Chua ◽  
Lee Ching Ng
Keyword(s):  
Clinical Symptoms ◽  
Detection Algorithm ◽  
Acute Stage ◽  
Serum Samples ◽  
Non Invasive ◽  
Fever Onset ◽  
Dengue Transmission ◽  
Dengue Diagnostics ◽  
Potential Tool

Dengue diagnosis is largely dependent on clinical symptoms and routinely confirmed with laboratory detection of dengue virus in patient serum samples collected via phlebotomy. This presents a challenge to patients not amenable to venipuncture. Non-invasive methods of dengue diagnosis have the potential to enhance the current dengue detection algorithm. In this study, samples from dengue infected patients were collected between January 2012 until September 2012 and September 2013 until December 2013 in two different setups. Panel A samples (blood, urine, and saliva) were collected daily when the 39 patients were hospitalised and during their follow-up visits while Panel B samples (saliva) were collected from 23 patients during the acute stage of dengue. Using DENV PCR on Panel A, from day 2 to day 4 post fever onset, serum showed the best overall positivity followed by saliva and urine (100%/82.1%/67.9%). From day 5 until day 10 post fever onset, serum and urine had similar positivity (67.4%/61.2%), followed by saliva (51.3%). Beyond day 10 post fever onset, DENV was undetectable in sera, but urine and saliva showed 56.8% and 28.6% positivity, respectively. DENV in urine was detectable up until 32 days post fever. Panel B results showed overall sensitivity of 32.4%/36% (RNA/NS1) for DENV detection in saliva. Our results suggest that the urine-based detection method is useful especially for late dengue detection, where DENV is undetected in sera but still detectable in urine. This provides a potential tool for the physician to pick up new cases in an area where there is ongoing dengue transmission and subsequently prompt for intensified vector control activities.

scholarly journals Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors: an operative technique and short-term outcomes of 20 consecutive cases

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiaorong Yan ◽  
Huiqing Wang ◽  
Cai Li ◽  
Yuanxiang Lin ◽  
Lin Lin ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Spinal Deformity ◽  
Tumor Recurrence ◽  
Clinical Symptoms ◽  
Short Term ◽  
Before And After ◽  
Intradural Extramedullary ◽  
Controlled Surgery

Abstract Background To present a surgical technique for the treatment of intradural extramedullary (IDEM) tumors by using endoscopically controlled surgery with open hemilaminectomy technique. Methods In this study, 20 patients with 22 IDEM tumors were enrolled. An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors. Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis. Results All the tumors in 20 patients were well removed. The clinical symptoms were significantly reduced in all the patients as well. The short-term follow-up data showed that there was no tumor recurrence or spinal deformity. Conclusion The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors. It may be an effective surgical method for treating IDEM tumors. Larger samples and longer follow-up data are needed to verify its long-term effectiveness.

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