scholarly journals The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy

2020 ◽  
Vol 10 (3) ◽  
pp. 317-328
Author(s):  
Dadi Hamdani ◽  
Awal Prasetyo ◽  
Anggorowati Anggorowati
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Intervention Group ◽  
Control Group ◽  
Anticipatory Nausea ◽  
Control Group Design ◽  
Significant Difference ◽  
The Mean

Background: One of the chemotherapy side effects on head and neck cancer patients is anticipatory nausea. However, the anticipatory nausea problem has not been properly resolved. Nausea might be psychologically reduced by hypnotherapy. There only have been very few studies conducted to examine the effects of hypnotherapy in alleviating anticipatory nausea.Purpose: This study aimed to determine the effect of hypnotherapy using Hanung induction technique on anticipatory nausea in head and neck cancer patients undergoing chemotherapy.Methods: This research employed a pre-post test of quasi-experiment with control group design. Consecutive sampling technique was used to obtain 64 subjects who met inclusion and exclusion criteria and were equally divided into the intervention and control groups. Hypnotherapy as the intervention was carried out in two sessions, each of which lasted for 20 minutes, with a week distance between sessions. The data were collected using a visual analog scale (VAS), which was used twice to measure anticipatory nausea and analyzed using the paired and independent-sample t-test.Result: The results showed that the mean score of anticipatory nausea in the intervention group reduced from 7.6±1.4 to 2.3 ±1.2 after hypnotherapy, while the mean in the control group increased from 6.4±1.6 to 6.7±1.4. There was a significant difference in the score of anticipatory nausea after the implementation of hypnotherapy between the intervention and the control group (p<0.001).Conclusion: The study concluded that hypnotherapy is effective in reducing the intensity of anticipatory nausea in head and neck cancer patients undergoing chemotherapy. Therefore, hypnotherapy can be applied by oncology nurses as an intervention in treating anticipatory nausea.

Prevention of cisplatin nephrotoxicity (CN) in head and neck cancer patients receiving concurrent chemoradiation (CCRT) by adding oral rehydration solution (ORS) to short hydration regimen: A randomized open-label controlled trial.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18560-e18560
Author(s):  
Aungsumal Maisrikrod ◽  
Siwat Sakdejayont ◽  
Jakkapan Rongmuang ◽  
Chirawadee Sathitruangsak ◽  
Patrapim Sunpaweravong ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Sample Size ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Controlled Trial ◽  
Control Group ◽  
Open Label ◽  
Total Fluid Intake ◽  
Significant Difference

e18560 Background: CN remains a frequent occurrence despite receiving standard fluid hydration, particularly for head and neck cancer patients undergoing CCRT. We aimed to investigate whether adding ORS to short hydration regimen can reduce CN. Methods: We conducted a randomized open-label controlled trial in patients with head and neck cancer receiving CCRT with 3-weekly cisplatin (≥ 60 mg/m²). Eligible patients were randomly assigned to receive short hydration regimen (2000 mL of normal saline on day 1) alone or in combination with 2000 mL of ORS on days -1, 2 and 3 of each cycle. All patients were instructed to drink at least 2000 mL of fluid. The primary end point was the incidence of ≥ gr 1 creatinine (Cr) elevation on day 8. The planned sample size was 160 (80 patients each arm). Results: Thirty-five patients in ORS group and 34 patients in control group (43% of planned sample size) were enrolled. Baseline characteristics were balanced between the two groups, except more patients in ORS group underwent surgery (35.3% vs. 22.9%), and had less feeding tube prophylaxis (76.5% vs. 88.6%), although there were not statistically significant. The mean dose of cisplatin on day 1 was significantly higher in ORS group (91.2 mg/m2 vs. 85.1 mg/m2, p=0.01). There was no difference of volume of total fluid intake and toxicities between the two groups. Less percentage of patients in ORS group developed ≥ gr 1 Cr elevation as shown in the Table, although there were not statistically significant. Conclusions: Although our interim analysis showed no significant difference of CN between the groups, there was a trend that addition of ORS might prevent acute and chronic kidney injury secondary to cisplatin. The completed enrollment is warranted to confirm this early findings. Clinical trial information: TCTR20200207005 . [Table: see text]

scholarly journals Evaluation of the prevalence and severity of xerophthalmia in head and neck cancers patients undergoing curative radiotherapy

2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Sowmya V ◽  
Dipika Jayachander ◽  
Vijna Kamath ◽  
Mithun SK Rao ◽  
Mohammed Raees Tonse ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Keratoconjunctivitis Sicca ◽  
Study Objective ◽  
Cancer Group ◽  
Curative Radiotherapy ◽  
Significant Difference ◽  
Rectal Cancers

  Background: The study objective was to assess the development of xerophthalmia [dry eye syndrome (DES) or keratoconjunctivitis sicca] in head and neck cancer patients undergoing radiotherapy.Methods: Twenty two head and neck cancer patients requiring more than 60 Gy of curative radiotherapy/chemoradiotherapy and ten patients requiring radiotherapy/ chemoradiotherapy for treating cancers in the non head and neck regions (like breast, oesophagus, prostate, cervix and rectal cancers) were also enrolled in the study. The development of DES was studied at the beginning (day 0, before the start of radiotherapy) at day 21 (after completion of 30 Gy) and on completion of the treatment (> 60 Gy). As a comparative cohort, people with non head and neck cancer needing curative radiotherapy were also evaluated for comparison.Results: There was no difference in degree of DES between the Head and Neck cancer cohorts and non head and neck group at the beginning of treatment. However there was a statistically significant difference (p < 0.001) between the two groups at both mid and end of RT time point. Inter comparison between the various time points in the head and neck cancer group showed that the incidence of DES increased with the radiation exposure and was significant (pre to mid p < 0.001; and mid to end p < 0.005). A negative (r = -0.262) correlation was seen between DES and distance.Conclusions: The study showed that lesser the distance from the epicenter of the radiation to the orbital rim more was the severity of DES.

scholarly journals Quantitative Assessment of Serum Magnesium Levels in Head and Neck Cancer: A Tertiary Hospital Based Case Control Study

2021 ◽  
pp. 249-257
Author(s):  
Surender Kumar ◽  
Neha Salaria ◽  
Deepak Verma ◽  
Uma Garg ◽  
Monika Verma
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Case Control Study ◽  
Serum Magnesium ◽  
Tertiary Care ◽  
Case Control ◽  
Control Group ◽  
Control Study

Background- Head and neck squamous cell carcinomas(HNSCC) are one of the most widespread malignancies worldwide. Trace elements such as magnesium are essential at cellular level, and it has been suggested that magnesium plays a role in carcinogenesis. Methods- A hospital based case control study was conducted in a tertiary care medical college with an aim to determine the levels of serum magnesium in patients with head and neck cancer and to  compare  the  levels  of  serum  magnesium  of head and neck cancer patients   with healthy matched control  group  and  derive significance if any. Results- HNSCC was mainly found in males of age group 46 to 55 years. The mean serum Mg value of head and neck cancer patients was 0.71± 0.18 mmol/l while that seen in controls was 0.85± 0.09 mmol/l which was significantly lower(p<0.001). Average serum magnesium levels in stages I, II, III and IV were 0.85, 0.849, 0.682 and 0.554 mmol/l respectively, and a statistically significant association was determined between the two. Conclusion- As the stage of cancer progressed, average magnesium levels decreased congruently, hence establishing that magnesium levels were undeniably correlated to onset as well as progression of HNC. These evidences could be utilized to identify role of magnesium asa potential prognostic biomarker to assess progression of disease or clinical response to various modes of therapy in head and neck cancer patients.

QOL assessment in head and neck cancer patients undergoing neoadjuvant chemotherapy and its impact on overall survival.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17519-e17519
Author(s):  
Sachin Dhumal ◽  
Vijay Maruti Patil ◽  
Vanita Noronha ◽  
Amit Joshi ◽  
Atanu Bhattacharjee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Treatment Options ◽  
Life Assessment ◽  
The Mean

e17519 Background: NACT (neoadjuvant chemotherapy) is one of the treatment options in advanced head and neck cancer (H&N cancer); however there is limited quality of life data available in these patients. Methods: Between August 2013- April 2014, 90 technically unresectable H&N cancer patients who were underwent NACT at our centre were selected for this analysis. EORTC QLQ-C30 and HN35 version 3.0 was used for quality of life assessment at baseline and after 02 cycles of NACT. PFS and OS was estimated by Kaplan Meier method. The mean change in QOL at various domains was calculated with 95% CI. The relationship between change in QOL domain and OS was analysed. Results: The median age of the cohort was 45 years (Range 21-65 years). The predominant subsite was oral cavity, in 62 patients (68.9%).The median PFS and OS was 10.53 months (95%CI 8.1-13.0) and 20.8 months (95%CI 15.1-26.5). The mean scores for all domains of QOL are shown in table 1. Conclusions: NACT leads to improvement in QOL in patients treated with head and neck cancers and its has impact on OS.[Table: see text]

scholarly journals Retrospective analysis of random and systematic errors in radiation therapy of head and neck cancer patients and its clinical predictive implications with VMAT treatment

2019 ◽  
Vol 7 (7) ◽  
pp. 2758
Author(s):  
Jui Deb ◽  
Santanu Chaudhuri ◽  
Debashis Panda ◽  
Sujit Nath Sinha ◽  
Sasi Kumar ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Systematic Errors ◽  
Guidance System ◽  
Reference Image ◽  
Cbct Image ◽  
The Mean ◽  
Immobilization Techniques

Background: The accuracy of radiotherapy is based on the matching of 2D portal/CBCT image with a reference image. The aim of this study is to determine the random and systematic setup errors (in cm) in radiotherapy of head and neck cancer patients and to derive the setup margin and its clinical implications.Methods: Author retrospectively reviewed the records of 25 head and neck cancer (HNC) patients treated with radiotherapy between Dec 2017 and July 2018. After immobilization, setup accuracy was assessed by registration of XVI image with planning reference image using Elekta XVI image guidance system and the isocenter correction was applied. For each patient 10 CBCT image sets were taken. The translational errors in X, Y and Z directions were used to estimate systematic (Σ) and random (σ) errors and to derive the final setup margin by using van Herk’s formula (2.5Σ + 0.7σ).Results: The mean translational errors ranges from -0.23 cm to 0.32 cm in Lateral (X), -0.15 to 0.16 cm in Longitudinal (Y) and -0.11 to 0.17 cm in vertical (Z) directions. The Mean and SD for systematic errors 0.21±0.13, 0.11±0.18, 0.14±0.11 and random error (in cm) are -0.03±0.33, 0.00±0.21 and 0.05±0.30 in X, Y and Z axis respectively. The final total margin for CTV to PTV including setup margin in the X, Y and Z directions (in cm) were 0.56, 0.61, and 0.47 respectively.Conclusion: Thus, the precise immobilization techniques are very important to reduce the setup margins, and the number of CBCTs during head and neck radiotherapy treatment.

scholarly journals Alteration in Oral Flora and Effect of Mucositis in Head and Neck Cancer Patients Undergoing Chemo-radiotherapy

2020 ◽  
Vol 14 (3) ◽  
pp. 2129-2135
Author(s):  
Reeta Maurya ◽  
Manodeep Sen ◽  
Madhup Rastogi ◽  
Somali Sanyal
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Oral Bacteria ◽  
Control Group ◽  
Oral Flora ◽  
Healthy Mucosa ◽  
History Of ◽  
Post Radiation

The main aim of this study is to determine the various types of oral bacteria and yeast. Present in oral flora of head and neck cancer patients at different stages of chemo-radiotherapy, and compare it with the control group (patients with contralateral healthy mucosa). Seventy seven patients with proven history of squamous cell carcinoma were included in the study. The oral mucosa profile was assessed for bacterial manifestations in swab samples from both the sites of the patients. The grade of mucositis was charted out for all patients during the second and third week of radiotherapy. The study revealed that all isolated oral flora showed a non-significant increase during radiotherapy, while there was a decrease in oral flora in post RT. However, E. faecalis showed a non- significant decrease during RT, while Citrobacter showed an increase. Candida albicans showed 83% non- significant decrease post- radiotherapy. When these floras were correlated with grade of mucositis, an insignificant increase in flora was found in G2 and G3 stage of mucositis. In this study, the effect of radiation was evaluated on oral flora of head and neck cancer patients and compared with contralateral healthy mucosa of the patients. Various changes were observed during and after radiation therapy. In patients with head and neck cancer the normal oral flora are replaced by pathogenic flora during radiotherapy, and the latter is responsible for infections in post- radiation phase.

scholarly journals The Accuracy of Individualized 3D-Printing Template-Assisted I125 Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Bin Qiu ◽  
Yuliang Jiang ◽  
Zhe Ji ◽  
Haitao Sun ◽  
Jinghong Fan ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
3D Printing ◽  
Head And Neck ◽  
Neck Cancer ◽  
Mean Deviation ◽  
Conformity Index ◽  
Seed Implantation ◽  
Significant Difference ◽  
Radioactive Seed ◽  
The Mean

PurposeTo evaluate the accuracy of individualized 3D-printing template-assisted I125 radioactive seed implantation (3D-PT assisted I125 RSI) for recurrent/metastatic head and neck cancer.Materials and MethodsFrom February 2017 to January 2020, clinical data of 41 patients (mean age, 58.5 ± 16.1 years; 28 males) with recurrent (48.8%)/metastatic (51.2%) head and neck cancer underwent individualized 3D-PT assisted I125 RSI under CT guidance in a single institute were retrospectively reviewed. Total 430 seed needles [mean, 10.5 (range 3–17) per patient] were inserted.ResultsAll seed needles were inserted manually in a single attempt with the technical success rate of 100% without major perioperative complications. The mean needle’s entrance deviation was 0.090 cm (95% Confidence Interval, 0.081–0.098). The mean intraoperative depth and angle of the needle were consistent with that of planned (6.23 ± 0.24 vs. 6.21 ± 0.24 cm, p = 0.903; 83.14 ± 3.64 vs. 83.09 ± 3.66 degrees, p = 0.985, respectively). The mean deviation between the needle’s planned and intraoperative depth and angle was 0.168 ± 0.024 cm and 1.56 ± 0.14 degrees, respectively. The postoperative dosimetry parameters, including D90, D100, V100, V150, V200, conformity index, external index, and homogeneity index, were all well-coordinated with planned dosimetry without significant difference (p = 0.515, 0.662, 0.958, 0.865, 0.872, 0.278, 0.456, and 0.989, respectively).ConclusionsWithin the limitation of this study, individualized 3D-PT assisted I125 RSI may be accurate in obtaining favorable postoperative dosimetry for patients with recurrent/metastatic head and neck cancer.Clinical Trial Registration[website], identifier [registration number].

A Quasi Experimental Study to Evaluate the Efficacy of Sesame Oil on Radiation Induced Xerostomia among patients with Head and Neck Cancer

2021 ◽  
pp. 523-527
Author(s):  
R. Suvitha ◽  
K. Kanchana ◽  
T. Nirmala
Keyword(s):  
Experimental Study ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sesame Oil ◽  
Control Group ◽  
Control Group Design ◽  
Quasi Experimental ◽  
Radiation Induced ◽  
And Control

A quasi experimental study to evaluate the efficacy of sesame oil on radiation induced xerostomia among patients with head and neck cancer. Non randomized quasi experimental pretest posttest control group design was adopted in this study. By using purposive sampling technique, 26 samples were selected based on inclusion criteria, 13 in experimental and 13 in control group. The demographic variables, clinical profile of the samples were collected, the level of Xerostomia was assessed by modified GRIX questionnaire in both experimental and control group. Intervention was given to experimental group and routine treatment was given to control group. It was identified that the mean level of Xerostomia among head and neck cancer patient in the experimental and control group was 51.08 and 30.4 respectively with mean difference of 20.54. Likewise the standard deviation of the experimental and control group was 4.63 and 4.92 respectively. The calculated ‘t’ value 10.96 was greater than the table value of 2.06 at 0.05 level of significance. Hence, it was concluded that sesame oil mouth rinsing is an effective method to reduce the radiation induced Xerostomia among patient with head and neck cancer.

Complications of Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients

1992 ◽  
Vol 101 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Sharon E. Gibson ◽  
Barry L. Wenig ◽  
James L. Watkins
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Neck Cancer ◽  
Intraoperative Complications ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Medical Problems ◽  
Endoscopic Gastrostomy

Percutaneous endoscopic gastrostomy (PEG) has been shown to benefit patients with resectable carcinoma of the head and neck. In order to determine whether patients with existing tumor or postresection anatomic changes of the upper respiratory tract can undergo this procedure with an acceptably low complication rate, 349 patients with attempted PEG were studied. The PEG procedure was successful in 114 of 122 carcinoma patients, as compared to 220 of 227 patients in a control group (patients with neurologic disease). Intraoperative complications preventing PEG placement included pharyngeal or esophageal obstruction, inadequate transillumination of the abdominal wall, and respiratory distress and occurred in 7% of carcinoma patients and 3% of controls. The incidence of airway obstruction during endoscopy was equal between groups (1%). Postoperative complications related to the gastrostomy tube were more frequent in the nonhead and neck cancer group (14% versus 5%). Younger age, fewer concomitant medical problems, and better nutritional status may account for this difference. These findings suggest that preoperative, postoperative, and unresectable head and neck cancer patients are appropriate candidates for PEG, and postgastrostomy performance appears superior to that in other patient populations.

CLO19-061: Clinical Features and Prognosis of Head and Neck Cancer in Patients With Esophagus Cancer

2019 ◽  
Vol 17 (3.5) ◽  
pp. CLO19-061
Author(s):  
Weihui Zheng ◽  
Weimin Mao ◽  
Jianlin Lou
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Survival Time ◽  
Neck Cancer ◽  
Survival Rates ◽  
Metachronous Cancer ◽  
Esophagus Cancer ◽  
Mean Survival Time ◽  
Significant Difference ◽  
The Mean

Objective: This study investigated the clinical and prognostic characteristics of head and neck cancer in patients with esophagus cancer. Methods: Information on 124 patients with head and neck cancer with esophagus cancer was collected from head and neck and thoracic surgery departments between January 2007 and December 2016 in Zhejiang Cancer Hospital. The incidence of synchronous and metachronous cancer was described. The clinical characteristics and prognosis were also compared in synchronous and metachronous cancer. The number of hospitalization and different treatments were analyzed the affection on the survival time. Results: 32 cases were synchronous cancer and 72 cases were metachronous cancer. The rate of surgery and the number of hospitalization were significantly different in synchronous and metachronous cancer (χ2=4.661; P<.05). The 1-year, 3-year, and 5-year survival rates were 39.9%, 19.9%, and15.2%, respectively in patients with synchronous cancer and the mean survival time was 18.4±6.2 months. In contrast, the survival rates were 78.7%, 77.8%, and 59.1% respectively in metachronous cancer and the mean survival time was 122.2±17.2 months. There was a significant difference between the 2 groups (χ2=10.934; P=.001). The number of hospitalizations greater than or equal to 5 times were significantly different from those with less than 5 times (χ2=10.574; P=.001). There was no statistically significant difference in the improvement of OS by single operation, chemotherapy, and target treatment. The P value was only slightly less than .05 in the radiation therapy. Conclusions: Head and neck cancer in patients with esophagus cancer have a high survival rate through active combined-modality therapies, especially in metachronous carcinoma.

Sign in / Sign up

Export Citation Format

Share Document