Negative Air Pressure on Wet Cupping in Decreasing Blood Pressures in Hypertensive Patients

Background: Wet cupping, furthermore mentioned cupping, decreases blood pressures through the level of negative air pressures added by hydrostatics filtration pressure to reinforce the power of fluids filtration in capillaries. However, an appropriate negative air pressure to decrease blood pressure remains an uncertainty.Purpose: This study aimed to analyze negative air pressure differences on cupping in decreasing blood pressures in hypertensive patients.Methods: This is a quasi-experimental design conducted in three Community Health Centers in Langsa City, Aceh, Indonesia. The samples were 36 hypertensive males with age from 45 to 55, who were randomly stratified into two groups with cupping pressures 400 mbar (n=18) as the control group; and 540 mbar (n=18) as the intervention group. The cupping session was performed to each group on T1 (alkahil) point and in the middle line of both shoulders blade points. The systolic blood pressure (SBP) and diastolic blood pressures (DBP) were measured by validated automatic sphygmomanometer. The follow-up periods were one week and two weeks. The data were then analyzed by repeated measures ANOVA.Results: Cupping pressure of 400 mbar decreased the mean of SBP and DPB with a p-value of 0.450 and 0.026, respectively after two weeks of intervention. Meanwhile, cupping pressure of 540 mbar decreased the mean of SBP and DBP with a p-value of 0.006 and 0.057, respectively. Tests of within-subjects resulted in the p-value of 0.250 (SBP) and 0.176 (DBP) after two weeks of intervention. There were no significant differences in SBP and DBP between the intervention group and the control group.Conclusion: The cupping pressure between 400 mbar and 540 mbar could reduce blood pressure; however, the cupping pressure of 540 mbar yielded greater effect in decreasing blood pressure than the 400 mbar. Negative air vacuum pressure loads on cupping to decrease blood pressure should be considered between 400 to 540 mbar, and further studies are needed.

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Pengaruh Jus Apel Terhadap Penurunan Tekanan Darah pada Lansia Hipertensi di Puskesmas Muara Kaman

Jurnal Ilmu Kesehatan ◽

10.30650/jik.v5i2.61 ◽

2018 ◽

Vol 5 (2) ◽

pp. 121-129

Author(s):

Siti Khoiroh

Keyword(s):

Blood Pressure ◽

Community Health ◽

Apple Juice ◽

Antihypertensive Drugs ◽

Intervention Group ◽

T Test ◽

Mean Difference ◽

Control Group ◽

P Value ◽

The Mean

Background : Hypertension is a condition of high blood pressure in the arteries that lasted continuously for the long term. Hypertension can be overcome in two ways: pharmacology and non-pharmacology. Pharmacology treatment usually use medicine while one of the ways for non-pharmacology treatment is to consumes apple juice.Research Objective : The aim of this research is to know the effect of apple juice on blood pressure decrease in elderly people with hypertension at Muara Kaman Community Health Center.Methods : The design of this research used quasi experimental design (quasi experiment) with pretest posttest control group design. The sample of the research was hypertensive respondents at Muara Kaman Community Health Center as many as 30 respondents were divided into 2 groups, 15 intervention groups and 15 control groups. The sampling technique used purposive sampling. The research instruments were stethoscope and sphygmomanometer, data analysis using t test dependent and t test independent.Results : There were a significant influence between pretest and posttest of apple juice in the intervention group (P value = 0,000; P <0.005). The mean difference in systolic blood pressure in the intervention group and the control group also had significant differences (P value = 0.002; P <0.05), where as the mean difference in diastolic blood pressure in the intervention group and the control group also had significant differences (P value = 0,039; P <0,05).The Conclusions : The results of this research showed that consumes apple juice gives an effect on the blood pressure of hypertensive patients by consumes regularly.The Suggestions : Nurses and the public can use apple juice as one of the ways to handling to hypertension sufferers besides antihypertensive drugs.

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PENGARUH TERAPI YOGA TERHADAP PENURUNAN TEKANAN DARAH PADA PENDERITA HIPERTENSI

Jurnal Perawat Indonesia ◽

10.32584/jpi.v3i1.181 ◽

2019 ◽

Vol 3 (1) ◽

pp. 36

Author(s):

Rr Sri Endang Pujiastuti ◽

Sawab Sawab ◽

Safitri Zummy Afiyati

Keyword(s):

Blood Pressure ◽

Health Workers ◽

Age Groups ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Yoga Therapy ◽

Decrease Blood Pressure ◽

Quasi Experimental ◽

And Control

Hipertensi disebut silent disease karena biasanya pasien tidak sadar bahwa dirinya mengalami hipertensi. Hipertensi dapat menyerang siapa saja dari berbagai kelompok umur maupun kelompok sosial ekonomi. Pengobatan Hipertensi tidak harus menggunakan tidakan farmakologis, namun hipertensi dapat diobat menggunakan terapi non farmakologis berupa terapi yang berbentuk meditasi berupa terapi yoga. Penelitin ini bertujuan untuk mengetahui pengaruh pemberian terapi yoga terhadap penurunan kecemasan dan tekanan darah pada penderita Hipertensi. Metode ini adalah desain Quasi-eksperimental dilakukan di Kelurahan Pedalangan RW 01. Sampel adalah 60 penderita hipertensi primer, yang secara acak dikelompokkan menjadi dua kelompok yaitu kelompok intervensi (n = 30) dan kelompok kontrol (n = 30). Hasil Analisa penelitian ini menunjukkan pada tekanan darah sistole dengan nilai p value 0,001 (p <0.05) dan tekanan darah diastole dengan nilai p value 0,000 (p <0.05) pada kelompok intervensi dan kontrol setelah dilakukan yoga. Ada pengaruh yoga terhadap penurunanmtekanan darah pada penderita hipertensi. Peneliti menyarankan kepada semua tenaga kesehatan untuk menerapkan terapi yoga kepada pasien hipertensi karena yoga mampu menurunkan tekanan darah. Kata kunci: Yoga, tekanan darah, hipertensi Abstract The effect of yoga therapy to decrease blood pressure in patients with hypertension. Hypertension is called the silent disease, it’s usually caused an patient not be aware that they was being hypertension. Hypertension can affect anyone of various age groups and socio-economic groups. Hypertension can treatment should not used pharmacological, measure, however hypertension can treatment by nonpharmacologycal teraphy a form of transcedental meditation or yoga. The purpose of this research is conducted to determine the effect of yoga therapy to decrease blood pressure in patients with hypertension. This method design Quasi-experimental done in Pedalangan village RW 01. The sample was 60 subject primary hypertension, who were randomized include 2 groups: there was intervention group (n = 30) and control group (n = 30). Analysis result Man Whitney experiment systolic blood pressure p value 0.001 (P <0.05) and diastolic blood pressure with p value 0.000 (p <0.05) in the intervention and control groups after yoga. There is the influence of yoga to lowering blood pressure in hypertensive patients. Researchers suggest to all health workers to apply yoga therapy to patients with hypertension because yoga can lower blood pressure.Keywords: Yoga, blood pressure, hypertension

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Pengaruh program brisk walking exercise terhadap penurunan tekanan darah pada penderita hipertensi

HOLISTIK JURNAL KESEHATAN ◽

10.33024/hjk.v15i2.4697 ◽

2021 ◽

Vol 15 (2) ◽

pp. 230-238

Author(s):

Septi Andrianti ◽

Ikhsan Ikhsan

Keyword(s):

Blood Pressure ◽

Intervention Group ◽

Systolic Pressure ◽

Exercise Program ◽

Control Group ◽

P Value ◽

Brisk Walking ◽

Quasi Experimental ◽

Walking Exercise ◽

The Mean

The effect of brisk walking exercise program on blood pressure for people with hypertension Background: Some patients with hypertensive only use antihypertensive drugs to decrease their blood pressure. There are alternatives and more effective as non-pharmacological alternatives to help decrease blood pressure.Purpose: To determine the effect of brisk walking exercise program on blood pressure for people with hypertensionMethod: Quasi-experimental design, the participants were divided into two groups (intervention group and nonintervention group). The sample of this study was 20 participants with contraindications taken by consecutive Sampling. Brisk walking exercise program for 20-30 minutes with an average speed of 4-6km/hour. Three times a week for two months. Data analyzed using a dependent t-test with a 95% confidence level.Results: The study showed that the mean of the intervention systolic pressure before intervention (154.00±10.75) with range (140-170) and after intervention (140.00±8.17) with range (130-160)(p-value=0.001). In the control group, mean the systolic pressure (143.00±8.23) with range (130-150) and after two months (135.50±5.50) with range (130-150). The mean of the diastolic pressure (Intervention group) before (97.00±6.75)with range (90-110) and after (85.00±4.71) with range (80-90). The control group (93.00±6.32) (80-100) and after (89.00±5.16) with range (85-95)(p-value=0.001)Conclusion: There was a significant effect of the brisk walking exercise program in the intervention group, which was stronger than the control group.Keywords: Brisk walking exercise; Blood pressure; Hypertension Pendahuluan: Beberapa penderita hipertensi hanya menggunakan obat antihipertensi untuk menurunkan tekanan darahnya. Ada alternatif dan lebih efektif sebagai alternatif non-farmakologis untuk membantu menurunkan tekanan darah.Tujuan: Untuk mengetahui pengaruh program brisk walking exercise terhadap penurunan tekanan darah pada penderita hipertensi.Metode: Quasi-experimental design, peserta dibagi menjadi dua kelompok (kelompok intervensi dan kelompok Kontrol). Sampel penelitiannya 20 partisipan tanpa kontraindikasi yang diambil secara Consecutive Sampling. Program brisk walking exercise selama 20-30 menit dengan kecepatan rata-rata 4-6km/jam. Tiga kali seminggu selama dua bulan. Data dianalisis menggunakan uji-t dependen dengan tingkat kepercayaan 95%.Hasil: Menunjukkan bahwa rerata tekanan sistolik intervensi sebelum intervensi (154,00±10,75) dengan rentang (140-170) dan setelah intervensi (140,00±8,17) dengan rentang (130-160)(p-value=0,001). Pada kelompok kontrol, rata-rata tekanan sistolik (143,00±8,23) dengan kisaran (130-150) dan setelah dua bulan (135,50±5,50) dengan rentang (130-150). Rerata tekanan diastolik (kelompok intervensi) sebelum (97,00±6.75) dengan rentang (90-110) dan setelahnya (85,00±4,71) dengan rentang (80-90). Kelompok kontrol (93.00±6.32) dengan rentang (80-100) dan setelahnya (89,00±5,16) dengan rentang (85-95)(nilai-p=0,001)Simpulan: Ada pengaruh yang signifikan dari program brisk walking exercise pada kelompok intervensi yang lebih kuat dibandingkan kelompok kontrol.

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The Effect of the Mobile ‘Blood Pressure Management Application’ on Hypertension Self-Management Enhancement: A Randomised Controlled Trial

10.21203/rs.2.1820/v2 ◽

2019 ◽

Author(s):

Ali Bozorgi ◽

Hamed Hosseini ◽

Hassan Eftekhar ◽

Reza Majdzadeh ◽

Ali Yoonessi ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Clinical Trial ◽

Repeated Measures ◽

Patient Adherence ◽

Intervention Group ◽

Public Hospitals ◽

Self Management ◽

Control Group ◽

Management Application

Abstract Background : Self-management of blood pressure is of great significance given the increasing incidence of hypertension and associated disabilities. With the increased use of mobile health in medicine, the present study evaluated the effect of the self-management application on patient adherence to hypertension treatment. Methods : This clinical trial was performed on 120 hypertensive patients who were provided with a mobile intervention for 8 weeks and followed-up to 24 th weeks. Data on the primary outcome (adherence to treatment) and secondary outcomes (adherence to the DASH diet, regular monitoring of blood pressure, and physical activity) were collected using a questionnaire and a mobile application, respectively. The inter-group change difference over time was analyzed using repeated measures ANOVA (General Linear Model). Results : The treatment adherence score increased by an average of 5.9 (95%CI: 5.0-6.7) in the intervention group compared to the control group. Scores of adherence to the low-fat and low-salt diet plans were 1.7 (95%CI: 1.3-2.1) and 1.5 (95%CI: 1.2-1.9), respectively. Moreover, moderate physical activity increased to 100.0 minutes (95%CI: 61.7-138.3) per week in the intervention group. Conclusion: The treatment and control of blood pressure require a multifaceted approach given its complexity and multifactorial nature. Considering the widespread use of smartphones , mhealth interventions can be effective in self-management and better patient adherence to treatments. Our results showed that this application can be used as a successful tool for hypertension self-management in patients attending public hospitals in developing countries. Trial registration: This study was registered in the Iran Randomized Clinical Trial Center under the number IRCT2015111712211N2 on 1 January 2016.

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EFFECTIVENESS OF LAVENDER AROMATHERAPY AND CLASSICAL MUSIC THERAPY IN LOWERING BLOOD PRESSURE IN PREGNANT WOMEN WITH HYPERTENSION

Belitung Nursing Journal ◽

10.33546/bnj.301 ◽

2017 ◽

Vol 3 (6) ◽

pp. 750-756

Author(s):

Sri Maisi ◽

Suryono Suryono ◽

Melyana Nurul Widyawati ◽

Ari Suwondo ◽

Suryati Kusworowulan

Keyword(s):

Blood Pressure ◽

Music Therapy ◽

Systolic Blood Pressure ◽

Pregnant Women ◽

Classical Music ◽

Combination Group ◽

Control Group ◽

P Value ◽

The Mean ◽

And Control

Background: Hypertension during pregnancy remains high in Indonesia. It is a major cause of maternal death. Aromatherapy lavender and classical music therapy are considered effective in lowering blood pressure in hypertension.Objective: To examine the effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension.Methods: A quasy experimental study with pretest-posttest control group design. There were 52 pregnant women with the inclusion criteria selected as samples using simple random sampling, divided into lavender aromatherapy group, classical music group, combination of aromatherapy and music group, and control group. Sphygmomanometer was used to measure blood pressure. Mann Whitney and Post Hoc test were used for data analysis.Results: Results showed that four groups have a significant decrease in systolic blood pressure after given intervention with p-value <0.05. The mean decrease of systolic blood pressure among four groups was: lavender group (5.77 mmHg), music group (7.23 mmHg), combination group (9.54 mmHg), and control group (3.67 mmHg); and the mean decrease of diastolic blood pressure was: the lavender group (2.77 mmHg), music group (0.61 mmHg), combination group (8.23 mmHg), and control group (3.42 mmHg).Conclusion: there was a significant effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension. However, the combination of both interventions was more effective than lavender aromatherapy or music therapy alone.

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Application of platysma muscle suture after thyroidectomy

Journal of Surgery and Trauma ◽

10.32592/jsurgery.2020.8.4.103 ◽

2020 ◽

pp. 147-150

Keyword(s):

Postoperative Pain ◽

Wound Infection ◽

Intervention Group ◽

Control Group ◽

P Value ◽

Platysma Muscle ◽

Significant Difference ◽

Duration Of Surgery ◽

The Mean ◽

Length Of Hospitalization

Introduction: Thyroidectomy is a common surgery in the neck area, in which the application of platysma muscle suture after thyroidectomy is still being discussed. This study was conducted to compare the application (currently common) or non-application of suture for platysma muscle. Methods: In this retrospective cross-sectional study, 117 patients underwent thyroidectomy, among which 63 cases without suturing platysma (control group) and 54 subjects with suturing platysma (Intervention group ) were examined in terms of postoperative pain based on visual analogue scale score measured 24 h post-operation. The samples were also investigated regarding hematoma and seroma, wound infection, length of hospitalization, scarring (1 year after surgery), duration of surgery, and the number of cases using opioids during the hospitalization. Patients with diabetes, previous neck surgery, coagulopathy, and radiation history were excluded from the study. The gathered data were analyzed statistically in SPSS software (version 18) using the Chi-square test and the Mann–Whitney U test. A p-value of less than (0.05) was considered significant. Results: Based on the findings, the mean age of the patients in the Intervention group was calculated at 51 years, of which 41 and 13 cases were females and males, respectively. In the Intervention group, 34 patients underwent complete thyroidectomy and 20 patients had hemithyroidectomy. The mean age score of subjects in the control group was calculated at 50 years, of which 44 and 19 patients were respectively female and male. No significant difference was revealed considering wound infection, length of hospitalization, created scarring, the amount of opioid use (opioids), and postoperative pain. However, only the length of surgery was different between the groups (P-value<0.05). Conclusions: There was no difference between wound and surgical complications and cosmetic results between both groups; nevertheless, due to the duration of the surgery and other benefits, such as consuming less thread, not suturing the platysma is recommended.

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The individual empowerment program improves glycemic and lipid controls in admitted type 2 DM patients

Diabetes Mellitus ◽

10.14341/dm8339 ◽

2018 ◽

Vol 21 (2) ◽

pp. 113-117

Author(s):

Ampornpan Theeranut ◽

Nonglak Methakanjanasak ◽

Pattama Surit ◽

Wasana Ruaisungnoen ◽

Kittisak Sawanyawisuth ◽

...

Keyword(s):

Intervention Group ◽

Control Group ◽

P Value ◽

Inpatient Setting ◽

Short Term ◽

The Mean ◽

The Individual ◽

Diabetes Patients ◽

Empowerment Program

Aim. To evaluate the short-term effects of the empowerment program on glycemic and lipid profiles in an inpatient setting for DM type 2 patients. Materials and methods. This was a quasi-experimental study conducted between October 2013 and June 2015. We enrolled diabetes patients admitted to the hospital, age over 35 years, and HbA1c 7%. During the admission, the intervention group received the empowerment course three times prior to discharge, the control group received standard diabetes and nursing care. All patients body weight, HbA1c, HDL-c, and LDL levels were evaluated at three and six months after discharge. All outcomes were compared between the control and intervention group. Results. A total of 57 diabetes patients participated in the study, with 27 in the intervention group and 30 in the control group. The intervention group had significantly higher HbA1c levels than the control group (10.3% vs 8.0%; p value 0.001). After discharge, the mean HbA1c and LDL-c levels of the intervention group were significantly lower than those of the control group at three and six months, while the mean HDL-c level of the intervention group was significantly higher than that of the control group at six months (1.54 vs 1.29 mmol/L; p value 0.001). The average body mass index of the intervention group was also significantly lower than that of the control group at six months (22.74 vs 25.54 kg/m2; p value = 0.016). Conclusion. The individual empowerment program improved short-term glycemic and lipid outcomes in admitted diabetes mellitus patients.

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The Effectiveness of Young Coconut Water and Watermelon Juice in Reducing Blood Pressure

10.53350/pjmhs211551313 ◽

2021 ◽

Vol 15 (5) ◽

pp. 1313-1322

Author(s):

S. Fadlilah ◽

A. Sucipto

Keyword(s):

Blood Pressure ◽

Nursing Students ◽

Coconut Water ◽

Control Group ◽

P Value ◽

Test Results ◽

Watermelon Juice ◽

Post Test ◽

The Mean ◽

Pressure Analysis

Background: Blood pressure is influenced by psychosocial (stress), genetic, age, gender, nutritional status, and lifestyle (diet, lack of fiber consumption, smoking, lack of physical activity). 30 ml of young coconut water contains 61 mg of potassium, 5.45 mg of sodium, and 1.3 mg of sugar, affecting blood pressure changes. Coconut water contains K minerals and is useful for lowering blood pressure. Whereaswatermelon contains anti-hypertensive content, namely sodium, beta carotene, and potassium. Watermelon is rich in water, amino acids, L-arginine, which can maintain healthy blood pressure. Aim: This study aims to determine the effect of young coconut water and watermelon juice on blood pressure in the 2013 nursing students of Respati University Yogyakarta. Methods: This type of research is a quasi-experimental design with a nonequivalent control group pre and post-test. The sample was taken by simple random sampling, namely the control group (18 respondents), the young coconut water group (18 respondents), and papaya juice (18 respondents). Data pre-posttest of each group was tested using Paired T-test. The comparison control-treatment group was tested using an independent-test. Results: The mean differences of systole and diastole pre-posttest blood pressure in the control group were -1.8 mmHg and -1.0 mmHg. The mean difference in systole blood pressure and the pre-posttest diastole of young coconut water groups were -3.1mmHg and -2.4 mmHg. The mean systole and diastole blood pressure in the pre-posttest watermelon juice group were -2.9 mmHg and -1.5 mmHg. The pre-posttest results of systole and diastole blood pressure analysis in the p-value control group were 0.100 and 0.450. The pre-post test results of systole and diastole blood pressure analysis of young coconut water groups gained p-value of 0.030 and 0.194. The pre-post test results of the juice watermelon group's systole and diastole blood pressure analysis gained p-value of 0.032 and 0.181. The posttest results of systole and diastole blood pressure analysis in the control group and young coconut water gained p-value of 0.014 and 0.157. The post-test results of the systole and diastole blood pressure analysis control group and juice watermelon gained p-value of 0.013 and 0.420. Conclusion: Consumption of young coconut water and watermelon juice affects systole blood pressure, but it does not affect diastole blood pressure in nursing students in 2013 in Respati University Yogyakarta. Keyword: Blood pressure, Coconut Water, Watermelon Juice

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Effect of an early mobilisation programme on pain intensity after laparoscopic surgery: a randomised clinical trial

BMJ Supportive & Palliative Care ◽

10.1136/bmjspcare-2020-002618 ◽

2020 ◽

pp. bmjspcare-2020-002618

Author(s):

Azam Dehghani ◽

Ali Hajibagheri ◽

Ismail Azizi-Fini ◽

Fatemeh Atoof ◽

Noushin Mousavi

Keyword(s):

Clinical Trial ◽

Laparoscopic Surgery ◽

Pain Intensity ◽

Repeated Measures ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Early Mobilisation ◽

Repeated Measures Analysis ◽

The Mean

BackgroundPain is a common complication after laparoscopic surgery. This study aimed to examine the effect of an early mobilisation programme on postoperative pain intensity after laparoscopic surgery.MethodsA randomised controlled clinical trial was conducted on 80 patients who underwent laparoscopic surgery in Shahid Beheshti Hospital in Kashan, Iran. The patients were randomly allocated to intervention (n=40) and a control (n=40) group. In the intervention group, an early mobilisation programme was implemented in two rounds. The patient’s perceived pain was assessed using a Visual Analogue Scale 15 min before and 30 min after each round of early mobilisation. Data were analysed through the independent samples t, χ2 and Fisher’s exact tests and the repeated measures analysis.ResultsThe repeated measures analysis showed that the mean pain scores have been decreased over time (F=98.88, p<0.001). Considering the observed interaction between time and the intervention, the t test was used for pairwise comparisons and showed that the mean pain score was not significantly different between the two groups in 15 min before the first round of early mobilisation (p=0.95). However, the mean pain in the intervention group was significantly less than the control group in all subsequent measurements (p<0.05).ConclusionEarly mobilisation programmes such as the one implemented in the current study are easy and inexpensive and can be implemented safely for the reduction of pain after laparoscopic surgeries.

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Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension

Journal of Neurosurgery Pediatrics ◽

10.3171/2009.1.peds08319 ◽

2009 ◽

Vol 4 (1) ◽

pp. 40-46 ◽

Cited By ~ 124

Author(s):

Gad Bar-Joseph ◽

Yoav Guilburd ◽

Ada Tamir ◽

Joseph N. Guilburd

Keyword(s):

Blood Pressure ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Intracranial Pressure ◽

Intracranial Hypertension ◽

Repeated Measures ◽

Intervention Group ◽

Decrease Blood Pressure ◽

Group 2 ◽

Group 1

Object Deepening sedation is often needed in patients with intracranial hypertension. All widely used sedative and anesthetic agents (opioids, benzodiazepines, propofol, and barbiturates) decrease blood pressure and may therefore decrease cerebral perfusion pressure (CPP). Ketamine is a potent, safe, rapid-onset anesthetic agent that does not decrease blood pressure. However, ketamine's use in patients with traumatic brain injury and intracranial hypertension is precluded because it is widely stated that it increases intracranial pressure (ICP). Based on anecdotal clinical experience, the authors hypothesized that ketamine does not increase—but may rather decrease—ICP. Methods The authors conducted a prospective, controlled, clinical trial of data obtained in a pediatric intensive care unit of a regional trauma center. All patients were sedated and mechanically ventilated prior to inclusion in the study. Children with sustained, elevated ICP (> 18 mm Hg) resistant to first-tier therapies received a single ketamine dose (1–1.5 mg/kg) either to prevent further ICP increase during a potentially distressing intervention (Group 1) or as an additional measure to lower ICP (Group 2). Hemodynamic, ICP, and CPP values were recorded before ketamine administration, and repeated-measures analysis of variance was used to compare these values with those recorded every minute for 10 minutes following ketamine administration. Results The results of 82 ketamine administrations in 30 patients were analyzed. Overall, following ketamine administration, ICP decreased by 30% (from 25.8 ± 8.4 to 18.0 ± 8.5 mm Hg) (p < 0.001) and CPP increased from 54.4 ± 11.7 to 58.3 ± 13.4 mm Hg (p < 0.005). In Group 1, ICP decreased significantly following ketamine administration and increased by > 2 mm Hg during the distressing intervention in only 1 of 17 events. In Group 2, when ketamine was administered to lower persistent intracranial hypertension, ICP decreased by 33% (from 26.0 ± 9.1 to 17.5 ± 9.1 mm Hg) (p < 0.0001) following ketamine administration. Conclusions In ventilation-treated patients with intracranial hypertension, ketamine effectively decreased ICP and prevented untoward ICP elevations during potentially distressing interventions, without lowering blood pressure and CPP. These results refute the notion that ketamine increases ICP. Ketamine is a safe and effective drug for patients with traumatic brain injury and intracranial hypertension, and it can possibly be used safely in trauma emergency situations.

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