scholarly journals Allelopathic and Cytotoxic Effects of Medicinal Plants on Vegetable Crop Pea (Pisum sativum)

CYTOLOGIA ◽  
2018 ◽  
Vol 83 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Sazada Siddiqui ◽  
Saad Alamri ◽  
Suleiman Al-Rumman ◽  
Mahmood Moustafa
Keyword(s):  
Medicinal Plants ◽  
Pisum Sativum ◽  
Vegetable Crop ◽  
Cytotoxic Effects

scholarly journals Antimicrobial and Cytotoxic Effects of Mexican Medicinal Plants

2011 ◽  
Vol 6 (12) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Maria del Rosario Jacobo-Salcedo ◽  
Angel Josabad Alonso-Castro ◽  
Luis A. Salazar-Olivo ◽  
Candy Carranza-Alvarez ◽  
Luis Ángel González-Espíndola ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Cytotoxic Effects ◽  
Antimicrobial Effects ◽  
Human Cancer Cell Lines ◽  
Guazuma Ulmifolia

The antimicrobial effects of the Mexican medicinal plants Guazuma ulmifolia, Justicia spicigera, Opuntia joconostle, O. leucotricha, Parkinsonia aculeata, Phoradendron longifolium, P. serotinum, Psittacanthus calyculatus, Tecoma stans and Teucrium cubense were tested against several human multi-drug resistant pathogens, including three Gram (+) and five Gram (-) bacterial species and three fungal species using the disk-diffusion assay. The cytotoxicity of plant extracts on human cancer cell lines and human normal non-cancerous cells was also evaluated using the MTT assay. Phoradendron longifolium, Teucrium cubense, Opuntia joconostle, Tecoma stans and Guazuma ulmifolia showed potent antimicrobial effects against at least one multidrug-resistant microorganism (inhibition zone > 15 mm). Only Justicia spicigera and Phoradendron serotinum extracts exerted active cytotoxic effects on human breast cancer cells (IC50≤30 μg/mL). The results showed that Guazuma ulmifolia produced potent antimicrobial effects against Candida albicans and Acinetobacter lwoffii, whereas Justicia spicigera and Phoradendron serotinum exerted the highest toxic effects on MCF-7 and HeLa, respectively, which are human cancer cell lines. These three plant species may be important sources of antimicrobial and cytotoxic agents.

Trypanocidal and Cytotoxic Effects of 30 Ethiopian Medicinal Plants

2011 ◽  
Vol 66 (11-12) ◽  
pp. 541-546 ◽  
Author(s):  
Endalkachew Nibret ◽  
Michael Wink
Keyword(s):  
Medicinal Plants ◽  
Trypanosoma Brucei ◽  
Human Cells ◽  
Chenopodium Ambrosioides ◽  
Meoh Extract ◽  
Trypanosoma Brucei Brucei ◽  
Promising Candidate ◽  
Cytotoxic Effects ◽  
Low Toxicity ◽  
Human Leukaemia

Trypanocidal and cytotoxic effects of traditionally used medicinal plants of Ethiopia were evaluated. A total of 60 crude plant extracts were prepared from 30 plant species using CH2Cl2 and MeOH. Effect upon cell proliferation by the extracts, for both bloodstream forms of Trypanosoma brucei brucei and human leukaemia HL-60 cells, was assessed using resazurin as vital stain. Of all CH2Cl2 and MeOH extracts evaluated against the trypanosomes, the CH2Cl2 extracts from five plants showed trypanocidal activity with an IC50 value below 20 μg/mL: Dovyalis abyssinica (Flacourtiaceae), IC50 = 1.4 μg/mL; Albizia schimperiana (Fabaceae), IC50 = 7.2 μg/mL; Ocimum urticifolium (Lamiaceae), IC50 = 14.0 μg/mL; Acokanthera schimperi (Apocynaceae), IC50 = 16.6 μg/mL; and Chenopodium ambrosioides (Chenopodiaceae), IC50 = 17.1 μg/mL. A pronounced and selective killing of trypanosomes with minimal toxic effect on human cells was exhibited by Dovyalis abyssinica (CH2Cl2 extract, SI = 125.0; MeOH extract, SI = 57.7) followed by Albizia schimperiana (CH2Cl2 extract, SI = 31.3) and Ocimum urticifolium (MeOH extract, SI = 16.0). In conclusion, the screening of 30 Ethiopian medicinal plants identified three species with good antitrypanosomal activities and low toxicity towards human cells. Dovyalis abyssinica might be a promising candidate for phytotherapy of trypanosomiasis

Phytochemical and Pharmacological Properties of Catharanthus roseus (Vinca)

2021 ◽  
Vol 1 (4) ◽  
pp. 429-434
Author(s):  
Gautam Kumar ◽  
Ravi Kumar ◽  
Girendra Kumar Gautam ◽  
Harshit Rana
Keyword(s):  
Medicinal Plants ◽  
Catharanthus Roseus ◽  
Essential Role ◽  
Pharmacological Properties ◽  
Clinical Use ◽  
Vinca Alkaloids ◽  
Cancer Disease ◽  
Cytotoxic Effects ◽  
Vinca Rosea

Vinca alkaloids obtained from Madagascar are a subset of drugs. Generally, they are naturally extracted from the Vinca rosea plant, Catharanthus roseus G, Don and show hyperglycemia activity as well as cytotoxic effects. It is used to treat various diseases such as diabetes, hypertension, cancer, asthma, inflammation, malaria, angiogenesis, brain imbalance, dysentery, and is also used as a disinfectant that occurs due to potent microorganisms. The vinca alkaloids are played an essential role to fight cancer disease. There are some major vinca alkaloids in clinical use: Vinblastin, Vincristine, Vindesine, tabersonine, vinorelbine, and Vinpocetine, etc. The flowers juice of Vinca rosea is utilized to treat several skin problems e.g. acne, eczema, and dermatitis. According to our opinion that it may be help scientists, ayurvedic practitioners, pharmacognosists, botanists, researchers, and students who are active in the field of medicinal plants research.

scholarly journals In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso

2013 ◽  
Vol 2 (1) ◽  
Author(s):  
Souleymane Sanon ◽  
Adama Gansane ◽  
Lamoussa P. Ouattara ◽  
Abdoulaye Traore ◽  
Issa N. Ouedraogo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Burkina Faso ◽  
Cytotoxic Effects ◽  
Antimalarial Agents ◽  
Potential Source ◽  
Crude Extracts ◽  
Cordia Myxa ◽  
Phytochemical Studies ◽  
Western Burkina Faso

Background: Resistance of malaria parasites to existing drugs complicates treatment, but an antimalarial vaccine that could protect against this disease is not yet available. It is therefore necessary to find new effective and affordable medicines. Medicinal plants could be a potential source of antimalarial agents. Some medicinal plants from Burkina Faso were evaluated for their antiplasmodial and cytotoxic properties in vitro.Methods: Crude dichloromethane, methanol, water-methanol, aqueous and alkaloids extracts were prepared for 12 parts of 10 plants. Chloroquine-resistant malaria strain K1 was used for the in vitro sensibility assay. The Plasmodium lactacte dehydrogenase technique was used to determine the 50% inhibitory concentration of parasites activity (IC50). The cytotoxic effects were determined with HepG2 cells, using the tetrazolium-based colorimetric technique, and the selectivity index (SI) was calculated.Results: Sixty crude extracts were prepared. Seven extracts from Terminalia avicenoides showed IC50 < 5 µg/mL. The IC50 of dichloromethane, methanol, aqueous and alkaloids extracts ranged between 1.6 µg/mL and 4.5 µg/mL. Three crude extracts from Combretum collinum and three from Ficus capraefolia had an IC50 ranging between 0.2 µg/mL and 2.5 µg/mL. Crude extracts from these three plants had no cytotoxic effect, with SI > 1. The other plants have mostly moderate or no antimalarial effects. Some extracts from Cordia myxa, Ficus capraefolia and Opilia celtidifolia showed cytotoxicity, with an SI ranging between 0.4 and 0.9.Conclusion: Our study showed a good antiplasmodial in vitro activity of Terminalia avicenoides, Combretum collinum and Ficus capraefolia. These three plants may contain antiplasmodial molecules that could be isolated by bio-guided phytochemical studies. 

scholarly journals Phytochemical Screening of Medicinal Plants and Study of the Effect of Phytoconstituents in Seed Germination

2020 ◽  
Vol 35 (2) ◽  
pp. 1-11
Author(s):  
Tinky Sharma ◽  
Binjita Pandey ◽  
Bishnu Kumar Shrestha ◽  
Gayatri Maiya Koju ◽  
Rojeena Thusa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Seed Germination ◽  
Medicinal Plants ◽  
Pisum Sativum ◽  
Cytotoxic Effect ◽  
Methanol Extract ◽  
Living Cells ◽  
Phytochemical Screening ◽  
Volatile Oils ◽  
Plant Parts

 Phytochemical screening of ten different locally available plant parts was done in methanol extract. Tannin, quinine, terpenoid, flavonoid, steroid, alkaloid, cardiac glycoside, glycoside, volatile oils, etc were the phytoconstituents found in plants. The study of the effect of phytoconstituents in the germination of Pisum sativum seeds revealed that the phytoconstituents present in plant extracts showed the cytotoxic effect in living cells i.e. in germinating Pisum sativum seeds. The phytoconstituents present in the plant extract showed an effect on cell proliferation and growth. Hence these plants could be used to develop drugs against cancer cells and also may be effective against microbes and bacteria

In vitro Cytotoxic Effects and Antibacterial Activity of Moroccan Medicinal Plants Aristolochia longa and Lavandula multifida

2016 ◽  
Vol 16 (2) ◽  
pp. 1-13 ◽  
Author(s):  
Mhamed Aneb ◽  
Ahmed Talbaoui ◽  
Abdelhakim Bouyahya ◽  
Houria Boury ◽  
Saaïd Amzazi ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Cytotoxic Effects
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