Starting and finishing a cardiac case: Sternotomy, hemostasis, and closure

2021 ◽  
Keyword(s):  
Mortality And Morbidity ◽  
Educational Videos ◽  
Cardiothoracic Surgeon ◽  
Significant Mortality

The cardiac multimedia literature is abundant, but a significant gap exists in educational videos demonstrating routine essential steps such as the sternotomy or the closure. These components are common and carry significant mortality and morbidity should a sternal complication occur, highlighting the importance for the cardiothoracic surgeon to master these steps.

scholarly journals Defence Medical Rehabilitation Centre (DMRC) COVID-19 Recovery Service

2021 ◽  
pp. e001681
Author(s):  
Oliver O'Sullivan ◽  
R Barker-Davies ◽  
R Chamley ◽  
E Sellon ◽  
D Jenkins ◽  
...  
Keyword(s):  
Occupational Medicine ◽  
Armed Forces ◽  
Acute Illness ◽  
Medical Rehabilitation ◽  
Rehabilitation Centre ◽  
Operational Effectiveness ◽  
Mortality And Morbidity ◽  
Recovery Service ◽  
Significant Mortality

Coronavirus disease 2019 (COVID-19) causes significant mortality and morbidity, with an unknown impact in the medium to long term. Evidence from previous coronavirus epidemics indicates that there is likely to be a substantial burden of disease, potentially even in those with a mild acute illness. The clinical and occupational effects of COVID-19 are likely to impact on the operational effectiveness of the Armed Forces. Collaboration between Defence Primary Healthcare, Defence Secondary Healthcare, Defence Rehabilitation and Defence Occupational Medicine resulted in the Defence Medical Rehabilitation Centre COVID-19 Recovery Service (DCRS). This integrated clinical and occupational pathway uses cardiopulmonary assessment as a cornerstone to identify, diagnose and manage post-COVID-19 pathology.

Postvaricella Acute Transverse Myelitis: A Case Presentation and Review of the Literature

PEDIATRICS ◽  
1978 ◽  
Vol 62 (2) ◽  
pp. 202-204
Author(s):  
John T. McCarthy ◽  
Jules Amer
Keyword(s):  
Transverse Myelitis ◽  
Sensory Loss ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Mortality And Morbidity ◽  
Acute Transverse Myelitis ◽  
Significant Mortality

Although the complications and sequelae of varicella are rare, they can cause significant mortality and morbidity in both the normal and compromised patient. Eight cases of "pure" acute transverse myelitis (ATM) following varicella have previously been reported in the literature. We report the ninth case of postvaricella ATM in a 9-year-old girl. Her course was characterized by paraplegia, sensory Loss, hvperesthesia, and incontinence of urine and feces. All patients, except ours, recovered fully from ATM.

scholarly journals Abdominal surgery in autoimmune and autoimmune-related diseases: A review

2021 ◽  
Vol 6 (2) ◽  
pp. 76-87
Author(s):  
Erdal Uysal ◽  
◽  
Mehmet Dokur ◽  
Gokturk Maralcan
Keyword(s):  
Autoimmune Disease ◽  
Early Detection ◽  
Abdominal Surgery ◽  
Autoimmune Diseases ◽  
High Mortality ◽  
Indirect Effects ◽  
Mortality And Morbidity ◽  
Abdominal Organs ◽  
The Relationship ◽  
Significant Mortality

Autoimmune diseases can have a widespread effect throughout the system and can cause high mortality and morbidity, depending on their involvement in the abdominal organs and systems. Most of the abdominal organs are damaged as a result of the direct or/ and indirect effects of autoimmune diseases. Therefore, abdominal surgeries should be performed to eliminate any complications related to these effects. There could be a significant relationship between abdominal surgery and autoimmune and autoimmune-related diseases. The aim of this study was to reveal the possible relationship between autoimmune and autoimmune-related diseases that cause significant mortality and morbidity. In this way, we further aimed at increasing the awareness of clinicians on this subject, along with providing them with the related publications on autoimmune and autoimmune-related diseases and abdominal surgery. Taking all these into consideration, autoimmune and autoimmune-related diseases can also influence the abdominal organs. The influence may be directly related to the involvement of the organ and system as a result of the autoimmune disease or indirectly related to the influence of the organs and systems. Such influence leading to complications may require urgent or elective abdominal surgery, which can further cause high mortality and morbidity. Therefore, it is significant for all clinicians, especially surgeons, to be aware of the relationship between autoimmune diseases and abdominal surgery. The early detection and treatment of the complications related to the abdominal involvement of autoimmune and autoimmune-related diseases could decrease mortality and morbidity.

scholarly journals Assessment of severity of acute pancreatitis over time

2020 ◽  
Vol 58 (2) ◽  
pp. 47-54 ◽  
Author(s):  
Florina-Alexandra Cofaru ◽  
Silvia Nica ◽  
Carmen FierbinȚeanu-Braticevici
Keyword(s):  
Acute Pancreatitis ◽  
Healthcare Systems ◽  
Optimal Management ◽  
Mortality And Morbidity ◽  
Global Consensus ◽  
Treatment Techniques ◽  
Severity Scores ◽  
Technological Developments ◽  
Improve Hospital ◽  
Significant Mortality

AbstractIn recent years there has been an increase in the incidence of acute pancreatitis worldwide. In spite of efforts to improve the treatment and care of patients with acute pancreatitis, to develop imaging investigations and interventional diagnostic and treatment techniques and to facilitate patients’ access to them, acute pancreatitis continues to be associated with significant mortality and morbidity, and the treatment of patients suffering from this disease entails significant costs for healthcare systems.Researchers are in a permanent quest to get to a global consensus for stratifying the severity of acute pancreatitis. We need this in order to offer the proper management for each patient diagnosed with this condition and to improve hospital and health system strategies.Over the years, it has been attempted to develop algorithms to support a swift assessment of patients with acute pancreatitis with a prediction of disease severity as close to reality as possible for optimal management. This has led to the development of classifications of severity and severity scores. These require a permanent updating to keep up with the technical and technological developments involved in investigating and treating the patient and encompassing the most recent studies.The goal of this paper is to go through these classifications and scores, emphasizing factors that should be taken into account, and reflecting upon their utility and upon the necessity of improving them.

scholarly journals Duplex TaqMan Hydrolysis Probe-Based Molecular Assay for Simultaneous Detection and Differentiation of Burkholderia pseudomallei and Leptospira spp. DNA

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Mohammad Ridhuan Mohd Ali ◽  
Lee Lih Huey ◽  
Phiaw Chong Foo ◽  
Yuan Xin Goay ◽  
Asmaliza S. Ismail ◽  
...  
Keyword(s):  
Burkholderia Pseudomallei ◽  
Simultaneous Detection ◽  
Qpcr Assay ◽  
Taqman Probe ◽  
Molecular Assay ◽  
Mortality And Morbidity ◽  
Leptospira Spp ◽  
Clinical Consequences ◽  
Reference Strains ◽  
Significant Mortality

Melioidosis and leptospirosis, caused by two different bacteria, Burkholderia pseudomallei and Leptospira spp., are potentially fatal infections that share a very similar spectrum of clinical features and cause significant mortality and morbidity in humans and livestock. Early detection is important for better clinical consequences. To our knowledge, there is no diagnostic tool available to simultaneously detect and differentiate melioidosis and leptospirosis in humans and animals. In this study, we described a duplex TaqMan probe-based qPCR for the detection of B. pseudomallei and Leptospira spp. DNA. The performance of the assay was evaluated on 20 B. pseudomallei isolates, 23 Leptospira strains, and 39 other microorganisms, as well as two sets of serially diluted reference strains. The duplex qPCR assay was able to detect 0.02 pg (~ 4 copies) Leptospira spp. DNA and 0.2 pg (~ 25.6 copies) B. pseudomallei DNA. No undesired amplification was observed in other microorganisms. In conclusion, the duplex qPCR assay was sensitive and specific for the detection of B. pseudomallei & Leptospira spp. DNA and is suitable for further analytical and clinical evaluation.

Recurrent Aortoenteric Fistula: Two Different Bridge Solutions

Vascular ◽  
2007 ◽  
Vol 15 (4) ◽  
pp. 235-237 ◽  
Author(s):  
Emiliano Chisci ◽  
Gianmarco de Donato ◽  
Francesco Setacci ◽  
Andrea Stella ◽  
Carlo Setacci
Keyword(s):  
Aortoenteric Fistula ◽  
Mortality And Morbidity ◽  
In Situ Replacement ◽  
Endovascular Grafting ◽  
Significant Mortality

A “recurrent” aortoenteric fistula (AEF) is very rare and in literature anecdotic. Currently, graft excision and extra-anatomic bypass are considered the treatments of choice, but are associated with significant mortality and morbidity. Herein, we describe the case of a “recurrent” AEF treated before definitive extra-anatomic bypass, by two different, staged bridge solutions: allograft in situ replacement and endovascular grafting. At 1, 3 and 6-month follow-up, the patient was asymptomatic and normally active.

Alcohol: Preventing Harmful Drinking

2011 ◽  
Vol 4 (11) ◽  
pp. 634-639 ◽  
Author(s):  
Matthew David Gee
Keyword(s):  
Alcohol Consumption ◽  
Early Identification ◽  
Brief Interventions ◽  
High Alcohol ◽  
Social Harm ◽  
Mortality And Morbidity ◽  
High Alcohol Consumption ◽  
Ideal Position ◽  
The Uk ◽  
Significant Mortality

Alcohol is more harmful than any other drug overall, when physical, psychological and social harm are taken into account. There were 8664 alcohol-related deaths in the UK in 2009. Every GP is estimated to see around 364 heavy drinkers every year and will see more who are drinking less heavily but whose alcohol consumption is still putting their health at risk. GPs are therefore in an ideal position to prevent the significant mortality and morbidity associated with high alcohol consumption. This can be done by early identification of those who are drinking more than is healthy and by providing brief interventions before drinking becomes harmful.

Acutely Bleeding Aortoduodenal Fistula: Staged Endovascular and Open Surgical Repair

Vascular ◽  
2009 ◽  
Vol 17 (4) ◽  
pp. 197-200 ◽  
Author(s):  
Pavlos Antoniadis ◽  
George Geropapas ◽  
Ekaterini Kounougeri ◽  
Dimitrios Staramos ◽  
Alexios Kalamaras ◽  
...  
Keyword(s):  
Surgical Repair ◽  
Upper Gastrointestinal Hemorrhage ◽  
Aortic Reconstruction ◽  
Aortoduodenal Fistula ◽  
Open Surgical Repair ◽  
Fatal Complication ◽  
Mortality And Morbidity ◽  
Reconstruction Surgery ◽  
Upper Gastrointestinal ◽  
Significant Mortality

Secondary aortoduodenal fistula is an uncommon but potentially fatal complication that can occur after aortic reconstruction surgery and usually presents with upper gastrointestinal hemorrhage. Taking into account the accompanying multiple comorbidities of those patients, conventional open surgical repair carries with it significant mortality and morbidity rates. The purpose of this case report is to describe the successful combined endovascular and open surgical repair of an acutely ruptured aortoduodenal fistula in a 67-year-old male patient. Four months after the procedure, the patient remains well.

scholarly journals Fragment-based approaches to TB drugs

Parasitology ◽  
2016 ◽  
Vol 145 (2) ◽  
pp. 184-195 ◽  
Author(s):  
CHIARA MARCHETTI ◽  
DANIEL S. H. CHAN ◽  
ANTHONY G. COYNE ◽  
CHRIS ABELL
Keyword(s):  
Infectious Disease ◽  
Developing Countries ◽  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis ◽  
High Quality ◽  
Mortality And Morbidity ◽  
Pharmaceutical Development ◽  
Resistant Strains ◽  
Drug Leads ◽  
Significant Mortality

SUMMARYTuberculosis is an infectious disease associated with significant mortality and morbidity worldwide, particularly in developing countries. The rise of antibiotic resistance in Mycobacterium tuberculosis (Mtb) urgently demands the development of new drug leads to tackle resistant strains. Fragment-based methods have recently emerged at the forefront of pharmaceutical development as a means to generate more effective lead structures, via the identification of fragment molecules that form weak but high quality interactions with the target biomolecule and subsequent fragment optimization. This review highlights a number of novel inhibitors of Mtb targets that have been developed through fragment-based approaches in recent years.

scholarly journals Serum calcium levels in newly detected essential hypertensive patients

2021 ◽  
Vol 8 (10) ◽  
pp. 1539
Author(s):  
Arumugam Aashish ◽  
Jayasingh Kannaiyan
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Serum Calcium ◽  
Systemic Hypertension ◽  
Total Serum ◽  
Newly Diagnosed ◽  
Mortality And Morbidity ◽  
Total Serum Calcium ◽  
The Mean ◽  
Significant Mortality

Background: Systemic hypertension is global disease responsible for significant mortality and morbidity. Essential or primary hypertension accounts for the majority of people with hypertension. Although our understanding of the pathophysiology of essential hypertension has grown a lot, its aetiology still remains hypothetical. Few studies in literature have found some correlation with serum calcium levels and blood pressure of the individuals.Methods: A total 200 patients, 100 newly diagnosed essential hypertensive and 100 normotensive patients were included in the study. A detailed history and clinical profile was taken. Blood sample was collected and serum calcium, serum albumin were determined and corrected calcium was calculated and the results were tabulated and appropriate statistical analysis was done.Results: The mean total serum calcium and corrected calcium levels were significantly lowered in essential hypertensive compared to the normotensive individuals. There was no correlation between total serum and corrected calcium levels against systolic and diastolic blood pressure. There was also no difference in serum total and corrected calcium levels among different subsets in essential hypertensive group.Conclusion: Essential hypertension still remains the most common form of hypertension present worldwide causing significant mortality and morbidity. Despite increased advances in medicine and large number of studies done in context with the cause of essential hypertension, its aetiology still remains hypothetical. Even though studies have shown some correlation of calcium fractions with hypertension, the aetiology is still unclear.

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